Coffea spp. - American Botanical Council

Coffee and Colorectal Cancer: Is Improved Survival a "Perk" of Coffee Drinking? [No abstract] Loftfield 2020

Reply to the Letter "Coffee consumption and extreme longevity: a risk assessment" [No abstract] Urtamo 2020

Response to Letter to the Editor: "Serum Metabolome of Coffee Consumption and its Association with Bone Mineral Density: The Hong Kong Osteoporosis Study". [No abstract] Li 2020

Letter to the Editor: "Serum Metabolome of Coffee Consumption and its Association with Bone Mineral Density: The Hong Kong Osteoporosis Study". [No abstract] Kawada 2020

Reply on "Coffee Consumption and Bone Health: A Risk Assessment" [No abstract] Coronado-Zarco 2020

Determined the acrylamide content in over 1000 food items using HPLC coupled with tandem mass spectrometry. Estimated acrylamide exposure using food consumption data of Korean National Health and Nutrition Examination Survey. Coffee was the main contributor of dietary acrylamide exposure in adults. Jeong 2020

Among 225 Israeli Ashkenazi Jewish Parkinson's disease patients screened for LRRK2 and GBA mutations, increased coffee and tea consumption levels were associated with older age of onset. Yahalom 2020

Coffee consumption was found to increase with increasing risk factor scores for hepatic steatosis in a population-based cross-sectional national health survey study (12,368 participants aged 25-74 years) examining independent and joint effects of lifestyle risk factors on fatty liver index. Nivukoski 2020

The intake of coffee, caffeine-rich, and non-alcoholic beverages was higher in uncontrolled chronic spontaneous urticaria patients than that in controlled patients according to a study examining dietary habits in adult Japanese patients with chronic spontaneous urticaria Matano 2020

Coffee alters the subsequent perception of taste by increasing sensitivity to sweet and decreasing the sensitivity to bitter, according to a study of 155 participants investigating the modularity effects of coffee consumption on immediate gustatory and olfactory sensitivity. Fjaeldstad 2020

Consuming more coffee/tea was associated with higher plasma concentrations of per- and polyfluoroalkyl substances in a study of 941 adults with pre-diabetes evaluating the relationship between diet and PFAS levels. Lin 2020

High dietary sodium, wine, spirits, high-caffeine coffee, and caffeinated energy drinks increased urine production in human studies according to a systematic review of studies (including 21 human and 28 rodent studies). The included studies were determined to be of variable quality. Alwis 2020

Regular coffee and caffeinated beverage consumption was strongly associated with smoking, serum lead levels, and poorer dietary habits according to data from the Third National Health and Nutrition Examination Survey (n=17752). Elhadad 2020

In a retrospective longitudinal study of 91,436 Korean adults, incidence of fatty liver was not associated with the amount of coffee consumption at baseline, but it was associated with the change in the amount of coffee consumption at the follow-up period. Chung 2020

Review of lifestyle risk factors in esophageal cancer noted inconclusive results in the literature on whether tea and coffee are risk factors. Zhao 2020

Among 3510 Korean pregnant women, consumption of =2 cups/day before pregnancy was associated with a higher risk of bleeding in the first 20 weeks of pregnancy, even in women aged 35 years or younger and those with normal body mass index. Choi 2020

Meta-analysis of genome-wide association studies indicated genetically predicted coffee consumption was not associated with stroke risk. Among coffee consumers, Mendelian randomization analysis did not indicate causal associations between level of consumption and risk. Qian 2020

Results from an umbrella review of 28 meta-analyses including 36 summary associations for 26 cancer sites revealed robust evidence that coffee intake was dose-dependently inversely related to the risk of liver cancer and endometrial cancer. Zhao 2020

In a meta-analysis of 232 observational studies (n=33,831,063) addressing the association between stomach cancer and behavioral factors, coffee was shown to negligibly associated with stomach cancer, with a OR (95% CI) of 0.99 (0.88, 1.11). Poorolajal 2020

During an investigation of saliva 8-hydroxyguanine (8-OHGUA) level as a potentially new oxidative stress biomarker, lower levels of 8-OHGua were observed in persons who moderately exercised or recently drank green tea or coffee. Watanabe 2020

Analysis of data from a cross-sectional study of 370 non-pregnant women aged 18-45 years from NE Thailand universities did not reveal coffee intake to be associated with prevalence of anemia or iron deficiency. Jamnok 2020

Data collected from 3-day DRs over the four seasons among 55 men and 58 women in Japan in order to generate an antioxidant database of foods representative of the typical Japanese diet revealed coffee to be among the most commonly consumed types of antioxidant-containing food. Tsubota-Utsugi 2020

A systematic review through May 2019 identified 1 cohort and 3 case-control studies (12,912 participants) that provided low quality evidence that low, medium, and high doses of caffeine intake do not appear to increase the risk of infertility. Bu 2020

Response to the letter to the editor by Tomoyuki Kawada, 'Coffee/tea consumption and depression: a risk assessment'. [No abstract] Elstgeest 2020

Intake of more than 1 cup of coffee per day was associated with a lower incidence of breast cancer among postmenopausal women in a study evaluating 10,812 middle-aged, Spanish female university graduates from the SUN prospective cohort. Sánchez-Quesada 2020

A study examining the association between lifestyle factors and semen quality in 1,311 men attending the Andrology clinic did not note an association between coffee intake and conventional semen parameters. Kaya 2020

In 492 community-dwelling cognitively normal Korean elderly individuals, higher cumulative lifetime coffee consumption was associated with higher cerebral volume of white matter hyperintensities in late life. Park 2020

Among 462 women aged 23 years, participants who reported drinking one or more high-calorie coffee drinks had poorer sleep quality, defined by the Pittsburg Sleep Quality Index, than those reporting drinking no high-calorie coffee drinks. Young 2020

Pooled data from 12 cohort studies, comprising of 2601 bladder cancer cases out of 501,604 participants, points to a positive association between coffee consumption and bladder cancer among male tobacco smokers that is unlikely to be causal. Yu 2020

Data from 1638 participants indicates no association between coffee intake and relative telomere length. Steiner 2020

Investigation of potential associations between lifestyle factors and Philadelphia chromosome negative myeloproliferative neoplasms (MPN) risk revealed an inverse association between consumption of caffeinated coffee and the risk of polycythemia vera. Podoltsev 2020

Coffee and coffee-based beverages comprised 2% of daily total polyphenol content intake of Canadian adolescents (n=108) surveyed from two southwestern Ontario high schools. Weinman 2020

Among 4,898 Korean subjects, the effect of coffee intake on dyslipidemia risk differed depending on genetic variants at the adenosine receptors (ADORA) loci in a sex-specific manner. Han 2020

Among a sample of 147 euthymic adults with bipolar disorder, multivariable analyses identified associations between the self-reported daily use of coffee, alcohol, tobacco, and the sleep/wake cycle, which may have a clinical impact on psycho-education strategies for those with BD. Gross 2020

Caffeine use during pregnancy was associated with reduced birth length but this effect was no longer significant after adjustment on potential confounding variables among 724 mothers in a large French urban area. Lamy 2020

Collection of electroencephalogram data recorded prior to, and post-consumption of, caffeinated coffee in 6 individuals in the presence of 7 photic stimuli of different frequencies for detecting the influence of coffee on the initiation of SSVEP signals in different regions of the brain. Pradhan 2020

Letter to the Editor: Coffee Consumption and Bone Health: A Risk Assessment [No Abstract] Kawada 2020

A study evaluating the psychosocial differences between patients with psoriasis in different phases of the disease (71 patients in exacerbation and 83 in remission) noted coffee consumption as a critical clinical variable. Almeida 2020

Women with Takotsubo syndrome (TS) were more likely to consume more cigarettes and coffee than healthy volunteers, while physical activity, smoking, and coffee consumption were similar in TS women and in women post-myocardial infarction (n=107). Harris 2020

Alcohol and coffee use was associated with an elevated cigarette demand among 88 treatment-seeking smokers. García-Pérez 2020

Is Caffeine or Coffee Consumption a Risk for New-Onset Atrial Fibrillation? A Systematic Review and Meta-Analysis [No abstract] Krittanawong 2020

Erratum for: Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. Ong JS, et al. Sci Rep. 2018. [No abstract] Ong 2020

Among 454 Indonesian teenagers, the prevalence of irritable bowel syndrome was high (30.2%), with major risk factos including female gender, bullying, age 14-16 years, history of constipation and diarrhea, eating nuts, and drinking coffee, tea, and soft drinks. Kesuma 2020

Greater consumption of coffee was observed to have a suggestive inverse association with glioblastoma risk in a prospective study among 379,259 participants (including 487 incident glioma cases) in the UK Biobank. Creed 2020

In a prospective study of 40 patients scheduled for 23G pars plana vitrectomy, vitreous samples harvested from habitual coffee drinkers contained significantly higher caffeine concentrations compared to non-coffee drinking controls. Epiretinal membranes did not contain detectable caffeine levels. Leisser 2020

Among 1,330 adults with untreated chronic hepatitis B infection in USA and Canada, at-risk alcohol use, current tobacco use and limited coffee consumption did not have an association with high ALT and FIB-4 values. Brahmania 2020

Intermediate levels of caffeinated coffee consumption (1-7 cups/week) were associated with a reduction in atrial fibrillation risk in two prospective Mediterranean cohorts (one of adults from a general population (n=18,983) and one of elderly participants at high cardiovascular risk (n= 6479)). Bazal 2020

Among habituated users (n=13), tolerance to central hypovolemia via lower body negative pressure was greater following consumption of caffeinated coffee relative to decaffeinated coffee or water. Pizzey 2020

Erratum: Combined Effect of Coffee Consumption and Cigarette Smoking on Serum Levels of Vitamin B12, Folic Acid, and Lipid Profile in Young Male: A Cross-Sectional Study [Corrigendum] [No abstract] [No authors listed] 2020

Consumption of coffee or green tea, the first and second largest dietary sources of total polyphenols, suppressed skin hyperpigmentation scores according to data from a cross-sectional survey of healthy Japanese women aged 30-60 years (n=244). Fukushima 2020

In a study investigating the association between diet and duodenal microbiome in 51 patients with liver cirrhosis, coffee consumption was associated with microbial richness and evenness. There was a dose-response association between coffee drinking and relative abundance of Veillonella. Hussain 2020

In a prospective population-based cohort study investigating excessive daytime sleepiness in 2,751 subjects over 5 years, moderate coffee consumption was found to be a protective factor against its incidence. Berger 2020

A dose-response meta-analysis of 11 studies (n=61,047) found no relationship between coffee consumption and c-reactive protein levels. However, the 3 largest studies observed significant relationships, which were inverse among European and US women and Japanese men and positive among European men. Moua 2020

Health deterioration over 3 y was associated with a higher frequency of reports of no regular coffee consumption during the subsequent 5 y among 718 coffee drinkers aged =60 y. This may imply that part of the reported health benefits of coffee consumption might be due to reverse causation. Ortolá 2020

Risk for Renal Carcinogenesis Due to Exposure to Ochratoxin A Contaminated Roasted Coffee: An Assessment From Thailand [No abstract] Joob 2020

Coffee Consumption and Extreme Longevity: A Risk Assessment [No abstract] Kawada 2020

After stratification by tribbles pseudokinase 1 (TRIB1)rs17321515 genotypes, coffee drinking remained significantly associated with a lower risk of coronary heart disease only among participants with GG genotype in a study of 1116 cases and 7853 controls. Liu 2020

A higher level of Bacteroides-Prevotella-Porphyromonas in the gut microbiota was observed in high consumers of coffee, who also had lower levels of lipoperoxidation in a study of 147 healthy subjects. González 2020

Higher coffee consumption was associated with lower total body fat percentage and trunk body fat percentage in a dose-response manner among women according to cross-sectional data from NHANES on adults aged 20-69 y. Cao 2020

The gut microbiota of people who consumed coffee was dominated by Bacteroides thetaiotaomicron followed by Phascolarctobacterium faecium and Eubacterium rectale in a study of feces from 104 Saudi volunteers (48% males). Harakeh 2020

Higher coffee consumption was associated with lower circulating levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a meta-analysis of 19 observational studies. Ding 2020

Patients with active Crohn's disease consumed less coffee and tea in a cross-sectional study on food consumption patterns in 60 patients with Crohn's disease aged 18-60 years. de Castro 2020

Ulcerative colitis patients and IBD patients with active disease consumed less coffee compared to controls according to results of a dietary survey of 493 inflammatory bowel disease patients and 1291 controls. Peters 2020

Caffeinated coffee, decaffeinated coffee, or caffeinated tea consumption was not associated with survival to 90 years after adjusting for confounders in a prospective cohort study among 27,480 older women from the Women's Health Initiative in 40 US clinical centers. Shadyab 2020

Among 508,747 men and women aged 20-79 participating in Norwegian cardiovascular surveys followed for an average of 20 years, hazard ratios for all cause mortality and cardiovascular disease related death for men and women were higher for those drinking unfiltered coffee than filtered coffee. Tverdal 2020

A systematic review and meta-analysis of 4 cohort studies (n=25,849) found decreased risk of incident chronic kidney disease among coffee drinkers compared with non-drinkers with the pooled risk ratio of 0.87. Srithongkul 2020

Mean forced expiratory volume to forced vital capacity ratio (a diagnostic measurement for COPD) was worsened with increasing coffee intake in a cross-sectional analysis of 15,961 Korean adults. Min 2020

Bahraini students (n=727) who consumed 400mg/day or more of caffeine showed twice as high of a risk for five symptoms: headaches, spells of terror or panic, feeling trapped or caught, worrying too much, or feelings of worthlessness. Jahrami 2020

Habitual coffee consumption may be causally related to increased odds of osteoarthrosis, other arthropathies, and overweight and lower odds of postmenopausal bleeding in a Mendelian randomization phenome-wide association study of 33,214 participants. Nicolopoulos 2020

In a cross-sectional study evaluating risk factors of irritable bowel syndrome among 181 medical and nonmedical students at Jouf University, coffee intake was a strong predictor of IBS status. Wani 2020

Among 203 mother-child pairs, caffeine in the maternal diet during the third trimester significantly correlated with caffeine content in hair collected from the newborn within 48 hours of birth. Lehtonen 2020

Analysis of data from NHANES 2011-2014 on 2,513 participants aged 60 or older showed L-shaped associations were apparent for coffee, caffeinated coffee, and caffeine with the DSST and CERAD cognitive test scores. Dong 2020

Among 1,114 adults, regardless of BMI, higher intakes of magnesium, dairy products, poultry, apples/pears, citrus fruits, and tea/coffee decreased the risk of developing unhealthy metabolic phenotype, while higher intakes of fast foods, organ meats, and potatoes increased the risk. Mirmiran 2020

A review summarizing and evaluating observational studies of dietary risk factors for primary liver cancer noted that coffee intake may decrease liver cancer risk. Yang 2020

Lead exposure from dietary sources in pregnant women in a Northern Swedish birth-cohort (n=581),was primarily associated with intake of game meat, tea, and coffee. Gustin 2020

Healthy individuals consuming caffeine regularly had a lower risk of Parkinson's disease (PD) at follow up, while PD patients consuming caffeine regularly presented a lower rate of PD progression, according to a meta-analysis of 13 studies. Hong 2020

A longitudinal study of 8780 civil servants aged 35-74 years at baseline initially free of hypertension observed a decreased risk of hypertension in never smokers drinking 1-3 cups of coffee per day, whereas risk among former and current smokers was not associated with coffee consumption. Miranda 2020

Detail the contribution of Mendelian randomization studies hitherto conducted for modifiable environmental exposures with the risk of rheumatoid arthritis to understand their roles in pathogenesis. The few studies examining the causal role of coffee consumption were inconsistent. Jiang 2020

Coffee consumption did not improve impaired driving performance in sleep deprived participants, and instead, performance further deteriorated. Lowrie 2020

Coffee intake of 0.5-3 cups/day during pregnancy was not associated with a higher risk of childhood acute leukemia; however, an intake of >3 cups/day resulted in aRR = 1.37, 95 % CI: 0.56, 3.32 according to data from two birth cohorts including 141,216 pregnancies. Madsen 2020

Consumption of =2 cups/day of decaffeinated coffee, compared to no decaffeinated coffee, was associated with lower risk of overall colorectal cancer and rectal cancer, while =2 cups/day of caffeinated coffee was associated with higher risk of rectal cancer in a prospective study of 107,061 adults. Um 2020

Energy drink consumption increases the complexity of the cardiovascular system in young adults significantly. Coffee and cola consumption have no significant effect on the non-linear parameters of heart rate variability. Caliskan 2020

Performance on self-administered cognitive functioning tests decreased with the consumption of 1 or more cups of coffee, while tea consumption was associated with poor performance on all tests in a study of at least 97,369 white participants aged 37-73 y from the UK Biobank. Cornelis 2020

Serial cross-sectional studies in 2012 (n=635) and 2018 (n=627) among adults in a rural Thai community showed instant coffee-mix consumption > 1 cup/week was associated with incidence of obesity. Sakboonyarat 2020

A cross-sectional survey found 40% of patients and the general public (n=430) and 65% of clinicians (n=235) believed local anesthesia failure could be due to excessive coffee consumption. Only 9% of clinicians were aware of scientific evidence regarding this potential phenomenon. Premnath 2020

Espresso coffee, caffeine and colon cancer Comment on: Caffeine and its main targets of colorectal cancer [No abstract] Mattioli 2020

Coffee consumption was not associated with the risk of colon cancer in Asian men and women according to results of a meta-analysis of 9 cohort studies. Bae 2020

Among 2735 CARDIA study participants, low-to-moderate daily coffee consumption from early adulthood to middle age was associated with better LV systolic and diastolic function in midlife. High daily coffee consumption (>4cups/day) was associated with worse LV function. Nwabuo 2020

Only caffeinated coffee was consistently associated with a protective effect for cutaneous melanoma in a systematic narrative review of 18 cohort studies investigating the association between anti-inflammatory foods and melanoma development. Fortes 2020

CYP1A2 rs762551, marginally associated with the risk of Parkinson's disease and also implicated in caffeine metabolism pathways, was associated with a decreased blepharospasm (BSP) risk (common among PD patients) in a SE European Caucasian cohort of 206 BSP patients and 206 healthy controls. Siokas 2020

There were an estimated 1,240,201 adult liver-related deaths worldwide in 2016. If all countries with per capita coffee intake =2 cups/ day increased to >2 cups/ day, the predicted total deaths would have been 630 947, while if they increased to = 4 cups/ day, the total would have been 360 523. Gow 2020

The rs75981965 SNP from circadian clock gene RORA was associated with sleep duration in 10112 Tawainese participants, and interactions between this SNP and environmental factors including coffee consumption further influenced sleep duration. Hou 2020

Total coffee consumption was inversely associated with functional disabilities involving lower-extremity mobility, general physical activity, leisure and social activities, and instrumental activities of daily living in a study of 7404 participants = 60 years old. Wang 2020

