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Scientific Name:
Matricaria chamomilla (syn. M. recutita, Chamomilla recutita)
Family Name:
Asteraceae/Compositae
Common Name:
German chamomile, blue chamomile
Evidence for Efficacy (Human Data)
Clinical Trials
A polyherbal mouthwash containing chamomile, peppermint oil, Aloe vera, and honey, administered for 6 weeks, decreased the severity scores and pain due to oral mucositis during the weeks 2 and 7 in head and neck cancer patients (N = 67) receiving radiotherapy, compared to chlorhexidine and placebo. Sahebnasagh 2023
A review of clinical and animal data on herbal treatments for burn wounds and sunburn reports on a combination of Matricaria chamomilla and Rosa canina providing superior benefits, compared to conventional treatment. Skowrońska 2023
A systematic review of 15 randomized controlled trials of topical treatments (pharmaceutical and other) of oral lichen planus found chamomile potentially beneficial as an adjunct therapy in association with first-line treatments. Serafini 2023
A systematic review with a meta-analysis of 20 studies on the effects of herbal medicine on the severity cyclic mastalgia listed chamomile among the agents that have significantly reduced mastalgia symptoms. Mirzaee 2022
In a randomized clinical trial conducted in primiparous pregnant women (N = 154), administration of Swedish massage with chamomile oil starting at the active phase of labor reduced labor pain scores, length of active phase and the second stage of labor, and increased maternal satisfaction, compared with control (routine care) and massage without oil. Eskandari 2022
In a randomized, controlled trial, a chamomile and saffron tea improved the efficacy of allopathic medications, improved brain derived neurotrophic factor, decreased C-reactive protein levels, and increased the availability of tryptophan in the brains of depressed patients (n = 60). Ahmad 2022
Topical application of chamomile oil three times a day reduced the intenisty of non-specific low back pain in prehospital emergency technicians (N = 90), compared to control. Shirzad-Siboni 2022
A systematic review and meta-analysis of 7 randomized controlled trials of various herbal treatments of attention deficit hyperactivity disorder in children and adolescents found a fair indication of the efficacy and safety of Matricaria chamomilla for the treatment of various symptoms of the condition. Dutta 2022
In a randomized, double-blind, placebo-controlled clinical trial (N = 96), use of a chamomile vaginal gel 5% for 12 weeks significantly improved all sexual function domains and the total female sexual function index score, compared to placebo, with no difference from a conjugated estrogen vaginal cream except in the domains of orgasm and sexual satisfaction. Bosak 2022
In a double-blind, controlled, randomized, phase II clinical trial, a topical formulation containing chitosan-coated Chamomilla recutita microparticles did not significantly reduce the overall incidence or time to develop radiodermatitis in women with breast cancer undergoing radiation therapy, but reduced those for grade 2 or higher of the condition and enhanced skin recovery at follow-up. (N=54) Garbuio 2022
A systematic review and meta-analysis of 29 controlled trials investigating 12 medicinal herbs as treatments for anxiety disorder found insufficient evidence to confirm either the effectiveness or ineffectiveness of chamomile for the condition. Zhang 2022
An assessment of clinical data conducted by an international team of leading academicians and clinicians, conducted with the goal of providing clinical guidelines on the use of plant medicine in psychiatric disorders, listed chamomile in the "Not Currently Recommended" category for the treatment of generalized anxiety disorder. Sarris 2022
According to the results of a randomized controlled trial (N = 38), aromatherapy massage with lavender, chamomile, and rosemary oil was effective in significantly reducing anxiety and depression in the elderly adults living in nursing homes. Mehrabian 2022
A systematic review found topical chamomile (1%-2.5% once to 4 times/day) to be effective in the prevention and/or treatment of oral mucositis induced by radiochemotherapy in cancer patients in 4 of the 6 selected clinical trials. de Lima Dantas 2022
