Coffea spp. - American Botanical Council

Elucidated the contribution of other bitter coffee constituents in addition to caffeine with functional calcium imaging experiments using mammalian cells expressing the cDNAs of human bitter taste receptors, sensory experiments, and in silico modeling approaches. Lang 2020

A review of studies using interventions that regulate the action of gastrointestinal peptides for treatment of nonalcoholic fatty liver disease noted that coffee functions on peptide YY. Tarantino 2020

Review described the effects and the mechanism of action of caffeine on sarcoplasmic reticulum, focusing on its use to study intracellular calcium dynamics in human muscle fibers in physiological and pathological conditions. Reggiani 2020

Coffea arabica and C. canephora extracts and their compounds selectively improved the in vitro growth of various probiotic bacteria. Regular C. arabica and C. canephora extracts inhibited the growth of E. coli, while the decaffeinated extracts promoted its growth. Sales 2020

Effects of Caffeine and Coffee on Human Functioning. [No abstract] Del Coso 2020

Roasted coffee extract at more than 2.5%(v/v) inhibited LPS-induced inflammatory responses in RAW264.7 cells. Pyrocatechol, a degradation product derived from chlorogenic acid during roasting, was found to inhibit the LPS-induced activation of NF-?B and also activated Nrf2. Funakoshi-Tago 2020

Polysaccharides from commercial espresso coffee and coffee extracts decreased cholesterol solubility and bile salts' concentration in an in vitro model of cholesterol bioaccessibility. Coffee lipid extracts also decreased cholesterol solubility but not bile salt concentration. Coreta-Gomes 2020

Administered extracts prepared from 7 functional foods (green tea, black tea, prickly pear cactus, black coffee, green coffee, pomegranate, and sumac) to a gut consortium culture encompassing 8 microbes which are resembling, to a large extent, the metabolic activities found in the human gut. Farag 2020

The cytokine suppressive activities differed among methanolic extracts of spent coffee grounds from 3 Arabica cultivars. Untargeted metabolomics analyses led to the putative identification of 26 metabolites with known anti-inflammatory activities. Ho 2020

Pre-incubating hemolysate with 1-methyluric acid, a caffeine metabolite, reduced the rate of nitrite-induced oxidation of HbA to methemoglobin (met-Hb) more effectively than caffeine itself. Das 2020

Caffeine levels were correlated with increased levels of the main red cell antioxidant, glutathione, and its metabolic intermediates in glutathione-dependent detoxification pathways of oxidized lipids and sugar aldehydes in 599 samples from the REDS-III RBC-Omics study. D'Alessandro 2020

Review summarized the most relevant literature available regarding the use of caffeine in different metabolic situations, such as oxidative and inflammatory status, as well as anaerobic and aerobic physical exercises. Barcelos 2020

Among the tested coffee compounds, only kahweol and cafestol were able to reduce IL-2 production significantly in PHA/PMA-activated T-lymphocytic Jurkat cells. The inhibition of kahweol was a bit stronger than cafestol. The mechanism of action is discussed. Park 2020

The mechanism behind the association of habitual coffee consumption with the lower risk of specific diseases may include the activation of an adaptive cellular response characterized by the upregulation of proteins involved in cell protection, notably antioxidant, detoxifying and repair enzymes. Kolb 2020

Coffee had antibacterial effect against cultured Streptococcus mutans isolated from saliva samples from 120 healthy 18-25 year olds with and without caries, in vitro. Godavarthy 2020

Review discussed the role of coffee chlorogenic acid and metabolites on glycaemic responses in light of epidemiological studies show a convincing long-term and dose-dependent protection of coffee and decaffeinated coffee against developing type 2 diabetes. Williamson 2020

Theophylline from green tea, coffee, and cocoa efficiently scavenged the unsaturated aldehyde acrolein, which may cause DNA cross-linking and the development of chronic diseases, through forming adducts. Jiang 2020

Characterized the effect of caffeic acid phenethyl ester and other phenolic compounds from coffee, tea, and soy products on DNA methylation in vitro. CAPE and other compounds can bind inside the DNA substrate-binding site in human DNMT1 with a favorable binding energy. Wang 2020

Trigonelline-loaded micelles strongly decreased IC50 value of oxaliplatin in resistant colon cancer cells, and trigonelline loaded 5Block micelle increased oxaliplatin-induced apoptosis in a Nrf2/ARE dependent manner. Trigonelline is one of the major alkaloids in raw coffee. Pirpour Tazehkand 2020

Systematic review of 13 studies indicated that caffeine increases the urinary excretion of calcium, sodium, and magnesium, in addition to a diuretic action with intake > 300-360 mg. Results suggested a potential protective effect against formation of urinary stones. Barghouthy 2020

Determined the main phenolic component, the antioxidant, and anti-inflammatory effect, as well as the role that gastrointestinal transit had on the bioavailability of bioactive compounds of ethanol/water/acetic acid extracts from coffee grounds (blonde, medium, and dark roasted). Vamanu 2020

Reviewed mechanisms by which coffee and its respective compounds affect the brain and its pathologies. Most of its effects are attributed to caffeine by the antagonism of adenosine receptors in the CNS; however, other constituents like chlorogenic acids have therapeutic promise. Wasim 2020

Ethiopian coffee samples from different localities of Yorgacheffe and Jimma showed strong antibacterial and antioxidant activity and substantial antioxidant content, while roasted, ground, and packed samples purchased from a coffee shop in Addis Ababa showed the lowest bioactivity. Tasew 2020

Chlorogenic acid, an active component of coffee, bound annexin A2, causing a decrease in the expression of NF-?B downstream anti-apoptotic genes, and inhibiting the proliferation of lung cancer A549 cells in animals and in vitro. Wang 2020

Studied the structural basis of caffeic acid (CA), a coffee-related natural compound, for conferring anti-Dabie bandavirus activity, aka severe fever with thrombocytopenia syndrome, to clarify the mechanism of action. The o-dihydroxybenzene backbone in CA and its analogs was a critical structure. Ogawa 2020

Troxerutin (a natural flavanoid present abundantly in coffee and other foods) attenuated cytotoxicity, genotoxicity, and mutagenicity initiated by hydrogen peroxide in human peripheral blood leukocytes and exerted no marked cytotoxic effects at 100 to 1000 µM in these PBLs after 24 hours. Cavalcanti 2020

Reviewed evidence on the association between coffee and prevention of different types of cancer, with particular emphasis on the molecular mechanisms and the bioactive compounds involved in its anticancer activity. Ismail 2020

Used coffee consumption and acrylamide exposure to illustrate the risk of evaluating an individual molecule independently of its complete food matrix. Nehlig 2020

Review focused on the effect of caffeine consumption on several neurological and psychiatric disorders with respect to sex differences to provide a better understanding of caffeine use as a risk or protective factor for those disorders. Jee 2020

Kahweol from coffee increased the levels of Nrf2 and HO-1 protein without increasing expression of the Nrf2 mRNA in AML12 cells and primary mouse hepatocytes. It also reduced Keap1 protein levels significantly without decreasing Keap1 mRNA levels. Seo 2020

Coffee samples showed considerable AHR-activating potencies in bioassay. Results of incubation with Caco-2 cells suggested rapid uptake and metabolization by epithelial cells. Expression of AHR-regulated gene CYP1A1 increased up to 41-fold and most Nrf2-pathway genes were up-regulated by coffee. Toydemir 2020

A hypothesis about heart-protective effects of polyphenol binding to low density lipoprotein (LDL) cited human supplementation studies showing that polyphenol metabolites from red wine, olive oil and coffee are found in LDL even after an overnight fast. Tung 2020

Human lens epithelial cells taken from lens capsules removed during cataract surgery were more resistant to UV radiation-induced apoptosis when the person consumed coffee containing 180 mg caffeine shortly before surgery. Kronschläger 2020

Review of knowledge of the role of coffee, energy drinks and their bioactive compounds in modulating hemostasis, offering hypothetical mechanisms of their action. Olas 2019

