The structural and physiochemical properties of Sophora japonica f. pendula galactomannans during maturation were analyzed and may be superior to alternative galactomannans.
Xu 2023
Scientific Name:
Styphnolobium japonicum, syn. Sophora japonica
Family Name:
Fabaceae
Common Name:
Sophora japonica, Japanese sophora
Evidence for Efficacy (Human Data)
Evidence of Activity
Other Information
Safety Data
Formulas/Blends
Dynamic Updates
Evidence of Activity
Analytical Chemistry
The nutritional attributes including fiber, protein, lipid, iron, unsaturated fatty acids, essential amino acids, amino acids, monosaccharides, phenolics, and flavonoid contents of Sophora japonica plant, flower, and bud were determined.
Tian 2022
Sophora japonica secondary metabolites showed seven trends during the five flower-maturity stages based on UPLC-ESI-QTRAP-MS/MS analysis, with flavonoids and phenolic acids having the most varied expressions and flower buds being rich in flavonoids, providing an empirical basis for informed harvesting.
Wang 2022
Rutin from Sophia japonica samples was successfully detected with satisfactory recovery by water-soluble fluorescent silicon nanoparticles prepared by one-pot hydrothermal method using 3-(2-aminoethylamino)propyldimethoxymethylsilane and amidol.
Pan 2022
Developed a HPLC-UV/HRMS method for the detection of sophoricoside, a glycoside from Sophora japonica fruit, which was used to detect adulterated samples without prior hydrolysis.
Bampali 2021
A method based on the changes in the composition before and after α-amylase activity was used to identify the active fraction of the ethanolic extracts of Sophora japonica var. violacea.
Zhang 2020
Identified rutin and quercetin as major antioxidant and tyrosinase-inhibitory compounds expressed during the early ontogeny in Styphnolobium japonicum flower buds.
Wang 2019
Isolated and purified two protease inhibitors from Sophora japonica seeds. The proteins were active against Gram-positive across a rang of pH and temperature.
Nabi 2018
Evaluated the yield and antioxidant activity of rutin from Sophora japonica flower bud extracted with an eutectic choline chloride/triethlene glycol solvent.
Peng 2018
Isolated and characterized three new isoflavone glycosides, together with 23 known ones, from the ethanolic extract of Sophora japonica flowers. Evaluated the activity of the isoflavones against triglyceride accumulation in HepG2 cells.
Shi 2017
Used MIL-101(Cr), a metal-organic framework matrix which did not exhibit self-signal interference with traditional organic matrices, in a spectroscopic method to identify quercetin in Sophora japonica.
Han 2017
Isolated and characterized eleven alkaloid compounds from the bark of Sophora japonica. [Article in in Chinese]
Pan 2016
Three flavonoids isolated from dried flowers of Sophora japonica inhibited the action of sortase A from Streptococcus mutans, a primary etiologic agent of human dental caries.
Yang 2016
Used using bioinformatics and biophysical tools to study the functional and conformational structural transitions of the Sophora japonica seed lectin. Evaluated structural dynamics, such as thermal denaturation, sugar affinity, and structural shifts in ionic solvent.
Yadav 2016
Optimized experimental conditions (liquid-to-solid ratio; microwave power; and extraction time) of microwave-assisted extraction of rutin; quercetin; genistein; kaempferol; and isorhamnetin from S. japonicum using response surface methodology.
Liu 2016
Developed an two-step ultrasonic extraction procedure to optimize rutin extraction from Sophora japonica. The method gave a higher extraction yield compared with existing ultrasound-assisted extraction and soxhlet extraction.
Liao 2015
Isolated a new maltol derivative, along with three known maltol derivatives and two flavonol glycosides from the dried flowers of Sophora japonica. Evaluated the compounds for Streptococcus mutans sortase A, a primary etiologic agent of human dental caries, inhibitory activity.
Yang 2015
Used near-infrared spectrometry for on-line determination and assessment of quality biomarkers from Sophora japonica extracts, such as rutin, a bioactive flavonoid.
Li 2015
Isolated and characterized two new isoprenoid flavanones, japonicasins A and B, from the leaves of Sophora japonica.
Zhang 2013
The ethanolic extract of Sophora japonica exhibited a high level of phenolics and flavonoids and exhibited a potent antiinflammatory and antioxidant activity.
