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DOSAGE AND DURATION OF ADMINISTRATION

DOSAGE AND DURATION OF ADMINISTRATION

Clinical trials on Sinupret were conducted on the commercial products available in Europe. The American products contain extracts of the same herbs in the same concentrations of those extracts, but the American products have different names, e.g., Sinupret® Plus/Sinupret® Adult Strength and Sinupret® Syrup for Kids. Also, the European liquid preparation for children contains alcohol (ethanol, 19% alcohol by volume) and the American syrup (Sinupret Syrup for Kids) contains a reduced amount (8% by volume or 0.56 mL per 7.0 mL serving). The manufacturer claims4 that there should be no effect on the blood alcohol content after taking Sinupret Syrup at the recommended doses. The company draws this conclusion from the fact that many common fruit juices contain naturally occurring ethanol (< 0.1-0.5% by volume) and that the intake of alcohol associated with Sinupret Syrup is comparable, or smaller, than the intake with fruit juice. Also, there are reports that show that blood alcohol concentrations after intake of very small amounts of alcohol are insignificant or irrelevant.5

Daily Dose in Clinical Trials:

The doses used in the clinical trials and reported in the Table of Clinical Trials (below) use the manufacturer’s recommended dose. All of the studies use the European products, namely:

Sinupret Sugar Coated tablets:

Adults—2 tablets, 3 times per day

Children ages 12 and older—1 tablet, 3 times per day

Sinupret Forte Sugar Coated tablets (Sinupret Plus/Sinupret Adult Strength):

Adults—1 tablet, 3 times per day

Sinupret Drops:

Adults—50 drops, 3 times per day

Children (6-12 years)—25 drops, 3 times per day

Children (2-6 years) —15 drops, 3 times per day

In clinical trials the duration of treatment varied from 7 to 21 days.

Manufacturer Dose Recommendations:

According to the manufacturer the dosing for the US products are as follows.

 

Sinupret Plus/Sinupret Adult Strength:

1 tablet, 3 times per day

 

Sinupret Syrup for Children:

2 to 5 years old— ½ teaspoon or 2.1 mL, 3 times per day

6 to 11 years old— ¾ teaspoon or 3.5 mL, 3 times per day

12 years or older—1½ teaspoons or 7.0 mL, 3 times per day