Hydroquinone, found in coffee among other substances, may have an antiplatelet effect via inhibition of thromboxane production. Additionally it has antioxidative and anti-inflammatory effects, and possibly inhibits COX. Chang 2019

Review summarized the bioactive components of common natural caffeine sources, including coffee, and analyzed the psychopharmacology of constituent phytochemicals: methylxanthines, polyphenols, and L-theanine, with focus on acute and chronic synergistic effects on mood and cognition. Schuster 2019

Yerba mate extract, green coffee bean phenolic extract, and 5-caffeoylquinic-acid showed antioxidant effects in endothelial cells, with DHCA (a microbial metabolite of 5-CQA) playing an important role in such protection; the extracts, 5-CQA, and metabolites DHCA and DHFA increased eNOS levels. Wang 2019

Acrylamide, present in wide range of foods including coffee, can upregulate adipogenesis likely through the regulation of mitogen-activated protein kinases (MAPKs) and 5' AMP-activated protein kinase (AMPK)-Acetyl-CoA carboxylase (ACC) activation. Lee 2019

Review focused on the relationship between coffee, caffeine, CGA, and adenosine, and their effects on ectonucleotidases activities, as well as on the modulation of purinoceptors from central nervous system and in peripheral tissue. Stefanello 2019

Kahweol acetate, a coffee-specific diterpene, markedly inhibited the cell proliferation enhanced by phorbol 12-myristate 13-acetate (PMA), and attenuated PMA-induced cell migration and invasion, in human fibrosarcoma cells. Choi 2019

Among 6 potentially active types of coffee compounds tested against a variety of human prostate cancer cell lines, kahweol acetate and cafestol inhibited the proliferation and migration of prostate cancer cells in a dose-dependent manner, with synergistic effects when combined. Iwamoto 2019

Erratum for: Caffeic acid, a coffee-related organic acid, inhibits infection by severe fever with thrombocytopenia syndrome virus in vitro. [J Infect Chemother. 2018] [No abstract] Ogawa 2019

Use of blood oxygen level-dependent (BOLD) signal in functional MRI showed that brain regions that with a significant vascular effect from caffeine (coffee) consumption coincide with those with a significant neuronal effect. Yang 2019

Coffee consumption and metabolic syndrome: a dose-response relationship. [No abstract] Kawada 2019

Mannooligosaccharides extracted from spent coffee grounds and fermented with human feces exerted a prebiotic effect on on gut microbiota by stimulating the growth of some beneficial genera. Short-chain fatty acids production also increased in a dose-dependent manner. Pérez-Burillo 2019

Evaluated the feasibility of using coffee silverskin as a functional material in cosmetics by evaluating its bioactive ingredients, antioxidative activity, cytoprotective effect, matrix metalloproteinase-1 (MMP-1)-inhibiting effect, and anti-melanogenesis effect. Xuan 2019

5-Hydroxymethylfurfural, found in coffee, exerted anti-inflammatory activity in the LPS-induced inflammatory response in RAW 264.7 cells by inhibiting the MAPK, NF-?B and Akt/mTOR pathways. Kong 2019

Dicaffeoylquinic acid isomers of chlorogenic acid (in coffee) had greater affinity to ameliorate oxidative stress via direct free radical scavenging activity, which related to their capacity to activate Nrf2 signaling, compared to caffeoylquinic acid isomers in inflamed differentiated Caco-2 cells. Liang 2019

Investigate the variation in gene expression of 4 mucins cocultured with Caco-2/HT29-MTX cells, in the presence antioxidant compounds, including cholorgenic acid found in coffee. Volstatova 2019

While single compounds such as chlorogenic acid and surfactin found in fermented green coffee bean extract (FGCBE) generally have cytotoxicity at low concentration in HepG2 cells, the effects are mitigated by other compounds in FGCBE. Overall, FGCBE has beneficial bioactivity. Kim 2019

Caffeic acid, a coffee compound, inhibited hepatitis C virus entry via its direct effect on viral particles. Tannic acid inhibited HCV RNA replication and particle egression as well as entry into host cells. Shirasago 2019

Coffee extract had a strong inhibitory effect on parasite Kudoa septempunctata in vitro. [Article in Japanese] Ohnishi 2019

Atractyligenin isolated from coffee silverskin inhibited multiple pathways in the human skin photoaging process in human dermal fibroblasts. Xuan 2019

Chlorogenic acid (CA) provides dual neuroprotection in rat pheochromocytoma cells via directly neutralizing free radicals and indirectly inducing expression of Nrf2-driven cytoprotective enzymes. Yao 2019

Caffeine exhibited anti-fibrotic effect against hypoxia-induced renal fibroblast activation through its antioxidant property to eliminate intracellular ROS, at least in part, via downstream catalase and Nrf2 mechanisms. Nilnumkhum 2019

Caffeine promoted brown adipose tissue (BAT) function at thermoneutrality in vitro. In humans, drinking coffee (but not water) stimulated the temperature of the supraclavicular region, which co-locates to the main region of BAT in adult humans, and is indicative of thermogenesis. Velickovic 2019

Review review discussed the knowledge of mechanisms of action of coffee and its bioactive compounds on lipid metabolism. Farias-Pereira 2019

Current data suggests µM concentrations of caffeine have a bimodal effect on MCF-7 breast cancer cells in vitro, with an initial increase in cell proliferation from 10 µM to 40 µM of caffeine and a potential starting concentration of cytotoxic effect at 80 µM of caffeine. Kazaks 2019

A comparative proteomics study found concordant and discordant changes in the cellular proteome of human endothelial cells induced by caffeine and EGCG. Chanthick 2019

Fasting serum samples collected from habitual coffee drinkers (n=47) showed that coffee intake was associated with 9, 8 and 29 candidate proteins related to cardiovascular, immuno-oncological and neurological pathways, respectively. Kuang 2019

Established cellular proteome datasets of Ea.hy926 human endothelial cells under physiologic condition and after treatment with 100 µM caffeine and epigallocatechin-3-gallate. Chanthick 2019

Coffee compounds inhibited the total bacterial load of saliva from 9 young adults which was inoculated into brain heart infusion medium. The compounds reduced the proportion of Streptococcus salivarius present, and increased that of S. mitis and S. infantis. Ogata 2019

Characterized the phytochemical profile of extracts from coffee husk, coffee silverskin, and cocoa shell and compared their relationship with the potential for reducing markers of inflammation, oxidative stress, adipogenesis, and insulin resistance in RAW264.7 macrophages and 3T3-L1 adipocytes. Rebollo-Hernanz 2019

Caffeine treatment significantly lowered tumor incidence and tumor growth rate in a carcinogen-induced tumor model, through decreased expression of PD1 on infiltrated cytotoxic T lymphocytes. Venkata Charan Tej 2019

A review of evidence (152 articles) for a physiologic role and effects of on dietetic and nutraceutical interventions on lipoprotein(a) level noted that coffee and tea intake may decrease Lp(a) level but recommended further research . Santos 2019

Kahweol, a coffee diterpene, promoted mitochondrial protection by the PI3K/Akt and p38 MAPK/Nrf2/HO-1 axis in H2O2-challenged human neuroblastoma SH-SY5Y cells. Fürstenau 2019

Coffee silverskin and husk phenolics inhibited adipogenesis and elicited adipocytes browning in vitro. Suppressing macrophages-adipocytes interaction alleviated inflammation-triggered mitochondrial dysfunction and insulin resistance. Rebollo-Hernanz 2019

Analyzed the proliferation and motile activity of prostate epithelial (Pnt2) and cancer cells (DU-145; PC-3) in the presence of bioavailable compounds from green coffee beans (GCB), wholemeal wheat bread, and its GCB-fortified variant. Gawlik-Dziki 2019

Coffee extract was antibacterial against dental cavity causing Streptococcus mutans at concentrations of 62.5-1000 mg/mL in vitro, while it was bacteriostatic but not bactericidal against Lactobacillus plantarum at 500-1000mg/mL. Results were compared to fluoride and chlorhexidine mouthrinses. Akhlaghi 2019

