An in vitro assessment found hop extracts likely safe for the treatment of non-psychotic mental disorders during pregnancy. Spiess 2022

An in-vitro safety assessment found extracts of hops to be free of genotoxic and cytotoxic activities to placental cells at artificially high concentrations. Spiess 2021

An entry in the Drugs and Lactation Database (LactMed) summarizes existing evidence on hops (Humulus lupulus) in relation to lactation from animal and human studies, including that hops is "generally recognized as safe" (GRAS) as a food by the U.S. Food and Drug Administration and some sources recommend avoiding hops during breastfeeding because of phytoestrogen content. [No authors listed] 2021