DESCRIPTION
French maritime pine bark extract is made by extraction of the outer bark of P. pinaster Aiton subsp. atlantica. The French subspecies atlantica of P. pinaster differs from the Iberian (Spanish) and Moroccan subspecies by its resistance against salt1 and its profile of phytochemical constituents.2
Table 1. Abbreviations & Symbols Used in this Monograph
Abbreviation/ Symbol |
Full Name |
5-LOX |
5-lipoxygenase |
8-oxoG |
8-oxo-7,8-dihydroguanine |
ACE |
angiotensin converting enzyme |
ADHD |
attention deficit hyperactivity disorder |
ADRP |
adipose differentiation-related protein |
AEs |
adverse effects |
ALP |
alkaline phosphatase |
AMPK |
AMP-activated protein kinase |
AST |
aspartate aminotransferase |
ALT |
alanine aminotransferase |
BMI |
body mass index |
BP |
blood pressure |
CaMKII |
calcium/calmodulin-dependent protein kinase II |
CARR U |
Carratelli unit |
CAT |
catalase |
Cmax |
maximal observed plasma concentration |
COX-1 |
cyclooxygenase-1 |
COX-2 |
cyclooxygenase-2 |
CRP |
C-reactive protein |
Cu/Zn-SOD |
copper-zinc superoxide dismutase |
CVI |
chronic venous insufficiency |
DHEA |
dehydroepiandrosterone |
DNP |
dinitrophenyl |
E2 |
estradiol |
FEV1 |
forced expiratory volume |
FSH |
follicle-stimulating hormone |
GGT |
gamma-glutamyl transpeptidase |
g-IFN |
gamma-interferon |
GI |
gastrointestinal |
GLUT4 |
glucose transporter 4 |
GnRH-a |
gonadotropin releasing hormone antagonist |
GPx |
glutathione peroxidase |
GR |
glutathione reductase |
GRAS |
generally recognized as safe |
GSH |
glutathione |
GST |
glutathione-S-transferase |
H2O2 |
hydrogen peroxide |
HbA1c |
glycosylated hemoglobin |
HDL |
high-density lipoprotein |
ICAM-1 |
intercellular adhesion molecule-1 |
IGF-1 |
insulin-like growth factor 1 |
IGFBP-3 |
IGF binding protein 3 |
INR |
international normalized ratio |
iNOS |
inducible nitric oxide synthase |
IP |
intraperitoneally |
IQ |
intelligence quotient |
IQCODE |
Informant Questionnaire on Cognitive Decline in the Elderly |
IV |
intravenous |
LDL |
low-density lipoprotein |
L-NMMA |
NG-monomethyl-L-arginine |
LPS |
lipopolysaccharide |
M1 |
δ-(٣,٤-dihydroxy-phenyl)-g-valerolactone |
M2 |
δ-(٣-methoxy-٤-hydroxy-phenyl)-g-valerolactone |
MDA |
malondialdehyde |
MMPs |
matrix metalloproteinases |
MMP-1 |
collagenase 1 |
MMP-2 |
gelatinase A |
MMP-9 |
gelatinase B |
Mn-SOD |
manganese superoxide dismutase |
NK-κB |
nuclear-factor-kappaB |
NHP |
Natural Health Product |
NO |
nitric oxide |
NSAID |
non-steroidal anti-inflammatory drug |
OA |
osteoarthritis |
ORAC |
oxygen radical absorption capacity |
OTC |
over-the-counter |
pCO2 |
partial pressure of carbon dioxide |
PK |
pharmacokinetics |
PLA2 |
phospholipase A2 |
PMNL |
polymorphonuclear leukocytes |
pO2 |
partial pressure of oxygen |
ROS |
reactive oxygen species |
SOD |
superoxide dismutase |
TBARS |
thiobarbituric reactive substances |
TLR4 |
Toll-like receptor 4 |
tmax |
time to maximum plasma concentration |
USP |
United States Pharmacopoeia |
UV |
ultraviolet |
VCAM-1 |
vascular cell adhesion molecule-1 |
WHQ |
women’s health questionnaire |
WOMAC |
Western Ontario and McMaster Universities |
The fresh bark is powdered and extracted with 70% ethanol and 30% water in patented equipment allowing an automated continuous process.3 After purification of the raw extract, the aqueous solution of the extracted constituents is spray-dried. The resulting fine, brownish powder is stable for 3 years if stored in a dry, dark environment. The extract is standardized to contain 70 ± 5% procyanidins, which consist of condensed catechin and epicatechin.4