Assessment of the prevalence of hypertension and its associated factors among adults residing in Arba Minch health and demographic surveillance site, Southern Ethiopia using a community-based cross-sectional survey noted those who did not use coffee and tea had a higher likelihood of hypertension. Chuka 2020

Compared to light consumption, high-moderate total coffee consumption had an inverse association with all-cause mortality among 117,228 Norwegian women. An adverse association seen between heavy filtered coffee consumption and all-cause mortality was not found in never-smokers. Lukic 2020

Coffee (but not tea or soft drink) consumption was significantly associated with a higher risk of open-angle glaucoma among Korean adults (n=6,681), especially men. Bae 2020

Investigation into causal associations of multiple lifestyle factors with heart failure risk by using Mendelian randomization found no associations of alcohol consumption, coffee consumption, and physical activity with heart failure. van Oort 2020

No significant association was observed between coffee consumption and gambling habits in a sample of Italian adolescents (n=15,833). [Article in En, Spanish] Buja 2020

Metanalysis of 50 observational studies and RCTs, totalling 1,322,133 participants and 21,030 cases, investigating associations between lifestyle factors and incident nephrolithiasis indicated that coffee consumption may be protective against nephrolithiasis. Lin 2020

Coffee consumption was positively associated with higher gait speed in an exploration of cross-sectional associations between coffee consumption and physical performance among oldest-old community-dwelling men in the Helsinki Businessmen Study (n = 126, mean age 87 years). Jyväkorpi 2020

No evidence for a causal association between coffee consumption and incidence of Crohn's disease or ulcerative colitis (12,194 CD cases, 12,366 UC cases, and 25,042 controls of European ancestry) was observed during Mendelian randomization analysis of SNPs associated with use of caffeine. Georgiou 2020

Depressive symptoms, alcohol and coffee consumption affected sleep onset latency, whereas circadian preference was strongly associated with bed and waketime in a study of 82 Italian university students. Cellini 2020

In patients with low coffee and caffeine consumption, osteoporosis risk was higher in the high polygenic risk scores best model (PRSBM) group than the low PRSBM group, according to data from a genome-wide association studies of 8845 individuals 40 to 65 y of age. Park 2020

A higher risk of rheumatoid arthritis was found among patients with higher caffeine intake and the CT genotype of ADOARA2A rs2298383, rs3761422 and rs2267076 SNPs among 82 rheumatoid arthritis patients treated with methotrexate. Soukup 2020

Coffee consumption was not associated with coronary artery disease or myocardial infarction in a study of 612 Japanese patients who underwent coronary angiography. Kishimoto 2020

No significant associations were identified between the intake of coffee with breast cancer risk (OR 0.84, 95% CI 0.64-1.10) in a study of 33,396 Japanese women aged 40-79 years investigating the association between intake of common alcoholic and non-alcoholic beverages and breast cancer risk. Sinnadurai 2020

No causal relationship was observed between single-nucleotide polymorphisms (SNPs) associated with habitual coffee consumption and multiple sclerosis risk according to a meta-analysis of 14,802 subjects with MS and 26,703 healthy controls of European ancestry from the UK Biobank. Lu 2020

Analysis of 7 studies indicated that coffee consumption was associated with a decrease in the risk for incident chronic kidney disease outcome, especially with =2 cups/day. There was a lower risk of incident end stage kidney disease, albuminaria, and death in coffee users. Kanbay 2020

Data from a questionnaire of 208 participants with inactive ulcerative colitis showed that 24% avoided coffee, 59% avoided dietary items to prevent relapse, 31% believed diet was the initiating factor for UC, and 37% believed diet could trigger relapse. Crooks B

Review of 17 studies showed acute increases in caffeine consumption may precede manic symptoms in bipolar patients through stimulant effect, sleep changes, and/or changes in lithium/medication metabolism. Increases in caffeine intake could be due to ongoing manic relapse or a prodromal sign. Frigerio 2020

In a large case-control study enrolling 694 Parkinson's disease (PD) patients and 640 healthy controls, coffee consumption (odds ratio: 0.6; 95% confidence interval [CI]: 0.4-0.9) was one of 9 factors found to independently modify PD risk. Daniele 2020

Increased consumption of coffee was associated with decreased risk of cancer progression in a prospective observational cohort study including 1171 patients with previously untreated locally advanced or metastatic colorectal cancer. Mackintosh 2020

The risk of non-alcoholic fatty liver disease among those who drank coffee compared to those who did not was significantly lower, and those with NAFLD who drank coffee had a reduced risk of liver fibrosis than those who did not according to meta-analyses of 11 eligible observational studies. Hayat 2020

Coffee (caffeine) consumption was one of 19 risk factors for type 2 diabetes identified by Mendelian randomization analyses of European summary level data and review of published MR studies. 15 protective factors were also named. Yuan 2020

Analyzed the effects of coffee in a systematic review aiming to determine which food or beverages consumed during cancer treatment might prevent recurrence, subsequent malignancies, treatment-related toxicity, or death that identified 19 relevant studies. Conigliaro 2020

Consumption of a green/roasted coffee blend was associated with decreased waist circumference, diastolic and systolic blood pressure, body weight, WC/hip and WC/height ratios, and triglycerides, in hypercholesterolemics. Sarriá 2020

In a multicenter case-control study comparing 1,293 cases of alcohol-related cirrhosis and 754 controls with equivalent alcohol exposure but no evidence of liver disease, controls were more likely to have been wine drinkers, coffee drinkers, tobacco smokers, and cannabis users than cases. Whitfield 2020

Coffee consumption was associated with reduced risk for lung cancer in an analysis of lifestyle and demographic data collected between 1990 and 2001 from 12,668 Thai participants were were followed through 2016. Kudwongsa 2020

No significant evidence for a causal protective effect of coffee intake on non-alcoholic fatty liver disease was seen in a 2-sample Mendelian randomization analysis using SNPs associated with habitual coffee intake and summary level data from a published GWAS of NAFLD (1122 cases, 399,000 controls). Zhang 2020

A systematic review and meta-analysis of 20 studies found a negative association between coffee consumption and the risk of hepatocellular carcinoma and/or liver cancer (relative risk of 0.69 (95%CI 0.56-0.85; p<0.001)). Higher doses of coffee were associated with lower risk. Bhurwal 2020

Observed significant, positive associations between elevated coffee intake (three or more cups of coffee per day) and neurocognitive performance in verbal fluency, psychomotor speed (coding) and executive functioning among a sample of 139 HIV-Hepatitis C coinfected people. Antwerpes 2020

Among 1,385 Saudi adults not previously diagnosed with diabetes, intake of =5 cups/week of Turkish coffee was associated with increased risk of dyslipidemia in men, while the same intake of American coffee had a protective effect. Enani 2020

Meta-analysis of 62 studies on the contribution of dietary factors to the risk of cardiovascular disease in the Korean population found a significant association between coffee consumption and CVD and triglycerides. Kim 2020

Among 57,075 postmenopausal women who were cancer-free at baseline, neither total, caffeinated nor decaffeinated coffee consumption were associated with invasive breast cancer risk nor with risk of hormone receptor positive or hormone receptor negative breast tumors at follow-up. McCullough 2020

Compared with coffee nonconsumers, each additional cup of coffee was associated with higher total cholesterol, HDL-cholesterol, and LDL-cholesterol concentrations and lower fasting triglycerides and C-reactive protein concentrations among 447,794 participants aged 37-73 from the UK Biobank. Cornelis 2020

In a multi-center CAP-Asia study of 555 patients with non-alcoholic fatty-liver disease, tea and coffee consumption were independently associated with high controlled attenuation parameter and liver stiffness, respectively. Zhang 2020

Weekly intake of 5 portions or more of red meat and Turkish coffee was associated with decreased odds of having dysglycemia in men in a cross-sectional study of 1403 Saudi adults not previously diagnosed with diabetes, including 328 with dysglycemia. Jambi 2020

Single-dose coffee consumption affected sex-specific host metabolic responses that relate to gut-microbe and energy metabolism in 30 healthy volunteers as measured by changes in urine and fecal samples. Chong 2020

Caffeinated and decaffeinated coffee intake and colorectal cancer: A risk assessment [No abstract] Kawada 2020

Coffee consumption was not significantly associated with the risk of lung, breast, colorectal, or prostate cancers or overall cancer risk for = 2 versus < 1 times/day in a nested case-control study including 1801 cancer cases and 3337 controls among African Americans. Schmit 2020

Consumption of green tea or coffee was associated with reduced all-cause mortality, while consumption of both beverages seemed to have an additive effect in a prospective study of 4923 Japanese patients with type 2 diabetes. Komorita 2020

Coffee presented the 3rd highest mean levels of acrylamide in the diets of people from different age groups in Koea. Lee 2020

Coffee intake during pregnancy was associated with increased odds of the incidence of undernutrition (AOR = 1.6) in a cross-sectional study of 844 pregnant women from the Tigray region of Ethiopia. Ayele 2020

A Southern German study investigating the relationships between gut microbiota alterations and Parkinson's disease (71 PD patients; 30 controls) found coffee to play a pivotal role as a covariate, with data suggesting that altered microbiota may mediate the protective effect of coffee consumption. Mikolasevic 2020

In a cross-sectional study of 1998 nonalcoholic fatty liver disease patients, frequent coffee consumers had the lowest prevalence of obesity, hypertension, dyslipidemia, and diabetes, and coffee intake was associated with lower controlled attenuation parameter and liver stiffness measurements. Mikolasevic 2020

Consumption of coffee 1-2 times per day and in quantities of 1 cup each time was associated with lower adjusted odds ratios for asthma according to data from the Korean Genome and Epidemiology study (n = 3146 with asthma; n = 158,902 non-asthma). Green tea and soda were not associated with asthma. Wee 2020

In an unmatched case-control study pregnant women attending public health facilities in Kacha Birra District, Southern Ethiopia, 117 with anemia and 227 controls, consumption of tea/coffee instantly after a meal was among significant predictors of anemia. Teshome 2020

A Glance Back at the Journal of Gerontology-Coffee, Dietary Interventions and Life Span. [No abstract] Duregon 2020

Coffee consumption and the combination of daily drinking coffee and eating bread at breakfast time were associated with lower proportions of visceral obesity and metabolic syndrome in a study of 3539 Japanese participants, while the combination also was associated with lower overall obesity. Koyama 2020

Ingestion of coffee and other certain foods as well as smoking status were the main influencing factors of exposure to polycyclic aromatic hydrocarbons in the urine of 110 lactating women living in Spain (2015). Fernández 2020

Hypothesized that the statistical and entropy-based features can efficiently detect the changes in the ECG signals, which is induced by coffee consumption, based on recorded ECG signals from 14 volunteers in pre- and post-coffee consumption conditions. Pradhan 2020

Unlike Tanzanian and Ethiopian coffees, Kenyan coffee suppressed the increase of postprandial interstitial glucose levels in this study. Kenyan coffee beans contain less anhydrous caffeine and more chlorogenic acid than Tanzanian and Ethiopian coffee beans. Okada 2020

Data from 25 countries showed an inverse linear correlation between coffee consumption in kg per person per year and estimated age-adjusted incidence (r = 0.5984, p = 0.0016) and mortality (r = 0.5877, p = 0.0020) of stomach cancer. Parra-Lara 2020

Metabolomic profiling of 368 subjects showed plasma concentrations of caffeine and its metabolites were lower in Parkinson's disease patients than in unaffected controls, more so among LRRK2+ carriers than among LRRK2- subjects. Dietary caffeine was also lower in LRRK2+/PD+ compared to LRRK2+/UC. Crotty 2020

Consumption of Ethiopian origin Arabica coffee was associated with an increase in serum free fatty acids and HDL and a decrease in triaclyglycerides in a cross-sectional study of 70 healthy individuals in Addis Ababa, Ethiopia. Gebeyehu 2020

A review of evidence regarding potential environmental, hormonal, and dietary risk factors for rheumatoid arthritis indicated that high consumption of coffee seems to be associated with an increased risk. Salliot 2020

No association was found between coffee or tea and depressive symptom clusters or past Major Depressive Symptom diagnoses in cross-sectional and longitudinal analysis based on baseline and 12-month-follow-up data in 941 overweight European adults with subsyndromal depressive symptoms. Pérez-Ara 2020

Elders in a Mediterranean cohort who consumed caffeinated coffee had better cognitive functioning than non-consumers when measured by a selection of tests after adjustment for confounders in a cross-sectional study (n=6427). Paz-Graniel 2020

Coffee consumption was associated with higher levels of 63 sphingolipids (29 sphingomyelins, 32 ceramides, a sphingosine-1-phosphate and a sphingosine) and lower levels of 13 acylcarnitines and alanine according to metabolomic analysis of the Singapore Prospective Study Programme cohort. Seow 2020

There was no overall sex-adjusted association between the highest consumption level of coffee and metabolic syndrome in a meta-analysis of 13 cross-sectional studies (n=280,803) and 2 longitudinal studies (n=17,014). Subgroup analysis revealed inverse associations in specific groups. Wong 2020

While thyme tea-drinking decreased the risk of primary dysmenorrhea by 63.2%, coffee drinking tended to increase the odds of severe dysmenorrhea in young female students in an institutional case-control study in the suburbs of Debre Berhan town, Ethiopia. Zeru 2020

3 cholesteryl esters positively associated with coffee intake showed inverse associations with diabetes risk, while 12 metabolites negatively associated with coffee showed positive associations with diabetes in data drawn from cohorts of female nurses, including 457 diabetes cases and 1371 controls. Hang 2020

Analysis of data derived from 2 large cohorts of medical professionals investigating the associations of coffee consumption with 14 plasma biomarkers in key metabolic and inflammatory pathways indicated favorable outcomes related to coffee consumption. Hang 2019

Analysis of data from the UK Biobank from 347,077 individuals indicated that heavy coffee consumption was associated with a modest increase in cardiovascular disease, but this association was unaffected by genetic variants influencing caffeine metabolism, including CYP1A2. Zhou 2019

Data from the longitudinal prospective Women's Health Initiative Observational Study (n=76,853) showed no association between coffee consumption and incident rheumatoid arthritis. Lamichhane 2019

Results from a web-survey assessing the prevalence of GERD among university students in central Italy and correlated lifestyle factors, including coffee. Martinucci 2019

No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in a large cohort of 142,196 men in the European Prospective Investigation into Cancer and Nutrition. Sen 2019

In healthy participants, coffee consumption did not affect platelet aggregation nor adversely affect testing thereof. Krekels 2019

A negative correlation between coffee and tea combined IgG levels and number of Hashimoto's thyroiditis related symptoms found during an evaluation of immunologic response to food allergens suggests possible beneficial effect of tea and coffee on HT disease symptoms. Kalicanin 2019

In a prospective study of 411 patients with newly diagnosed prostate cancer on an active surveillance protocol, patients with low/moderate coffee intake and the AA fast caffeine metabolizer genotype were less likely to experience grade progression than nonconsumers. Gregg 2019

Data from a 5-year population-based cohort study of 2,604 participants including 328 patients with chronic Hepatitis B virus (HBV) infection indicated that coffee consumption was not associated with fibrosis progression or hepatocellular carcinoma risk in chronic HBV patients. Chen 2019

Coffee consumption was among risk factors associated with human papilloma virus-positive cases mong 594 participants between 4-60 years old in northern Thailand investigated and genotyped for human papillomavirus (HPV). Bumrungthai 2019

A meta-analysis of evidence did not support an association between the consumption of coffee or tea and subarachnoid hemorrhage risk. Rui 2019

Data from 2302 elderly Koreans found that the prevalence of knee osteoarthritis tended to increase with increasing coffee consumption, but did not reach statistical significance until the level of consumption of 7 cups or more daily. Bang 2019

Pooled analyses of 8 international, prospective cohort studies including 351,565 individuals did not reveal significant associations between coffee, tea, or caffeine intake and risk of amyotrophic lateral sclerosis (ALS) mortality. Petimar 2019

An investigation into the relationship between total plasma homocysteine, serum vitamin B12, and folate concentrations in Turner syndrome patients noted that coffee consumption was among lifestyle factors important for homocysteine metabolism. Calcaterra 2019

Consumption of coffee and tea was not significantly associated with changes in depressive symptoms among 1058 Italian adults. Elstgeest 2019

A review summarizing current evidence regarding lifestyle, exercise, and nutrition in the pathogenesis of glaucoma noted that moderate intake of hot tea and coffee has been reported to be possibly protective against developing glaucoma or its progression. Perez 2019

Analysis of a prospective study of 17,065 middle-aged Spanish university graduates demonstrated that the intake of flavonoids, of which coffee was a major source, was inversely associated with risk of cardiovascular events. Mendonça 2019

Genome-wide association studies of middle aged Korean adults found that subjects with high genetic risk scores for insulin resistance may be susceptible to increased insulin resistance by 50% and its risk may be exacerbated by consuming more than 10 cups coffee/week or 220 mg caffeine/day. Daily 2019

Systematic review of cohort studies and meta-analysis provided quantitative data suggesting that coffee consumption plays a role in reducing the risk of all-cause mortality, with similar inverse associations found for caffeinated and decaffeinated coffee. Li 2019

Among 88 apparently healthy men, analysis of data from a food frequency questionnaire did not reveal an association between coffee consumption and biomarkers of subclinical atherosclerosis. Acosta-Navarro 2019

Data from the prospective Singapore Chinese Health Study of 63,257 adults aged 45-74 years found that consumption of caffeinated drinks, including coffee, was associated with reduced risk of non-melanoma skin cancer. Oh 2019

A cross-sectional study conducted in Indonesian adults found that coffee intake was negatively correlated with adiposity, and this was independent of total caffeine intake. The -866?G/A UCP2 gene variation was found to influence the relationship between coffee intake and adiposity. Muhammad 2019

A multicenter retrospective case-control study of 1347 Chinese patients with rosacea and 1290 controls did not find a correlation between coffee consumption and incidence of any subset of rosacea. Yuan 2019

Data from a prospective community-based cohort study (n=360) of lifestyle factors associated with Parkinson's disease indicated that coffee consumption was protective against time to Hoehn & Yahr stage 3, cognitive decline, and mortality. Paul 2019

A study of 506 Thai participants using a self-matched case-crossover design found that physical exertion, coffee and tea consumption were associated with a higher risk of myocardial infarction in the subsequent hour. Lohsoonthorn 2019

A dose-response meta-analysis of 13 high-quality cohort studies (959,992 participants and 3851 cases) found that coffee consumption was found to increase the risk of pancreatic cancer, with each cup/day increasing risk by 5.87%. Li 2019

Narrative review provided an overview of evidence for the positive impacts and risks of coffee consumption on human health. The best available evidence from research indicates that drinking coffee up to 3-4 cups/day provides health benefits for most people. Saeed 2019

An investigation into associations between modifiable risk factors, including coffee consumption, and osteoporosis among women aged 50-74. Medrela-Kuder 2019