Bioinformatics analysis of gene expression profile of human colon cell line HT-29 in the exposure of caffeic acid identified CTSZ, AFF4, DHRS2, and HMGCS1, known as active agents in cancer progression, as the central differentially expressed genes in the PPI network constructed in this study. Rezaei-Tavirani 2019

Coffee extract and chlorogenic acid demonstrated antibacterial activity against the periodontopathogen Porphyromonas gingivalis in a disk diffusion test, and chlorogenic acid reduced associated protease activity. Tsou 2019

Coffee, tea, yerba mate, and guarana water extracts decreased pro-inflammatory cytokines and increased anti-inflammatory cytokines levels, and induced overexpression of cytokine genes in 24-hr cultures of non-activated human peripheral blood mononuclear cells and yeast-activated human neutrophils. Alves 2019

High molecular weight coffee melanoidins, caffeic acid and 3-caffeoylquinic acid effectively scavenged a-dicarbonyl compounds in vitro. Results corroborated the idea that antioxidant-rich indigestible materials could limit formation of advanced glycation end-products across the GI tract. Zhang 2019

Kahweol (coffee diterpene) pretreatment prior to methylglyoxal challenge suppressed mitochondrial membrane potential loss and bioenergetics decline and prevented ROS and RNS generation in human neuroblastoma SH-SY5Y cells by a mechanism associated with PI3K/Akt and p38 MAPK/Nrf2 signaling pathways. de Oliveira 2019

Preventive effect of coffee and tea on amyotrophic lateral sclerosis. [No abstract] Kawada 2019

Evidence on coffee consumption and pancreatic cancer: not great, not terrible. [No abstract] Marko 2019

Author response to a Letter to the Editor entitled: Preventive effect of coffee and tea on amyotrophic lateral sclerosis. [No abstract] Pupillo 2019

Aqueous extracts of green and roasted Coffea arabica combined with vitamin C induced a concentration-dependent increase of apoptotic features as well as oxidative stress and DNA single strand breaks in cancerous MCF-7 cells. El-Garawani 2019

Coffee consumption and cirrhosis-related complications with special reference to hepatocellular carcinoma. [No abstract] Kawada 2019

Analysis of coffee charcoal extract revealed presence of trigonelline, neochlorogenic acid, chlorogenic acid, caffeine, cryptochlorogenic acid, feruloylquinic acid isomers, and a caffeoylquinolacton. Coffee charcoal inhibited cytokine release from LPS-challenged human THP-1 macrophages. Weber 2019

Investigated several food commodities and miscellaneous products, including coffee samples, for their effect on the in vitro activities of alcohol dehydrogenase (ADH) and/or aldehyde dehydrogenase (ALDH) enzymes, which may alleviate hangovers by facilitating elimination of acetaldehyde. Srinivasan 2019

Evaluated the polyphenol content and antioxidant capacity of common beverages including a coffee blend of roasted and green beans. The coffee blend showed an average polyphenol recovery after in vitro gastrointestinal digestion of 78%. Baeza 2018

Single arabinose residues, present at the non-reducing end of polymeric compounds, are relevant to the stimulatory activity of instant coffee extract in BALB/c mice spleen B lymphocytes mediating innate and acquired immunity. Ferreira 2018

A pharmacological review of cholorogenic acid, a caffeoylquinic acid isomer found in green coffee extracts. Therapeutic roles include antioxidant, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, neuroprotective, anti-obesity, anti-hypertension, among others. Naveed 2018

Green coffee and roasted coffee aqueous extracts were found to be selectively cytotoxic in vitro to cancerous cells (MCF-7 cell line) causing cell death with no cytotoxicity on normal human lymphocytes especially at lower doses. El-Nabi 2018

Caffeine restored the adenosine-induced decrease of both intrinsic membrane excitability and excitatory synaptic transmission in the human pyramidal neurons through antagonism of post-synaptic A1R. Kerkhofs 2018

Systematic review analyzed the effects of coffee and its components on muscle glycogen metabolism. Various coffee components had a neutral or positive role in the metabolism of glucose and muscle glycogen, whereas no detrimental effect was described. Available evidence was limited. Loureiro 2018

Ex vivo study showed that chlorogenic acid, polyphenol found in coffee, inhibited carbachol-induced contractions of mouse urinary bladder by partly increasing cAMP levels via adenylyl cyclase activation. Kaneda 2018

Why coffee reduces heart disease risks. [No abstract] Xu 2018

Green and roasted coffee extracts and their main components, 5-O-caffeoylquinic acid and melanoidins, can hinder amyloid beta-peptide on-pathway aggregation and toxicity in a human neuroblastoma SH-SY5Y cell line. Ciaramelli 2018

Evaluated the polyphenolic composition of green and variously roasted coffee beans and differential toxicity in myoblasts and endothelial cells. All coffee extracts improved cell redox status, and coffee compounds displayed cell- and tissue-specificity. Priftis 2018

Extracts from lightly roasted and green coffee beans caused dose- and roasting-dependent effects on nuclear factor erythroid 2-related factor 2 (Nrf2) target gene expression in myoblasts and endothelial cells. Priftis 2018

Caffeine showed a downregulatory effect on cytokine activity and genes related to several autoimmune diseases including lupus and rheumatoid arthritis, in peripheral blood mononuclear cells Iris 2018

Caffeic acid (CA) inhibited Hepatitis C virus (HCV) replication. CA modulated Keap1/Nrf2 interaction via increasing p62 expression, leading to stabilization of Nrf2 and HO-1 induction, and elicit IFNa antiviral response to suppress HCV replication. Shen 2018

Caffeic acid, a coffee-related organic acid, acted on severe fever with thrombocytopenia syndrome (SFTS) virus and inhibited viral infection and spread in permissive human hepatoma Huh7.5.1-8 cells, mainly by inhibiting the binding of SFTSV to the cells. Quinic acid did not inhibit SFTS infection. Ogawa 2018

The lighter roast extracts, cinnamon in particular, reduced cell growth in HT-29 (colon) and SCC-25 (oral) cancer cell lines more than darker roasts. 'Cinnamon' roast had the greatest total phenolic content, antioxidant activity, and gallic and caffeic acid levels. Muharram 2018

At 5 µM, javamide-II (found in coffee), not caffeine, inhibited TNF-a production in PMA/PHA-treated lymphocytic Jurkat cells. Data suggested the mechanism of action is inhibition of ERK phosphorylation. Park 2018

Reviewed the mechanisms involved in the chemotherapeutic activity of caffeine. Mechanistically, caffeine has been shown to affect cell cycle progression at checkpoints, induce apoptosis, and inhibit drug efflux from cells. Tej 2018

Cafestol, a coffee diterpene, inhibited cyclic-strain-induced inflammatory molecule secretion, possibly through the activation of HO-1 and Sirt1 in vascular endothelial cells. Hao 2018

In isothermal titration calorimetry (ITC) and molecular docking simulation models, metabolites of chlorogenic acids were observed to strongly interact with butyrylcholinesterase, an enzyme associated with Alzheimer's disease. Budryn 2018

Biscuits containing antioxidant dietary fiber extracted from spent coffee grounds had blood sugar regulating effects when exposed to simulated digestion in vitro. Vázquez-Sánchez 2018

Green as well as roasted extracts from Coffea arabica (Brazil and Decaf) and C. canephora exhibited strong antimutagenic activity in vitro. Roasting enhanced the activity of the Brazil coffee but not in the Decaf or C. canephora. Priftis 2018

Caffeine reduced thiols depletion and induced pro-apoptotic effects selectively in melanoma cells in vitro, demonstrating a chemopreventative effect. Wrzesniok 2018

Review summarized the evidence on potential mechanisms by which coffee affects liver steatosis, fibrosis, and hepatic carcinogenesis. Alferink 2018

A review of ferulic acid (FA) theorized that FA mediates some of the broad health benefits associated epidemiologically with frequent consumption of whole grains, anthocyanins, coffee, and unrefined plant-based foods, and cited a study on the molecular basis of FA's anti-inflammatory effects. McCarty 2018

