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CHEMISTRY

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Sinupret is an herbal preparation made from 5 herb extracts.

Sinupret Sugar Coated tablets contain elder flowers (powdered, 18 mg), primrose flowers with calyx (powdered, 18 mg), common sorrel herb (powdered, 18 mg), European vervain herb (powdered, 18 mg), and gentian root (powdered, 6 mg).

Sinupret Forte Sugar Coated tablets contain twice the concentration of Sinupret Sugar Coated tablets; specifically it contains the hydroethanolic extract of elder flowers (powdered, 36 mg), primrose flowers with calyx (powdered, 36 mg), common sorrel herb (powdered, 36 mg), European vervain herb (powdered, 36 mg), and gentian root (powdered, 12 mg).

Sinupret drops contain 29 g hydroethanolic extract (drug/extract ratio 1:11) from gentian root (cut), primrose flowers with calyx (cut), common sorrel herb (cut), elder flowers (cut), and European vervain herb (cut) in a 1:3:3:3:3 proportion. The extraction solution is 59% v/v ethanol, and the drops contain 19% of alcohol by volume.

Sinupret Plus/Sinupret Adult Strength contains hydroethanolic extracts of elder flowers (powdered, 36 mg), primrose flowers with calyx (powdered, 36 mg), common sorrel herb (powdered, 36 mg), European vervain herb (powdered, 36 mg), and gentian root (powdered, 12 mg).

Sinupret Syrup for Kids contains 10 g of a hydroethanolic extract (drug/extract ratio 1:11) from gentian root (cut), primrose flowers with calyx (cut), common sorrel herb (cut), elder flowers (cut), and vervain herb (cut) in a 1:3:3:3:3 proportion. The extraction solution is 59% v/v ethanol, and the drops contain 8% of alcohol by volume.

Elder flower (Sambucus nigra) contains flavonoids (up to 3%) composed mainly of flavonol glycosides (astragalin, hyperoside, isoquercitrin, and rutin up to 1.9%) and free aglycones (quercetin and kaempferol); minerals (8-9%), mainly potassium; phenolic compounds (approximately 3% chlorogenic acid); triterpenes (approximately 1%) including α- and β-amyrin; triterpene acids (approximately 0.85% ursolic and oleanolic acids); sterols (approximately 0.11%); volatile oils (0.03-0.3%) composed of approximately 66% free fatty acids (linoleic, linolenic, and palmitic acids) and approximately 7% alkanes; mucilage; pectin; plastocyanin (protein); sugar; tannins.6-10

Primrose (Primula officinalis) flowers with calyx contains numerous flavonoids (i.e. rutin and quercetin), carotinoids, and salicylic acid derivatives.1 The calyces also contain saponins.11

Common sorrel (Rumex acetosa) contains polysaccharides, ascorbic acid, oxalates (including calcium oxalate), tannins, anthranoids, aglycones, physcion, aloe-emodin, aloe-emodin acetate, emodin, rhein, quinoids, flavonoids (i.e. quercetin and glycosides), hydroxycinnamic acid derivatives (i.e. ferulic acids), and phenylpropanoid.1,12-14 All of the active compounds have not been identified.14 The leaves may contain 0.3% oxalate (oxalic acid) and 7-15% tannins.14

European vervain (Verbena officinalis) herb contains iridoid glycosides (i.e. verbenalin and hastatoside), triterpenic acids, sterols, caffeoyl derivatives (i.e. chlorogenic acid and verbascoside), hydroxycinnamic acid derivatives, bitter substances, and flavonoids.1,15-17 The aerial parts contain high amounts of ursolic acid and oleanolic acid and its derivatives.16 Vervain also contains volatile oil with citral, terpenes, and terpene alcohols.1

Gentian (Gentiana lutea) root contains secoiridoid bitter principles gentiopicroside (2-4%) and amarogentin (0.025-0.084%) [bitterness value=58,000,000]; oligosaccharides gentianose and gentiobiose (2.5-8.0%); (gentisic, caffeic, and protocatechuic) phenolic acids: phytosterols; polysaccharides inulin and pectin; tannin; lupiol and β-amyrin triterpenes; xanthones (approximately 0.1%), mainly gentisin, isogentisin, gentisein, and gentioside; and traces of volatile oil.6-10,18,19