The use and safety of Styphnolobium japonicum flower and flower bud as a dietary supplements is reviewed by the United States Pharmacopeia with no serious adverse events or toxicity reported in the clinical or animal studies. Madden 2022

Sophora japonica extract induced oxidative/nitrosative stress-mediated impairment of the mechanism for free radicals scavenging of male mouse germ cells. Solek 2018

Sophoricoside, a isoflavone glycoside from Sophora japonica, reduced the number of implanted embryos in a dose-dependent manner in female mice via altering uterine morphology and compromising endometrial receptivity. Zhou 2014

Sophora japonica aqueous extract induced histidine starvation in Salmonella typhimurium TA98, TA100 strains and induced chromosomal aberration and micronucleus assays in mice. Yin 1991

The spectrophotometric examination and acute toxicity of rutins obtained from Fagopyrum esculentum (buckwheat) and Sophora japonica. [No abstract available] Harrisson 1950