Styphnolobium japonicum, syn. Sophora japonica

Pretreatment with a polyherbal combination including Sophora japonica, Salvia rosmarinus, and Zingiber officinale upregulated Nrf2-dependent cytoprotective genes and increased cellular defenses against cumene hydroperoxide-induced oxidative stress and downregulated cholesterol biosynthesis genes and decreased cellular cholesterol levels in hepatocellular carcinoma cells. Hybertson 2022

Rutin, a glycoside of quercetin extracted from flower buds of Styphnolobium japonicum, exhibited enhanced selectivity for and enhanced stabilization of guanine-enriched quadruplex structures over double stranded DNA compared to quercetin. Moleculae docking simulations revealed stacking to be the predicted primary mechanism of interaction. Ribaudo 2020

Polysaccharides extracted from Sophora japonica flower buds attenuated UVB-induced damage in human keratinocytes (HaCaT cells). Li 2019

At doses between 12.5 and 25 μM, rutin, a flavonoid glycoside from Sophora japonica, exhibited a protective effect against cisplatin-induced nephrotoxicity via inhibiting the p53/caspase signaling pathway in human mesangial cells. Zhang 2019

Review of the interaction of plant extracts with central nervous system receptors cited inhibition of agonist-induced activity of the human neurokinin-1 receptor by Styphnolobium japonicum extract, as an example. Lundstrom 2017

Evaluated the fruit methanolic extract of Styphnolobium japonicum for larvicidal activity against Culex pipiens mosquito. Koc 2016

Sophora japonica flower bud extract exhibited H1-receptor antagonistic activity and attenuated cerebral vasoconstriction via 5-HT2 and TXA2/PG receptors. Nguyen 2016

The dried ripe fruit extract of Styphnolobium japonicum exhibited anti-inflammatory activity via inhibiting proinflammatory mediators and cytokines through the inactivation of NF-κB, ERK and JNK in lipopolysaccharide-stimulated RAW 264.7 macrophages. Choi 2016

Troxerutin, a flavonoid from the extracts of Sophora japonica, exhibited a protective effect against UVB-induced damage by regulating miRNA expression in HaCaT cells. Lee 2014

Genistein, an isoflavone from Sophora japonica, was identified as the key phytoestrogen in the dichloromethane extract of S. japonica fruit in stimulating osteoblast differentiation in C3H10T1/2 mesenchymal stem cells. Yoon 2013

Sophoricoside, an isoflavone glycoside from Sophora japonica, exhibited a protective effect against 2,4-dinitrochlorobenzene-induced acute and chronic contact dermatitis via inhibiting mainly NF-κB signaling in B cells. Lee 2013

Screened methanol extracts of 40 plants from the Egyptian and Thailand folk medicines for their estrogen agonist and antagonist activities using the yeast two-hybrid assay system expressing ERα and ERβ. S. japonica exhibited an estrogenic effect only after naringinase treatment. El-Halawany 2011

The ethyl acetate extract of S. japonica fruit (EtOAc) inhibited adipocyte differentiation in C3H10T1/2 mesenchymal stem cells and 3T3-L1 preadipocyte cells. It was suggested that its polyphenols, mostly likely genistein, mediated the anti-adipogenic effects. Jung 2011

Examined 25 traditional Chinese herbal medicines that might be useful for skin-whitening and skin health. Sophora japonica extract exhibited antioxidant activity, high phenolic content, and anti-tyrosinase activity in human epidermal melanocytes. Wang 2006

Sophoricoside, an isoflavone glycoside isolated from immature fruits of Sophora japonica, exhibited inhibitory activity against IL-5 and cyclooxygenase activity but not against COX-2 synthesis or against the production of reactive oxygen species. Hak Kim 2003

Sophora japonica lectin bound to wounded skin cells after the skin was injured. Binding decreased and reached the lowest affinity after 15 minutes, then subsequently increased and reached highest affinity after 2 hours. [Article in Chinese] Li 1999

Isolated isoflavonoids of sophoricoside, including genistein, orobol, and genistin, from the fresh fruit of Sophora japonica as the inhibitors in the IL-5 bioassay of mIL-5-dependent Y16 proliferation, using activity-guided fractionation. Min 1999

Evaluated several plant extracts using in vitro inhibition of tyrosinase and DOPA auto-oxidation activity, with a view to developing melanogenesis inhibitors. Sophora japonica extract inhibited mushroom tyrosinase activity. Lee 1997

Sophora japonica lectin did not bind to normal human peripheral nerves. Matsumura 1993

Evaluated the antihemostatic effect of isorhamnetin, isolated from the dried buds of Sophora japonica. Ishida 1989

Studies on antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. VI. On the antihemorrhagic principle in Sophora japonica. [No abstract available] Ishida 1987

The Sophora japonica agglutinin lectin, a N-acetylgalactosamine binding protein, recognized glycoprotein-bound large carbohydrates from teratocarcinoma embryonal carcinoma cells. Ozawa 1985

Interaction in the antibacterial activity of flavonoids from Sophora japonica L. to Propionibacterium. [Article in Japanese] [No abstract available] Kimura 1984

Antimicrobial activity of a tincture of Japanese pagoda tree (Sophora japonica) and of the essential oil of sweet flag (Acorus calamus. [Article in Russian] [No abstract available] Danilevskiĭ 1982

Nominally galactose-specific lectins from Sophora japonica and Ulex europeus inhibited IgE-mediated histamine release while causing little if any histamine release themselves in the mixed peritoneal cells from the rat. Bach 1975

History of Record

ORIGINAL RESEARCH BY: Oren Rabinowitz, MSc

October 2020

LATEST UPDATES BY: Antonia Kaz

March 2023