Synthesis of meta-analyses found that caffeine ingestion improved exercise performance in a broad range of exercise tasks. Ergogenic effects of caffeine on muscle endurance, muscle strength, anaerobic power and aerobic endurance were substantiated. Grgic 2019

A meta-analysis of prospective cohort studies did not find evidence for the association between coffee consumption and colorectal cancer risk. Coffee consumption was related with a decreased risk of colon cancer in a subgroup analysis of never-smokers and in Asian countries, Micek 2019

A systematic review and meta-analysis of 26 prospective studies found varying association between consumption of coffee with all colorectal cancers and its subsets depending on caffeination of the coffee, gender, and ethnicity. Sartini 2019

A retrospective study on factors related to the source of Helicobacter pylori infection of patients at a tertiary referral center in Apulia (Italy) notes that the number of cups of coffee consumed per week correlated significantly with H. pylori status. Monno 2019

A cross-sectional study of 763 female high school students in Kuwait noted that drinking coffee was significantly associated with dysmenorrhea in multivariable analysis. Al-Matouq 2019

A cross-sectional study of 170 participants with nonalcoholic fatty liver disease investigating relationships between major dietary patterns and hepatic fibrosis noted that coffee consumption had a protective role in hepatic fibrosis independent of other risk factors. Soleimani 2019

Findings from a meta-analysis of 11 articles suggested that higher consumption of coffee was found to have a protective effect against risk of brain cancer, especially in Asian populations. Song 2019

Coffee Drinking and Risk of All-Cause Mortality and Cardiovascular Diseases. [No abstract] Hirakawa 2019

In a large Japanese cohort study, coffee consumption frequency was inversely associated with all-cause mortality in both genders, and was inversely associated with risk of mortality from cerebrovascular disease in men and heart disease in women. Sado 2019

Coffee-related cues prompted higher arousal levels in participants even in the absence of ingestion. Chan 2019

A meta-analysis of 20 case-control studies including 40,140 participants found no significant association between total coffee, caffeinated coffee, or caffeine intake and risk of ovarian cancer. There was evidence for an inverse relationship between decaffeinated coffee and ovarian cancer risk. Shafiei 2019

A cross-sectional study among 365 hormonal contraceptive users in Harar town, Eastern Ethiopia noted that drinking coffee twice/week was among predictors of dyslipidemia Sufa 2019

Coffee Intake and Chronic Kidney Disease. [No abstract] Kawada 2019

Among those undergoing orthotopic liver transplantation for hepatocellular carcinoma (n=90), coffee intake was associated with a lower risk of recurrence and higher survival following OLT, partly due to antagonist activity of caffeine on adenosine-A2AR mediated growth-promoting effects on HCC cells. Wiltberger 2019

Among 67,569 full-term Norwegian mother-infant pairs, moderate prenatal caffeine exposure ( Modzelewska 2019

In a study of 1126 middle-aged Japanese male workers, an inverse association between coffee consumption and 3% oxygen desaturation during a nights sleep was found in overweight and non-smoking workers. Takabayashi 2019

Data from Taiwanese adults aged 30-70 showed coffee drinking was significantly associated with higher high-density lipoprotein (HDL) levels in women but not men after adjusting for confounders including rs1800588 (LIPC) and rs1800775 (CETP) variants. Hsu 2019

A Japanese population-based prospective cohort study of adults over 35 found that drinking coffee, even 1 cup/d, was inversely associated with all-cause mortality and mortality from cardiovascular, infectious and digestive diseases. Yamakawa 2019

Data from the prospective UK Biobank cohort indicated that high intake of total fluid, especially tea, coffee, and alcohol (but not water) and consumption of fruit and foods high in fibre are linked with a reduced likelihood of developing kidney stones. Littlejohns 2019

Investigation of the long-term effects of caffeine and consumption of coffee and tea on the occurrence of cardio-renal events among an Iranian population with low coffee and high tea consumption. Coffee intake was found to be protective, while tea intake or its associated factors may increase risk. Gaeini 2019

Results of a longitudinal study of 1920 adults over 40 y in Tanushimaru suggest that higher coffee consumption may have a protective effect against all-cause death due to reducing resting heart rate. Nohara-Shitama 2019

A meta-analysis of 40 studies (3,852,651 subjects) found moderate coffee consumption was associated with reduced all-cause and cause-specific mortality, compared to no consumption. The inverse association between coffee and all-cause mortality was consistent by potential modifiers except region. Kim 2019

A dose-response meta-analysis of observational studies did not observe an association between coffee intake and non-Hodgkin's lymphoma risk. Mirtavoos-Mahyari 2019

A prospective Danish cohort study found that women consuming 1-5 cups of coffee vs. O had a 1.5x higher probability of achieving a pregnancy or a live birth when receiving intrauterine insemination. No associations were found between coffee and achieving a pregnancy or a live birth from IVF/ICSI. Lyngsø 2019

In a population-based prospective cohort of 471,779 participants from the UK Biobank, evidence showed that coffee consumption was inversely associated with hepatocellular carcinoma. Tran 2019

A broad-based case-control survey study on 52 patients with auto-brewery syndrome and their household members noted that those with ABS consumed less coffee than those without the disease. Cordell 2019

A study of 45 professional teenage female gymnasts in Poland and 40 controls examining menstrual disorders noted that coffee consumption was a risk factor for premenstrual syndrome and premenstrual dysphoric disorder. Czajkowska 2019

Data from a prospective study in Finnish male smokers found that coffee drinking was not associated with urinary tract cancers risk. Hashemian 2019

A meta-analysis of case-control and cohort studies found that high or intermediate coffee intake might have protective effects against oral cavity cancer. He 2019

In a study of 2278 US adults that examined the association of caffeine and 13 of its direct and indirect metabolites with hypertension, the final metabolites of caffeine but not caffeine itself were associated with reduced odds for hypertension. Ngueta 2019

Analysis of a community-based cross-sectional study of 940 pregnant mothers noted that the risk of undernutrition was decreased by 43% among those pregnant mothers who consumed coffee only sometimes as compared to daily consumers. Dadi 2019

Data from 2964 participants from a Spanish cohort and 8999 from a UK cohort, aged =60 y, indicated that habitual caffeinated coffee consumption was associated with a lower risk of falling. Machado-Fragua 2019

Analysis of food-frequency questionnaire data from middle aged adults in the UK Biobank study did not support an association between coffee consumption and colorectal cancer risk. Bradbury 2019

A summary of the latest findings on the association between coffee intake and liver cancer risk notes that accumulated evidence, with consistency across study designs and populations, suggests coffee intake probably reduces the risk of liver cancer. Inoue 2019

Among 100 pregnant women in the Warsaw region, no relationships were found between caffeine intake and neonatal weight, length, head and chest circumference, or fetal growth overall. Wierzejska 2019

The intake of food with high antioxidant potential and rich in polyphenols was associated, slightly but independently of other factors, with lower risk of hypertension in Polish adults. Irrespective of sex and arterial hypertension, coffee and tea were the basic dietary sources of the antioxidants. Waskiewicz 2019

Results of a meta-analysis of cohort studies conducted in Japan suggested that coffee consumption has a significant role in preventing liver cancer. Tamura 2019

A pooled analysis of 8 population-based cohort studies in Japan found that coffee consumption up to 5 cups/day was overall protective in relation to all-cause mortality, with varied findings based on analysis by gender and tobacco use. Abe 2019

In a retrospective case-control study, daily coffee consumption of more than 1 cup seemed to provide a protection from synchronous colorectal cancer. Compared with those without daily coffee consumption, patients with daily coffee consumption had significantly higher 5-year overall survival. Kuo 2019

Is coffee bad for reproduction? Maybe not, after all. [No abstract] Chavarro 2019

Among 1,837 participants, drinking coffee or tea was not associated with gastric reflux symptoms or erosive esophagitis. Wei 2019

A cross-sectional study found metabolites associated with caffeine and coffee and lipid metabolism may reflect the inflammatory potential of the diet. Potential differences by BMI and the linkage to disease outcomes require further study. Tabung 2019

Analysis of Kangbuk Samsung Cohort Study data from 80,173 individuals revealed that suicide risk was high in both men and women who consume four or more cups of coffee a day. Park 2019

In a cross-sectional study of 1992 women aged 65-94 years, coffee intake was associated with a lower prevalence of depressive symptoms. Results suggest that not only caffeine but other substances in coffee or factors related to coffee intake may be involved in the inverse relationship. Kimura 2019

The untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging. Low 2019

Meta-analysis of epidemiologic studies suggested that higher coffee intake might be modestly associated with reduced adiposity, particularly in men. Lee 2019

A cross-sectional study investigating the differences in cranio-cervical muscle tenderness scores between patients with episodic migraines with and without neck pain did not find an association between coffee intake and the presence of neck pain. Yu 2019

In a large prospective cohort, the risk of incident hypertension in women was inversely associated with the total antioxidant capacity(TAC) from fruit/vegetables, wine, and miscellaneous sources, while associations with TAC from coffee, tea, and chocolate were not significant. Villaverde 2019

Coffee/tea consumption and depression: a risk assessment. [No abstract] Kawada 2019

Matched nested case-control studies of liver cancer (n?=?221 cases) and fatal liver disease (n?=?242 cases) in the ATBC cohort (N?=?29,133) identified 9 coffee metabolites and trigolline, a coffee biomarker, associated with coffee intake and each endpoint. Loftfield 2019

Among 751 cancer-free women within the Nurses' Health Study II cohort, adolescent caffeine intake was not associated with premenopausal mammographic breast density. Yaghjyan 2019

Meta-analysis of data from 13 case-control studies found a positive association between coffee consumption and bladder cancer among never smokers. Yu 2019

A community-based case-control study found that drinking coffee was among the main factors associated with an increased likelihood of developing noncommunicable disease among adults in Mecha district, Ethiopia. Demilew 2019

A prospective study of 558 mother-child pairs showed that maternal antenatal, but not paternal or grandparental, caffeine intake was associated with higher offspring adiposity and obesity risk at age 5 and 9 y, with stronger associations observed for coffee caffeine than tea caffeine. Chen 2019

An evaluation of the impact of sociodemographic characteristics, lifestyle, medical history and work exposure on semen quality in young Chinese men noted that coffee consumption was unrelated to any measured semen parameters. Pokhrel 2019

A study testing the contribution of several health-promoting behaviors on markers of psychological and physiological function noted that while perceived respect scores were associated with lower daily cortisol output, coffee consumption was positively related to daily cortisol and alpha-amylase. Strahler 2019

A meta-analysis of 16 studies investigating the role of beverage intake in the development of Crohn disease found no significant association between coffee intake and the risk of Crohn disease. Yang 2019

A comprehensive review of literature from 2000 onwards, including prospective studies, nested case-control studies, and meta-analysis, regarding the relation between diet and Parksinson's disease risk, found some evidence for a potential protective effect of coffee. Boulos 2019

Meta-analysis of 444 cases of mothers of children with childhood acute myeloid leukemia and 1,255 age- and sex-matched controls from 8 studies revealed a positive association with increasing maternal coffee intake during pregnancy and leukemia in the child. Karalexi 2019

In 284 patients with de novo Parkinson's disease, male coffee drinkers had dose-dependently lower rest tremor scores than non-drinkers. Non-motor symptoms scores were not significantly different between coffee drinkers and non-drinkers. Cho 2019

Analysis using Mendelian randomization of 46,155 cancer cases and 270,342 controls of White British ancestry from the UK Biobank cohort revealed no observational association between coffee intake and overall cancer risk or cancer death. Ong 2019

Substituting coffee for sugar-sweetened beverages (250 g/d) was associated with a 21% lower incidence of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study of 8 European countries (n = 27,662). Imamura 2019

Does Coffee Reduce the Risk of Atrial Fibrillation? [No abstract] Aleong 2019

A prospective study of men in the Physicians' Health Study (N=18,960) assessed hazard ratios for incidence of atrial fibbrillation (AF) for a range of coffee consumption from rarely/never to 4+ cups/day. Data suggested a lower risk of AF in men who reported coffee consumption of 1-3 cups per day. Bodar 2019

A dose-response analysis of 10 studies involving 379,825 participants including 1,254 thyroid cancer (TC) cases revealed a relative risk of 0.75, indicating that high coffee consumption was a protection factor of TC. The occurrence of TC was reduced by 5% with each 1 cup/day increment. Shao 2019

A meta-analysis of 8 cohort and case-control studies demonstrated possible evidence that increased coffee intake is related to a reduced risk of colon adenoma. However, because of latent confusion and different exposure classification, this finding should be carefully considered. Wang 2019

Habitual coffee consumption is associated with the 12q24 (stronger in males) and 7p21 loci in two Japanese cohorts. Jia 2019

Prospective study data from large health care professionals cohorts did not reveal any significant associations between coffee intake and glioma risk. Cote 2019

Data from a multiethnic prospective cohort study of 1,235 midlife women found consumption of coffee was associated with common carotid artery intima-media thickness in an inverted J-shaped pattern. Wang 2019

According to data from the Korea National Health and Nutrition Examination Survey 2012-2016 (n=14,578), coffee consumption was inversely correlated with prevalence of diabetes mellitus in middle-aged adults. Lim 2019

A prospective cohort study of 620 men and 685 women aged 60-85 years found no significant association between coffee intake and cognitive decline, while reduced risk was found among those who consumed green tea. Shirai 2019

Coffee was the most commonly consumed antioxidant food/beverage among climacteric women participating in an extension university program in Brazil. There was a significant negative correlation between Beck Depression Inventory scores and polyphenol intake. de Oliveira 2019

Analysis of summary-level data from the Atrial Fibrillation Consortium (n=588,190) revealed no causal association between habitual coffee consumption and risk of atrial fibrillation. Yuan 2019

A meta-analysis of 16 prospective studies comprising 2,122,816 participants and 11,848 bladder cancer cases did not find an association between coffee consumption and risk of bladder cancer. Dai 2019

Early onset Parkinson's disease (PD) was the only PD subtype inversely associated with coffee consumption in a Greek case-control study including 686 Parkinson's disease cases and 356 controls. Angelopoulou 2019

Those consuming >6 cups daily had 23% lower risk of gallstone disease (GSD) compared to non-drinkers in a sample of 104,493 individuals from Denmark's general population. Genetic predisposition for caffeine among this population corresponded well with actual intake as well as lowered risk for GSD. Nordestgaard 2019

Coffee intake was among the lifestyle factors negatively associated with nocturnal urination frequency in a cross-sectional study including 5683 community residents averaging 64.5 years old. Tabara 2019

Genetically predicted coffee intake was not associated with bone fractures or bone mineral density in a Mendelian randomization study using summary-level data from UK Biobank (n=426,824). Yuan 2019

A hospital-based case-control study of 2,169 Chinese women aged 24-84 found no association between overall coffee drinking and breast cancer risk. However, instant coffee intake was positively associated and brewed coffee intake was negatively associated with breast cancer risk. Lee 2019

In 114 chronically hepatitis B virus-infected adults, a reduction of HBV DNA level was observed in those drinking 3 or more cups of coffee per day, and a reduction of hepatitis B surface antigen level was observed in those drinking 2 cups per day. Chook 2019

In a prospective, non-randomzied study, coffee intake was found to be a protective factor against the decrease in bone mineral density among 27 women associated with using depot medroxyprogesterone acetate (DMPA), a progestin-only contraceptive. Quintino-Moro 2019

Among 352 Chinese colorectal cancer patients who provided dietary information, the intake of whole grain, fruit, and coffee consumption were associated with higher survival rate. Sun 2019

A cross-sectional descriptive study investigating eating and nutritional habits and their relationship with the severity of disease in 31 clinically stable patients with schizophrenia under outpatient treatment noted that 83.9% of patients used to drink coffee daily. [Article in English, Spanish] Zurrón Madera 2019

In a study of 1,169 patients with actinic keratosis, coffee consumption was associated with a lower risk of developing keratinocyte carcinoma after a median follow-up of 1.8 years. Tokez 2019

In a prospective observational study of 36 healthy subjects, coffee consumption was associated with ocular biometric changes, including increased aqueous depth and anterior chamber depth and decreased lens thickness, for at least 4 hours after consumption. Uzun 2019

Coffee consumption and hepatocellular carcinoma in patients with HBeAg negative chronic hepatitis B. [No abstract] Chen 2019

Drinking an extra cup of coffee per day conferred a protective effect against chronic kidney disease and albuminuria in genome-wide association study and Mendelian randomization analyses of large datasets from the UK Biobank and the CKDGen Consortium. Kennedy 2019

Coffee intake was associated with zinc deficiency among pregnant women in Ethiopia according to a systematic review and meta-analysis of 7 studies. Berhe 2019

In a population-based prospective cohort of 63,257 Singaporean Chinese adults, coffee consumption was associated with a higher risk of developing lung cancer, while black tea intake was associated with a lower risk. Seow 2019

In a cross-sectional study of 117 young healthy men in Jordan, mean serum total cholesterol was higher in heavy coffee consumers, regardless of whether they smoked tobacco, compared to moderate coffee consumers. LDL-C levels were higher in coffee consumers who didn't smoke than those who did. Abu-Taha 2019

Data from 110 diabetes patients and 96 healthy control in Saudi Arabia showed no correlation between coffee intake, glycated hemoglobin, obstructive sleep apnea risk, sex, and daytime sleepiness. Elnour 2019

A study analyzing coffee consumption patterns of 14,132 Korean adults showed that coffee consumption, regardless of type, was associated with a reduced prevalence of metabolic syndrome in Korean women. Kim 2019

Robust metabolite panels for highly specific prediction of boiled or filtered coffee intake were established in a nested case-control metabolomics study of Swedish adults. An inverse association between the metabolite panel of filtered coffee and type 2 diabetes risk was observed. Shi 2019

A systematic review of 4 cohort and 4 case-control studies among Japanese populations on coffee and liver cancer revealed a week to strong inverse association (relative risk for one cup increase is 0.72). Coffee drinking probably decreases the risk of primary liver cancer among this population. Tanaka 2019

In 48,308 middle-aged female nurses free of gastroesophageal reflux symptoms at baseline, coffee consumption of more than 6 servings a day was associated with higher risk of GER symptoms than no coffee consumption. Mehta 2019

A nationwide cross-sectional study using data from the general Korean population found no significant differences in serum uric acid levels between non-coffee-drinkers and coffee drinkers in both men and women. Jung 2019

A cross-sectional study of 1871 pregnant mothers attending antenatal care in south west Ethiopia showed occasional caffeine intake was associated with anemia. Gudeta 2019

A metabolomic study of two cohorts totaling 564 healthy community-dwelling adults found metabolites associated with habitual coffee intake were positively associated with bone mineral density at the lumbar spine and femoral neck. Chau 2019

According to recurrence quantification analysis of EEG signals at 7 frequencies of photic stimuli, caffeinated coffee can alter the steady-state visual evoked potentials response, which is used for controlling the brain-computer interface devices for rehabilitative applications. Tarafdar 2019