In a randomized controlled clinical trial (N = 73), a chamomile extract cream, administered for 2 weeks, significantly improved the symptoms of vulvovaginal candidiasis, with 88.9% of women achieving recovery. Shiravani 2021
In a controlled clinical trial, compound chamomile and lidocaine hydrochloride gel effectively relieved pain, reduced edema, and accelerated edema regression after surgery in children with hypospadias (N = 116). [Article in Chinese] Zhang 2021
In a placebo-controlled clinical trial (N = 118), Chamomile (Matricaria) capsules were more effective than placebo in reducing menstrual-related mood disorders. Najafi Mollabashi 2021
A review of six clinical trials found mouthwashes containing 1% Matricaria chamomilla essential oil to be efficient in controlling gingival bleeding in patients undergoing fixed orthodontic treatment. Panagiotou 2021
A systematic review of clinical trials on the role of medicinal plants in facilitating childbirth identified two trials reporting positive effects of chamomile. Ivari 2021
In a randomized controlled clinical trial (N = 70), use of concentrated oxygen inhalations with added chamomile oil reduced prolonged hospital stay by an average of 5 days, decreasing the duration of local respiratory and general intoxication symptoms, with 88.0% v. 57.0% absolute efficacy in respiratory failure correction (odds ratio, 0.19 [0.06-0.61]), in patients with complicated forms of acute respiratory viral infections. Shorikova 2021
A combination of tea tree oil and chamomile oil, administered as a swab for 8 weeks, provided better symptomatic relief to patients with seborrheic blepharitis (n = 26), compared to baby shampoo. Mergen 2021
A systematic review of 7 clinical trials found chamomile to be effective for the treatment of primary dysmenorrhea and to reduce menstrual bleeding. Niazi 2021
Intranasal application of an isotonic seawater spray containing chamomile liquid extract enhanced nasal mucociliary clearance and SNOT-22 scores, compared with isotonic spray or irrigation alone, in allergic rhinitis patients (N = 123) receiving steroid treatment. Atar 2021
A systematic review of clinical trials on medicinal herbs for treatment of oral mucositis induced by oncological therapy in cancer patients found Matricaria chamomilla presenting promising results, such as a reduction in severity, lesion incidence, and improved pain control. Eubank 2021
A review of available evidence found limited data in support of chamomile use for reduction of antipsychotic-induced hyperprolactinemia. Rusgis 2021
A systematic review of 3 randomized controlled trials on the effects of organic unprocessed products in treating gingivitis during treatment with fixed orthodontic appliances found chamomile mouthwash to be effective in significantly reducing plaque and gingival bleeding as soon as the treatment started, with apparent reductions in biofilm accumulation and gingival bleeding throughout the study's follow-up. Papadopoulou 2021
A review of clinical trials using plant products to relieve dermatitis associated with ionizing radiation includes studies performed with Matricaria chamomilla products. Kalekhan 2021
In a randomized controlled clinical trial, soft and prolonged massage with chamomile oil strongy improved visual analog scale and outcome scores in patients (n = 48) with knee osteoarthritis, compared to dry cupping. Islam 2021
In a randomized controlled trial (N = 183), one month of inhalation aromatherapy with chamomile essential oil decreased the levels of stress, anxiety, and depression in older community-dwelling adults. Ebrahimi 2021
In a single-blind randomized controlled trial, topical chamomile 3% oral gel decreased the severity of oral mucositis and associated pain in patients (N = 45) receiving chemotherapy, compared with the conventional treatment. Ahmed Elhadad 2020
A randomized controlled study (N = 210) investigated the effectiveness of three herbal preparations based on extracts of St. John's wort, chamomile, calendula, yarrow, shepherd's purse, and tea tree oil in vaginitis. Duric 2020
In a randomized, double-blind, placebo-controlled clinical trial (N = 74), intranasal application of an extract of chamomile (Matricaria chamomilla) alleviated the clinical symptoms of chronic rhinosinusitis in human patients. Nemati 2020