Chlorogenic acids and caffeic acid, found in coffee, inhibited glutamate dehydrogenase (GDH) activity in a dose-dependent manner and decreased intracellular ATP levels in chick embryo retina cells. Domith 2018

The a-glucosidase inhibitory activity of coffee extracts was well correlated with their degree of roast, in vitro. Only fractions obtained from dark and very dark roasted coffee exhibited inhibitory capacity. Alongi 2018

Kahweol, a coffee-specific diterpene, decreased the lipopolysaccharide-induced production of interleukin 1 alpha, interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha in primary kupffer cells and primary hepatocytes. Seo 2018

(-)-Epigallocatechin gallate from green tea, but not chlorogenic acid from coffee, suppressed epidermal growth factor-induced osteoblast migration through inhibiting p38 MAPK activation in vitro. Kawabata 2018

Chlorogenic acid isomers ameliorated oxidative stress and activated the Nrf2-Keap1-ARE-signaling pathway, reducing inflammation in Caco-2 intestinal cells. Coffee intake exposes consumers to the six major CGA isomers. Liang 2018

Unlike epigallocatechin gallate from green tea, chlorogenic acid from coffee was not able to inhibit insulin-like growth factor-I stimulated migration of osteoblast-like cells in vitro. Kawabata 2018

IP-HPLC results showed that dialyzed coffee extract induced the expression of proteins beneficial to human health in RAW 264.7 cells and enhanced anti-angiogenic signaling in HUVECs. Yoon 2018

Kahweol, a coffee-specific diterpene, preferentially inhibited cell proliferation and induced cell death through the induction of a caspase 3-dependent pathway in HER2-overexpression breast cancer cell lines. The mechanism by which it exerts its potent anticancer efficacy is elucidated. Oh 2018

Validated assays show chlorogenic or phenolic acids from coffee are poor inhibitors of human salivary a-amylase and rat intestinal maltase. Thus they are unlikely to modify post-prandial glycaemia, and unlikely to be the mechanism by which coffee can reduce the risk of developing type 2 diabetes. Nyambe-Silavwe 2018

In human neuroblastoma SH-SY5Y cells, coffee drastically reduced Aß accumulation in culture medium, while pyrocatechol (produced from chlorogenic acid during roasting), reduced Aß production in the cells. Both reduced BACE1 expression. Results indicate a protective effect in Alzheimer's. Fukuyama 2018

Evaluated the bioactivity of phytocomplexes extracted from coffee cherry pulp, a waste product of the coffee industry. Specifically, pre-treatments analysis demonstrated the ability of coffee pulp extracts to prevent IL-8 release by gastric epithelial cells. Magoni 2018

A review summarizing the suspected non-dopaminergic neuroprotective mechanisms and the possible beneficial effects of the xanthine derivatives in Parkinson's disease (PD) stated that the consumption of coffee correlates with a reduced risk of PD. Kasabova-Angelova 2018

Analysis of whole-blood derived, microarray based mRNA gene expression data from 957 cancer-free Norwegian women identified genes that were differentially expressed between high and low consumers of coffee, positing interpretations pointing toward influence on metabolic pathways and inflammation. B Barnung 2018

Extracts from green and light roasted beans exhibited particularly strong bioactive capacity as measured by antiproliferative activity, using MTT assay, and their influence on the cell cycle and apoptosis by flow cytometry analysis, when compared to darker roasts. Bauer 2018

In vitro data suggest that inhibition of amyloid-beta and tau aggregation by phenylindane 6 (formed during the roasting of coffee beans, higher quantities found in dark roast coffees) is a plausible mechanism by which coffee may provide neuroprotection against Alzheimer's and Parkinson's disease. Mancini 2018

Coffee intake, glucose metabolism and gene polymorphisms: response to Kawada. [No abstract] Robertson 2018

All coffee fruit extracts (green, yellow, red) displayed similar chromatographic profiles by chlorogenic acid > caffeoylquinic acid > caffeic acid. Different colors of raw coffee fruit possessed inhibitory adipogenesis activity in 3T3-L1 adipocytes Duangjai 2018

Cafestol inhibits urotensin II-induced interleukin-8 expression and cell proliferation via Nrf2/heme oxygenase-1-dependent mechanism in endothelial cells. These findings provide novel insight into the signaling pathways that may be important in mediating the effects of cafestol. Tsai 2018

Coffee polyphenols had a profound effect on the expression levels of many metabolic and antioxidant genes possibly through the nuclear factor (erythroid-derived 2) like-2 (Nrf2) pathway in myoblasts. Priftis 2018

Kahweol significantly inhibits the differentiation of 3T3-L1 adipocytes without being cytotoxic, an effect stemming from an ability to inhibiti key adipogenic regulators. Kim 2018

Comparison of crude and high-temperature treated coffee oils (both green and roasted) in terms of antioxidant and antimicrobial properties using Fourier Transform Infrared spectroscopy. Unheated green coffee oil was the most effective against tested bacteria. Raba 2018

Review summarized the molecular mechanisms and the experimental and epidemiological evidence supporting the chemopreventive effect of coffee. [Article in Czech] Neuwirthová 2017

Reviewed the effects of polyphenols on oxidative stress in atherosclerosis-related ischemic heart disease and stroke. Cheng 2017

A review of literature on the effects of botanicals, including Coffea arabica, on modulation of brain-derived neurotrophic factor, which is involved in different central nervous system diseases. Sangiovanni 2017

In lithium-treated RAW 264.7 macrophages, concomitant treatment with a xanthine-catechin mixture potentialized Li-induced anti-inflammatory effects by intensification of the following: GSK-3β inhibition, reduction of proinflammatory cytokines, and increase of an anti-inflammatory cytokine. Barbisan 2017

Results from in vitro study suggest that caffeine indirectly suppresses lipid accumulation in 3T3-L1 adipocytes through decreasing secretion of inflammatory cytokines from Caco-2 cells. Mitani 2017

Chlorogenic acid may suppress lipopolysaccharide-induced nitric oxide and interleukin-1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells. Kim 2017

After consuming caffeinated coffee, human panelists were more likely to report less perception of sweet taste when subsequently drinking a sweetened beverage, supporting evidence that adenosine receptors modulate taste. Choo 2017

Using NMR spectroscopy, molecular docking, surface plasmon resonance and ex vivo assays of the breast cancer cell line MDA-MB-231, this study elucidates the molecular basis of the activity of chlorogenic acid and natural extracts from coffee beans as chemoprotective dietary supplements. Palmioli 2017

Low concentrations of coffee inhibited proliferation of Caco-2 human colon carcinoma cells without affecting cell viability, and also reduced KRAS proto-oncogene, GTPase gene expression in a dose-dependent manne. Increasing duration of coffee bean roasting increased the reduction of KRAS expression. Nakayama 2017

After being processed in a simulated digestion-fermentation model, hydrolyzed spent coffee grounds exhibited high chemoprotective activity in HepG2 cells against oxidative stress, and demonstrated a high prebiotic activity. Panzella 2017

Unlike (-)-epigallocatechin gallate (a primary green tea flavonoid), chlorogenic acid did not upregulate the synthesis of osteoprotegerin induced by bone morphogenetic protein-4 (BMP-4) in osteoblast-like MC3T3-E1 cells. Fujita 2017

Drinking caffeinated coffee acutely improves endothelium-dependent microvascular responses in the forearm skin, while endothelium-independent responses to PORH and SNP iontophoresis are not affected. Blood flow in the fingertip decreases markedly during the 1st hr after drinking caffeinated coffee. Tesselaar 2017

Of 4 leukemia cell lines tested, treatment with cafestol exhibited the highest cytotoxicity agains HL60 and KG1 cells, with results in HL60 similar to exposure to cytarabine (Ara-C), an antileukemic drug. Co-treatment reduced cell viability in HL60 to a greater extent than either treatment alone. Lima 2017

The depletion of AMPK alleviated reduction in lipid accumulation from kahweol treatment in 3t3-L1 cells, suggests that inhibition of lipid accumulation by kahweol is dependent on AMPK activation. Baek 2017