Associations between coffee consumption and all-cause and cause-specific mortality in a Japanese city: the Takayama study - CORRIGENDUM. [No abstract] Yamakawa 2019

Clinical assessment and multimodal neuroimaging of 411 non-demented older adults revealed lifetime coffee intake of =2 cups/day was significantly associated with a lower cerebral beta-amyloid positivity compared to coffee intake of <2 cups/day, even after controlling for potential confounders. Kim 2019

According to data from the 2007-2014 National Health and Nutrition Examination Survey, a linear relationship could be found between caffeine intake and a higher risk of recurrent kidney stones overall and in subgroup analyses. Sun 2019

Review of the most important nutritional components and diets associated with longevity noted that a high intake of coffee is associated with a reduced risk for all-cause mortality. Ekmekcioglu 2019

In a case-control study of 600 pregnant women in Eastern Zone of Tigray, Ethiopia, drinking coffee/tea with or immediately after a meal daily was associated with anemia. Berhe 2019

A cross-sectional study of 227 adults aged 40-59 years at low-cost housing flats in Kuala Lumpur indicated that the main food sources of polyphenol intake included coffee with milk, and a higher polyphenol intake was associated with a lower neck circumference. Rosli 2019

During the menstrual phase of 88 Chinese female university students,intake of tea, black coffee, and carbonated beverages was higher in the group with a high negative affect scale score than in the low score group. Bu 2019

A cross-sectional analysis carried out on 82995 participants within the UK Biobank cohort showed that short objective sleep duration (<6 hours) correlated with high coffee intake. Zhu 2019

A study of 36 vegans and 36 omnivores noted that coffee was among foods that most positively to a dietary pattern that was directly associated with all fecal bile acids. Elevated concentrations of fecal bile acids may be related to an increased risk of colorectal cancer. Trefflich 2019

Coffee and Alcohol Consumption and Trends in Colorectal Cancer Morbidity in Poland. [No abstract] Jarosz 2019

Consumption of tea, coffee, and caffeine was negatively associated with coronary artery stenosis in a cross-sectional study of patients undergoing coronary angiography. Coffee intake was negatively associated with engagement for coronary artery bypass graft surgery. Javadi 2019

Consumption of coffee, energy drinks, and nicotine was positively associated with the Westside Test Anxiety Scale exam anxiety score in a cross-sectional survey of 214 first-year Bosnian-Herzegovinian university students. Kusturica 2019

Analysis of data from 13,374 Spanish university graduates initially free of hypertension found an inverse association between regular coffee consumption and the risk of hypertension in women only, which was strongest among those with a low adherence to the Mediterranean diet. Navarro 2019

Reply to: "Coffee consumption and decreased all-cause mortality - What is the true estimate of effect?" [No abstract] Protopopescu 2018

Data from the Australian Longitudinal Study on Women's Health (n=7580) indicate that middle-aged women who drink 1-2 cups of coffee or >1 cup of tea/day are more likely to meet the moderate-to-vigorous physical activity guidelines than those who drink <1 cup/day. Torquati 2018

Investigation into potential biases inherent in studying the relationship between early-pregnancy coffee consumption and subsequent health outcomes. Leviton 2018

A systematic review of 15 studies (7 cohort, 6 cross-sectional, 1 case control and 1 randomized control trial) regarding the impact of coffee or caffeine consumption on non-malignant respiratory outcomes found that it was associated with some positive effects. Alfaro 2018

Findings from a genome-wide association study among Japanese individuals idicated that the 12q24.12-13 locus is associated with habitual coffee consumption. Nakagawa-Senda 2018

In a population-based cohort study not restricted to women seeking pregnancy, no association was found between coffee, tea, or total caffeine consumption and the risk of primary infertility. Í Soylu 2018

Chronic coffee consumption was not associated with changes in striatal dopamine active transporter (DAT)-single photon emission computed tomography (SPECT) imaging in Parkinson's disease patients. The number of years patients drank coffee was correlated with an increase of age of PD at onset. Gigante 2018

A dose-response meta-analysis of prospective cohort studies found an inverse relationship between coffee consumption and breast cancer incidence in postmenopausal women. Lafranconi 2018

Review evaluated the evidence on the effect of habitual coffee consumption on cardiovascular incidence and mortality, comparing effects in healthy people and those with active disease. Rodríguez-Artalejo 2018

Comment on: Association of Coffee Consumption With Total and Cause-Specific Mortality Among Nonwhite Populations. [Ann Intern Med. 2017][No abstract] Gunter 2018

Comment on: Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study. [Ann Intern Med. 2017][No abstract] Kivimaki 2018

Pre-clinical atherosclerosis is associated with low coffee consumption and low adherence to Mediterranean Diet in pre-menopausal women. [No abstract] Mattioli 2018

Among 1,040 participants with type 1 diabetes in the Finnish Diabetic Nephropathy Study, high coffee intake was associated with increased risk of metabolic syndrome, especially its blood-pressure component. Stutz 2018

A systematic review and meta-analysis of observational studies suggested that high consumption of coffee and tea may reduce the risk of depression, while high consumption of soft drinks may increase the risk of depression. Kang 2018

Review summarized the literature examining the relationship between dietary intake, including coffee, and risk of colorectal cancer. Pan 2018

Coffee consumption and gout: a Mendelian randomisation study. [No abstract] Larsson 2018

Restless leg syndrome is known to be rare in sub-Saharan Africa. Among 310 pregnant and non-pregnant Nigerian women, no cases were found among pregnant women, and the prevalence of RLS symptoms in the non-pregnant women was associated with a few risk factors, including coffee consumption. Fawale 2018

Data from 193,439 Scandinavian participants showed that in never smokers, there was an increased risk of bladder cancer among heavy filtered or total coffee consumers and of stomach cancer among heavy boiled coffee consumers. Filtered coffee consumption may reduce risk of pancreatic cancer. Lukic 2018

A cross-sectional study of 196 early-stage, treatment-naive Parkinson's disease patients found a negative association between coffee consumption and the severity of the mood/cognition domain of non-motor symptoms. Cho 2018

Pooled analysis from 8 cohort studies in Japan (n=320,322) showed coffee drinking was not materially associated with colorectal cancer risk in men or women. Subsite analysis showed a lower risk of colon cancer in females drinking =3 cups coffee/day. Kashino 2018

An investigation of associations of intake of frequently consumed food with urinary metals concentrations among 558 pregnant women in the Seattle-Tacoma area of Washington state found that urinary cadmium concentration was negatively associated with coffee intake in early pregnancy. Osorio-Yáñez 2018

Coffee and Colorectal Cancer: Grounds for Prevention? Comment on: Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality. [Gastroenterology. 2018] [No abstract] Cross 2018

Coffee consumption and decreased all-cause mortality - What is the true estimate of effect? [No abstract] Chitsaz 2018

In 10 healthy adult volunteers consuming 400 mg dry Green coffee bean extract daily for 30 days, metabolomics analysis showed an induction of fatty acids metabolism. Peron 2018

A hospital-based cross-sectional study in adult hypertensive Sudanese patients found that drinking coffee was not associated with uncontrolled blood pressure. Omar 2018

A meta-analysis of 9 cross-sectional studies found that coffee consumption was associated with a lower level of C-reactive protein. Zhang 2018

Among 202 Japanese subjects who participated in a 1-year physical activity counseling intervention, higher caffeine consumption was correlated with higher moderate-vigorous physical activity and peak oxygen consumption among women. No caffeine-related effects were found in men. Tripette 2018

Data from the Korean National Health and Nutrition Examination Survey showed that daily coffee consumption is closely associated with tooth loss in Korean adults. Song 2018

Data from a Danish cohort revealed no consistent evidence of associations between baseline coffee consumption and subsequent 6-year changes in adiposity measures. Increased coffee consumption was weakly associated with a decreased concurrent gain in body weight, fat mass and waist circumference. Larsen 2018

Data from the Netherlands Cohort Study show differing associations between coffee and tea intake and mortality in men versus women. In women, coffee was related to lower overall and cause-specific mortality, while in men it was associated with higher cancer and cardiovascular mortality. van den Brandt 2018

A study found no association between coffee consumption and overall oral microbiota diversity. Peters 2018

A meta-analysis of 11 studies comprising 457,010 participants and 2,628 incident cases showed an inverse relationship between coffee consumption and incidence of esophageal cancer in East Asia participants, but not in Euro-America participants. Zhang 2018

Coffee and the risk of hepatocellular carcinoma: misleading analysis of the data. [No abstract] Huang 2018

Prospective data from the ATTICA study of 453 healthy men and 400 women noted increased coffee consumption to be among determinants of healthy ageing. Kollia 2018

Exfoliative Esophagitis Caused by Habitual Ingestion of Very Hot Coffee. [No abstract] Schertl 2018

Results from a study investigating modifiable factors associated with high-density lipoprotein (HDL) status in 4,414 adults aged =30 years residing in Taiwan found that LDL was associated with lower LDL in women in general, and also in menopausal women. Chang 2018

Data from a population-based prospective cohort of 63,257 Chinese adults aged 45-74 years suggest that drinking coffee =4?cups/day is associated with a higher hip fracture risk, while a moderate intake may alleviate risk in postmenopausal women. Dai 2018

A study investigating the prevalence of laryngopharyngeal reflux (LPR) in patients with gastroesophageal reflux disease noted that coffee consumption appeared to be negatively associated with LPR. Mosli 2018

Data from the UK Biobank from 126,182 postmenopausal women suggested that coffee consumption might be associated with increased breast cancer risk in women who used hormones in the past. Yaghjyan 2018

A prospective study including 71,l178 people provided evidence that coffee consumption was positively associated with the risk of aortic valve stenosis in a dose-response manner after adjustment for age, sex, smoking, and other risk factors. Larsson 2018

Can 'omics' studies provide evidence for causal effects of coffee consumption on risk of type 2 diabetes? [No abstract] van Dam 2018

Results of a cross-sectional study conducted in 7 high schools noted daily consumption of coffee was among risk factors for frequency of menstruation-related headache. Carman 2018

Pooled data from 8 case-control studies suggest that high coffee intake during pregnancy may increase risk of childhood acute lymphoblastic leukemia. Milne 2018

A cross-sectional case-control study on 221 treatment-naive psoriatic patients found differential effects on psoriasis and metabolic syndrome depending on quantity of coffee consumed and smoking status. Barrea 2018

Results from a meta-analysis of 30 prospective studies with 1,185,210 participants and 53,018 incident type 2 diabetes (T2D) cases indicated that coffee consumption is inversely associated with risk of T2D. Carlström 2018

An adult sleep study found that those participants with higher stress levels consumed more grains, meat and eggs, soju, and coffee products than the lower stress group, and had worse sleep quality. Kim 2018

A cross-sectional study found that habitual consumption of >3 cups/d of coffee was associated with decreased odds of coronary calcification and subclinical atherosclerosis among never smokers. Miranda 2018

Assessed the cancer risks from long term exposure to polycyclic aromatic hydrocarbons through consumption of common food products, including coffee, in 8 sections of the Indian population. Singh 2018

Among 14,209 participants aged 45-64 in a prospective cohort, those who drank higher amounts of coffee had lower risk of incident chronic kidney disease after adjusting for covariates. Hu 2018

A prospective study of seniors found consumption of =?2 cups of coffee/day was associated with lower risk of impaired agility in women and obese persons, with lower risk of impaired mobility in women and those with hypertension, and lower risk of disabilities in daily living in those with diabetes. Machado-Fragua 2018

Among 1,199 mother-child pairs in Japan, higher maternal caffeine consumption (13% of which was contributed by coffee overall) during pregnancy was independently associated with a reduced risk of peer problems in the children at age 5. Miyake 2018

Coffee is noted as an important risk factor for bruxism (clenching or grinding of the teeth) among adults in a summary of risk factors in adults and children. Kuhn 2018

Energy Expenditure May Explain Why Coffee Drinkers Have Lower Mortality.[No abstract] Lewis 2018

Coffee and caffeine consumption in women affected by hypertension.[No abstract] Mattioli 2018

Results from a meta-analysis of 12 cross-sectional studies suggest that coffee consumption was associated with higher circulating adiponectin levels in women, and lower circulating leptin levels. Zhang 2018

Relationship between espresso coffee consumption and preclinical atherosclerosis in a Mediterranean population. [No abstract] Mattioli 2018

Among 8,717 subjects with normal renal function in a prospective Korean cohort, daily coffee intake was associated with decreased risk of the development of chronic kidney disease. Jhee 2018

Is Sugar-Sweetened Beverage Consumption a Possible Confounder in the Inverse Association Between Coffee and Kidney Disease? [No abstract] Natella 2018

In Reply to 'Is Sugar-Sweetened Beverage Consumption a Possible Confounder in the Inverse Association Between Coffee and Kidney Disease?' [No abstract] Hu 2018

Results of a cross-sectional study among 1,500 residents of Qom, Iran indicated that drinking coffee was not associated with increased risk of gastroesophageal reflux disease (GERD). Yadegarfar 2018

Findings from this meta-analysis indicated that moderate coffee consumption may not be associated or may be weakly inversely associated with the risk of colorectal cancer in the Japanese population. Horisaki 2018

A population-based case-control study found that coffee intake was positively associated with latent autoimmune diabetes in adults in carriers of high-risk HLA genotypes, whereas no association was observed in non-carriers. Rasouli 2018

In a French nationwide multicenter cohort of HIV-Hepatitis C virus-co-infected patients, high coffee intake was associated with a low risk of liver fibrosis even in patients with high-risk alcohol consumption. Yaya 2018

A case-control study of 500 rheumatoid arthritis patients and 500 healthy controls found that consumption of more than 1 cup of coffee per month might have preventative effects on developing RA. Rambod 2018

Data from a cross-sectional study of older Japanese investigating whether consumption of green tea or coffee was associated with oral health-related quality of life (OHRQoL) showed no statistically significant association between coffee consumption and OHRQoL in men. Nanri 2018

In a prospective multiethnic study including 167,720 participants in Hawaii and Los Angeles, coffee intake was associated inversely with liver, ovarian, and thyroid cancers and melanoma, and with endometrial cancer among women with BMI >30 kg/m2. Park 2018

Developed a simple method of simultaneous determination of aluminum, barium, calcium, copper, iron, magnesium, manganese, nickel, strontium, and zinc in brews of ground and soluble coffee using inductively coupled plasma optical emission spectrometry. Pohl 2018

In a Norwegian cohort of 3,503 participants, measurement of plasma trigonelline levels performed well as a marker of coffee intake. Midttun 2018

A meta-analysis of 17 studies involving 233,617 participant showed that daily drinking of more than 3 cups of coffee was associated with a significantly increased risk of myocardial infarction in men, but not in women. Mo 2018

Among adolescents aged 14-15 years and 18-19 years, habitual caffeine consumption did not predict blood pressure level, but higher caffeine intake was associated with modestly increased vascular resistance at rest, during stress, and during recovery from stress. James 2018

Analysis of data from cohort of 476,160 men and women from 10 European countries suggested a possible inverse relationship between phenolic acid intake (highly correlated with coffee consumption) and colon cancer risk in men and a possible positive relationship with rectal cancer risk in women. Zamora-Ros 2018

A Mendelian randomization meta-analysis in 415,530 participants of European ancestry provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory. Zhou 2018

Results of a meta-analysis of 8 studies comprising 787,076 participants and 3,541 ovarian cancer cases showed that coffee intake was not associated with ovarian cancer risk. Berretta 2018

Coffee consumption and risk of hypertension. [No abstract] Kawada 2018

A pilot study in healthy women found chlorogenic acid may have antihypertensive effects, and affects resting energy expenditure, and body temperature. Acar-Tek 2018

A cross-sectional study of women who underwent fertility treatment in Taiwan noted that coffee consumption was among factors associated with a lower fertility-related quality of life. Cheng 2018

Results from a meta-analysis strengthen strengthen the evidence of a protective effect of coffee consumption on the risk of endometrial cancer and further suggest that increased coffee intake might be particularly beneficial for women with obesity. Lukic 2018

A cross-sectional study of 1,241 students in Latin American schools of medicine found that steady coffee drinking was among factors associated with dyspepsia. Talledo-Ulfe 2018

Results of a Mendelian randomization analysis on public datasets of coffee consumption genome-wide association studies meta-analyses on coffee intake from 8 white cohorts support the observation that coffee consumption is associated with increased risk of osteoarthritis. Lee 2018

Among a prosepctive subcohort of 3185 Canadian women, coffee and/or caffeine was associated with reduced risk of endometrial cancer but, probably, associated with increased risk of breast cancer among premenopausal or normal weight women. Arthur 2018

Data from two prospective studies in Spanish elderly populations showed that coffee consumption was associated with lower cardiovascular disease related mortality. Torres-Collado 2018

Among 9,752 Korean adults, the relationship between the prevalence of dry eye syndrome and level of coffee consumption did not reach statistical significance. Jeong 2018

A meta-analysis of 4 observational studies (n=351,137) demonstrated a significantly decreased risk of pancreatitis among heavy coffee-drinkers. Wijarnpreecha 2018

A study among 16-29 year old women in Ukraine found that coffee consumption was associated with iron deficiency states. Kuzminska 2018

Investigation of the effect of lifestyle and demographic factors on classic and functional semen parameters among 328 subjects who underwent semen analysis revealed an association between total sperm count and semen volume with daily coffee intake. Shi 2018

A summary and discussion of relevant evidence regarding the association between caffeine consumption and kidney stone risk reduction. Peerapen 2018

In 162 cognitively normal elderly Korean adults, MRI analysis of the pineal gland revealed that smaller volume of pineal parenchyma was associated with higher cumulative lifetime coffee consumption. This reduction in volume may impair the quality of sleep in late life. Park 2018

Review limited literature on potential environmental (lifestyle) risk factors for latent autoimmune diabetes in adults (LADA) noted that there is some indication of potential effects of induction of autoimmunity exerted by intake of coffee. Carlsson 2018

Data from a case control study indicated that intake of an antioxidant-rich plant-based diet, both with and without non-enzymatic antioxidant activity from coffee, is associated with decreased colorectal cancer risk. Amiano 2018

In a prospective cross-sectional study among 684 Malaysians of Malays, Chinese, and Indian ancestry, chocolate and coffee were significant triggers for migraine compared to tension-type headache. Tai 2018

Among 358 undergraduate medical students in Southern India, frequent consumption of tea or coffee was among risk factors noted to be significantly associated with a diagnosis of GERD. Arivan 2018

Data from a prospective cohort of 63,257 Chinese men and women aged 45-74 in Singapore indicated that the consumption of =2 cups of coffee/d may reduce the risk of end-stage renal disease, especially among men. Lew 2018

Coffee was not noted as a dominant risk factor associated with the prevalence of kidney disease in diabetes mellitus among a large cohort in Indonesia. Mihardja 2018

Data from 130,966 European participants aged 40-69 years from the UK Biobank showed that coffee consumption is inversely associated with risk of gout. Alleles at several SNPs associate with lower coffee consumption and higher risk of gout, but largely influence gout risk directly. Hutton 2018