In a randomized, double-blind clinical trial (n = 32), use of a 5% chamomile (Matricaria chamomilla) vaginal gel reduced pain during sexual intercourse and increased sexual satisfaction in postmenopausal women. Bosak 2020
In a randomized controlled trial (n = 24), a chamomile (8.35%) gel delayed the onset and reduced the symptom frequency of radiation-induced dermatitis in head-and-neck cancer patients. Ferreira 2020
In a double-blind, randomized, placebo-controlled trial (N = 75), a Matricaria chamomilla (1%) mouth rinse, administered for 1 month, improved measures of chronic periodontitis, compared to placebo, with but insignificant improvements in probing pocket depth and clinical attachment level. Agarwal 2020
A network analysis of randomized controlled trials found chamomile mouthwash to be superior to placebo for preventing the onset of intolerable oral mucositis (odds ratio, 0.09; 95% confidence interval, 0.01 to 0.52) in cancer patients. Zhang 2020
In a randomized controlled trial, aromatherapy with chamomile-lavender essential oil reduced anxiety in clinical nurses (N = 120). Zamanifar 2020
In a randomized, double-blind clinical trial (N = 118), a chamomile capsule (250 mg, 3 times/day, from 7 days before menstruation till the next onset) reduced menstrual bleeding in female medical students, with no significant difference in duration and interval between periods. Mollabashi 2020
In a randomized controlled clinical trial, foot massage with chamomile oil reduced fatigue and improved quality of life in male hemodialysis patients (N = 120). Habibzadeh 2020
In a randomized, double-blind clinical trial (N = 128), inhalation of 5% chamomile oil (5 cm from the nose at 4, 8, and 12 hours after surgery for 15-20 minutes) decreased pain intensity following cesarean section in primiparous women. Zardosht 2020
A double-blind randomized study found no statistical difference in worsening of the eczema, following administration of freeze-dried German chamomile tea or placebo capsules, in individuals with suspected contact allergy to Asteraceae plants. Lundh 2020
In a 2-month clinical study (n = 30), a toothpaste containing sodium monofluorophosphate, xylitol, and extracts of Chamomilla recutita, Arnica montana, Echinacea purpurea, and Salvia officinalis was more clinically efficient than the control toothpaste in patients with gingivitis and periodontitis. Kharaeva 2020
Intake of a chamomile syrup (2.5 ml/day, for 30 days) increased absolute neutrophil counts in children with acute lymphoblastic leukemia (N = 40), compared to the placebo. Daneshfard 2020
Aromatherapy massage with lavender and chamomile aromatic oils (20 min before bedtime, three sessions within a week) induced statistical differences in anxiety and sleep quality scores, compared to the control and placebo massage groups, in patients with burns (N = 105). Rafii 2020
A systematic review of clinical studies (8 RCTs) found chamomile to be an effective herbal remedy for the treatment of premenstrual syndrome. Khalesi 2019
A Matricaria chamomilla (chamomile) extract (1500 mg/day, orally, for 8 weeks) showed antidepressant activity in subjects with generalized anxiety disorder with comorbid depression, in addition to anxiolytic effects. Amsterdam 2019
In a randomized, triple-blind, placebo-controlled clinical trial, a combination of chamomile (250 mg), fennel (30 mg), and saffron (15 mg), orally administered for 12 weeks, improved physical and psychological symptoms of menopause. Mahdavian 2019
A systematic review of alternative medicine treatments of nausea and vomiting in pregnancy found evidence of the effects of chamomile being superior to placebo. Khorasani 2019
A meta-analysis of randomized control trials found significant therapeutic effects of chamomile administration on sleep quality and on generalized anxiety disorder (after 2-4 weeks of treatment), but no changes in insomnia severity index and state anxiety. Hieu 2019
In a double-blind randomized clinical trial, a herbal mixture containing Matricaria chamomilla, administered for 5 days, decreased cough severity and nighttime awakenings in children with asthma and common cold, compared to placebo. Javid 2019
Aromatherapy with a combination of orange, chamomile, and lavender essential oils decreased pain experienced during catheterization in oncology patients. Ilter 2019
