Chrysin, a flavonoid found in chamomile tea, as well as apigenin, acacetin, and pinocembrin potently inhibited CYP3A4 activity, suggesting potential for herb-drug interactions. Kondža 2021

A study reports on the in-vitro interactions of standardized extracts from 9 medicinal plants, including Matricaria chamomilla (syn. M. recutita), and CYP3A4 and CYP2D6 enzymes, responsible for the metabolism of about 50% and 30%, respectively, of commercial pharmaceutical drugs. Feltrin 2020

Intake of chamomile tea increases the risk of bleeding when taken concomitantly with warfarin, according to the systematic review. Tan 2020

Addition of 0.5% chamomile appeared to enhance bracket bonding immediately after bleaching in human teeth. Baidas 2020

a-Bisabolol, a sesquiterpene found in Matricaria chamomilla, potentiated the action of tetracycline against Staphylococcus aureus and reduced the minimum inhibitory concentration of norfloxacin to a clinically relevant value, putatively via efflux pump inhibitory activity. Pereira da Cruz 2020

A study reports on the combined use of Matricaria chamomilla oil and differentiated stem cells loaded on a poly L-lactic acid-based scaffold loaded for blood glucose control in a rabbit model of diabetes. Fazili 2020

Administration of mitomycin C in a chamomile oil nanoemulsion decreased the half-maximal inhibitory concentration (IC50) of the drug against human breast cancer cells by a factor of 21.94, and protected Ehrlich ascites carcinoma-bearing mice from the drug-induced hepatotoxicity. Al-Otaibi 2019

A nanoformulation combining chamomile essential oil and the chemotherapeutic drug mytomicin C increased nuclear fragmentation in HeLa cervical cancer cells, suggesting increased cytotoxicity. Alkhatib 2018

A survey of women in early pregnancy or immediately postpartum, conducted to identify potential herb-drug interactions, revealed a minor interaction between ondansetron and chamomile that may affect pregnancy-related risks. McLay 2017

A review of potential drug-herb interactions in elderly patients with inflammatory bowel disease includes the evidence on chamomile, among other herbs and herbal preparations. Rahman 2017

An ethanolic extract of Matricaria chamomilla positively interacted with diclofenac and indomethacine, reducing the effective doses of the drugs by more than two-fold, in rat models of inflammation and gastric injury. Ortiz 2017

A 10% solution of a Matricaria recutita hydroethanolic extract increased absorption of the marker compounds (14)C-caffeine (3-fold increase) and (14)C-salicylic acid (2-fold increase), in an in vitro porcine skin diffusion system. Muhammad 2016

Synergistic interactions between Matricaria chamomilla ethanolic extract and diclofenac, producing augmented antinociception, were putatively identified; three major terpenoids in the extract (α-bisabolol, bisabolol oxide A, and guaiazulene) showed COX-inhibitory activity. Ortiz 2016

Chamomile is one of the nine commonly used plants evaluated to have major severity interactions with warfarin. Ge 2014

Increased concentrations of cyclosporine have been reported in patients due to chamomile, according to the review. Colombo 2014

Possible interactions of an aqueous extract of Matricaria recutita with radiolabeling of blood constituents and with the distribution of the radiolabeling material (sodium pertechnetate) in rats were investigated. Garcia-Pinto 2013