Prospective data from 502,641 participants from the UK Biobank indicated that coffee drinking was inversely associated with mortality, including among those drinking 8 or more cups daily and those with genetic polymorphisms indicating slower or faster caffeine metabolism. Loftfield 2018

In 2622 participants aged 75+ from a prospective German cohort, no evidence was found for coffee to have a protective effect against cognitive decline or Alzheimer's disease. Weyerer 2018

A meta-analysis of selected studies representing 176,675 subjects found the incidence of atrial fibrillation was not increased by coffee consumption, and that there was a lower incidence of AF when caffeine consumption exceeded 436 mg/day. Abdelfattah 2018

A review on the genetic biomarkers that presage environmental determinants of exfoliation syndrome noted that prospective studies have implicated higher coffee consumption and lower dietary folate intake in association with incident XFS Pasquale 2018

Among primary breast cancer patients, coffee consumption was negatively associated with tumor-specific IGF1R levels among normal-weight patients. IGF1R did not explain the association between coffee intake and improved prognosis among normal-weight tamoxifen- or radiotherapy-treated patients. Björner 2018

In a matched multicenter case-control study including 307 multiple sclerosis patients and 307 healthy controls, drinking coffee daily was noted as being independently associated with a decreased risk of MS. Al Wutayd 2018

In 145 community-based elderly individuals, an inverse association of coffee consumption with cognitive performances was observed. Moderate to heavy coffee drinking was associated with better white-matter preservation and cerebral flow notably in cognitively stable elders. Haller 2018

Among participants 30-79 years old in a national Korean health survey (n=8,246), coffee consumption was associated in a dose-responsive manner with a lower risk of metabolic syndrome among women, but had no significant associations in men. Kim 2018

Among 609 middle-aged medical personnel in NE Poland, excessive coffee consumption was among lifestyle factors that significantly increased the likelihood of recurring low-back pain. Citko 2018

Among 1,277 residents of Comalcalco, Mexico, there was no significant relationship between coffee consumption and the prevalence for type 2 diabetes, despite observed protected effects in other regions of the world. Gil-Madrigal 2018

Coffee consumption and gout: a Mendelian randomisation study. [No abstract] Lee 2018

Among 219,279 middle-aged adults attending cardiovascular screening in Norway, coffee and wine consumption were inversely associated with alcoholic liver disease death. Total alcohol consumption was adversely associated with alcoholic liver disease death, modified by level of coffee consumption. Tverdal 2018

Results from an observational study of 402 middle-aged Japanese men visiting the hospital for a regular check up suggested that ND2-237 Leu/Met polymorphism modifies the association of coffee consumption with serum chloride levels in this population. Kokaze 2018

A review of Mendelian randomization studies of coffee and caffeine consumption and possible causal role on risk of type 2 diabetes, cardiovascular disease, Alzheimer's disease, Parkinson's disease, gout, osteoarthritis, cancers, sleep disturbances and other substance use. Cornelis 2018

Among 14,413 university students initially free of depression who followed a Mediterranean diet, those who drank 4 or more cups of coffee daily were less prone to depression, as defined by physician diagnosis along with new onset of antidepressant medication use, than those who drank less than 1. Navarro 2018

Analysis of data from 4,863 US adults with chronic kidney disease showed an inverse association between caffeine consumption and all-cause mortality. Bigotte 2018

Analysis of data from a large national survey indicated that frequent consumption of green tea, coffee, or caffeine was associated with a reduced prevalence of self-reported lifetime depression in Korean adults. Kim 2018

In 62 community dwelling adults between 19-77 y.o., those who habitually consume greater amounts of caffeine demonstrated diminished sensitivity to painful stimuli in a laboratory setting. Overstreet 2018

Results from a Mendelian randomization analysis of public datasets did not support causal associations between coffee consumption and the development of rheumatoid arthritis and systemic lupus erythematosus. Bae 201

A case-control study investigating the role of nutritional factors in cyclic breast pain noted that compared to the mastalgia group, the control group consumed more coffee. However, the authors propose that nutritional factors contribute less to the risk of mastalgia than is generally thought. Idiz 2018

Results from a cross-sectional population-based survey among 533 São Paulo-based adults showed that the genetic predisposition to hypertension was modified by coffee consumption. Miranda 2018

Assessment of factors associated with coffee consumption among an elderly population in Spain (n=903). Self-reported hypertension was associated with a lower consumption of caffeinated coffee, while pre-existing diabetes was associated with a higher consumption of decaffeinated coffee. Torres-Collado 2018

A study of 309,797 never-smoking women as well as a meta-analysis of results from this cohort and 3 smaller prospective studies found little or no statistically significant association between coffee consumption in never smokers. Zhou

Consumption of coffee was listed among risk factors for prevalence of Helicobacter pylori infection in a cross-sectional study of 201 dyspeptic patients in northwest Ethiopia. Negash 2018

A case-control study of Parkinson's disease in Egypt evaluating gene-environment interactions noted that the risk of PD was reduced by coffee consumption. Rösler 2018

An institution based cross-sectional study in Ethiopia found that coffee consumption and hookworm infection were factors significantly associated with anemia among pregnant women. Kumera 2018

A cross-sectional study among couples with natural planned conception in Addis Adaba, Ethiopia, noted that women who drink more than 3 cups of coffee/day had significantly higher odds of sub-fecundity, defined by a waiting time-to-pregnancy of over 12 months. Kassa 2018

High coffee consumption was among factors associated with longer or prolonged colonic transfer time. Bohlin 2018

Among 1878 Italian adults with pre-diabetes and 2139 with type II diabetes, a lower risk of either condition was observed in coffee drinkers compared to non-drinkers. Mirmiran 2018

Analysis of data from a prospective cohort study of 82,737 women showed that increased caffeine intake from coffee was inversely associated with risk of incident rosacea. Li 2018

Among 333 pregnant women in an institutional based unmatched case control study in Durame Town, Ethiopia, consuming coffee or tea immediately after food was among major determinant factors of anemia. Weldekidan 2018

Analysis of prospective data from 14,208 middle aged participants indicated that coffee drinkers may be at a lower risk for liver-related hospitalizations, supporting current evidence that low and moderate levels of coffee may be protective to the liver. Hu 2018

Data from 941 Irish mother-child pairs indicated that maternal caffeine intake from both coffee and tea is associated with adverse birth outcomes including lower birth weight, shorter birth length, smaller head circumference, shorter gestational age, and others. Chen 2018

Results from a dose-response meta-analysis of prospective data from 7486 dementia cases diagnosed among 328,885 individuals do not support an association between coffee consumption and risk of Alzheimer's disease or overall dementia. Larsson 2018

Data from a prospective population-based cohort of 28775 Swedish adults older than 65 years found no associations between coffee consumption and the risk of dementia. Larsson 2018

Data from a national Korean survey of adults aged 19-64 years (n=8387) suggest that moderate coffee consumption of 3-4 times/d is inversely associated with the metabolic syndrome. The association between heavy coffee consumption of =5 times/d and the metabolic syndrome varied by obesity status. Kim 2018

An observational, cross-sectional, multicenter study of 373 hemodialysis patients in Portugal found that drinking 3 or more coffees daily increases the risk of a higher diastolic blood pressure, potassium, and albumin and interdialytic weight gain in hemodialysis patients. Caetano 2018

Data from NHANES of adults with diabetes demonstrated a dose-dependent inverse relationship between caffeine consumption and all-cause mortality in women but not in men. No significant association between caffeine consumption and cardiovascular or cancer mortality was observed. Neves 2018

Results from a national Korean health study noted that coffee intake was associated with lower serum ferritin levels in Korean adults. Sung 2018

Results from analysis of data from 13,448 adult participants of a national Korean health survey suggest a protective effect of coffee on hearing loss and tinnitus. Lee 2018

Among 1202 participants who responded to a cross-sectional online survey in Arabic language, coffee was among dietary items reported to increase irritable bowel syndrome symptoms. Bardisi 2018

Meta-analysis of data from 54 epidemiological studies involving more than 43,000 bladder cancer patients found that increasing intake of coffee was a risk factor for bladder cancer incidence. Hong 2018

A dose-response meta-analysis of 7 articles presented a non-linearity curve relationship of coffee and non-fatty liver disease occurrence while coffee consumption >3 cups per day reduced NAFLD significantly. Chen 2018

Coffee, tea, and cardiovascular morbidity and mortality. [No abstract] Lavie 2018

A cross-sectional online survey measuring symptoms of psychosis in a healthy adult population found no correlations between psychotic symptoms and caffeine, coffee, tea, and cola consumption. [Article in Hungarian] Ágoston 2018

In a birth cohort in Ribeirão Preto, Brazil, data from 7,607 women and their newborns did not support a relationship between high caffeine intake during pregnancy and low birth weight or preterm birth. Vitti 2018

Data from a European prospective cohort of 476,108 adults indicated that consumption of coffee was not associated with thyroid cancer risk. Zamora-Ros 2018

In moderate to heavy coffee drinkers who had their dose of caffeine tapered from 300mg per day to 0mg over the course of 5 days, awareness of dose reductions had a nocebo withdrawal effect, and removing this awareness through deception reduced withdrawal symptoms. Mills 2018

Among 1328 Chinese adult participants in the Shanghai High-Risk Diabetic Screen Study project, coffee intake was independently and positively related to pancreatic beta cell function in a large high-risk diabetic population. Gao 2018

Link between coffee and atrial fibrillation debunked? [No abstract] Mattioli 2018

According to meta-analysis of 19 prospective studies, coffee intake is negatively associated with gout risk, whereas it may be associated with increased hyperuricemia risk in women but decreased risk in men. Li 2018

Among a highly educated middle-aged Mediterranean cohort of 19,888 participants, total coffee consumption had an inverse linear association with the risk of all-cause mortality that was strongest among participants older than 54. Navarro 2018

Data from a prospective study including 630 patients showed plasma caffeine and other methylxanthines were associated with worsening of metabolic parameters in patients receiving psychotropic treatments known to induce metabolic disturbances. Delacrétaz 2018

Data from a prospective cohort study including 30,824 Japanese adults over age 35 years indicated that coffee consumption significantly reduces liver cancer risk and suggests that caffeine intake may not account for this association. Tamura 2018

Data from 2682 Tawainese adults indicated that coffee drinking was significantly associated with higher T-scores and thus a lower risk of osteoporosis in men and premenopausal women. Chang 2018

In a cross-sectional population-based study of 1542 participants exploring the relationship between diet, diabetes, and prediabetes, coffee was significantly inversely associated with prediabetes in men. Breuninger 2018

Evaluation of the daily per drinker intakes of total phenolics, total flavonoids, and antioxidants from coffee in the Korean diet. Lee 2018

In a survey of 330 pregnant women visiting a Malaysian antenatal clinic, coffee consumption was identified as a major risk factor for urinary incontinence. Mohd Yusoff 2018

Among 7255 Korean adults aged 40-69 y, a dietary pattern characterized by a relatively high intake of kimchi, beef, other meat, fish, and coffee in men was associated with selected biomarkers of diabetes, and with incident diabetes only in obese men. Lee 2018

A comparison between outpatient compensated/decompensated patients with cirrhosis from Turkey and the United States found that coffee consumption was among dietary factors associated with higher gut microbial diversity, which was associated with a lower risk of 90-day hospitalizations. Bajaj 2018

A cross-sectional study of 2819 middle-aged South Italian participants did not reveal an association between coffee intake and any lower odds of hepatic steatosis in either non-alcoholic or alcoholic forms. Veronese 2018

In 4130 cancer-free women from the Nurses' Health Study I & II cohorts, associations of decaffeinated coffee with mammographic breast density differ by woman's menopausal status. Associations of regular coffee and caffeine with mammographic breast density may differ by hormone therapy status. Yaghjyan 2018

Two-sample Mendelian randomization analyses found little evidence for causal relationships between nicotine, alcohol, caffeine and cannabis use. Verweij 2018

A meta-analysis of cohort studies provided evidence that consumption of coffee was inversely associated with the risk of hypertension in dose-response manner. Xie 2018

Data from the Danish National Birth Cohort indicated that drinking more than 3 cups/day of coffee was associated with the highest risk of fetal death, spontaneous abortion, and stillbirth for all smoking status. The combined effect of smoking and coffee intake is coffee-dose-dependent. Morales-Suárez-Varela 2018

An Italian case-control study indicates that coffee consumption could be a protective factor against incidence of amyotrophic lateral sclerosis (ALS). Pupillo 2018

Analysis of data from 1678 participants of the retrospective, cross-sectional National Health and Nutrition Examination Survey revealed no association between the consumption of coffee, iced tea, decaffeinated tea and soft drinks, and glaucoma risk. Wu 2018

Mendelian randomization performed using SNPs associated with coffee and caffeine consumption revealed no evidence indicative of a strong association between epithelial ovarian cancer and genetically predicted coffee of caffeine levels. Ong 2018

In 1410 adult men in the Third National Health and Nutrition Examination Survey (1988-1991), coffee consumption was associated with higher sex hormone-binding globulin concentration, implicating a possible connection between coffee and prostate cancer, among other conditions. Frey 2018

Analysis of data from the Nurse's Health Study and Health Professionals Follow-up Study illustrated an association between consumption of caffeinated and decaffeinated coffee after diagnosis of colorectal cancer (CRC) with lower risk of CRC-specific dead and overall death. Hu 2018

Data from one of the largest prospective cohort studies in Japan indicated that coffee was not associated with risk of lung cancer, despite observing an increase in the risk for small cell carcinoma. Narita 2018

A cross-sectional analytical study of female Saudi adolescents did not observe a correlation between vitamin D status and coffee intake. Al-Raddadi 2018

In a study simultaneously examining commonly proposed risk and protective factors for sleep deprivation over time among a cohort of Canadian secondary school students, no longitudinal effect was observed when students increased their caffeine consumption. Patte 2018

A prospective, large-scale population-based cohort study in Japan found a decreasing dose-response relationship between coffee consumption and the risk of myelodysplastic syndromes (MDS) among men. Residual confounding by smoking may impact findings regarding acute myeloid leukemia and MDS risk. Ugai 2018

Analysis of observational data supports an inverse association between coffee intake and plasma leptin and chitinase-3-like protein 1 levels. The novel coffee-CHI3L1 association warrants further investigation given links between CHI3L1 and health conditions associated with coffee intake. Cornelis 2018

A prospective analysis of 21,403 men aged 40-75 found no significant association between long-term coffee intake and the risk of erectile dysfunction. Lopez 2018

A cross-sectional survey of 7960 apparently healthy Japanese men aged 22-86 showed that the intake of total polyphenol including coffee as a major contributor was inversely associated with serum γ-glutamyltransferase (GGT) concentration. Taguchi 2018

Analysis of data collected in the 2003-2004 National Health and Nutrition Examination Survey revealed a significant positive trend between the consumed amount of coffee and acrylamide hemoglobin adduct levels in adolescents, adults, and seniors. Duke 2018

Among middle-aged Swedish men, plasma enterolactone (ENL) concentration was positively but weakly associated with consumption of coffee. This same study investigated associations between ENL and prostate cancer risk. Wallström 2018

A cross-sectional study of Polish adults over 20 years old revealed an inverse relationship between coffee consumption and metabolic syndrome. Micek 2018

Prospective metabolomics data from 3986 participants showed that trigonelline levels (a metabolite marker for coffee intake) in the urine was associated with a decrease in hemoglobin A1c over time, indicating better blood glucose control. Friedrich 2018

A case-control study comparing caffeine consumption indicated that daily caffeine intake was higher in patients with Menière's disease than in patients with vertigo of different origin and control subjects. Results suggest caffeine intake should be reduced in those with higher risk of this disease. Sánchez-Sellero 2018

A 39-year-old man developed thunderclap headaches during a hospital stay for accidental superficial burns. Diffuse segmental vasocontriction was observed in his MRI scan. Prior to admission, he was consuming excessive amounts of caffeine which was slowly tapered and stopped over weeks. Kalladka 2018

In a longitudinal cohort of patients with autosomal doominant polycystic kidney disease, coffee drinkers did not have a statistically significant different kidney size compared to non-coffee drinkers. Girardat-Rotar 2018

In 77 healthy young adults who recorded dietary intake and related experience of momentary wellbeing for 4 consecutive days, better momentary wellbeing was experienced after consumption of coffee. Strahler 2018

Results of a systematic review and meta-analysis of cohort and case-control studies indicated that nonmelanoma skin cancer was negatively associated with coffee consumption in a dose-dependent manner. Vaseghi 2018

A prospective cohort study between 1991-2009 including 15,590 pregnancies from 11,072 women with no history of spontaneous abortion (SAB) found that pre-pregnancy coffee consumption at levels ≥4 servings/day is associated with increased risk of SAB, particularly at weeks 8-19. Gaskins 2018

Data from a Greek prospective study of 3042 healthy adults revealed a J-shaped association between daily coffee drinking and the risk for a first CVD event in a 10-year period. Drinking the equivalent of 1-2 cups/daily had protective effect for those without metabolic syndrome at baseline. Kouli 2018

An overview of epidemiological and research data indicated that long-term consumption of coffee is associated with a lower risk of developing type 2 diabetes. Exploration of synergistic effects of coffee compounds and mechanisms involved. Rebelo 2017

Review of the interactions between genetic, lifestyle, and environmental risk factors for multiple sclerosis noted that high coffee consumption was associated with a reduced risk of MS incidence. Olsson 2017

Epigenome-wide DNA methylation levels were associated with habitual coffee consumption from two studies with blood (2100 and 215 participants), and one with saliva samples (256 participants). Chuang 2017

Use of ECOHAIR® spray, containing extracts of C. arabica and Larrea divaricata, by patients with noncicatricial alopecia for 3 mos improved the overall hair volume and appearance; it increased its thickness, induced hair growth, and decreased hair loss. No adverse local reactions were observed. Alonso 2017

Alcohol or coffee to help keep melanoma at bay]. [No abstract][Article in French] Schmutz 2017

Erratum to: Coffee, tea and caffeine intake and the risk of non-melanoma skin cancer: a review of the literature and meta-analysis. [Eur J Nutr. 2017] [No abstract] Caini 2017

Erratum for: Coffee and tea breaks for liver health. [J Hepatol. 2017] Petta 2017

A review of meta-analyses of observational and interventional studies of coffee consumption and any health outcome found it seems generally safe within usual levels of intake, with summary estimates indicating largest risk reduction for various health outcomes at 3-4 cups/day. Poole 2017

A study of heavy drinking subjects with and without alcoholic hepatitis (AH) found a higher prevalence of AH among heavy drinkers with PNPLA3 G/G and G/C genotypes regardless of coffee consumption status and a higher prevalence of AH among heavy drinkers who were not regular coffee drinkers. Liangpunsakul 2017

Among 72 psychiatry resident practitioners at 2 Italian university hospitals, consumption of coffee was associated with greater likelihood of poor sleep quality. Concerto 2017