A systematic review assessed the evidence for the potential anxiolytic effect of aromatherapy, including that with the essential oil of chamomile, in women during the first stage of labor. Ghiasi 2019
A systematic review of nonpharmacological interventions for the improvement of sleep quality in nursing home residents found promising evidence of the positive effects of a chamomile extract. Shang 2019
A comprehensive review of clinical evidence identified one trial investigating the therapeutic potential of Matricaria chamomilla (chamomile) in neuropathy. Ebrahimi 2019
In a randomized, open-label, multicenter, comparative study, a formulation containing marshmallow root, chamomile flowers, walnut leaves, yarrow herb, oak bark, and dandelion herb decreased the symptoms of acute tonsillitis in children. The therapeutic benefits were observed on the 4th day. Popovych 2019
In a randomized controlled trial, a combination of myrrh, chamomile flowers, and coffee charcoal prevented the decreases in short-chain fatty acids associated with unfavorable health outcomes, in patients with ulcerative colitis. Langhorst 2019
A phase I blind, controlled, non-randomized, single-dose clinical trial found a formulation containing chamomile microparticles coated with chitosan to be safe for topical use in healthy subjects. [Article in English, Portuguese, Spanish] Garbuio 2018
A review of randomized clinical trials found chamomile to be associated with decreased nausea in pregnancy, compared to placebo. Sridharan 2018
In a randomized controlled trial, topical application of chamomile oil improved postoperative appetite and bowel activity following cesarian section, compared to placebo and no intervention. Khadem 2018
Inhalation of chamomile aroma had no effect on the duration or number of contractions in primipara women at the first stage of delivery; it decreased the intensity of contractions in dilatation of 5-7?cm. Women receiving the treatment reported greater satisfaction. Heidari-Fard 2018
A randomized clinical trial showed oral administration of chamomile (370 mg in capsules, three times/day for 3 months) to decrease total testosterone levels in women of child-bearing age with polycystic ovary syndrome. Heidary 2018
In a clinical study, oral administration of Matricaria chamomilla beverages decreased systolic and diastolic blood pressure and heart rate in both normotensive and hypertensive human subjects. Awaad 2018
A review of randomized controlled trials conducted between 1996 and 2016 identified chamomile as a promising treatment for anxiety and/or depression. Yeung 2018
A double-blind, placebo-controlled study found topical chamomile (M. chamomilla) oleogel, standardized for chamazulene and apigenin, to decrease pain, nausea, vomiting, photophobia, and phonophobia in human subjects with migraine without aura. Zargaran 2018
In an open-label clinical trial of chamomile extract for moderate-to-severe generalized anxiety disorder, symptom improvement was associated with higher morning cortisol levels and a greater decrease in cortisol through the day. Keefe 2018
In a double-blind, randomized, placebo-controlled clinical trial, a Matricaria chamomilla extract effectively reduced breast pain in women with mild to moderate mastalgia. Saghafi 2018
In a single-blind, randomized, controlled trial, chamomile extract (200 mg, in capsules, twice a day for 28 consecutive days) improved sleep quality in the elderly dwellers of a nursing home in Iran, compared to placebo. Adib-Hajbaghery 2017
In a randomized, double-blind clinical trial, topical chamomile decreased the incidence and delayed the development of phlebitis, a common side effect of intravenous amiodarone, an antiarrhythmic drug, in patients receiving the treatment. Sharifi-Ardani 2017
A randomized controlled trial (n = 176) found a combination of Matricariae chamomilla L. [sic], Melissa officinalis, and tyndallized Lactobacillus acidophilus HA122 significantly more effective than simethicone for the treatment of infantile colic. Martinelli 2017
A randomized control trial found significant effects of oral Matricaria chamomilla extract (400 mg twice daily after lunch and dinner, for 4 weeks) on sleep quality in the elderly, compared to placebo. Abdullahzadeh 2017
An open-label randomized controlled trial found chamomile essential oil to be safe for use in clinical settings during the management of neuropathic pain in diabetic patients. Gok Metin 2017
