Matricaria chamomilla (syn. M. recutita, Chamomilla recutita)

A natural formulation of silver nanoparticles synthesized with an aqueous extract of Matricaria chamomilla inhibited oral squamous cell carcinoma (HSC-4, Ca9-22, and HSC-3) cells in vitro. Yang 2022

A study reports on the physicochemical properties and cytotoxic activities of phytosomes containing Matricaria chamomilla extract in combination with Curcuma longa and Withania somnifera extracts against breast cancer cells. Govindaram 2022

A study determined the physicochemical and biological properties, such as absorbency, thermal stability, and effects on cell viability, of biomedical acrylic hydrogels modified with Matricaria chamomilla extract. Jamroży 2022

An experimental toothpaste containing Matricaria chamomilla (80 mg/g) reduced total bacterial counts, including S. mutans and Lactobacillus spp., and prevented demineralization of bovine enamel samples, compared to control. Braga 2022

A study reports on the development of a novel nanoemulsion containing extracts of fennel, anise, chamomile, linseed, pomegranate fruit peel for the treatment of inflammatory bowel disease. Alshahrani 2022

A study characterized supercritical CO2 extracts of chamomile and several other plants in terms of yield (being highest for chamomile at 5%), composition, and antioxidant activity. Čižmek 2021

A biosheet composed of hoof keratin extracted from biological waste, gelatin, and coated with Matricaria recutita extract induced rapid re-epithelialization, while showing antimicrobial properties, in a wound model. Sellappan 2021

Use of 50% ethanol (v/v) for the extraction of Matricaria chamomilla flowers resulted in extracts with the highest contents of vitamin C and polyphenolic compounds. Ultrasound-assisted extraction provided further increases in the levels of polyphenols and antioxidant capacity. Žlabur 2020

Electrospun nanofibrous wound-dressing patches loaded with sustained-release 15-30 wt% chamomile showed high antibacterial activity, which increased with chamomile content, only the 30%-chamomile mats negatively affecting cell viability. Shokrollahi 2020

Enzymatic treatment of Matricaria chamomilla aqueous infusions resulted in a higher inhibitory activity against pancreatic lipase, compared to the unmodified infusion. Franco 2020

Matricaria chamomilla essential oil trapped in chitosan nanocapsules showed activity against cutaneous leishmaniasis. Karam 2020

A study characterized polyethylene terephthalate-chamomile oil blends with anticoagulant properties for blood contact applications. Fadel 2020

A study investigating the effects of temperature on the biological activities of subcritical water extracts of Matricaria chamomilla found that extracts obtained at 115?°C showed the highest cytotoxicity, while those obtained at 65 °C inhibited a-amylase most strongly. Cvetanovic 2019

A study investigated the effects of different pressures (10-90 bar) on the recovery of phenolic compounds from chamomile using subcritical water extraction methodology, deemed the cutting-edge technique for the extraction of the plant's bioactive constituents. Cvetanovic 2018

Silver nanoparticles biosynthesized using an aqueous extract of Matricaria chamomilla showed cytotoxic effects against lung cancer cells in vitro. Dadashpour 2018

A study investigated the effects on the physical properties of ointments from the addition of a chamomile extract obtained in supercritical carbon dioxide conditions. Klimaszewska 2018

Starch-based nanocomposite hydrogel scaffolds containing zeolite nanoparticles and a chamomile extract healed chronic refractory (nonhealing) ulcers in five patients, with no hypersensitivity reactions. Salehi 2017

Lipid core nanocapsules loaded with a-bisabolol, a major constituent of chamomile essential oil, reduced inflammation and lung tissue injury in a mouse model of acute, lipopolysaccharide-induced pulmonary inflammation. D'Almeida 2017

An analytical study determined the polyphenol levels in corn puffed cereals prepared with the addition of chamomile (3%-20%). Blicharski 2017

Matricaria chamomilla florets fermented by Lactobacillus plantarum showed reduced phenolic content, but enhanced antioxidant activity, as well as antitumor activity in vitro. Park 2017

Addition of a supercritical-CO2 extract of chamomile (up to 0.7%) to hand dishwashing liquid reduced the irritant activity of the formulations and transepidermal water loss, and improved the skin hydration level. Wasilewski 2016

Electrospun poly-L-lactide acid scaffolds were coated with Matricaria chammomila oil, seeded with adipose mesenchymal stem cells, and inserted into the pancreatic area of rabbits. After 21 days, there was significantly increased insulin expression in the scaffold coated with chamomile oil. Fazili 2016