Among participants in a cross-sectional study to determine the prevalence of peptic ulcers in Arar city, Northern Saudi Arabia, coffee drinking, physical stress, spicy food, prolonged use of NSAID and H. pylori infection were the reported risk factors. Albaqawi 2017

The amount of coffee with additives (sugar and non-dairy creamer) consumed per day by Korean women was positively correlated with the prevalence of obesity in this cross-sectional study. Lee 2017

Results from a dose-response meta-analysis of case-control and cohort studies provides evidence for an association between coffee/caffeine intake and the risk of spontaneous abortion. However, no association was found between coffee and natural fertility or outcomes of fertility treatment. Lyngsø 2017

In a hospital-based case control study of 94 white males, structural equation modeling analysis revealed a positive direct link between leucocyte telomere length and coffee, and association between bladder cancer risk and cumulative exposure to coffee. Pavanello 2017

A systematic review and meta-analysis of epidemiological studies revealed no significant association between coffee consumption and ulcerative colitis risk, though there was a non-significant tendency toward an inverse relationship. Nie 2017

A cross-sectional online survey of 302 individuals in Arar City, Saudi Arabia identified coffee consumption as one of the most commonly reported risk factors for gastroesophageal reflux disease (GERD) symptom flare-up. Alsulobi 2017

Data from an anonymous internet-based cross-sectional survey on impact of dietary factors and lifestyle on mental distress indicated that in matured adults (compared to young adults), mood may be partially reliant on abstinence of food that activates the sympathetic nervous system, such as coffee. Begdache 2017

A systematic review of prospective studies and meta-analysis indicated that moderate coffee intake is not associated with higher risk of hypertension (HPT) in the general population and in fact a non-linear inverse dose-response relationship occurs between coffee consumption and risk of HPT. D'Elia 2017

Mendelian randomization analysis investigating which potentially modifiable risk factors are associated with Alzheimer's disease noted that there was suggestive evidence for potential associations between higher coffee consumption and higher odds of Alzheimer's. Larsson 2017

Data from 3,321 Korean individuals did not reveal a statistically significant relationship between coffee consumption and metabolic syndrome in women or men. Shin 2017

A population-based case-control study in Catania, southern Italy found that higher intake of hydroxybenzoic acids and caffeic acids were associated with lower risk of advanced prostate cancer (PCa). High intake of caffeic acid and ferulic acid may be associated with reduced risk of PCa. Russo 2017

In 15 healthy male volunteers, consumption of pure caffeine significantly impacted total antioxidant capacity, glutathione (GSH), oxidized glutathione (GSSG), GSH to GSSG ratio, lipid hydroperoxides and malondialdehyde plasma levels, indicating that caffeine has antioxidant properties. Metro 2017

Among 10,432 Taiwanese individuals in a population-based door to door survey, consumption of coffee was associated with a lower risk of dementia. Lee 2017

Global metabolomic profiling in the blood of 220 advanced stage non-small cell lung cancer revealed a panel of metabolites including metabolites in caffeine metabolism pathway that may predict survival outcome. Shen 2017

A cross-sectional study of Portuguese adults did not reveal an association between the prevalence of Helicobacter pylori infection and coffee intake. Amaral 2017

The impact of coffee consumption on fibrosis and steatosis in HIV-HCV co-infected patients. [No abstract] Carrieri 2017

Results of a case-control study based on data collected from two large oncology hospitals in Vietnam indicated that in southern Vietnamese women, drinking more than a cup of coffee per day was among factors associated with a higher risk of breast cancer. Trieu 2017

In a sample of 1374 unselected adult men and women from the general population, a positive association between caffeine intake and abstract reasoning exists in those who are CC homozygous of the -163C>A polymorphism of CYP1A2 gene. Casiglia 2017

An urban clinic-based case-control study in Sri Lanka found that among their participants, coffee drinkers were significantly less likely to have Parkinson's disease and were older at PD onset. Wijeyekoon 2017

A serum metabolomic profile of glioma identified years in advance of clinical diagnoses is characterized by altered signals in arginine/proline, antioxidant, and coffee-related metabolites. The observation provides new potential leads regarding the molecular basis relevant to biomarkers for glioma. Huang 2017

Mendelian randomization analyses of data from northern European subjects, using the s16969968 genetic variant as a proxy for smoking heaviness in all studies and rs4410790 and rs2472297 as proxies for coffee consumption, indicates that higher cigarette consumption causally increases coffee intake. Bjørngaard 2017

Data from 27,296 adults from 8 European countries showed that coffee consumption was positively associated with a more diverse fatty acid composition in blood serum. This in turn was associated with a lower incidence of type 2 diabetes. Imamura 2017

A cross-sectional descriptive study of 500 adults in Saudi Arabia, coffee consumption was associated with the risk of various cancers in males and females. AlSaeed 2017

Among 340 women undergoing in-vitro fertilization for infertility or pregenetic diagnosis for autosomal recessive diseases, there was no association between consumption of unsweetened coffee or caffeine and IVF outcome. Machtinger 2017

Data from two large prospective cohorts of health professionals support previous findings that increased caffeine intake may be associated with a decreased Parkinson's disease risk in men and in women who have never used post-menopausal hormones. Kim 2017

Data from 3710 participants in the Multi-Ethnic Study of Atherosclerosis cohort without history of known liver disease did not reveal an association between coffee consumption and subclinical cardiovascular disease, nor future risk of major CVD events, regardless of non-fatty liver disease status. Simon 2017

In 151 patients with frontotemporal dementia, no association was found for coffee intake. Tremolizzo 2017

In an ongoing French nationwide prospective cohort of patients co-infected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV), elevated coffee consumption at baseline was associated with a 50% reduced risk of all-cause mortality. Carrieri 2017

In a study examining whether the genetic variation determining habitual coffee consumption affected glycemic changes in response to weight-loss dietary intervention, participants with a higher genetic risk score showed a greater reduction of fasting insulin with a low-fat diet than high-fat. Han 2017

In a cross-sectional study. increasing coffee consumption was associated with increased levels of adiponectin among women. Leptin levels were inversely associated with coffee consumption among both men and women. Results suggest adipocyte function contributes to coffee's metabolic effect. Lee 2017

A meta-analysis of 22 observational studies did not reveal a significant association between coffee consumption and renal cell carcinoma. Wijarnpreecha 2017

A dose-response meta-analysis on prospective cohort studies through March 2017 found that an increase in coffee consumption of 1 cup per day was associated with 3% reduction in melanoma risk, suggesting that coffee intake may be inversely associated with melanoma incidence. Micek 2017

Coffee was found to be among the most foods most frequently found to trigger gastro-esophageal reflux symptoms among patients attending the Centre Study Association on Food Intolerance and Nutrition of Ferrara. Caselli 2017

Among 1,355 Indian Administrative Service and medical postgraduate aspirants aged 18-35 the prevalence and risk for low back pain was not found to be associated with coffee intake. Ganesan 2017

A meta-analysis of 28 case control and cohort studies including 42,399 prostate cancer patients revealed no significant positive associations between coffee consumption and prostate cancer. Coffee consumption was associated with reduced localized prostate cancer risk. Xia 2017

Findings from a meta-analysis summarizing evidence from prospective cohort and case-control studies suggest that increased coffee consumption is associated with decreased risk of liver cancer, but not biliary tract cancer. Godos 2017

Comment on: Association of coffee consumption and chronic kidney disease: A meta-analysis. [Int J Clin Pract. 2017] [No abstract] Kennedy 2017

A prospective study of 4365 Dutch Patients aged 60-80 y who had experienced a myocardial infarction within the past 10 years found that while 96% of the patients drank coffee, those drinking greater than 2 cups per day had a lower risk for cardiovascular or ischemic heart disease related mortality. van Dongen 2017

A questionnaire of patients from public hospitals revealed an inverse association between coffee intake and colorectal cancer risk, mainly among men. Ronco 2017

Survey data from participants aged 45-75 years in a study investigating associations between functional gastrointestinal disease and intake of certain foods (including FODMAPs) and beverages (including coffee) revealed that coffee was associated with a decreased risk of abdominal pain and bloating. Moding 2017

A dose-response meta-analysis of 7 prospective cohort studies found that increased coffee consumption is associated with a modest decrease in risk of hypertension. Smoking status is a potential effect modifier on the association between coffee consumption and risk of hypertension. Grosso 2017

Among 1304 adults surveyed in a rural area of South China (the Baotun community of Dongguan), the occurrence of functional dyspepsia was associated with coffee consumption, among other dietary factors. Xu 2017

A systematic review and meta-analysis of relevant literature showed an inverse relationship between high coffee consumption and the risk of oral and pharyngeal cancers. Miranda 2017

Analysis of a cross-sectional study of 3987 Korean adults aged 30-74 years revealed that coffee consumption was associated with a lower risk of coronary heart disease in women. Noh 2017

Prospective data from a sample of northern Swedish adults, blood lead concentration was positively associated with consumption of brewed coffee among female never-smokers and men. Wennberg 2017

Data from 469,047 US adults who were cancer free at baseline indicated a positive association between coffee and bladder cancer among ever smokers but not never smokers, suggesting that there may be residual confounding may be an explanation for the positive findings. Loftfield 2017

Prospective data from 95,807 Japanese subjects aged 40-69 years at baseline revealed no significant association between coffee and the risk of malignant lymphoma or multiple myeloma. Ugai 2017

Among 922,896 Cancer Prevention Study II participants aged 29-84, there was a nonlinear association between coffee consumption and all-cancer death among current smokers and former smokers. Among nonsmokers, there was an inverse association with death from various individual cancers. Gapstur 2017

A prospective cohort study of 18,838 adults in Atlantic Canada found that compared with non-coffee drinkers, females who drank ≥4 cups/day coffee were more likely to experience major depression, with adjustment for sociodemographic and behavioral factors, chronic disease status, and body mass index. Yu 2017

Data from Minnesota Colon Cancer Control Study of 46,551 participants 50-80 years old indicate that intake of coffee was not associated with colorectal cancer mortality. Shaukat 2017

Maternal coffee and tea consumption ≥8 cups/d during pregnancy at 15 weeks of gestation was associated with behavioral disorders in 11-year old offspring in a Danish cohort. The fetal brain seems to be more sensitive to caffeine exposure at 15 weeks of pregnancy compared with 30 weeks of gestation. Hvolgaard Mikkelsen 2017

A population-based study of postmenopausal Polish women found that higher dietary polyphenol intake (DPI), but not the dietary total antioxidant capacity (DTAC), was inversely associated with cardiovascular disease. Beverages, mainly coffee and tea, contributed in more than 40% to dietary DPI. Witkowska 2017

Among urban-living Nigerian women, habitual sleep duration of less than 7 hours was associated with a trend toward a higher likelihood of coffee consumption. Fawale 2017

Data from a cross-sectional study from the ELSA-Brasil cohort of 15,105 individuals (aged 35-74) suggest that while coffee consumers had reduced values of heart rate variability, most of the effects seem to be related to the higher prevalence of unhealthy habits in coffee users. de Oliveira 2017

Analysis of a prospective cohort study using NHANES data (n=17,594) showed that moderate caffeine intake was associated with a decreased risk of all-cause mortality, regardless of the presence or absence of coffee consumption. Tsujimoto 2017

Results of a prospective cohort study of participants from 10 European countries indicated that coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country, but there were distinctions between men and women. Gunter 2017

Data from the prospective population-based Multiethnic Cohort study of people aged 45-75 years at baseline showed that higher consumption of coffee was associated with lower risk for death in African Americans, Japanese Americans, Latinos, and whites, but not Native Hawaiians. Park 2017

A cross-sectional study of 2377 nondiabetic women found that high coffee and caffeine intakes were associated with a reduced risk of low sex hormone-binding globulin, a risk factor for type 2 diabetes. Associations were restricted to women with BMI≥25 or being postmenopausal. Pihan-Le Bars 2017

A case-control study in the Mecca region of Saudi Arabia found that healthy dietary patterns, including coffee intake of 1 or more cups/day, decreased the risk of colorectal cancer in participants. Azzeh 2017

A case report of a 45-y-old Caucasian femal with a history of bipolar disorder with psychotic features experiencing dramatic clinical remission after cessation of medication treatment and engagement of lifestyle interventions, including coffee enemas. Brogan 2017

Comment on: J-shaped relationship between habitual coffee consumption and 10-year (2002-2012) cardiovascular disease incidence: the ATTICA study. [Eur J Nutr. 2018] [No abstract] Ayubi 2017

Comment on: J-shaped relationship between habitual coffee consumption and 10-year (2002-2012) cardiovascular disease incidence: methodological issues. [Eur J Nutr. 2017] [No abstract] Kouli 2017

A case-control study that surveyed patients with renal cell carcinoma and matched controls found an inverse relationship between caffeinated coffee consumption and RCC risk, while decaffeinated coffee was associated with an increased risk of aggressive clear cell RCC. Antwi 2017

Results of a systematic review up to Nov 2016 suggests that caffeine intake, possibly through sperm DNA damage, may negatively affect male reproductive function. Howwver, Evidence from epidemiological studies on semen parameters and fertility is inconclusive. Ricci 2017

[Article in Chinese] Analysis of a survey of GERD and non-GERD outpatients in Third Xiangya Hospital indicated that coffee preference was markedly correlated with GERD. Yuan 2017

A report of a patient with bipolar disorder whose psychiatric symptoms were ameliorated with the elevation of lithium concentrations after the reduction of excessive daily coffee consumption. Review of literature suggests that excessive consumption may exacerbate BPD through multiple mechanisms. Kunitake 2017

Data from a large Italian multicenter case-control study indicated that consumption of more than 4 cups of coffee daily is associated with an increased risk of non-Hodgkin's lymphomas, especially the follicular subtype. The risk increased with years of exposure. Parodi 2017

Caffeine use was not associated with greater reported sleep disturbances in military personnel with PTSD, possibly because those with elevated insomnia symptom severity abstained from any caffeine, or because insomnia symptoms were elevated in this sample. McLean 2017

Cross sectional study of 5826 adults from the National Health and Nutrition Examination Survey showed that caffeine consumption was inversely related to telomere length, while coffee intake was positively related to telomere length. Tucker 2017

Data from an ongoing prospective population-based cohort (n=2424) showed the consumption of herbal tea and daily consumption of three or more cups of coffee was related to the presence of lower liver stiffness, independent of a great number of other lifestyle and environmental factors. Alferink 2017

Cross-sectional data from the 2008-2011 Korea National Health and Nutrition Examination Survey indicated that consuming at least 3 cups of coffee per day was associated with a lower prevalence of sarcopenia in elderly men. Chung 2017

A European case-control study examining possible risk and protective factors for the occurrence of sporadic pancreatic endocrine neoplasms noted that drinking coffee was more frequent in cases with localized, rather than metastatic, disease at diagnosis. Valente 2017

Analysis of data from the Tobacco and Genetics consortium and the UK Biobank indicates that amount of coffee consumption is unlikely to have a major causal impact upon amount of cigarette smoking. Coffee compounds investigated did not significantly inhibit the rate of nicotine metabolism in vitro. Ware 2017

A genome-wide methylation study in 4 European cohorts (n=3096) did not identify any individual sites associated with differential methylation in relation to coffee consumption. Ek 2017

Data from 936 healthy pregnancies from the WHISTLER birth cohort indicated that daily caffeine consumption of more than 300mg, compared to less than 100 mg, is possibly associated with an increase in gestational age at birth. van der Hoeven 2017

The relationship between postmenopausal women's sclerostin levels and their bone density, age, body mass index, hormonal status, and smoking and consumption of coffee and dairy products. [No abstract] Namlı Kalem 2017

Analysis of data from several large prospective cohorts of health professionals indicated that higher coffee consumption might attenuate the genetic associations with BMI and obesity risk. Wang 2017

Analysis of data pooled from two French national population-based case-control studies revealed no association between childhood brain tumors and the mother drinking coffee during the pregnancy. Bailey 2017

Lower coffee consumption was associated with incident excessive daytime sleepiness in a longitudinal community study of 2157 adults over 5 years. Jaussent 2017

A cross-sectional study in Korean adults aged ≥40 years (n=6906) found that light coffee consumption was protective against sarcopenia in men, whereas frequent coffee consumption produced a higher risk for obesity, especially in women. Kim 2017

Consumption of Italian-style coffee may reduce prostate cancer risk, according to data from a population cohort study of 6,989 men ≥50 years old. Cellular confirmation was seen in 2 human prostate cancer cell models, where caffeine exerted both antiproliferative and antimetastatic activity. Pounis 2017

2 case-control studies among Japanese indicated that coffee consumption might contribute to prevention of colorectal cancer, especially distal colon cancer. Nakagawa-Senda 2017

Systematic reviews conducted as a component of the National Population Health Study of Neurological Conditions identified coffee intake as associated with a decreased risk of dystonia and Parkinson's Disease. Krewski 2017

An updated systematic review and dose-response meta-analysis of prospective studies did not reveal evidence that coffee was associated with colorectal risk. Vieira 2017

[Article in English, Portuguese] A cross-sectional study of 150 women undergoing urodynamic testing analyzed factors, including coffee intake, that may be associated with urinary incontinence. Silva 2017

In a prospective cohort study of 72,680 Swedish adults (aged 45 - 83 years) who were free of cancer at baseline, those consuming 2 or more cups of coffee a day had a reduced risk of gallbladder cancer than those consuming 1 or less. Larsson 2017

Cross-sectional analysis of 1929 participants of the NHLBI Family Heart Study without known coronary heart disease did not provide evidence for an association between coffee consumption and prevalent coronary-artery calcium in adult men and women. Patel 2017

Data from the Health Survey of São Paulo (ISA-Capital), a population-based study (n=557), indicated that coffee intake of 1-3 cups/day and its polyphenols were associated with lower odds of elevated systolic blood pressure, diastolic blood pressure, and hyperhomocysteinemia. Miranda 2017

A systematic review of observational studies noted that diets rich in certain foods, including coffee, have been detrimentally associated with the quality of semen, while a high intake of caffeine by males had a negative influence on chance of pregnancy or fertilization in their partners. Salas-Huetos 2017

Among subjects with Parkinson's disease taking creatine, caffeine intake was associated with more rapid progression of the disease, influenced by GRIN2A phenotype, demonstrating a 4-way interaction. Neither caffeine intake nor GRIN2A genotype alone were associated with rate of progression of PD. Simon 2017

Coffee Drinking and Alcoholic and Nonalcoholic Fatty Liver Diseases and Viral Hepatitis in the Multiethnic Cohort. [No abstract] Setiawan 2017

A cohort study was conducted to evaluate the impact of potential risk factors, such as coffee, on relapse of gastroesophageal reflux disease in primary care patients successfully treated with a proton pump inhibitor. López-Colombo 2017

Analysis of data from 832 asymptomatic Taiwanese male subjects indicated that coffee was not associated with incidence of asymptomatic erosive esophagitis. Chang 2017