Troxerutin, a flavonoid present in tea, coffee, cereal grains, and a variety of fruits and vegetables, potentiated 5-FU-induced anti-tumor effect in human gastric cancer cells with resistance to 5-fluorouracil through suppression of p-STAT3/NF-κB (p65 and p50) and Bcl-2. Xu 2017

3,4-Dimethoxycinnamic acid, a bioavailable coffee component, demonstrated prion inhibition in vitro. DMCA affected prion protein oligomer formation reducing the oligomer content by 30-40%, and enhanced SH-SY5Y cell viability treated with prion oligomers. Zanyatkin 2017

A series of bioassays indicated that coffee and its residues have embryocidal activities with impacts that are carried over onto the adult lifespan of dengue vectors. These effects may significantly reduce the vectorial capacity of these insects. Dieng 2017

Green coffee extract showed no zone of inhibition against periodonto-pathogens Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis using agar disc diffusion method. Mehrotra 2017

A product containing myrrh, chamomile, and coffee charcoal, suppressed chemokine gene expression of activated human monocyte-derived macrophages, and chamomile and coffee charcoal extracts enhanced interleukin-10 release. This supports historical use in Germany for relief of GI complaints. Vissiennon 2017

The presence of catechol groups in chlorogenic acid and caffeic acid allows scavenging of intracellular ROS, thereby inhibiting H₂O₂-induced IL-8 production via suppression of PKD-NF-κB signaling in human intestinal epithelial cells. Shin 2017

Chlorogenic acid had no effect on the PGE2-stimulated release of osteoprotegerin in MC3T3-E1 cells. Kuroyanagi 2017

Kahweol induces apoptosis through activating transcription factor 3-mediated pathway in human colorectal cancer cells. Park 2017

In vitro study of specific chlorogenic compounds from coffee demonstrated that 3,4-O-dicaffeoyl-1,5-γ-quinide exerted potent antiviral effects against respiratory syncytial viruses and mild antiviral activity against herpes simplex viruses, adenovirus, and influenza virus. Sinisi 2017

Lyophilized Colombian coffee infusions exerted a cytoprotective effect against oxidative stress in Caco-2 cells, with improvement in cell viability and a reduction of intracellular ROS. Bedoya-Ramírez 2017

Caffeic acid, a dietary hydroxycinnamic acid abundant in coffee, suppressed several aspects of high glucose-induced endothelial dysfunction through the modulation of intracellular redox status controlled by the transcription factor Nrf2. Fratantonio 2017

In human neuroblastoma cells, coffee strongly induced vascular endothelial growth factor, which has neurotrophic and neuroprotective effects on neuronal and glial cells, via an activation of HIF-1α. Results suggest a mechanism that may be related to coffee's protective effects on neural disorders. Kakio 2017

Konaberry extract (Coffea arabica) was identified as a histone deacetylase inhibitor in nuclear HeLa cell lysates during a high-throughput screening of 1600 commonly used neutraceuticals and food-based phenolics. Mazzio 2017

In vitro study of green coffee bean extract, yerba mate phenolic extract, primary phenolic and methylxanthine constituents, and their main metabolites on platelet activation. Baeza 2017

Green coffee extract and its phenolic components and metabolites decreased cell viability and proliferation of various lines of human carcinoma cells. Amigo-Benavent 2017

Chlorogenic acid inhibited the proliferation of HepG2 cells and the progression of HepG2 xenograft. CGA induced the inactivation of ERK1/2 and suppressed the expression of MMP-2 and MMP-9 in HepG2 xenograft tissue, indicating it may be a chemopreventative agent for hepatocellular carcinoma. Yan 2017

Review of the molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee. Pan 2016

Evaluation of the effects of javamide-I and the its O-methyl ester on Sirt inhibition, p53 acetylation and cell death revealed that the O-methyl modification in javamide-I may play a critical role in increasing p53 acetylation, activating caspase, and eventually inducing the THP-1 cell death. Park 2016

Quercetin, flavones, chlorogenic acid and caffeine protected SH-SY5Y cells from neurotoxic effects induced by lipopolysaccharide plus interferon-γ or interferon-γ released from activated microglia and astrocytes. Evidence indicated quercetin is the major neuroprotective component in coffee. Lee 2016

Caffeic acid displayed a broader profile of neuroprotection against a diverse range of stressors than its parent polyphenol, chlorogenic acid (found in high concentration in coffee) or the other major metabolites, ferulic acid and quinic acid, in primary cultures of rat cerebellar granule neurons. Taram 2016

Chlorogenic acid, the main polyphenol in coffee induced a direct endothelium-dependent vasodilation ex vivo in rat aortic rings by increasing NOS, COX and EDHF signalling pathways. However, in higher concentrations it had a negative impact on vascular relaxation. Tom 2016

Both ex vivo and in vitro experiments demonstrated that the effect of coffee consumption or caffeine treatment on inflammation mediators is individual specific. Muqaku 2016

Kahweol, a coffee-specific diterpene, inhibited markedly the proliferation of human colorectal and decreased cyclin D1 protein level in HCT116, SW480 cancer cell lines. Park 2016

Cells deficient in the DNA repair protein Fanconi Anemia D2 are hypersensitive to the cytotoxicity and DNA damage induced by caffeic acid. Individuals with Fanconi Anemia or with sporadic mutations in FANCD2 may be hypersensitive to the carcinogenic activity of coffee. Burgos-Morón 2016

Spent coffee grounds (SCG), rich in dietary fiber, exerted anti-inflammatory activity, mediated by short-chain fatty acids production from colonic fermentation of its dietary fiber, by reducing the release of inflammatory mediators. López-Barrera 2016

In an in vitro angiogenesis model, both cafestol palmitate (CP) and kahweol palmitate (KP), the main diterpene esters present in coffee, inhibited angiogenesis steps on human microvascular endothelial cells, with KP exerting more potent effects than CP. Moeenfard 2016

In vitro and in vivo comparative study of cosmetic ingredients Coffee silverskin and hyaluronic acid. [No abstract] Rodrigues 2016

Erratum for: Influence of coffee genotype on bioactive compounds and the in vitro capacity to scavenge reactive oxygen and nitrogen species. [J Agric Food Chem. 2015] [No abstract] Poerner Rodrigues 2016

More angioedema from instant coffee, but not from caffeine. [No abstract] Dvoretzky 2016

Coffee and Protein Metabolism. [No abstract] [No authors listed] 2016

Data from 7,607 subjects analyzed by logistic regression models indicated that the effect of caffeine on type 2 diabetes risk is modulated by a variant of CYP1A2. Platt 2016

Troxerutin, a flavonoid present in coffee, scavenged superoxide, nitric oxide, and other model stable radicals in a cell-free system, and protected different cell types against peroxyl radical-induced apoptosis, necrosis, and mitotic death, likely via free-radical scavenging. Panat 2016

In studies of isolated murine aortic rings and cultured human aortic endothelial cells, pretreatment with 10-μM chlorogenic acid (CGA; abundant in coffee) protected against HOCl-induced endothelial damage, likely via increased production of nitric oxide and induction of Hmox-1. Jiang 2016

Chlorogenic acid exhibited an analgesic effect by promoting voltage-gated potassium channels activation and inactivation in small-diameter trigeminal ganglion neurons under inflammatory condition induced by prostaglandin E2. Liu 2016

Caffeine restricted cell proliferation of primary human keratinocytes, HaCaT cell line, and inhibited cell migration, in a dose-dependent manner. Topical application of caffeine in a human ex vivo wound healing model impeded epithelization. Ojeh 2016

Caffeine suppressed lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 cells, possibly by regulating NF-κB activation and MAPK phosphorylation. Caffeine inhibited LPS-induced nitric oxide production in zebrafish. Hwang 2016

Evaluated the antioxidant activity of ethanol or hot water extracts from the residues of coffee after brewing. Kim 2016

Supercritical fluid CO2 extract of spent coffee grounds attenuated melanogenesis in B16F10 cells by downregulation of protein kinase A, phosphatidylinositol-3-kinase, and mitogen-activated protein kinases signaling pathways, which may be due to linoleic acid and oleic acid. Huang 2016