A systematic review of randomized controlled trials identified promising evidence for the effectiveness of a herbal compound preparation including Matricaria chamomilla for the treatment of diarrhea in children. Anheyer 2017
A double-blind randomized phase III study investigated the efficacy of chamomile, aloe vera, calendula, and propolis in the prevention of acute mucositis during chemoradiotherapy in head and neck cancer patients. Marucci 2017
In a clinical setting, a chamomile extract, along with Aznol mouthwash and Hangeshashinto, alleviated stomatitis completely following 2 weeks of therapy in lung cancer patients treated with afatinib. Kato 2017
Chamomile cream alleviated episotomy pain in women 1-2 weeks following delivery. Aradmehr 2017
In a double-blind, randomized, placebo-controlled clinical trial, topical administration of a chamomile oil (Matricaria chamomilla; for 4 weeks) improved symptom severity and functionality in patients with mild-to-moderate carpal tunnel syndrome. Hashempur 2017
This open-label trial of chamomile extract was administered to patients entering treatment for Generalized Anxiety Disorder (GAD) with more favorable self-generated expectancies for the treatment experience greater improvement and fewer adverse events. Keefe 2017
In a double-blind clinical trial, administration of chamomile (two 500-mg capsules every 8 hours) induced labor in 92.5% of post-term pregnant women (compared to 62.5% in the placebo group). Gholami 2016
In a double-blind, placebo-controlled trial, a mouthwash with 1% Matricaria chamomilla extract (used immediately after brushing, for 1 min, in the morning and evening, for 15 days) decreased visible plaque and gingival bleeding indices in patients with gingivitis. Goes 2016
In a randomized, double-blind, placebo-controlled trial, a herbal mouthwash prepared with chamomile (Matricaria recutita) and Mentha piperita significantly reduced pain intensity, dryness, dysphagia, and the need for narcotic analgesics, in patients with oral mucositis. Tavakoli Ardakani 2016
In a double-blind, randomized clinical rial, chamomile (Matricaria chamomilla) pharmaceutical grade extract (500-mg capsule 3 times daily) significantly reduced moderate-to-severe symptoms of generalized anxiety disorder, and prolonged time-to-relapse. Mao 2016
In an open-label, randomized clinical trial, oral chamomile (Matricaria chamomilla) extract (pharmaceutical grade; 1500 mg/day for up to 8 weeks) showed clinically meaningful reduction in generalized anxiety symptoms with a response rate comparable to conventional anxiolytics. Keefe 2016
In a clinical trial, a Matrica mouthwash containing chamomile extract was not as effective as 0.2% chlorhexidine mouthwash in preventing bacterial growth in patients with endotracheal tubes in an intensive care unit. Azimi 2016
Clinical efficacy of a solution composed by sodium bicarbonate and alginate, aloe vera, propoli, chamomile, calendula and honey, in the treatment of minor recurrent aphthous stomatitis in children. [No abstract] Bardellini 2016
Chamomile (Matricaria chamomilla) extract (2 times/day in 500-mg capsules, in addition to a standard antiemetic therapy) reduced the frequency of vomiting similarly to ginger in Iranian women with breast cancer, undergoing chemotherapy. Sanaati 2016
Cryotherapy with chamomile infusion (swishing ice around the oral cavity for at least 30 min) reduced the incidence and severity of oral mucositis, compared to placebo, in patients with cancer receiving 5-fluorouracil and leucovorin. Dos Reis 2016
The protocol of a clinical study assessing the efficacy of a gel made with chamomile (Chamomilla recutita) vs. a urea cream in the prevention of acute radiation dermatitis in patients with head and neck cancer is presented. Ferreira 2016
A review of randomized controlled trials (RCTs) of dietary supplements (including Matricaria chamomilla) for primary or secondary dysmenorrhoea found limited evidence that chamomile was more effective than NSAIDs (one RCT, 160 women). Pattanittum 2016
Chamomile (Chamomilla recutita) did not offer significant relief of labor pain in normal pregnant women. Zafar 2016
A chamomile (Matricaria chamomilla) and linseed (Linum usitatissimum) saliva substitute produced greater relief of dry mouth symptoms, thick saliva, and difficulty in swallowing, compared to a conventional saliva substitute, in elderly patients with xerostomia. Morales-Bozo 2016