Longitudinal analyses of population studies revealed that higher trigonelline (a known marker of coffee consumption) levels in the urine were related to a higher decline in free thyroxine (T4) levels over time. The risk of hypothyroidism was higher in subjects with high baseline trigonelline. Friedrich 2017

A cross-sectional study investigating risk factors for rapid eye movement sleep behavior disorder in community-dwelling residents ≥50 years old found that use of coffee or tea was not significantly associated with altered risk. Ma 2017

Among Korean male high school students, students with short sleep times consumed a greater amount of coffee than others. Jun 2017

In a study of Australian children aged 8-12, 87% of the sample consumed caffeine (mainly coffee/tea and soda), and total caffeine intake was associated with sleep routine, morning tiredness, restless sleep, and internalizing behavioral problems. Watson 2017

Reanalysis of a large population based case-control study carried out in Italy (a country with high coffee consumption and low use of green tea) did not find an association between regular use of coffee and any type of leukemia. Parodi 2017

Among Indian college students, coffee/tea consumption was associated with excessive daytime sleepiness. Kaur 2017

Among 126 Korean patients with weekly typical GERD symptoms, dietary items known to be frequent symptom inducers included coffee. Choe 2017

Results of a Korean multi-center cross-sectional study showed that high coffee consumption was associated with a 38% lower odds ratio for stroke in women. The inverse association was strongest among healthy women who were not obese, hypertensive, diabetic, smokers, or alcohol drinkers. Lee 2017

Among postmenopausal patients, effects of sclerostin levels on bone density are independent from age, and they are not affected by consumption of coffee and milk. Kalem 2017

A systemic review and meta-analysis of case-control and cohort studies found no significant association between coffee consumption and thyroid cancer risk. There may be potential biases and confounding variables; further studies are called for. Han 2017

Data from 14,082 participants in the prospective Atherosclerosis Risk in Communities Study indicated that consumption of ≥4 cups/d compared with none was inversely associated with incident peripheral arterial disease. Ogilvie 2017

A retrospective cross-sectional study of 1018 patients with non-alcoholic fatty liver disease, hepatitis C virus, or hepatitis B virus found that those drinking 2 or more cups of coffee per day had a lower liver stiffness, which may indicate less fibrosis and inflammation. Hodge 2017

Cross-sectional data from Bavarian adults indicated that sleep duration was associated with coffee/black tea intake, with higher intake among short duration sleepers. Kleiser 2017

Among 223 students at a Turkish Nursing school, coffee consumption was associated with sleep quality as measured by the Pittsburg Sleep Quality Index, Yilmaz 2017

A meta-analysis of 4 observational studies with 14,898 individuals demonstrated no significant association between coffee consumption and chronic kidney disease in males. However, future studies are called for to assess a potential inverse relationship in females. Wijarnpreecha 2017

Results from systematic review of human studies (almost entirely observational studies) indicate that consumption of coffee might have protective effects against depression. García-Blanco 2017

A study exploring associations between dietary intake, physical activity, and sleeping habits, and the presence of non-alcoholic fatty liver disease found that those with NAFLD drank less coffee than controls. Katsagoni 2017

An analysis of 10,367 participants investigating associations between coffee consumption and metabolic syndrome found slightly different reactions to nutritional factors modifying metabolism, such as coffee, between individuals with normal BMI versus those with excessive body mass. Suliga 2017

Two meta-analyses found a significantly decreased risk of NAFLD among coffee drinkers and significantly decreased risk of liver fibrosis among patients with NAFLD who drank coffee on a regular basis. The definition of regular coffee consumption varied between studies, limiting the meta-analysis. Wijarnpreecha 2017

A prospective analysis of 145,886 participants in the Multiethnic Cohort found that coffee drinking protected against acute pancreatitis not associated with gallstones. Setiawan 2017

In 6508 participants from the Multi-Ethnic Study of Atherosclerosis, regular coffee consumption was not statistically associated with coronary artery calcium progression or cardiovascular events. Miller 2017

Using 2 genetic variants associated with caffeine intake as proxies for coffee consumption in a sample of 46,687 men of European ancestry, no clear evidence linking the genetic risk score with prostate cancer risk, grade of disease, or with all-cause mortality in men with prostate cancer. Kaneva 2017

Results from a prospective study of 120 subjects with non-alcoholic fatty liver disease (NAFLD) showed consumption of coffee did not modify the estimated impact of lifetime alcohol consumption on fibrosis severity in NAFLD. Hagström 2017

A case-control field study found type 2 diabetic patients may self-medicate with caffeine to alleviate daytime sleepiness. Urry 2017

A cross-sectional study including 28,822 women of reproductive age did not find an association with coffee consumption and endometriosis incidence after adjusted analysis. Saha 2017

A Copenhagen study identifying determinants of clinical gallstone events during long-term follow-up of participants unaware of their gallstones found no significant associations with coffee consumption and gallstone events. Shabanzadeh 2017

Among 28,561 individuals in a European cohort, consumption of 3-4 cups of coffee/day was associated with decreased risk of mortality in men and women, of cardiovascular disease mortality in men, of all cause and cancer mortality in non-smoking women, and all cause mortality in non-drinking men. Grosso 2017

A literature review and meta-analysis of observational studies found coffee intake appeared to exert a moderate protective effect against basal cell carcinoma development, probably through the biological effect of caffeine. Caini 2017

Results from a house-to-house survey of community members from 3 villages in Uttar Pradesh indicated that consumption of tea/coffee was a risk factor for functional gastrointestinal disorders. Ghoshal 2017

A systematic review and meta-analysis of prospective cohort studies providing a precise quantification of the inverse relation between coffee consumption and the risk of hepatocellular carcinoma, and adds evidence to the presence of an even stronger negative association with chronic liver disease. Bravi 2017

Meta-analysis of 19 prospective cohort studies involving 2,046,575 participants and 22,629 patients with colorectal cancer found consumption ≥ 5 cups of coffee daily was significantly associated with a decreased risk of colorectal cancer. Gan 2017

Coffee and green maté tea demonstrated the highest antioxidant capacity among commonly consumed plant foods in Brazil. Coffee alone contributed, on average, 66% of total annual dietary antioxidant capacity consumption. Torres 2017

Pooled data from two cohort studies in Miyagi Prefecture, NE Japan (n=73,346) illustrated a significant inverse relationship between coffee consumption and the risk of bladder cancer. Sugiyama 2017

Analysis of data from the European Prospective Investigation into Cancer and Nutrition (1992-2000), a large cohort study, consumption of caffeinated coffee was inversely associated with melanoma risk among men, but not among women. Caini 2017

A cross-sectional population-based survey in Sao Paulo among 169 individuals aged 20 or older found that lysophosphatidylcholine (a pathological component of oxidized-LDL) profiles differed according to coffee intake, showing a possible benefit on inflammatory and oxidative processes. Miranda 2017

A hospital-based case control study found that coffee consumption was inversely associated with odds of glioma; such that individuals in the top category of coffee consumption wer 91% less likely to have glioma compared with those in the bottom category. Malmir 2017

Analysis of a survey of 1482 school-children aged 12-19 did not determine coffee consumption to be an independent risk factor for vertigo and dizziness. Filippopulos 2017

A dose-response meta-analysis of 12 studies suggests that increased coffee consumption is associated with decreased risk of endometrial cancer or postmenopausal cancer. Lafranconi 2017

A case-control study of 100 post-menopausal females with newly-diagnosed osteoporosis and 100 matched controls evaluated the impact of potential risk factors including smoking, coffee drinking, and alcohol consumption. Bijelic 2017

Data from 164 patients with acute alcoholic hepatitis (AH) and 131 heavy-drinking controls with no liver disease indicated that regular coffee consumption was associated with lower risk of AH in heavy drinkers. Lourens 2017

A case-control study showed former coffee drinkers had a higher risk of Barrett's esophagus, which was higher with duration, for late quitters, and for those who began drinking later. No association with BE was found with current drinkers. Light drinkers had a higher risk of erosive esophagitis. Filiberti 2017

A systematic review and meta-analysis of cohort and case-control studies suggested increased consumption of caffeinated coffee and, to a lesser extent, decaffeinated coffee are associated with reduced risk of hepatocellular carcinoma. Quality of evidence may be low. Kennedy 2017

Self-reported caffeinated coffee intake was positively associated with 24-h urinary excretions of paraxanthine, theophylline and caffeine, whereas reported intakes of decaffeinated coffee and other caffeinated beverages showed no association. Petrovic 2016

Presentation of the relationship between the consumption of selected foods rich in bioactive compounds with anticancer activity, including coffee, and the development of colorectal carcinoma, based on selected studies. [Article in Polish] Marciniak 2016

A systematic review of studies regarding the psychological factors associated with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis identified coffee consumption as among the most important behavioral factors related to the diseases. Macavei 2016

A population-based case control study and meta-analysis evaluating gene-enviornment interaction in Parkinson's disease observed interactions between polymorphisms in genes encoding for adenosine A2A receptor and cytochrome P450 1A2 and coffee consumption. Results also suggest survivor bias. Chuang 2016

[Article in Chinese] A case-control study of 593 oral squamous cell carcinoma (OSCC) patients and 1,128 controls in Fujian province found no significant association between coffee intake and OSCC. Yan 2016

Analysis of large Danish data sets revealed that observationally, coffee intake was associated with U-shaped lower risk of cardiovascular disease and all-cause mortality; however, genetic variants associated with caffeine intake were not associated with risk of CV disease or all-cause mortality. Nordestgaard 2016

Data from the Korean National Health and Nutrition Examination Survey suggest that coffee consumption may be associated with reduction of metabolic syndrome in Korean women, after adjusting for life-style factors, socioeconomic status, and nutritional profile. Kim 2016

A meta-analysis of 3 cohort and 4 case-control studies found no evidence to support an association of coffee consumption with the risk of lymphoma. Han 2016

A birth cohort study of 3485 children born in Pelotas, Brazil in 2004 did not reveal any association between maternal caffeine consumption during pregnancy and ADHD in the child at the age of 11 years. Del-Ponte 2016

[Article in Hungarian] A survey of 455 adults in the South-Transdanubia region of Hungary indicated that consumption of coffee influenced quality of sleep. Fusz 2016

Meta-analysis of 20 prospective cohort studies indicated a significant linear dose-response inverse relationship between coffee consumption and liver cancer risk. Yu 2016

According to a cross-sectional survey using a convenience sample of 300 young adults from 3 Korean universities, coffee consumption was a predictor of sleep quality in men aged 20-40 years of age. Chang 2016

Data from a hospital based cross-sectional study among adult hypertensive patients at Jimma University Specialized Hospital hypertension clinic in southwest Ethiopia indicated that coffee use was significantly associated with uncontrolled blood pressure. Asgedom 2016

In fibromyalgic female patients, consumption of foods rich in polyphenols, such as coffee, as associated with lower numbers of tender points. Costa de Miranda 2016

Results from a Mendelian randomization study found that genetically predicted coffee consumption was not associated with type 2 diabetes, depression, or Alzheimer's disease, in contrast to observational findings. It was also unrelated to childhood cognition and ischemic heart disease. Kwok 2016

A population-based case-control study in Canada from 2001-2012 did not find an increased risk for epithelial ovarian cancer associated with the consumption of coffee. Leung 2016

A systemic review of studies regarding sleep bruxism (SB) found that the odds for SB seem to increase almost 1.5 times for those who drank more than 8 cups of coffee a day. Bertazzo-Silveira 2016

Results of a cross-sectional study comparing Korean immigrants and indigenous Japanese subjects did not reveal a difference between the groups regarding the association between coffee and liver enzymes. Kim 2016

Results from a population-based case-control study in Montreal, Canada did not provide strong support for associations between consumption of coffee or black tea with lung cancer. Pasquet 2016

A hospital-based case-control study observed an increased risk of oncohematological diseases associated with coffee intake. Cerliani 2016

A meta-analysis of observational studies found no evidence for an association between coffee/caffeine consumption and the risk of urinary incontinence. Sun 2016

Results from a small small study indicated that estimated CYP1A2 enzyme activity and thus speed of caffeine metabolism was higher in those with type 2 diabetes than those without the condition; this was possibly due to higher intake of caffeine, a known inducer of CYP1A2 enzyme activity. Urry 2016

Higher coffee consumption was associated with lower risk of elevated aminotransferase concentration in Korean adults. Oh 2016

A dose-response meta-analysis of prospective cohort studies found coffee consumption is associated with decreased risk of mortality from all-cause, cardiovascular disease, and cancer; however, smoking modifies the observed risk. Grosso 2016

A comprehensive meta-analysis of cohort studies exploring association between coffee and most cancer types indicated that coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk. Wang 2016

An review of the findings of the Norwegian Tromsø study (1974-2016) noted that a survey in 1979 revealed the cholesterol increasing effect of coffee. Njølstad 2016

A systemic review and meta-analysis of 5 African epidemiological studies did not find coffee intake to be a potential risk factor for resistant hypertension. Nansseu 2016

A case-cohort study including 8,086 type 2 diabetes cases and 11,035 participants found a possible interaction of TCF7L2 variants and an incretin-specific genetic risk score with coffee consumption in relation to the risk of type 2 diabetes. InterAct Consortium 2016

Data from Japanese cohort of 106,234 subjects followed from 1990 or 1993 until 2012 found an inverse relationship between consumption of ≥3 cups coffee/day and brain tumor risk in total subjects and in women. Glioma risk also tended to decrease. Ogawa 2016

Data from a cross-sectional study of 80 adults in Australia suggested that shorter sleep is associated with greater caffeine consumption, and that consumption is greater in adults with reduced sleep quality. Watson 2016

Among 608 female university students in Turkey, consumption of coffee was associated with increased risk of PMS. İşik 2016

A cross-sectional study of 320 Syrian university students found consumption of 3 cups of coffee daily was a risk factor for irritable bowel syndrome. Al Saadi 2016

A meta-analysis of 11 epidemiological studies confirmed the inverse association between coffee consumption and hepatocellular carcinoma risk. The protective effect can be detected among healthy population and patients with chronic liver diseases. Bai 2016

Findings from a community-based cross-sectional study among 992 Chinese men showed that consumption of coffee was independently and significantly associated with osteoporosis (OP). The prevalence of OP was less frequent in Chinese men with moderate coffee intake. Yu 2016

Results from a prospective clinic-based uncontrolled study of 108 migraine patients who consumed caffeine drinks daily indicated that caffeine abstinence was associated with better efficacy of acute migraine treatment. Lee 2016

A Norwegian study comprising >100,000 live-born children found maternal total daily caffeine consumption (coffee, tea, and soft drinks) before and during pregnancy was not associated with cerebral palsy risk in children. An increased risk associated with caffeinated soft drinks was observed. Tollånes 2016

Among 330 healthy and nonsmoking Korean young adult males, current coffee consumption level was not associated with bone mineral density or bone metabolism-related markers according to the calcium intake level. Choi 2016

Coffee intake was found significantly associated with development of bladder tumor in younger aged patients in an eastern Indian study. Singh 2016

Investigation of the association between dietary habits and atopic dermatitis in 17,497 adults in a 2009-2011 Korean survey found that a dietary pattern distinguished by high coffee intake was associated with decreased prevalence of atopic dermatitis. Park 2016

Systemic analysis of 22 population studies involving 7,631 cases and 1,019,693 controls indicated that coffee consumption might be associated with a decreased risk of gastric cancer in a dose-response manner. Xie 2016

Consumption of 1 cup of coffee resulted in increase in total trefoil and total higher order aberrations of the eye without any effect on pupil diameter in healthy subjects. Ultrastructural changes in the cornea following coffee intake might be of relevance to the alterations in ocular aberrations. Bardak 2016

A study investigating the correlation between liver cancer mortality and food consumption in Serbia between 1991-2010 revealed a negative correlation between coffee consumption and age-adjusted liver cancer mortality, but only for the eldest men, aged 65 years or older. Ilić 2016

Erratum for: Is coffee consumption associated with a lower risk of hyperuricaemia or gout? A systematic review and meta-analysis. [BMJ Open. 2016] [No abstract] [No authors listed] 2016

A study of 28 subjects found no correlation between coffee intake and telomere length. Kasielski 2016

A systematic review and meta-analysis of 11 observational studies could not validate the association between coffee consumption and a lower risk of hyperuricaemia. Zhang 2016

Swedish population based case-control study data illustrated that coffee comprised 62% of dietary antioxidant intake. Intake of ≥6 cups of coffee/day was associated with reduced risk for high grade prostate cancer. Total antioxidant intake from diet was not associated with prostate cancer risk. Russnes 2016

Findings from a case-control study nested within the prospective Nurses' Health Study II suggested that caffeine intake is not associated with PMS or specific symptoms, including breast tenderness. Purdue-Smithe 2016

A cross-sectional study among 3240 individuals from the Sichuan Tibetan region found that consumption of coffee was correlated with incidence of hypertension. Huang 2016

Survey data from 133 surgical residents at various public sector hospitals in Pakistan did not reveal an association between consumption of coffee/tea and the development of burnout syndrome. Malik 2016

A meta-analysis of prospective cohort studies before November 2015 indicated that every 1-cup increase in coffee consumption was associated with an 1% increase in pancreatic cancer risk. Nie 2016

EPIDEMIOLOGY. High-profile cancer reviews trigger controversy. [No abstract] Kupferschmidt 2016

What is the relationship between coffee and lung cancer? [No abstract] Comment on: Coffee consumption and the risk of lung cancer: an updated meta-analysis of epidemiological studies. [Eur J Clin Nutr. 2016] Sherman 2016

A dose-response meta-analysis of 2 prospective studies indicated that drinking coffee habitually following acute myocardial infarction was associated with a reduced risk of mortality. Brown 2016

Perceived stress among a diverse sample of male and female college freshmen was associated with past week coffee consumption. Errisuriz 2016

Data from the prospective Nurses' Health Study revealed that higher total coffee consumption was associated with longer telomeres among female nurses compared to non-drinkers. Liu 2016

Among 159 university students surveyed, 69% consumed coffee or espresso in the last month. The frequency of most risk behaviors, sleep disturbances, and mental illness diagnoses was not significantly different between the high-end and general population of coffee drinkers. Kelly 2016

Energy drink and coffee consumption among early adolescents are concurrently associated with similar psychopathology symptoms. Longitudinally, the associations between these beverages and psychopathology differ, indicating that these substances have differing implications for development over time. Marmorstein 2016

Analysis of the urinary excretion of 34 dietary polyphenols, including those from coffee, and their associations with diet and lifestyle factors in 475 European adults. The large geographical variations in urinary polyphenols observed are largely determined by food preferences. Zamora-Ros 2016

In 57 generally healthy Japanese females, plasma chlorogenic acid level had negative associations with fasting blood glucose, glycated hemoglobin and C-reactive protein, supporting previous findings that coffee polyphenols have anti-diabetic effects. Lee 2016

A cross-sectional study found that the longevity-associated mitochondrial DNA 5178 cytosine/adenine polymorphism modified the effects of coffee consumption on abnormally elevated levels of serum liver enzymes in male Japanese health check-up examinees. Kokaze 2016

