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1. Scientific Brochure: Sinupret/forte for Sinusitis and Inflammation of the Respiratory Tract. Neumarkt, Germany: Bionorica; January 2002.

2. Top phytopharmaceuticals in Germany. London: IMS Pharmatrend International; 2006-2008.

3. Sinupret use in Germany: IMS Pharmatrend International; 2003.

4. Bionorica. Alcohol in phytopharmaceutical products/food supplements. Personal Communication. Feburary 2 2008.

5. Brand N. Alkohol in Arzneimittein [In German]. Deutsche Apotheker Zeitung. 1996;136(4):25-32.

6. Blumenthal M, Goldberg A, Brinckmann J, eds. Herbal Medicine. Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000.

7. Bradley PR, ed. British Herbal Compendium. Bournemouth: British Herbal Medicine Association; 1992; No. 1.

8. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. 2nd ed. New York: John Wiley & Sons, Inc.; 1996.

9. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press; 1996.

10. Wichtl M, Bisset NG, eds. Herbal Drugs and Phytopharmaceuticals. Stuttgart: Medpharm Scientific Publishers; 1994.

11. Blumenthal M, Busse WR, Goldberg A, et al., eds. The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. Austin, TX: American Botanial Council; 1998.

12. Schwartner C. Chemical and pharmacological investigations on Rumex Acetosa L. Phytomed. 1996;1:146.

13. Choe S, Hwang B, Kim M, al. e. Chemical components of Rumex acetellosa L. Korean J Pharmacog. 1998;29:209-216.

14. Ulbricht CE, Basch EM, eds. Natural Standard Herb & Supplement Reference: Evidence-Based Clinical Reviews. St Louis, MO: Elsevier Mosby; 2005.

15. Recio MC, Giner RM, Manez S, Rios JL. Structural considerations on the iridoids as anti-inflammatory agents. Planta Med. Jun 1994;60(3):232-234.

16. Speroni E, Cervellati R, Costa S, et al. Effects of differential extraction of Verbena officinalis on rat models of inflammation, cicatrization and gastric damage. Planta Med. Mar 2007;73(3):227-235.

17. Casanova E, Garcia-Mina JM, Calvo MI. Antioxidant and antifungal activity of Verbena officinalis L. leaves. Plant Foods Hum Nutr. Sep 2008;63(3):93-97.

18. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris: Lavoisier Publishing; 1995.

19. ESCOP. Gentianae radix. Monographs on the Medicinal Uses of Plant Drugs. Exeter, UK: European Scientific Cooperative on Phytotherapy; 1997.

20. Maune S, Schubert S, Schafer D. Antimicrobial effects of a herbal medicinal product--a better understanding of host-defense mechanisms. Paper presented at: World Allergy Congress; June 26-July 1, 2005; Munich, Germany.

21. Glatthaar B, Hämmerle H. Neumarkt, Germany: Bionorica; 1995.

22. Ismail C. Pharmacology of Sinupret. Recent results on the rational for the Sinupret compound [In German]. HNO. 2005;53(Suppl 1):S38-42.

23. Schmolz M, Ottendorfer D, Marz RW, Sieder C. Enhanced resistance to Sendai virus infection in DBA/2J mice with a botanical drug combination (Sinupret). Int Immunopharmacol. Sep 2001;1(9-10):1841-1848.

24. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Phytotherapy. 1999;149:202-208.

25. Curle P, Fraimbault V. The secretolytic action of herbal drugs assessed by the phenol red secretion test new data for old herbal drugs and a combination. Paper presented at: 4th and International Congress on Phytotherapy.; Sept 10-13, 1992; Munich, Germany.

26. Schmolz M. Immunological features of extracts from Radix Gentianae, Flores Primulae, Flores Sambuci, Herba Verbenae, and Herba Rumicis as well as from a combination hereof (Sinupret). Paper presented at: 4th and International Congress on Phytotherapy; Sept 10-13, 1992; Munich, Germany.

27. Farinacci M, Colitti M, Sgorlon S, Stefanon B. Immunomodulatory activity of plant residues on ovine neutrophils. Vet Immunol Immunopathol. Jun 28 2008.

28. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med. Feb 9 1989;320(6):365-376.

29. Stierna P, Tcacencu I, Georen S, Berglof A, Sanstedt K. Positive effect of antiinflammatory treatment in a murine model of bacterial rhinosinusitis. Paper presented at: 19th Congress of the European Rhinologic Society (ERS) and the XXIIth I.S.I.A.N, 2002; Ulm, Germany.

30. Tcacencu I, Sanstedt K, Ismail C, Stierna P. Anti-inflammatory effect of an herbal combination preparation in a murine model of bacterial rhinosinusitis. Paper presented at: Phytopharmaka und Phytotherapie-Forschung und Praxis; Oct 10-12, 2002; Berlin, Germany.

31. Company Core Data Sheet. Neumarkt, Germany: Bionorica; 2008.

32. Ismail C, Wiesel A, Marz RW, Queisser-Luft A. Surveillance study of Sinupret in comparison with data of the Mainz birth registry. Arch Gynecol Obstet. Feb 2003;267(4):196-201.

