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Scientific Name:
Humulus lupulus
Family Name:
Common Name:
hop, hops
Evidence of Activity
Literature Reviews
A literature survey-based study analyzed the relationship between mood-related effects of different herbal therapeutics used for the treatment of mild mood disorders, including Humulus lupulus, and their effects on gut bacterial communities. Korczak 2023
Humulus lupulus L. a potential precursor to human health: High hops craft beer. [No abstract] González-Salitre 2023
An article provides an overview of the role of programmed cell death in osteoporosis and its potential regulation by natural products, including xanthohumol. Li 2022
A review provides a quantitative literature analysis and updated summary on the pharmacological activities of hop (H. lupulus) compounds, including pharmacokinetic and clinical studies, as well as relevant information on other Humulus species. Carbone 2022
A review presents a summary of the health benefits of xanthohumol, focusing on the techniques used for its extraction from the solid waste obtained in beer production. Vicente de Andrade Silva 2022
An update on medicinal plants for depression, anxiety, and stress lists hops among the botanicals that have consistently been shown in clinical trials to relieve mild forms of the conditions. Kenda 2022
An article suggests that the bitter acids in hops may improve mood and cognitive function via vagus nerve stimulation. [Article in Japanese] Ano 2022
A review suggests the necessity of clinical studies to evaluate the effects of xanthohumol on the prevention and progression of COVID-19. Rossi 2022
A review identified xanthohumol among several prenylated flavonoid compounds that have shown promising antimicrobial activity against multiple pathogens affecting wound healing. Sychrová 2022
A review focuses on the antiaging effects of several plant compounds, including xanthohumol. Taylor 2022
A review presents the evidence of the antibacterial properties of bioactive constituents of hops, primarily lupulone and xanthohumol, in view of their potential efficacy against multidrug-resistant bacteria. Fahle 2022
A review attempts to expose the multimodal anticancer potential of xanthohumol, including inhibition of tumor cell functioning, activation of apoptosis, and suppression of metastasis, angiogenesis, cancer stemness, and drug resistance, resulting in reduced tumor aggressiveness. Hamedani 2022
A review provides a comprehensive summary of the potential beneficial effects as well as toxicity of 8-prenylnaringenin, the most potent phytoestrogen known to date, found mainly in hops. Pohjanvirta 2022
An article presents a review of the antioxidants from hops, their potential biological activities against diseases such as cancer and metabolic syndrome, and study prospects. Zugravu 2022
A review of the pharmacokinetics and cardiometabolic effects of xanthohumol finds that its intake is well tolerated and safe in both animals and humans, but the evidence of the effects on body weight and cardiovascular disease risk factors is insufficient. Neumann 2021
A review of clinical and safety data on the use of herbal products did not find the data for hops (Humulus lupulus) to fully support their use for alleviation of the symptoms of menopause and other gynecological disorders, such as premenstrual syndrome and dysmenorrhea. Kenda 2021
A review summarizes the biological activities of β-myrcene, a monoterpene reportedly abundant in hops with alleged anxiolytic, antioxidant, anti-ageing, anti-inflammatory, and analgesic properties. Surendran 2021
A review focuses on the properties of hop-derived components in beer related to neuroprotection. Vazquez-Cervantes 2021
A review summarizes the molecular effects of xanthohumol, a prenylated chalcone in hops (Humulus lupulus), on cancer cells, including modulation of multiple signaling pathways and tumor suppressor proteins, resulting in the inhibition of the growth and proliferation of the cells. Girisa 2021
A review of estrogenic medicinal herbs lists hops (Humulus lupulus) among the plants known to alleviate menstrual and menopause symptoms. Echeverria 2021
A review of the structural characteristics, biological activities, distribution in plants, and biosynthesis of prenylated chalcones includes data on xanthohumol as one of the most representative molecules of the class. Zhou 2021