Chamomile oil-loaded nanocapsules were prepared. Venturinil 2016

The optimal parameters for the preparation of herbal liquors with Matricaria recutita (bisabolol oxide A quantified by GC) are described as: 70% (v/v) of ethanol, 40 g/L plant concentration, and a maceration process of 3 weeks. Rodríguez-Solana 2016

Fortification of yoghurts with chamomile (Matricaria recutita) decoction increased the antioxidant activity of the final product, without affecting the pH or nutritional value of the yoghurt. Caleja 2016

Use of ultrasound during preliminary maceration did not increase essential oil yield from Chamomilla recutita flowers. Kowalski 2015

The ligulate flowers of Chamomilla recutita were fermented (using native chamomile enzymes) to obtain product with higher levels of apigenin aglycone. The product was further subjected to UHPLC-MS-MS analysis and antimicrobial, cytotoxicity, and antioxidant assays. Cvetanović 2015

Replacement of methylparaben in cosmetic emulsions with an extract of Matricaria chamomilla was not effective in controlling the growth of human skin microflora. Herman 2014

Viscosity of a chamomile tea prepared with gum-based thickener (a common method of managing dysphagia in the elderly) was not significantly different from that of water. Garin 2014

Preparation of chamomile-loaded wound dressing mats based on electrospun nanofibrous poly(ɛ-caprolactone)/polystyrene blends was optimized. Motealleh 2014

All-natural composite wound dressing films were prepared of essential oils (including that of blue chamomile) dispersed in sodium alginate, and their antimicrobial activities against Escherichia coli and Candida albicans were tested. Liakos 2014

The estimated yield of essential oil components extracted from chamomile (Chamomilla recutita) by pressurized liquid extraction process was shown to depend on purge time, temperature, compound volatility, and solvent characteristics. Wianowska 2014

With an aim to develop bioadhesive films from chitosan and pullulan with added plant extracts, many extracts including Matricaria chamomilla were tested in vitro for antimicrobial activity against P. gingivalis and A.actino-mycetemcomitans, using agar diffusion and microdilution methods. Rodriguez-Garcia 2010

Malathion residue detection on fresh marjoram, mint, and chamomile were 0.18, 0.23, and 0.083 mg/kg, respectively while none detected in dry chamomile (limit of 0.013 mg/kg) Ahmed 1998

Of 27 poorly preserved chamomile samples in Brazil all were Matricaria recutita flowers containing contaminants; only half had adequate essential oils and only 20% had phenolic constituents with a spasmolytic effect [Article in Portuguese] Brandao 1998

Viscosity of camomile oil = 51.2 mPa.s. Microcapsules can be formed by gelation of alginate emulsified with the oil Esquisabel 1997

Organochlorine pesticide residues in black tea, camomile, and linden. Fernandez 1993

Mixture of Eleutherococcus, alpha-tocopherol acetate, methyuracil, milfoil, nettle leaves, wort and camomile leaves for 32 metallurgists suffering of gastroduodenal diseases [Article in Russian] Karnaukh 1990

Commercial chamomile is a mixture of particle sizes from course, 4 mm (aprox. 70%) to fine particles less than 0.71 mm (approx. 15%). Particle sizes should not exceed 2 mm for tea [Article in German] Hagenstrom 1990

Mixture for chronic hyposecretory gastritis, chronic hepatocholecystitis and angiocholitis includes Achillea millefolium, Urtica dioica, Cichorium, Polygonum, Matricaria chamomilla, Helichrysum arenarium, Calendula, corn stigmas, Humulus [Article in Russian] Krivenko 1989

"White-headed" or double flowered and "yellow-headed" varieties appear different and yield essential oils with different composition. White has more anti-inflammatory and sedative activity Rossi 1988

Evaluation of therapeutic properties of a chamomile-containing toothpaste [Article in Polish] Ruszynska 1986

Variation in the content and the composition of the essential oils in flower heads of Matricaria chamomilla L. during its ontogenetical development. Gasic 1986

No mites were found in samples of lupine and camomile in Egypt Zaher 1986

Tanacetum parthenium has been sold in flower markets under the misleading name, "chamomile" [Article in German] Hausen 1981

Attempts at the "industrial lyophilization" of medicinal plants. II. Roman camomile (Anthemis nobilis " (no abstract) [Article in French] Debelmas 1966

Relaxant mixture of Kava root, Passion flower, Chamomile flowers, hops and Schizandra fruit No Refrence Found

History of Record

ORIGINAL RESEARCH BY: Soaring Bear, Ph. D.

1998

MAJOR REVISION BY: Michael C. Tims

June 2001

LATEST UPDATES BY: Pavel Axentiev, MS

March 2023