Zhang 2011
Extractio with aqueous alcohol in combination with purifying with macroporous resin column chromatography is an efficient way to manufacture the total flavonoid from S. japonica. Colorimetric and the HPLC methods are useful for quality control.[Article in Chinese]
Wang 2010
Isolated and characterized a new isoflavone glycoside, along with nine known ones, from the stem bark of Sophora japonica. Evaluated the activity of the isoflavones against aldose reductase.
Park 2010
Bioassay-guided isolation of the main active constituents from the naringinase-treated methanol extract of S. japonica identified the aglycones genistein and kaempferol as the main phytoestrogens. Kaempferol was nearly equipotent to genistein as an estrogen agonist.
El-Halawany 2010
Anaylzed the flavonol tetraglycoside profile of the fruits and flowers of Styphnolobium japonicum by LC-MS and other spectroscopic techniques to aid the chemical authentication.
Kite 2009
Isolated and characterized active compounds of Sophora japonica. A new compound, N-feruloyl-N'-cis-feruloyl-putrescine, a putrescine derivative, exhibited cellular tyrosinase inhibition activity in human epidermal melanocytes.
Lo 2009
Optimized capillary electrophoresis, in conjunction with reverse-phase high-performance liquid chromatography electrospray ionization quadrupole time of flight-tandem mass spectrometry and inductively-coupled mass spectrometry to analyze the seed extract of Sophora japonica.
Helmja 2009
Isolated four flavonoids and six flavonoid-glycosides from the ethanolic extract of Sophora japonica. Evaluated the compounds for anti-platelet activity.
Kim 2008
Isolated and characterized two new isoflavone triglycosides, together with five known compounds, from the small branches of Sophora japonica.
Tang 2008
Isolated and characterized two new isoflavone tetraglycosides, along with six known compounds, from the leaves of Sophora japonica.
Tang 2008
Isolated four flavonoids and four isoflavonoids on a cross-linked agarose gel from the pericarp of Sophora japonica pods.
Liu 2007
Used high-speed counter-current chromatography combined with macroporous resin column separation to isolate and purify six flavones from Sophora japonica.
Sun 2007
Isolated and characterized two flavonol tetraglycosides, comprising a trisaccharide at C-3 and a monosaccharide at C-7, from the leaves of Styphnolobium japonicum.
Kite 2007
Isolated and purified four kinds of flavonoids and four kinds of isoflavonoids from the pericarp of Sophora japonica via adsorption chromatography on cross-linked agarose gel.
Qi 2007
Used capillary electrophoresis and electrochemical detection to measure phytoestrogens from the pericarp, seed, and flowers of Sophora japonica.
Chu 2005
Analyzed two galactomannan fractions purified from seeds of Styphnolobium japonicum. [Article in Russian]
Smirnova 2004
Self-aggregation of sophoragrin, a mannose/glucose-specific lectin in Sophora japonica was shown to be a unique homopolymerization due to the sugar-specific interaction. The insoluble polymer of sophoragrin is dissociated by interaction with B-SJA-I into various soluble complexes.
Ueda 2004
Isolated and characterized a new flavonol tetraglycoside from the seeds of Sophora japonica.
Wang 2003
Sophoricoside, an isoflavonone glycoside of S. japonica n inhibitor of interleukin (IL)-5. Structural requirements for this activity include planarity of chromen-4-one ring, existence of phenolic hydroxyl at 4-position of B ring, and introduction of benzyloxy at 5-position.
Jung 2003
Isolated and characterized a new flavonol triglycoside, as well as two known ones, from the butanolic extract of the pericarps of Sophora japonica fruit. Antioxidant activity and cytochrome inhibition potential were measured for all compounds.
Tang 2002
Used a linear potential scan polarography and cyclic voltammetry method to measure Vitamin P content in the pharmaceutical preparation of the medicinal plant Sophora japonica.
Song 2002
Isolated and characterized a new coumaronochromone derivative, sophorophenolone, along with 13 known compounds, from the pericarp of Sophora japonica fruit.
Tang 2002
Isolated and characterized two new kaempferol triglycosides from Sophora japonica extract. [Article in Chinese]
Tang 2001
Isolated and characterized four new isoflavone triglycosides, together with nine known compounds, from the pericarps of Sophora japonica fruit.
Tang 2001
Improved rutin extraction from Sophora japonica flower buds by ultrasound assisted-extraction was dependent on the solvent employed. A methanolic extraction gave a significant reduction in extraction time and an increase in maximum yield.
Paniwnyk 2001
Etracted, isolated, and purified the total saponin fraction from Sophora japonica seeds. Five triterpene glycosides were identified, including one new one.