The biological activities of xanthohumol, a prenylated flavonoid found in the inflorescence of Humulus lupulus (hop), in various cancers and its possible use in cancer prevention and treatment are reviewed, along with its pharmacokinetics. Harish 2021
Evidence of mechanisms of action, effectiveness, and safety for the most commonly used plants in the treatment of sleep disorders, incuding valerian, lemon balm, passionflower, chamomile, jujube, and hops (Humulus lupulus), is summarized. Lelli 2021
A review of preclinical data on the anticancer and antitumor effects of xanthohumol is presented, including signalling cascades, cancer subtype targets, inhibition of tumor progression, and nanotherapy. Tuli 2021
A review summarizes the unique nature of Humulus lupulus phytoestrogen flavonoids (8-, 6-, and 6,8-prenylnaringenin and 8-geranylnaringenin) and their biological activities (anticancer, neuropreventive, antinflamatory, and antimicrobial). Tronina 2020
Matured hop bitter acids and iso-a-acids, the main bitter-tasting compounds in beer, enhance cognitive function and memory with the involvement of norepinephrine and dopamine mediated neurotransmission networks and vagus nerve activation, also ameliorating neuroinflammation. Ayabe 2020
A review provides the evidence for traditional European medicinal plants such as Humulus lupulus that may be effective as a monotherapy or supportive therapy for controlling neuronal and other symptoms of dysmenorrhea. Gomathy 2019
Correction to The Multiple Biological Targets of Hops and Bioactive Compounds. [No abstract] Bolton 2019
A review analyzes the potential role of (non-alcoholic) beer, hops being its major ingredient, in the prevention of neurodegenerative disorders, including Alzheimer's disease. Sánchez-Muniz 2019
An article reviews the potential of Humulus lupulus to combat chronic diseases, with a focus on bitter acids and xanthohumol. Lin 2019
A review summarizes the phytochemical constituents in beer and discusses the effects of beer consumption in health and disease. Osorio-Paz 2019
A review focuses on the relationship between the phenolic compounds in beer (including xanthohumol) and gut microbiota. Quesada-Molina 2019
A review addresses health-promoting properties of hops raging from antioxidative and sedative to anti-inflammatory and anti-carcinogenic, as well as proposing novel approaches to studying the plant chemistry and utilization of waste hop biomass from breweries. Knez Hrnčič 2019
Xanthohumol may prevent thrombosis by ameliorating platelet mitochondrial dysfunction, according to the review. Fuentes 2019
Multiple biological effects of hops, mainly due to the constituent xanthohumol, include phytoestrogenic, anti-inflammatory, and anti-obesity activities, inhibition of aromatase, induction of detoxification, as well as inhibition of multiple P450 enzymes. Bolton 2019
Xanthohumol has been able to inhibit Staphylococcus aureus biofilm-associated infections, according to the review. Suresh 2018
A review focuses on fruity and floral aroma compounds in beer, discussing the relevant aspects of terpenoid production in Humulus lupulus (hops). Holt 2018
The potential of nutraceuticals, including xanthohumol (from hops), to combat inflammation associated with chronic diseases is reviewed. Gupta 2018
Xanthohumol was among the dietary phytochemicals known to inhibit toll-like receptors, important in both innate and adaptive immunity, along with the likes of resveratrol, sulforaphane, and curcumin. Chen 2018
Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus, comprising up to 3-5% of the dry-mass of the female inflorescences of both species, are reviewed. Nuutinen 2018
The anticancer activities of xanthohumol, a prenylated flavonoid from hops (H. lupulus) and their mechanisms are reviewed. Jiang 2018
Hop-derived prenylflavonoids are among the few natural compounds with a potential to contribute to the nonaggressive, differentiation-based therapy of various cancers, according to the review. Mijatović 2018
Therapeutic potential of 8-prenylnaringenin in the treatment of menopausal and post-menopausal symptoms, as well as prevention of bone resorption and inhibition of tumor growth is reviewed, including discussion of potential adverse effects of long-term consumption of phytoestrogens. Štulíková 2018
Potential effects on women's health of phytoestrogens other than from soy and including hop 8-prenylnaringenin, among others, are reviewed. van Duursen 2017