Coffee consumption, smoking, and Parkinson's disease? The beneficial role of hydrogen sulfide. [No abstract] Cakmak 2016

Analysis of hydroalcoholic extracts of Turkish traditional coffee for enzyme inhibition action using enzyme-linked immunosorbance microtiter assays against enzymes linked to Alzheimer's and Parkinson's disease. Samples were also tested for antiradical, metal-chelation capacity, and reducing power. Erdem 2016

Analysis of 77 plasma proteins in a sample of 976 individuals, found that consumption of fatty fish, drinking moderate amounts of coffee and exercising reduced the predicted chronological age by approximately 2-6 years. Enroth 2015

Caffeic acid, found in coffee, decreased the metabolic stress induced by high glucose in endothelial cells, which allowed the activation of survival mechanisms mediated by a different modulation of NF-κB-related signaling pathways and to the activation of anti-apoptotic proteins. Natarelli 2015

The inhibition of caffeine on the growth of HL7702-HBx and HepG2-HBx cells was most obvious at 800 μM caffeine and at caffeine treatment for 7 days. The PGE2 secretion and the expression of mPGES-1 and EGR1 were downregulated, whereas PPARγ expression was upregulated. Ma 2015

Hypertensives May Safely Consume Ethanol and Coffee in Moderation. [No abstract] Comment on: When and how to recommend 'alternative approaches' in the management of high blood pressure. [Am J Med. 2015] Keller 2015

Results from in vitro study suggest that chlorogenic acid, a major phenolic acid in coffee, enhances the TNF-α-stimulated interleukin-6 synthesis in osteoblasts (MC3T3‑E1 cells). Yamamoto 2015

In human skeletal muscle cells, incubation with either cafestol or caffeic acid, bioactive substances in coffee, increased insulin secretion, while cafestol also enhanced glucose uptake. Mellbye 2015

Examination of the antioxidant activity of 13 coffee varieties in both green and roasted coffee bean extracts using DPPH and (ABTS•+)-radical scavenging assays. Additional testing for protective effects against peroxyl and hydroxyl radical‑induced DNA strand cleavage and on cellular redox status. Priftis 2015

Among Czech women aged 18-59, coffee and wine were identified as higher contributors of ochratoxin A intake compared to other population groups sampled. Ostry 2015

Caffeoylquinic acid (common coffee component) and its isomers inhibited porcine Pancreatic Lipase activity according to a competitive mode where binding and interaction with the catalytic triad of Ser153, His264 and Asp177 simultaneously occurred. Hu 2015

In vitro, caffeine both accelerated the process of the aggregation, and altered the nature of mature aggregates, of α-synuclein, present in Lewy bodies, the pathological hallmark of Parkinson's disease. This may account for the positive association between drinking coffee and developing PD. Kardani 2015

Cafestol,a coffee diterpene, inhibited osteoclast formation in a dose-dependent manner and suppressed their bone-resorbing activity, to a milder extent than kahweol, another coffee-specific diterpene. Cafestol also promoted osteoblast differentiation. Fukuma 2015

Coffee may lower risk of malignant melanoma. [No abstract] Printz 2015

New evidence for link between coffee and risk of endometrial cancer. [No abstract] Rochman 2015

Chlorogenic acid,found in foods such as coffee, stimulated transepithelial secretion in primary murine nasal septal epithelial and human sinonasal epithelial. Results suggested that effects are dependent on CFTR-mediated pathways. Illing 2015

In vitro data suggest that the pentapeptide YGSRS, from coffee bean, affected the production of several types of cytokines from activated human peripheral T cells, which may modulate Th2 type immunity. Nakamura 2015

Treatment with chlorogenic acid (CGA), a coffee polyphenol, protected primary cultures of mouse cerebral cortex from glutamate neurotoxicity by regulating Ca(2+) entry into neurons. Mikami 2015

In a stirred, anaerobic, pH-controlled, batch culture fermentation model of the distal colon, incubation of coffee samples with human fecal microbiota let to rapid metabolism of chlorogenic acids (CGA). CGA was found to amplify specific bacterial populations that may benefit host health. Mills 2015

In HT-29 human colon adenocarcinoma cells kahweol, a coffee-specific diterpene, inhibited cell growth by promoting apoptosis and suppressing HSP70 expression. The 3 other coffee constituents tested (caffeine, caffeic acid, and chlorogenic acid) did not demonstrate cytotoxic action. Choi 2015

Filtered extracts of coffee and decaffeinated coffee both suppressed tryptophan breakdown and neopterin formation in mitogen-stimulated human peripheral blood mononuclear cells, demonstrating anti-inflammatory and immunosuppressive actions that may improve mood by increasing tryptophan availability. Gostner 2015

Caffeic acid, a major organic acid derived from coffee, treatment inhibited the initial stage of hepatitis C virus (HCV) infection in human hepatoma-derived cells in both HCV genotypes 1b and 2a. Tanida 2015

In rat embryonic precursor neuroretinal cells exposed to hydrogen peroxide, treatment with maltol increased cell viability and attenuated DNA fragmentation. Song 2015

An in vitro assay using targeted mass spectrometry indicated that coffee did not modulate catalase expression in macrophages, but led to a highly significant increase of heme oxygenase-1 expression. Zaenglein 2015

HNSCC cells treated with cafestol, a coffee diterpene, showed a dose-dependent reduction of cell viability and apoptosis induction. Combination with irradiation showed a reduction of clonogenic survival compared to each method alone. In 2 of the cell lines a significant additive effect was observed. Kotowski 2015

Elucidated the mechanism of induction of Nrf2 pathway and phase II enzymes by caffeic acid in ovarian carcinoma cell lines. Sirota 2015

Caffeine efficiently inhibited hepatitis C virus replication in a dose-dependent manner at non-cytotoxic concntrations in Huh-7.5 cells. The data suggested caffeine may be a new agent for anti-hepatitis c virus therapies. Batista 2015

Evaluation of aqueous, hydroalcoholic and ethanolic coffee silverskin extracts showed them to be a a safe source of natural antioxidants with antifungal and antibacterial activity and no cytotoxicity, with potential usefulness for cosmetic applications. Rodrigues 2015

Coffee consumption and risk of type 2 diabetes. [No abstract] Palatini 2015

In vitro assays indicate that caffeic acid, found in coffee, acted as an antioxidant through an iron chelating mechanism, preventing the formation of free hydroxyl radicals and, therefore, inhibiting Fenton-induced oxidative damage. Genaro-Mattos 2015

In vitro screening of green coffee extract against periodontogenic bacteria demonstrated effective antimicrobial activity against Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans. Bharath 2015

Trigonelline, in many dietary food plants, including coffee, inhibited Hep3B cell migration through downregulation of nuclear factor E2-related factor 2-dependent antioxidant enzymes activity. Liao 2015

Impact of diet & exercise on HCV-infected patients. [No abstract] [Article in Japanese] Kawaguchi 2015

Control of cough after common cold. Antitussive agents, steroids and coffee with honey. [No abstract][Article in German] [No authors listed] 2014

Data from a human study suggests that when examining the role of the Nrf2/ARE pathway in the regulation of antioxidative and chemopreventive phase II efficacy, individual genotypes should be included when considering the potency of bioactive foods, like coffee and their therapeutic potential. Hassmann 2014

Combination of caffeine or coffee, before treatment with melatonin elicits an additive antiamyloidogenic effects in N2a/APP cells, probably through inhibition of Aβ oligomerization and modulation of the Akt/GSK3β/Tau signaling pathway. Zhang 2014

Colorectal cancer cell death can be augmented by inhibiting all survival pathways induced by pro-apoptotic agents. The apoptotic effect of butyrate, a diet-derived histone deacetylase inhibitor, is augmented by other dietary agents that modulate survival pathways (e.g., propolis and coffee extract). Bordonaro 2014

Lack of replication of the GRIN2A-by-coffee interaction in Parkinson disease. [No abstract] Ahmed 2014