A 2% chamomile gel (twice daily for 1 month) was not more effective than placebo in the treatment of burning mouth syndrome. Valenzuela 2016
A combination of chamomile, silverweed, licorice, angelica, blessed thistle, and wormwood extracts (Gastritol® Liquid) reduced symptoms vomiting and retching in ambulatory patients, including diabetics, in an open, non-interventional study. Wegener 2016
Drinking chamomile tea for 2 weeks reduced the scores of physical symptoms-related to sleep inefficiency and symptoms of depression in Taiwanese postpartum women. Chang 2016
Chamomile tea (3 g/150 mL hot water, 3 times/day immediately after meals for 8 weeks) decreased glycosylated hemoglobin, serum insulin levels and insulin resistance and improved the antioxidant status in subjects with type 2 diabetes mellitus. Zemestani 2016
Topical application of standardized Matricaria chamomilla oil (twice daily for 4 weeks) improved the symptomatic and functional status of patients with severe carpal tunnel syndrome, compared with placebo, however, did not affect the electrodiagnostic parameters. Hashempur 2015
A chamomile mouthwash, with honey, reduced the incidence of severe, radiation-induced stomatitis down to 5.7% (compared to 17.6% in the control group) in patients with head and neck cancers. Bahramnezhad 2015
Topical Matricaria recutita oil (for 6 weeks) reduced the frequency of nocturia in children with monosymptomatic nocturnal or daytime enuresis. Sharifi 2015
Clinical evidence for the anti-emetic effect of chamomile in early pregnancy was re-assessed in this update of the 2014 Cochrane review. Matthews 2015
Topical Matricaria chamomilla oil (3 times/day for 3 weeks) reduced the need for acetaminophen in patients with osteoarthritis of the knee, with no reported adverse events. Shoara 2015
An extremely mild shampoo containing the chamomile compound bisabolol reduced scabbing and erythema in volunteers with hair transplants. Schweiger 2015
Participants with insomnia experienced no difference between the placebo or a chamomile monopreparations in randomized clinical trials, according to the results of the systematic review and meta-analysis. The number of adverse events was similar or smaller [than that of placebo]. Leach 2015
A 1% Chamomilla recutita extract mouthwash was beneficial for oral mucositis prevention in patients undergoing stem cell transplantation, in a randomized phase II clinical trial. Braga 2015
Consumption of chamomile tea (3 g/150 mL hot water) three times per day immediately after meals for 8 weeks decreased HbA1C, insulin levels, and insulin resistance (HOMA-IR), as well as blood lipids in patients with type 2 diabetes. Rafraf 2015
A chamomilla tincture mouthwash reduced the number of ulcers, pain, and burning sensation in patients with recurrent aphthous stomatitis, with no adverse side effects, compared to placebo. Seyyedi 2014
A systematic review and meta-analysis of randomized controlled trials comparing standard peristomal skin care with adjunctive treatments, including German chamomile, were performed. Tam 2014
This trial demonstrated no significant difference between two treatment groups in the intention-to-treat or per-protocol using a combination of myrrh, chamomile and coffee charcoal, compared to those treated with the standard treatment mesalazine in patients with ulceritive colitis. Langhorst 2014
A mouth rinse with pomegranate and chamomile plant extracts was effective showing antimicrobial and anti-inflammatory properties similar to that of chlorhexidine 0.12%. Batista 2014
A Matricaria chamomila extract (100 mg t.i.d.) was more effective than mefenamic acid in reducing emotional symptoms of premenstrual syndrome after two cycles of intervention; the reduction of physical symptoms was similar between the groups. Sharifi 2014
A chamomile extract-based mouthwash inhibited the growth of Staphylococcus aureus and S. pneumoniae, in a trial comparing its effects with those of chlorhexidine gluconate 0.2%, PersicaTM, and saline. Darvishi Khezri 2013
Consumption of a beverage composed of chamomile, meadowsweet and willow for 4 weeks decreased IL-1β and IL-6 levels, knee and lower back pain in healthy adults. Yet there was no significant antiinflammatory effects and the evidence is therefore inconclusive. Drummond 2013