The evidence of hepatoprotective activities of chalcones, to which class belongs xanthohumol, is reviewed. Karimi-Sales 2017
A systematic review identified hops among the ten phytomedicines that possess both preclinical and clinical evidence of GABA-modulating activity relevant for anxiety. Savage 2017
The article aims to review recent advances in the study of chemical constituents of Humulus lupulus and their pharmacological activities. [Article in Chinese] Lin 2017
The utility of hop cones (Humulus lupulus) and their constituents for metabolic syndrome prevention and therapy is discussed. Dostálek 2017
The article presents evidence supporting the hypothesis that bitter compounds from hops (Humulus lupulus) may induce secretion of glucagon-like peptide 1 (GLP-1) through the activation of bitter taste receptors (T2R) in the gut, with consequent improvement of glucose homeostasis. Barrea 2017
The review covers potential benefits of moderate beer consumption, including reduction of osteoporosis risk and amelioration of vasomotor symptoms, for women during menopause. Sandoval-Ramírez 2017
The estrogenic activity of hops (Humulus lupulus) is noted in the review on the use of botanical medicine for women's health. Dietz 2016
The relevant mechanisms of action of hops constituents for amelioration of menopausal vasomotor symptoms are reviewed. Abdi 2016
Discrepancies between in vitro and in vivo data of the effects of xanthohumol are discussed. Willson 2016
The cancer-preventive and chemotherapeutic potential of prenylated chalcones and flavonoids, including notable compounds from hops, such as xanthohumol, isoxanthohumol, 6-prenylnaringenin, and 8-prenylnaringenin, is reviewed. Venturelli 2016
The evidence of the significant effects of xanthohumol, among several other antioxidants, on endometriosis is reviewed. Harlev 2015
A review of anticancer activities shown by natural chalcones, including xanthohumol, is presented. Leon-Gonzalez 2015
The evidence of the hepatoprotective actions of xanthohumol, a prenylated flavonoid from hop, is reviewed, and the potential use of xanthohumol-enriched hop extracts in chronic liver disease, especially in obese patients, is discussed. Weiskirchen 2015
Isoxanthohumol, a compound found in beer, inhibits the activation of carcinogens, inhibits the production of prostate specific antigen (PSA), has an antiproliferative activity against human cancer cells, and suppresses the expression of proinflammatory genes. Żołnierczyk 2015
The current knowledge of the biotransformation of hop flavonoids, including a list of microbial enzymatic reactions associated with gastrointestinal microbiota, is reviewed. Karabín 2015
The review provides a pharmacological profile of xanthohumol, one of the bioactive compounds in hops. Liu 2015
The chemopreventive and angiopreventive properties of selected phytochemicals found in common beverages, including xanthohumol from beer, with the focus on their molecular mechanisms, are reviewed. Rossi 2014
Xanthohumol lupulones (from hop) are included in this review of plants and plant-derived products with a promising potential in the treatment of acne. Sinha 2014
The benefits and liabilities of essential oils and aroma-active compounds, including those from hops, methods for assaying them in raw materials and beverages, and the means by which the levels are regulated are reviewed. Ameh 2014
In vivo and in vitro evidence and proposed mechanisms of chemoprevention against hepatocellular carcinoma of xanthohumol are reviewed. Okano 2011
Health benefits and biological activities of xanthohumol and beer, as well as the chemistry and biotechnological aspects of xanthohumol are reviewed. Magalhães 2009
The chemopreventive activities of hop-derived compounds in beer, i.e. prenylated chalcones and flavonoids as well as alpha- and iso-alpha-acids, as well as the bioavailability and efficacy in vivo studies, are reviewed. Gerhäuser 2005
The occurrence of 8-prenyl flavonoids in various foods is reviewed. Branca 2005
The biological activities of xanthohumol and 8-prenylnaringenin, the major pharmacological principles of hops, as well as their biosynthesis, are reviewed. Stevens 2004
The health benefits associated with non-alcohol components in beer are reviewed. Kondo 2004
"Bust-enhancing" herbal products were found to contain 8-prenylnaringenin, a phytoestrogen from hops. Fugh-Berman 2003
History of Record
November 1999
MAJOR REVISION BY: Michael C. Tims, PhD. candidate
June 2001
March 2023