Glutamate receptor gene GRIN2A, coffee, and Parkinson disease. [No abstract] Comment on: Lack of replication of the GRIN2A-by-coffee interaction in Parkinson disease. [PLoS Genet. 2014] Hamza 2014

The hydrolysis of caffeoylquinic, but not feruloylquinic acids, by enterocyte and pancreatic esterases is potentially a contributing mechanism to small intestinal absorption of chlorogenic acids from coffee. da Encarnação 2014

ABT-737 alone had no effect on apoptosis, but cafestol, a major coffee bean compound, markedly enhanced ABT-737-mediated apoptosis in Mcl-1-overexpressed Caki cells, human glioma U251MG cells, and human breast carcinoma MDA-MB231 cells. Woo 2014

In vitro testing of chicory-coffee combinations on dental biofilm and caries development found that coffee reduced the adherence of Streptococcus mutans to a glass surface while chicory exerted antibacterial effect. Sharma 2014

Coffee and the pancreas: a half life of medical truth. [No abstract][Article in French] Frossard 2014

Coffee reduced the accumulation of lipids during adipocytic differentiation of mouse preadipocyte 3T3-L1 cells and inhibited the expression of the peroxisome proliferator-activated receptor γ (PPARγ) expression. The inhibitory activity was produced by the roasting of the coffee beans. Aoyagi 2014

Kahweol is a coffee-specific deterpene. Kahweol-treated cells showed significantly decreased cell viability and increased nuclear condensation and an increased sub-G1 population in oral squamous cell lines, HN22 and HSC4. Chae 2014

Can too much coffee cause atrial fibrillation? How about cocoa or cola drinks? [No abstract] [No authors listed] 2014

In vitro testing of plant extracts on common oral pathogens showed Coffee canephora extract was the most effective plant extract tested against periodontal pathogens as well as Candida albicans. Mehta 2014

Characterization of the interactions of chlorogenic acids and their derivatives, abundant in coffee, with human serum albumin by fluorescence spectroscopy. Sinisi 2014

Chlorogenic acid (CGA), found in foods such as coffee, is a likely a substrate of melanin, but the metabolic product(s) of CGA may suppress melanogenesis in B16 murine melanoma cells by inhibiting tyrosinase activity. Li 2014

Catechol, present in plant-derived products such as coffee, exhibited anti-platelet and anti-inflammatory effects ex vivo in rabbit platelets. These effects were mediated by inhibition of COX, ROS and TXA2 production as well as ERK/p38 phosphorylation. Chang 2014

Treatment of hepG2 cells stably expressing an aryl hydrocarbon receptor gene with coffee robustly stimulated AhR-mediated transcription in reporter gene assays, demonstrating that coffee is a strong AhR activator. Ishikawa 2014

Treatment with caffeine protected human neuronal cells against prion-mediated neurotoxicity in vitro, and these neuroprotective effects may be mediated by caffeine-induced autophagy signals. Moon 2014

In vitro testing of teeth enamel fragments revealed an inhibitory action of Coffea canephora extract against dental biofilm. Meckelburg 2014

Coffee - a stimulant for the liver. [No abstract][Article in German] [No authors listed] 2014

Letter: gut microbiota modulation contributes to coffee's benefits for non-alcoholic fatty liver disease. [No abstract] Comment on: Review article: coffee consumption, the metabolic syndrome and non-alcoholic fatty liver disease. [Aliment Pharmacol Ther. 2013] Shen 2014

Fractionation and analysis by molecular weight of prepared instant coffee, and valuation for possible immunostimulatory actions. Passos 2014

Kahweol, an antioxidant diterpene present in coffee beans, inhibited tumor cell proliferation and clonogenicity and induces apoptosis in several kinds of human tumor cells, especially against MDA-MB231 breast cancer cells. Cárdenas 2014

Identification of pyridinium compounds formed upon trigonelline pyrolysis during coffee roasting, and in vitro demonstration that pyridinium compounds display mild antithrombotic properties due to stimulation by prostacyclin release and inhibition of platelet aggregation. Kalaska 2014

Comprehensive proteomic and metabolomic analyses elucidated the metabolic alterations underlying the effects of coffee consumption. Takahashi 2014

Letter: coffee and chronic liver damage. Comment on: Review article: management of chronic hepatitis C in patients with contraindications to anti-viral therapy. [Aliment Pharmacol Ther. 2014] [No abstract] Cardin 2014

In vitro studies demonstrated that caffeine and its analog CGS 15943 block proliferation in hepatocellular carcinoma and pancreatic cancer adenocarcinomacell lines by inhibiting the PI3K/Akt pathway. Edling 2014

In human colorectal cell line LS174T, incubation with coffee stimulated secretion of fibroblast growth factor 19, which is part of an enterohepatic pathway linked with the etiology and remission of type 2 diabetes following Roux-en-Y gastric bypass surgery. Styer 2014

N-Methylpyridinium antrigonellined, a degradation product of trigonelline upon coffee roasting, appeared to stimulate cellular energy metabolism in HepG2 cells in vitro. Riedel 2014

Coffee consumption linked to a reduction in prostate cancer recurrence.[No abstract] Printz 2014

An in vitro study on the liberation of free fatty acids from human adipocytes following short term (2 h) and long-term (192 h) exposure to Svetol®, a decaffeinated green coffee bean extract enriched in chlorogenic acids. Flanagan 2014

Comment on: Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality. [J Am Coll Cardiol. 2013] [No abstract] Siasos 2014

Drinking coffee burns hepatic fat by inducing lipophagy coupled with mitochondrial β-oxidation. [No abstract] Ding 2014

Impact of advanced glycation end product (AGE)-rich foods, including coffee extract, on WI-38 human lung fibroblasts under different cell culture conditions. Coffee extract appeared to be cytotoxic. Nasss 2014

An investigation of the biochemical activity, chemical composition, and microstructure of coffee before and after flaking. Flaking enhanced NF-κB inhibition activity, possibly through the release of melanoidins from crushed cell microstructures. Chu 2013

Coffee component hydroxyl hydroquinone (HHQ) has significant apoptotic effect on MDA-MB-231 and MCF-7 breast cancer cells in vitro. HHQ was also validated as a ligand for PPARγ by docking procedure. Shashni 2013

Coffee preparation: does it affect our health? [No abstract] de Pablo 2013

Isolation and confirmation of chlorogenic acids (CHAs) from three major instant coffee brands. In vitro testing suggested the major CHAs are antioxidant compounds able to inhibit H2O2-induced apoptosis via suppressing mitochondrial membrane depolarization and caspase-9 activation in the cells. Park 2013

Biodegradation of ochratoxin A (OTA), a common coffee contaminate, was reduced in the presence of the coffee matrix in a human colon simulator. Coffee temporarily altered the fermentation pattern towards lower ammonia and higher acetate and propionate production. Ouethrani 2013

Spent coffee extracts rich in caffeoylquinic acids, mainly dicaffeoylquinic acids, and caffeine (Arabica filter and Robusta espresso) exhibited antioxidant and genoprotective properties in HeLa cells, in vitro. Bravo 2013

Coffee reduces SULT1E1 (estrogen sulfotransferase ) expression in human colon carcinoma Caco-2 cells thereby enhancing estrogenic activity in the colon. Isshiki 2013

An antifungal peptide Cc-GRP from Coffea canephora seeds with sequence homology to glycine-rich proteins exerts membrane permeabilization and nuclear localization in fungi yeasts, Fusarium oxysporum & Colletotrichum lindemuthianum. Zottich 2013

The study reports on the characterization of a putative peroxidase-encoding gene from Coffea arabica (CaPrx) that is expressed in early stages of root-knot nematode (RKN) infection. Severino 2012

A profile of antioxidant gene expression in cultured human colon adenocarcinoma Caco-2 cells treated with both roasted and non-roasted coffee extracts, respectively, was investigated using Real-Time polymerase chain reaction (PCR) array technology. Yazheng 2012

Inhibitory properties of Coffea canephora extract against oral bacteria and its effect on demineralisation of deciduous teeth was examined and data suggest that light roasted C. canephora extract is beneficial as an anticariogenic substance. Antonio 2011