Gorbacheva 1996
Sophora japonica lectin, major protein in the phloem tissue, is biosynthesized most vigorously in autumnal new tissue. It is mainly consumed in the outermost bark regions, where dilatation occurs and-or where cork cambium is differentiated.
Baba 1991
Isolated and characterized a new D-mannose/D-glucose-specific lectin from the bark of Sophora japonica.
Ueno 1991
Aspartate aminotransferase was partially purified from extracts of germinating seeds of Sophora japonica. Evaluated the ability of the enzyme to use 4-substituted glutamic acids as amino group donors and their corresponding 2-oxo acids as amino group acceptors.
Winter 1989
Developed and evaluated a method for determining the total flavonoid content in Sophora japonica via colorimetric titration.
Xu 1989
Evaluated commercially available Sophora japonica plant parts and traditional extraction techniques using high performance liquid chromatography. Rutin, quercetin, sophoricoside, sophorabioside and genistein were identified in the plant parts.
Liu 1989
Measured the distribution and localization of bark and leaf lectins of Sophora japonica via postembedding immunogold electron microscopy. Leaf and bark lectins were found to be exclusively sequestered in the protein-storage vacuoles of these tissues.
Herman 1988
Isolated and characterized five N-acetyl-galactosamine-specific lectins from the bark of the legume tree Sophora japonica.
Hankins 1988
Determination of rutin and immersion of the pod of Sophora japonica L. and its processed products. [Article in Chinese] [No abstract available]
Xu 1988
Elucidated the structure of the N-glycosidic carbohydrate involved in glycoprotein conjugation from Sophora japonica lectin.
Fournet 1987
A processing technic for huaimi tan (Sophora japonica). [Article in Chinese] [No abstract available]
Cui 1987
Purified two lectins from the leaves of Sophora japonica and sequenced the N-terminal amino acids.
Hankins 1987
Isolated and crystallized Sophora japonicalectins from bark, seeds, and two different lectins from leaves. Characterized five of the crystal forms by X-ray diffraction.
McPherson 1987
Sophora japonica agglutinin, as well as two other legume lectins, exhibited a new pattern of oligosaccharide heterogeneity expressed as a newly established family of N-linked heptasaccharide glycans.
Ashford 1987
Developed a hapten inhibition of adsorption assay to explore the sugar binding specificity of the Sophora japonica.
Chien 1975
Qualitative and quantitative study of the flavonoid content of the different organs of Sophora japonica at different stages of development. [No abstract available]
Balbaa 1974
Purification and properties of the hemagglutinin from Sophora japonica seeds. [No abstract available]
Poretz 1974
Inhibition by carbohydrates of 4 lectins sensitive to galactose (Cytisus sessilifolius L., Coronilla varia L., Genista scoparia Lam., Sophora japonica L.). Consequence of the substitution by electron attracting radicals [Article in French] [No abstract available]
Bétail 1974
Purification of hemagglutinins from Sophora japonica seeds by affinity chromatography. [No abstract available]
Terao 1973
The effect of electrical discharge on the kinetics of rutin extraction from Sophora japonica. [Article in German] [No abstract available]
Elenkov 1973
Structures of the galactomannans from seeds of Annona muricata, Arenga saccharifera, Cocos nucifera, Convolvulus tricolor, and Sophora japonica. [No abstract available]
Kooiman 1971
Conclusive structure clarification and complete synthesis of sophorabioside, a glycoside from Sophora japonica L. [Article in German] [No abstract available]
Farkas 1968
Partial purification of the hemagglutinating protein of Sophora japonica. [No abstract available]
Miller 1967
Oligosaccharides and Oligosaccharases of Sophora japonica, Sophora tetraptera, and related species. [No abstract available]
Bailey 1964
Anti-O(H) Agglutnin in Seeds of Sophora Japonica L. [No abstract available]
Nakajima 1963
Comparative investigation of the amino acid composition of the linden flower (Tilia) and Sophora japonica. [Article in Russian] [No abstract available]
Iankov 1962
Contributions to the study of indigenous Sophora japonica flowers as a raw material for the extraction of rutoside. [No abstract available]
Constantinescu 1961
Phytoagglutinins of the fruit and seed of Sophora japonica. [Article in French] [No abstract available)]
Tetry 1955
History of Record
ORIGINAL RESEARCH BY: Oren Rabinowitz, MSc
October 2020
LATEST UPDATES BY: Antonia Kaz
March 2023