33. Heifetz SA. The umbilical cord: obstetrically important lesions. Clin Obstet Gynecol. Sep 1996;39(3):571-587.

34. EUROCAT. Surveillance of congenital anomalies (1980-1994). Brussels: Scientific Institute of Public Health-Louis Pasteur; 1997.

35. Lynberg MC, Edmonds LD. Surveillance of birth defects. New York: Van Norstrand Reinhold; 1992.

36. Itingen R. 14 range-finding study with Sinupret mixture of active ingredients in the rat. Neumarkt: Plantamed Arzneimittel Gmbh; 1998.

37. Walsrode IFG. Fertility Study with 20-day sacrifice in male and female Wistar rats treated orally with “Sinupret Liquidum” and “Sinupret Dragees. Neumarkt: Bionorica Arzneimittel GmbH; 1991.

38. Walsrode IFG. Teratogenicity study on “Sinupret Liquidum” and “Sinupret Drageekerne” by oral application to Wistar rats. Neumarkt: Bionorica Arzneimittel GmbH; 1985.

39. Richold M, Jones E, Fenner LA. Ames metabolic activation test to assess the potential mutagenic effect of Sinupret. Huntington Research Centre, Cambridgeshire England. Neumarkt: Bionorica Arzneimittel GmbH; 1983.

40. CCR R. In vivo/in vitro unscheduled DNA synthesis in rat hepatocytes with Sinupret-mixture of active ingredients. Neumarkt: Plantamed Arzneimittel GmbH; 1998.

41. Bionorica. Internal communication.; 2008.

42. Ernst E, Marz RW, Sieder C. Acute bronchitis- benefits of Sinupret. Comparative post-marketing surveillance study involving 3,187 patients. Fortschritte Der Medizin. 1997;115:3-7.

43. Ernst E, Sieder C, Marz RW. Adverse drug reactions to herbal and synthetic expectorants. Inter J Risk Safety Med. 1995;7:219-225.

44. Guo R, Canter PH, Ernst E. Herbal medicines for the treatment of rhinosinusitis: a systematic review. Otolaryngol Head Neck Surg. Oct 2006;135(4):496-506.

45. Neubauer N, Marz RW. Placebo-controlled, randomized double-blind clincial trial with Sinupret sugar-coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomed. 1994;1:177-181.

46. Biebach K, Kramer A. Effective treatment of rhinosinusitis in children. Pad. 2004;10.

47. Kraus P, Schwender W. Randomized, open comaprative study with Sinupret sugar-coated tablets vs. Gelomyrtol F. conducted at the Germany army hospital in Amberg. Paper presented at: 4th and International Congress on Phytotherapy.; Sept 10-13, 1992; Munich, Germany.

48. Braum D, Marz RW. Randomised, open comparative study of Sinupret versus N-acetylcysteine in cases of sinusitis. Neumarkt, Germany: Bionorica; 1990.

49. Melzer J, Saller R, Schapowal A, Brignoli R. Systematic review of clinical data with BNO-101 (Sinupret) in the treatment of sinusitis. Forsch Komplementmed. Apr 2006;13(2):78-87.

50. Berghorn K, Langer W. Doppelblindstudies Sinupret tropfen vs. plazebo auf basis einer therapie mit antibiotikum und abschwellenden nasentropen bei akuter sinusitis.: Bundeswehrkrankenhaus Wildbad; 1990.

51. Simm KJ, Pape HJ. Doppelblindstudie Sinupret vs. Mucosolvan, mit/ohne abschwellendem nasenspray bei akuter sinusitis. Hamburg, Germany: Gemeinschaftspraxis; 1992.

52. Wahls M. Randomisierte kontrollierte doppelblindstudie Sinupret tropfen vs. Mucosolvan tropfen bei akuter sinusitis.: Bundeswehrkrankenhaus Detmold, Bundeswehrkrankenhaus Muchen; 1990.

53. Richstein A, Mann W. Treatment of chronic rhino-sinusitis with Sinupret. Schewiz Zschr GanzheitsMedizin. 1999;11(6):280-283.

54. Pinnow R, Egentenmaier J. Sinupret sugar-coated tablets vs Mucret resp. sinupret drops vs. Mucosolvan drops in uncomplicated acute (tracheo)-bronchitis. Paper presented at: 4th and International Congress of Phytotherapy; Sept 10-13, 1992; Munich, Germany.

55. Egentenmaier J, Marz RW. Double-blind study of Sinupret dorps versus Ambroxol drops in acute uncomplicated (tracheo-) bronchitis. Neumarkt, Germany: Bionorica; 1991.

56. Behr B, Marz RW. Post-marketing surveillance study in acute tracheo-bronchitis: synthetic secretolytics and mucolytics in comparison to a phytomedicine. Paper presented at: 4th and International Congress on Phytotherapy; Sept 10-13, 1992; Munich, Germany.