Coffee extract & products induced nuclear translocation of NF-κB in macrophages, Caco-2 cells, & primary human intestinal microvascular endothelial cells (up to fivefold, p<0.001). Consumption of coffee and roasting products may be able to induce nuclear NF-κB translocation in the human gut. Sauer 2011

The study investigated dopamine release and Ca(2+)-mobilization in pheochromocytoma cells (PC-12 cells) after stimulation with two lyophilized coffee beverages prepared from either Coffea arabica (AR) or C. canephora var. robusta (RB) beans and constituents thereof. Walker 2011

Coffea arabica leaves extract (CAE), its hydrolysates (CAH), chlororgenic acid and caffeic acid, were studied for their anti-photoaging effect and the results suggest that CAE can prevent photo-damage in skin through inhibiting MMP expression and MAP kinase pathway. Chiang 2011

A low molecular mass arabinogalactan-protein (AGP) composed of galactose and arabinose with a low protein content, isolated from the instant coffee powder of Coffea arabica beans, has been tested on antitussive (in vivo) and immunomodulating (ex vivo) activities. Nosáľová 2011

High molecular melanoidins isolated from coffee beans of varying roasting degree were found to be efficient inhibitors for the zinc-containing matrix metalloproteases MMP-1, MMP-2, and MMP-9 5 which play a pivotal role in pathogenesis of colorectal cancer. De Marco 2011

Aluminum induces changes in oxidative burst scavenging enzymes in Coffea arabica L. suspension cells with differential Al tolerance. Ramírez-Benítez 2011

It is demonstrated that down-regulation of Bcl-2 & c-FLIP contributes to sensitizing effect of kahweol, a coffee-specific diterpene, found in the beans of Coffea arabica, on TRAIL-mediated apoptosis in cancer cells. Um 2010

Coffee drinking may be associated with a decreased risk of dementia/Alzheimer's disease (AD). This may be mediated by caffeine and/or other mechanisms like antioxidant capacity & increased insulin sensitivity & open possibilities for prevention or postponing the onset of dementia/AD. Eskelinen 2010

Legumin-like proteins from seeds of Coffea arabica (CaL-1 & CaL-2) & C. racemosa (CrL-1& CrL-2) were isolated by gel filtration & reverse-phase chromatography. The insecticidal properties of purified proteins were tested against Callosobruchus maculatus using artificial diets. Coelho 2010

Measurement of intracellular ph in human stomach cells is considered as a new approach to evaluate the gastric acid secretory potential of coffee beverages. This is a suitable screening model to investigate the effects of coffee beverages & the components on human parietal cells. Weiss 2010

Study isolated and identified the microbiota present during the semi-dry method of coffee processing using polyphasic methods and evaluated microbial diversity with PCR-DGGE. Vilela 2010

It is shown that coffee beverage contains both low molecular weight compounds and high molecular weight melanoidin and non-melanoidin components with a strong ability to interfere in vitro with the Streptococcus mutans traits relevant for cariogenesis. Stauder 2010

Eighteen lactic acid bacteria (LAB) strains, isolated from coffee pulp silages were characterized according to both growth and gallic acid (GA) consumption. Prussian blue method was adapted to 96-well microplates to quantify GA in LAB microcultures. Guzmán-López 2009

Coffee consumption exceeding 3 cups per day advanced the age of Parkinson's disease (PD) onset by 4.8 years. Tea consumption and smoking can delay the age of PD onset, while coffee drinking may have the opposite effect. Kandinov 2009

Chlorogenic acid (5-CQA) is a kind of polyphenol & is richly included in green coffee beans. The inhibitory effects of 5-CQA & its components, caffeic acid (CA) & quinic acid (QA), on the two porcine pancreas alpha-amylase (PPA) isozymes, PPA-I & PPA-II were investigated. Narita 2009

It is shown that roasted coffees are high in lipophilic antioxidants and chlorogenic acid lactones, can protect neuronal cells against oxidative stress, and may do so by modulation of the ERK1/2 and JNK signaling pathways. Chu 2009

The anti-cariogenic effects against alpha-haemolytic streptococci showed by polyphenols from cocoa, coffee, and tea suggest to a possible application of these beverages in the prevention of pathogenesis of dental caries. Ferrazzano 2009

The in vitro effects of green coffee (C. arabica L.) oil on the synthesis of collagen, elastin, and glycosamino glycans and in the release of transforming growth factor-beta1 and granulocyte-macrophage colony-stimulating factor (GM-CSF) by human skin fibroblasts were evaluated. Velazquez PeredaMdel 2009

[Coffee "breaks" Alzheimer's disease.] No abstract available. Tabaton 2009

Review summarized the active components, pharmacologic properties, and clinical effectiveness of a number of natural antioxidant ingredients including soy, feverfew, mushroom extracts, teas, Coffea arabica (CoffeeBerry), Pinus pinaster (Pycnogenol), and Polypodium leucotomos. Berson 2008

Few of the bioactivities of coffee, documented are antioxidant activity, anticarcinogenic activity, antimutagenic activity etc. The compounds responsible for chemoprotective effects of coffee are mainly polyphenols including chlorogenic acids & their degradation products. George 2008

Coffee brew has the ability to inhibit lipid peroxidation completely in a rat liver microsome biological system. The protective effect is underpinned by antiradical properties, reducing power & metal chelating ability of the components, each contributing to a different extent. Daglia 2008

Roasted coffee extract possesses antibacterial activity against a wide range of microorganisms, including Staphylococcus aureus and Streptococcus mutans, whereas green coffee extract exhibits no such activity. Daglia 2007

Low molecular weight compounds released from melanoidin (isolated from brewed coffee after ultrafiltration with a 10 kDa cutoff membrane) after gastrointestinal digestion exerted the highest antioxidant activity, even higher than compounds bound ionically to melanoidins. Rufián-Henares 2007

Chemical structures and fermentability of soluble dietary fiber obtained from a standard filter coffee beverage (Coffea arabica, origin Colombia, medium roasted) by human intestinal bacteria were investigated. Gniechwitz 2007

It is suggested that at least part of the anti-diabetic effects of coffee consumption is due to inhibition of 11beta-hydroxysteroid dehydrogenase type 1-dependent glucocorticoid reactivation. Atanasov 2006

5-(Hydroxymethyl)-2-furfural (HMF), a pyrolysate of carbohydrate isolated from instant coffee (Coffea arabica L.), selectively inhibits the activities of mammalian DNA polymerase lambda (pol lambda) and terminal deoxynucleotidyltransferase (TdT) which are family X pols, in vitro. Mizushina 2006

The in vitro antimicrobial activity of commercial coffee extracts and chemical compounds was investigated on nine strains of enterobacteria. The antimicrobial activity investigated by the disc diffusion method was observed in both the extracts and tested chemical compounds. Almeida 2006

87 culturable endophytic bacterial isolates in 19 genera were obtained from coffee plants collected in Colombia, Hawaii, & Mexico. This is the first survey of endophytic bacteria diversity in various coffee tissues, and the first study reporting endophytic bacteria in coffee seeds. Vega 2005

The effects of both coffee components and coffee extract on the electrical responses of GABA(A) receptors expressed in Xenopus oocytes were studied. The aqueous extract of coffee dose-dependently inhibited the GABA-elicited responses. Hossain 2003

Green & roasted coffees of two most used species, Coffea arabica & C. robusta, several commercial coffee samples & known coffee components were analyzed for their ability to interfere with Streptococcus mutans' sucrose-independent adsorption to saliva-coated hydroxyapatite beads. Daglia 2002

Enzymatic conversion of type B to O erythrocytes with Coffea (coffee bean) alpha-D-galactosidase was first described by Harpaz & Flowers. An ELISA and soluble oligosaccharide substrates were used to study deantigenation of B erythrocytes with the Coffea enzyme. Phillips 1996

[Antifungal properties of 1,3,7-trimethylxanthine, isolated from Coffea arabica.] No abstract available. Rizvi 1980