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Scientific Name:
Humulus lupulus
Family Name:
Common Name:
hop, hops
Evidence for Efficacy (Human Data)
Observational Studies/Case Reports
In a cross-over single-blinded study involving healthy young men and women (N = 14), administration of a beverage containing 0.125 mg xanthohumol prevented the induction of IL-1β and IL-6 cytokine levels and sCD14 protein release by stimulating peripheral blood mononuclear cells ex vivo. Jung 2022
Abdominal cramps and vaginal hemorrhages were developed by two 54-year-old women after taking a hop-containing herbal product (MenoCool) for 2-5 months. van Hunsel 2015
In this review of phytoestrogens and other plant-derived compounds for the treatment of menopause-related conditions, the ability of xanthohumol to inhibit adipogenesis and induce osteogenesis is potentially viewed as clinically useful. Schilling 2014
The potential effectiveness of 8-prenylnaringenin, an estrogenic compound from hops, and hop extracts in general for the treatment of menopausal complaints is reviewed. Keiler 2013
This review focuses on the potential benefits of beer compounds, derived from hops, for skin health. Chen 2013
The biological activities of hop flavonoids and their biotransformation products are compared. Bartmanska 2013
The antitumor activity of chalcones, including those found in the genus Humulus, and the underlying mechanisms of action are reviewed. Zhang 2013
Xanthohumol from hops is among the spice-derived compounds which target various gene products dysregulated in cancer and are the subject of this review. Sung 2012
Xanthohumol is among the plant constituents with the highest effectiveness for the treatment of benign prostatic hyperplasia. Azimi 2012
Comment on "Prenylated chalcone xanthohumol associates with histones in breast cancer cells--a novel target identified by a monoclonal antibody." (Wyns 2012) [No abstract] Kapoor 2012
Xanthohumol is featured in this review as an example of a stable biological reactive intermediate, hence not having the associated toxicity. Dietz 2011
The ability of xanthohumol to affect the redox state of cancer cells is mentioned in this review. Jacob 2011
The chemopreventive properties of xanthohumol against colorectal cancer are reviewed. Araújo 2011
Hops, among other botanicals, is reviewed for potential usefulness in the treatment of sexual dysfunction in climacteric women. Mazaro-Costa 2010
The activity of hop bitter acids is reviewed. Van Cleemput 2009
Sleep disorders: a single dose administration of valerian/hops fluid extract (dormeasan) is found to be effective in improving sleep. [No abstract] Ross 2009
The literature examining mechanisms of botanical and dietary supplement ingredients used for their effects on memory, insomnia, mood and anxiety is reviewed. Weeks 2009
The review of the potential of plant polyphenols as anti-invasive cancer agents features xanthohumol as one of the promising compounds. Bracke 2008
A review of the morphological, phytochemical profile, ethnomedicinal uses, and known pharmacological activities of hops is presented. Zanoli 2008
On the cover. Hop. [No abstract] Weber 2008
The article focuses on the role of chemopreventive molecules, such as xanthohumol, on the inhibition of angiogenesis in cancer and premalignant tumors. Noonan 2007
Botanical sedatives. [Article in German] [No abstract] Unger 2007
Potential mechanisms of the sleep-inducing action of a combination of valerian and hop extracts are proposed. Brattström 2007
A case of a 57-years-old female farmer with occupational airborne dermatitis and hand dermatitis to hop (Humulus lupulus) was reported. Spiewak 2002
A patient who presented 4 times with systemic urticaria with arthralgias and fever treated by corticosteroids with efficacy was reported and the wild hop (Humulus lupulus) finally proved to be the causal factor. [Article in French] Pradalier 2002
[Contact urticaria from hops (Humulus lupulus) in a patient with previous urticaria-angioedema from peanut, chestnut and banana.] Estrada 2002
History of Record
November 1999
MAJOR REVISION BY: Michael C. Tims, PhD. candidate
June 2001
March 2023