Generalized anxiety disorder (GAD): efficacy of standardized Matricaria recutita (German chamomile) extract in the treatment of generalized anxiety disorder. [No abstract] Ross 2013
Polysaccharide-polyphenolic conjugates isolated from Matricaria chamomilla decreased aggregation of platelet isolated from healthy donors and patients receiving anti-platelet medication. Bijak 2013
A combination of myrrh, dry extract of chamomile flowers and coffee charcoal showed nearly identical efficacy with the standard drug mesalazine in the treatment of ulcerative colitis, in a clinical setting. Langhorst 2013
A combination of luteolin (>95% pure) from chamomile, quercetin, and rutin in olive kernel oil, administered for 26 weeks, reduced symptoms of autism in children. Taliou 2013
The efficacy of Chamomilla recutita against ultraviolet erythema was tested in healthy humans. An anti-inflammatory effect was evident, however, the results did not reach statistical significance. [Article in German] Beikert 2013
A chamomile based mouth wash showed antibacterial effects against oral pathogens Streptococcus pneumoniae and Staphylococcus aureus; however, chlorhexidine gluconate 2% was more effective in reducing the number of colonies, in humans. Baradari 2012
According to the results of a randomized controlled trial, a pharmaceutical-grade extract of Matricaria recutita, standardized to 1.2% apigenin, may provide meaningful antidepressant activity in addition to its previously reported anxiolytic activity. Amsterdam 2012
In a randomized, double-blind clinical trial, a 10% chamomile extract cream was not significantly different from placebo in treating eczema lesions. Shimelis 2012
Chamomile (270 mg twice daily for 28 days) failed to improve sleep patterns in adults with chronic primary insomnia relative to placebo. Zick 2011
A solution of German chamomile, applied to peristomal skin lesions, produced faster healing (mean, 8.89 vs. 14.53 days) and better control of pain and itching, compared to 1% topical hydrocortisone, in colonostomy patients. Twice-daily application facilitated healing of peristomal skin lesions. Charousaei 2011
Preliminary findings confirm the anxiolytic effect of Matricaria recutita, according to the review of clinical herbal studies. Sarris 2011
A metabonomic strategy, utilizing high-resolution 1H NMR spectroscopy with chemometric methods was applied to study human responses to chamomile tea ingestion in volunteers. After chamomile ingestion there was an increased urinary excretion of hippurate & glycine with low creatinine level. Wang 2005
The effects of different polyphenol-containing beverages on Fe absorption from a bread meal were estimated in adult human subjects from the erythrocyte incorporation of radio-Fe. Compared with a water control Inhibition of Fe absorption from the bread meal by chamomile was 47%. Hurrell 1999
In a double-blind, randomised trial with 79 childeren, pectin-chamomile added to the usual rehydration method ended the diarrhea in 3 days for 33/39 compared with 23/40 in the normally treated group [Article in German] de la Motte 1997
Chamomile mouthwash did not alleviate 5-fluorouracil toxicity in a double-blind, placebo-controlled clinical trial with 164 patients Fidler 1996
Skin penetration studies of Camomile flavones apigenin, luteolin and apigenin 7-O-beta-glucoside with 9 healthy, female volunteers for 7 hours Merfort 1994
Chamomile or hamamelis cream were inferior to hydrocortisone for UV induced skin inflammation Korting 1993
Kamillosan cream had about the same therapeutic results as 0.25% hydrocortisone and was better than the non-steroidal anti-inflammatory agent, 5% bufexamac, as well as to 0.75% fluocortin butyl ester, in a trial with 161 patients [Article in German] Aertgeerts 1985
Protection against insects infesting stored chamomile [Article in Czech] Neubauer 1969
The purpose of this study is to investigate novel methods from CAM aimed at alleviating chronic pain related to functional bowel disorders in children. To that end, the use of Chamomile teas as a form of botanical therapy will be investigated. ClinicalTrials.gov
History of Record
ORIGINAL RESEARCH BY: Soaring Bear, Ph. D.
1998
MAJOR REVISION BY: Michael C. Tims
June 2001
LATEST UPDATES BY: Pavel Axentiev, MS
March 2023