A Sophora japonica flower bud aqueous extract containing flavonoids and polyphenols significantly reduced serum hyperuricemia levels, inhibited xanthine oxidase activity in blood and liver, and protected against high uric acid-induced kidney damage in a mouse hyperuricemia model. Jiang 2022

Sophora japonica flower extract and rutin, a flavonoid phytochemical, exhibited a protective effect against experimentally induced colitis in mice, including significantly improving colonic permeability and partially restoring gut microbiota dysbiosis, via modulating the NF-κB signaling pathway and attenuating composition of the gut microbiota. Liu 2022

Isorhamnetin, a flavonoid from Sophora japonica flowers, exhibited a protective effect against potassium oxonate and hypoxanthine-induced hyperuricemia by reducing uric acid levels and improving renal function in mice likely via xanthine oxidase inhibitory activity. Wang 2021

A study evaluated gender-specific longevity-enhancing effects of 12 Chinese herbal medicines, including Sophora japonica, in fruit flies. Li 2021

Administration of Sophora japonica extract in isolate or in combination with Scutellaria baicalensis exhibited a protective effect against hypertension-induced chronic kidney disease in rats by modulating the gut microbiome and short chain fatty acid biosynthesis, improving the intestinal barrier function, reducing inflammation, decreasing indoxyl sulfate biomarkers, and inhibiting oxidative stress. Guan 2021

Sophoricoside, a triterpene from Sophora japonica, improved 2,4,6-trinitrochlorobenzene-induced atopic dermatitis in mice via inhibiting CD4+ T cell differentiation and subsequent immune response. Kim 2021

The methanolic extract of the flower buds of Sophora japonica exhibited a protective effect against 1-fluoro-2,4-dinitrofluorobenzene-induced contact dermatitis by suppressing scaling, erythema, and skin thickening and reducing epithelial hyperplasia and immune cell infiltration in six-week-old Balb/c male mice. The genes up-and downregulated were predicted using network pharmacology and the specific interactions were modeled using docking simulations. Kim 2021

Sophoricoside, an isoflavone glycoside from Sophora japonica seeds, exhibited a protective effect against allergic rhinitis and asthma by inhibiting mast cell activation and CD4 + T cell differentiation in ovalbumin-sensitized mice. Lee 2021

Sophoricoside, an isoflavone glycoside from Sophora japonica seeds attenuated lipopolysaccharise-induced in a murine model of acute lung injury by promoting the expression and nuclear translocation of Nrf2 in a dose dependent manner. Wu 2021

Sophora japonica fruit extract exhibited a protective effect against atypical adenomatous hyperplasia-induced prostatic hypertrophy and inflammation via the inhibitory effect of effect on clusterin, IGF, IL-6, IL-8, TNF-α, expression and the promotion of TGF-β1 expression. Elberry 2020

Sophorae japonica flower bud extract, in combination with other herbal flower bud extracts, exhibited anticancer activity by enhancing short-chain fatty acid-producing bacteria in the gut of ApcMin/+ mice, strengthening epithelial tight junction complexes and inducing an immune response. Xia 2020

A traditional Chinese herbal formula including S. japonica and Lonicera japonica flowers dramatically inhibited tumor growth in B16F10 melanoma-bearing mice. Reprograming the immune microenvironment, partially mediated by inhibiting STAT3 signaling, contributed to the anti-melanoma mechanisms. Liu 2019

A traditional Chinese herbal formula composed of Sophora japonica flowers and Lonicera japonicae flowers inhibited B16F10 melanoma metastasis in mice. Regulation of the miR-let-7a/f-CCR7 pathway contributed to the anti-metastatic mechanisms. Liu 2019

Styphnolobium japonicum hydroalcoholic fruit extract exhibited antioxidant activity via decreasing basal reactive oxygen species and increasing levels of stress response enzyme enzymes against juglone and malondialdehyde in nematodes and mice, respectively. Thabit 2019

Both a traditional Chinese herbal formula containing Styphnolobium japonicum and seven other herbs, and matrine, one of its alkaloids, exhibited anti-inflammatory and anti-oxidative activities against colon cancer HT29 cells and in DSS-induced colitis in mice. Fang 2018

Sophoricoside, an isoflavone glycoside from Sophora japonica, exhibited a hepatic protective effect in high fructose diet fed male mice. Li 2018

The ethanolic extract of Sophora japonica flowers and Lonicera japonica flowers exhibited anti-melanoma activity partially by inhibiting STAT3 signaling. Li 2017

The total flavonoid extract of Sophora japonica alleviated pancreas and kidney damage in a streptozotocin-induced diabetic mice model. Wang 2017

Styphnolobium japonicum dried fruit extract exhibited a protective effect against type II collagen-induced arthritis in BALB/c mice. Han 2017

Isolated seven flavones from the seeds of Sophora japonica. Sophoricoside, an isoflavone glycoside, exhibited a protective effect against ovarectomy-induced osteoporosis in rats. Abdallah 2014

In addition to decreasing lipogenesis in HepG2 cells and increasing glucose uptake in C2C12 myotubes, sophoricoside, an isoflavone glycoside isolated from Sophora japonica, lowered postprandial hyperglycaemia in starch-loaded C57BL6/J mice. Wu 2013

Diet supplementation with Sophora japonica fruit reduced weight gain, as well as serum and hepatic triglycerides and high-density lipoprotein cholesterol in high fat-diet fed mice. Park 2009

Genistein, a flavonoid purified from Sophora japonica, exhibited a protective effect against ovariectomy-induced osteoporosis after the 4th week of treatment in rats. The effect was similar to that of soybean genistein. Wang 2006

Sophora japonica extract reduced common carotid artery-induced cerebral infarction area and neurological deficit induced by ischemia-reperfusion in rats. Lao 2005

Sophoricoside, an isoflavone glycoside isolated from immature fruits of Sophora japonica, exhibited a reduction of carrageenin-induced paw edema in mice when administered orally or intravenously. Hak Kim 2003