Results from the prospective Women's Health Initiative cohort indicated that compared to nondrinkers, moderate and high coffee drinkers had an increased incidence of colorectal cancer, especially with moderate drip brew or high nondrip brew coffee intake. Groessl 2016

Data from a 5-year cohort study of 600 community-dwelling women aged 55-74 years at baseline showed coffee consumption to be positively associated with lumbar spine and total hip bone mineral density. Hirata 2016

In 256 healthy premenopausal women followed for ≤2 menstrual cycles, caffeine intake was associated with reduced testosterone levels and decreased risk of anovulation. Schliep 2016

A door-to-door survey of all residents aged ≥40 years in a rural Ecuadorian village revealed no effect of caffeine intake on sleep quality. Del Brutto 2016

Among subfertile women trying to conceive receiving support at Swedish fertility clinics, 13.6% drank more than 3 cups of coffee per day. Joelsson 2016

Among the adult population in two Korean cities, consumption of instant coffee was significantly correlated with the presence of benzophenones in the urine. Kim 2016

Data from 5,145 cases and 4,097 controls from a population-based case-control study in northern Israel showed coffee consumption was inversely associated with the risk of colorectal cancer in a dose-response manner. Schmit 2016

Comment on: Letter by Aubin et al Regarding Article, "Association of Coffee Consumption with Total and Cause-Specific Mortality in 3 Large Prospective Cohorts". [Circulation. 2016] [No abstract] Ding 2016

Comment on: Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective Cohorts. [Circulation. 2015] [No abstract] Aubin 2016

A systematic review and meta-analysis of epidemilogical studies among the Japanese population found conflicting evidence between cohort studies and case control studies regarding the impact of coffee drinking on the risk of colorectal cancer. Akter 2016

A a meta-analysis to clarify the potential association between the single nucleotide polymorphism rs762551 AA genotype, which confers fast caffeine metabolism, and caffeine consumption found a siginficant association, particularly among male, younger, and Caucasian subjects. Denden 2016

Analysis of data from 2,914 participants from the population-based Rotterdam Study revealed higher coffee consumption was cross-sectionally associated with a lower occurrence of lacunar infarcts and better executive function, but also with smaller hippocampal volume and worse memory function. Araújo 2016

A survey of 800 Dutch university students revealed that coffee beverages were the most prevalent sources of caffeine intake, and that participants had poor knowledge on the relative caffeine content of caffeinated beverages. Mackus 2016

Coffee, caffeine and non-alcoholic fatty liver disease? [No abstract] Kennedy 2016

Review summarized evidence from observational studies and intervention trials regarding nutritional aspects in the treatment of non-alcoholic fatty liver disease noted evidence from observational studies on potential benefit of coffee. Zelber-Sagi 2016

Mit Kaffeegenuss Gallensteine vermeiden.[Article in German] Comment on: Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease. [Aliment Pharmacol Ther. 2015] Storr 2016

An updated meta-analysis of 20 prospective cohort studies before Nov 2015 found that coffee consumption may weakly increase the risk of pancreatic cancer. Dose-response analysis indicated that every 1-cup increase in coffee consumption was associated with an 1% increase in pancreatic cancer risk. Nie 2016

A review of environmental factors and their interactions with risk genotypes in multiple sclerosis (MS) epidemiology noted high coffee consumption is associated with decreased MS risk. Hedström 2016

An update meta-analysis of 20 cohort studies found that high coffee consumption was associated with a reduced pancreatic risk, but there were potential confounders and bias that could not be excluded from results. Ran 2016

Data from 91,767 women in the prospective Norwegian Women and Cancer study showed a modestly reduced risk of cancer in women drinking between 3-7 cups of coffee daily, but increased risk of lung cancer for >7 cups daily that is likely caused by residual confounding due to smoking. Lukic 2016

Among hypertensive participants in a cross-sectional study of Spanish seniors, habitual coffee consumption was associated with uncontrolled blood pressure compared to non-coffee drinkers. Lopez-Garcia 2016

A study investigating blood lead levels and related exposure factors among the general adult population of northern France noted that consumption of coffee was a factor associated with increased mean blood lead levels. Tagne-Fotso

Results from a survey of 242 healthy Japanese individuals under aged 65 participating in a medical brain-screening program showed that silent brain infarction was less common in those drinking 3 cups or more of coffee per day. Nakaguchi 2016

Results from a systematic review and analysis of 7 observational studies suggest that coffee consumption could have a protective role against liver fibrosis in non-alcoholic fatty liver disease patients. Coffee consumption is also associated with less likelihood of having metabolic syndrome. Marventano 2016

A cross-sectional study including 112 obese individuals undergoing bariatric surgery, liver biopsy, and histological diagnosis observed that obese individuals with elevated coffee consumption exhibited lower frequencies of NASH, although with no statistical significance in this sample. Barros 2016

Results from a prospective cohort study of 1204 non-diabetic subjects aged 18-45 years showed that coffee consumption increased the risk of cardiovascular events in a linear fashion in hypertension. Palatini 2016

Data from 2 prospective Swedish cohorts illustrated no association between coffee consumption and risk of non-gallstone related acute pancreatitis, nor evidence of effect modification by alcohol intake. Oskarsson 2016

In a Dutch cohort study, coffee consumption was associated with a slightly higher estimated glomerular filtration rate, but not associated with changes in eGFR over 15 years, indicating low-moderate coffee consumption is likely not a concern for kidney health in the general population. Herber-Gast 2016

A meta-analysis of 11 case-control and 4 cohort studies indicated that coffee consumption appears to have a protective benefit in oral cancer. Li 2016

Explored lifestyle factors, including coffee consumption, in relation to metabolic syndrome among patients receiving abdominal ultrasonography in Seoul, South Korea. Ki 2016

A survey-based cross-sectional population study of adult Singaporeans aged 21 or above found consumption of coffee to be a factor associated with prevalence of irritable bowel syndrome. Siah 2016

A meta-analysis of 11 prospective studies including 29,155 participants indicated that while higher coffee consumption was associated with reduced risk for Alzheimer disease, it was not associated with the different measures of cognitive decline or dementia on the whole. Liu 2016

Time to wake up and smell the coffee? Coffee consumption and multiple sclerosis. [No abstract] Comment on: High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies. [J Neurol Neurosurg Psychiatry. 2016] Wijnands 2016

Data from 2 population-representative case-control studies from Sweden and the US showed that high consumption of coffee (exceeding 900 mL daily) was associated with a substantially reduced risk of multiple sclerosis. Hedström 2016

Analysis of a structured interview, neuropsychological assessment, and relevant clinical and laboratory data found a significant association between espresso coffee use and a better cognitive function in HIV-infected patients. Bragança 2016

Systematic review and meta-analysis of 9 studies between 1999-2014 showed that coffee intake of 1 cup/day or more was associated with reduction of the risk of gout. Women required more coffee to lower serum uric acid than men. Park 2016

Results from a study including 3,497 prediabetic patients in South Korea indicated that the risk of diabetes progression was lowest in patients who drank black coffee 3 or more times per day. Lee 2016

Coffee consumption was associated with delayed disease progression in alcoholic liver disease and primary sclerosing cholangitis patients with end-stage liver disease. It was also associated with increased long-term survival after liver transplantation. Friedrich 2016

Compared prevalence of cataract blindness in different countries with the amount of caffeine consumed there (per capita coffee consumption). Incidence of cataract blindness was found to be lower in groups consuming higher amounts of coffee in comparison to the groups with lower coffee intake. Varma 2016

Findings from an Italian case-control study suggested a favorable role of a diet high in total antioxidant capacity on endometrial cancer risk, which can be partially driven by coffee consumption. Rossi 2016

A dietary pattern involving higher consumption of coffee, chocolate, and ice cream was negatively associated with the prevalence of atopic dermatitis in Korean adults. Park 2016

A systematic review and meta-analysis of cohort and case-control studies suggested that caffeinated coffee might have chemopreventive effects against malignant melanoma. Liu 2016

In a population-based, cross-sectional study of postmenopausal Korean women, subjects in the highest quartile of coffee intake had 36% lower odds for osteoporosis compared to those in the lowest quartile, after adjusting for various demographic and lifestyle confounders (including hormonal factors). Choi 2016

Caffeine Consumption and Cardiovascular Risks: Little Cause for Concern. [No abstract] Comment on: Consumption of Caffeinated Products and Cardiac Ectopy. [J Am Heart Assoc. 2016] Wilson 2016

Evaluation of dietary patterns and cardiac ectopy using 24-hour Holter monitoring among Cardiovascular Health Study participants found no relationship between chronic consumption of caffeinated products and ectopy. Dixit 2016

Among adults surveyed in Sao Paulo, coffee was the top dietary contributor for polyphenols. Miranda 2016

Systematic review and meta-analysis of cohort and case-control studies found that an increase in daily coffee consumption of two cups substantially reduce the risk of cirrhosis. Kennedy 2016

A meta-analysis of observational studies published between 1980-2015 found showed that while total caffeine intake was not associated with the prevalence or hepatic fibrosis of non-alcoholic fatty liver disease (NAFLD), regular coffee caffeine consumption may reduce hepatic fibrosis of NAFLD. Shen 2016

Among adults participants from the general population in the Netherlands and the UK, tobacco smoking was positively associated with consumption of caffeine, primarily from coffee. Treur 2016

A prospective study of 30 community-dwelling women found reduction of potentially irritating beverages, including coffee, resulted in improvement in lower urinary tract symptoms, but adherence to elimination protocols was difficult to achieve and maintain. Some confounding factors identified. Miller 2016

Findings from a meta-analysis of case-control and cohort studies found that maternal coffee consumption during pregnancy was not significantly associated with the occurrence of total neural tube defects or spina bifida in offspring. Li 2016

A meta-analysis of 13 prospective cohort studies through Sept 2014 involving 1,324,559 participants found coffee consumption to be associated with an increased risk of gastric cardia cancer, particularly among Americans. However, smoking and body mass index may be confounding effects. Deng 2016

Findings from experimental trials involving completion of modular arithmetic tasks suggest that performance pressure and caffeine shape cognitive performance via distinct mechanisms, rather than a shared one. Boere 2016

Analysis of survey data of Japanese subjects aged 65 yrs and older, living in Ohsaki City, found coffee consumption was significantly associated with a lower risk of incident dementia, especially among women, non-smokers, and non-drinkers. Sugiyama 2016

Data from a cross-sectional study among US veterans did not support an association between consumption of coffee and the risk of Barrett's esophagus. Sajja 2016

A large prospective study of 29,985 postmenopausal women found neither caffeinated coffee nor caffeine intake was associated with mean systolic or diastolic pressure, and that neither intake of coffee nor caffeine was associated with the risk of hypertension. Qin 2016

Letter: coffee consumption and gallstone disease - a cautionary note on the assignment of exposure values in dose-response meta-analyses. Authors' reply. [No abstract] Zhang 2016

Letter: coffee consumption and gallstone disease - a cautionary note on the assignment of exposure values in dose-response meta-analyses. [No abstract] Comment on: Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease. [Aliment Pharmacol Ther. 2015] Crippa 2016

Results from comparison of the consumption of coffee and caffeinated beverages between 494 weight loss maintainers and 2,129 individuals from general population suggested that caffeinated beverages may support weight loss maintenance. Icken 2016

A systematic review and meta-analysis of 9 observational studies (927,173 study participants) revealed some evidence for the beneficial effects of regular coffee consumption on melanoma. There was possible publication bias at play. Yew 2016

A population-based prospective cohort study in Japan found no clear association between coffee consumption and the risk of biliary tract, gallbladder, or extrahepatic bile duct cancer. Makiuchi 2016

Systematic review of observational studies (346,913 individuals and 8146 cases) revealed a nonlinear J-shaped relation between coffee consumption and risk of depression, suggesting a protective effect of coffee against depression. Grosso 2016

Data from a large-scale Japanese population-based prospective cohort study showed that participants who consumed 5 or more cups of coffee per day had a significantly higher hazard ratio for subarachnoid hemorrhage compared with the participants who consumed less than 1 cup of coffee a day. Sakamaki 2016

In 23 subjects suffering from rhinitis and allergic asthma, there was a direct association between the intake of coffee and the abundance of Clostridium, Lactococcus and Lactobacillus in their fecal microbiota. Cuervo 2016

A meta-analysis of observational studies published between 1999-2015 (159,805 participants) suggested that coffee consumption is non-linearly associated with a lower risk of metabolic syndrome. Shang 2016

A meta-analysis with dose-response analysis of 11 observation articles found that coffee and caffeine consumption were significantly associated with decreased risk of depression, in a nonlinear manner. Wang 2016

Coffee drinking was inversely associated with cardiovascular disease in 673 individuals aged 65-100 years from "Blue Zone" designated locale, Ikaria Island, Greece. Chrysohoou 2016

An investigation into the relationship between some eating habits and iron status during pregnancy in a sample of 219 healthy pregnant women in southern Bulgaria showed that pregnant women with a high frequency of coffee consumption had lower values of body iron. Bivolarska 2016

Data from 2,046 non-demented participants in a community-dwelling population indicated that consuming >1 cup of coffee and 1-3 glasses of alcohol is related to better gait; smoking is related to worse gait. Gait is an important health indicator, relating strongly to risk of falling and mortality. Mirza 2016

Data derived from 2,725 Polish participants showed an association between coffee consumption and incidence of hypertension that was related to smoking status. Consumption of 3-4 cups of coffee per day decreased the risk of hypertension in non-smoking men and women only. Grosso 2016

Examination of polyphenol intake in a sample of 246 UK women aged 18-50 years found flavanols and hydroxycinnamic acids were the most important contributors to the polyphenols consumed, owing to tea and coffee consumption. Older women consumed more polyphenol-containing foods and beverages. Yahya 2016

A cross-sectional epidemiology study among Singaporean Chinese residents aged ⩾40 years found coffee intake to be among lifestyle factors associated with high risk of hypertension. Li 2016

In 307 patients who underwent endoscopy to remove a colorectal tumor, increased coffee consumption increased colorectal tumor recurrence in the distal colon, but had a tendency towards reducing recurrence in the proximal colon. High consumption reduced the overall risk of recurrence of tumors. Nakamura 2016

A dietary pattern encompassing 'sweet foods, coffee, and tea' was inversely associated with total femur bone mineral density in a cross-sectional study of 156 postmenopausal and osteoporotic Brazilian women aged over 45 years. de França 2016

In adults at increased risk of cardiovascular disease and diabetes mellitus, decaffeinated coffee and caffeine consumption were associated in an opposing pattern with retinal vessel calibers, while regular coffee did not associate with retinal vessel calibers. Karatzi 2016

A questionnaire of 1065 Russian adults found that the rate of coffee drinking was higher among those with GERD than those who did not suffer from that condition. Bor 2016

Data from nearly half a million participants in the US NIH-AARP Diet and Health Study indicate that associations between coffee consumption and lung cancer are confounded by tobacco smoking, and that adjusting for this factor drastically decreases the hazard ratio of coffee consumption. Guertin 2016

A systematic analysis of population-based studies (12,276 cases and 102,516 controls) suggested that coffee intake was associated with an increased risk of lung cancer, and that this risk was modified by gender, country of residency, and smoking tobacco. Xie 2016

Data from the 1988-1994 NHANES III study on participants aged ≥17 years old indicated that heavier daily coffee consumption was associated with decreased stroke prevalence, despite smoking tendency in heavy coffee drinkers. Liebeskind 2016

The European Prospective Investigation into Cancer and Nutrition cohort study found that coffee, tea, and fruits were the most important food sources of total phenols among European populations. Zamora-Ros 2016

Analysis of population representative data from the National Health and Nutrition Examination Survey III (8608 patients) found no association with all-cause mortality or specific cardivascular mortality and coffee consumption. Loomba 2016

A meta-analysis of epidemiologic studies found that coffee consumption is associated with a reduced risk of cutaneous melanoma. Wang 2016

Review focused on chronotype, gender and general health found that"eveningness" was associated with use of alcohol, coffee and stimulants. Fabbian 2016

Pooled estimates from a systematic review and meta-analysis of 8 prospective cohorts and 13 case-control studies indicated that when the potential confounding effect from smoking is controlled for, coffee drinking does not appear to be a lung cancer risk factor. Galarraga 2016

Coffee drinking during pregnancy was a risk factor for childhood acute lymphoblastic leukemia. Erratum for: The associations between maternal factors during pregnancy and the risk of childhood acute lymphoblastic leukemia: A meta-analysis. [Pediatr Blood Cancer. 2015] Yan 2016

[Article in German][Orthopedists need the most coffee].[No abstract] Comment on: Black medicine: an observational study of doctors' coffee purchasing patterns at work. [BMJ. 2015] Füeßl 2016

A cross-sectional study of 9,009 subjects found that skin autofluorescence (SAF), a noninvasive marker of advanced glycation end products, significantly and independently associated several clinical and lifestyle factors in the nondiabetic population, including coffee consumption. van Waateringe 2016

Data from 57,053 Danish participants aged 50-64 years showed that compared with no intake, coffee consumption was inversely associated with atrial fibrillation incidence. Mostofsky 2016

Consumption of coffee may be considered an independent risk indicator of periodontal disease in Korean male adults, according to data from 16,730 respondents. Han 2016

The occurrence of premenstrual dysphoric disorder among Indian medical students was associated with total tea/coffee intake as well as change in tea/coffee intake under stress. Mishra 2015

An observational study on the prevalence of anemia among schoolchildren in Kerala, India found the incidence of anemia was associated with regular intake of tea/coffee along with major meals. S 2015

Coffee lowers in a study blood pressure. [No abstract] [Article in German] Comment on: Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions. [Hypertension. 2015] Zidek 2015

Coffee consumption and risk of levodopa-induced dyskinesia in Parkinson's disease: The FRAGAMP study. [No abstract] Nicoletti 2015

Higher coffee consumption was found to be a risk factor for isolated diastolic hypertension among sampled individuals from the Han and Uygur populations in Xinjiang, China. Liu 2015

Data from food frequency questionnaires of 610 healthy elderly Japanese individuals showed that beverages such as coffee contributed highly to the overall intake of polyphenols. Taguchi 2015

Among 63,652 live-born singleton babies in the Danish National Birth Cohort, maternal coffee consumption did not modify the increased risk for offspring asthma associated with acetaminophen used during pregnancy. Liu 2015

A study of doctors' coffee consumption at work at a large teaching hospital in Switzerland found that doctors commonly use coffee as a stimulant and surgeons drink more coffee than physicians. Giesinger 2015

Among all women, high levels of caffeine and caffeinated coffee intake were associated with significantly lower levels of micronuclei. There was no significant relationship between caffeine, coffee, tea and soda intake and the other markers of DNA repair capacity and oxidative stress. Nikitina 2015

Among 258 patients with tinnitus surveyed, almost 6% reported that consumption of coffee/tea made their tinnitus worse. Pan 2015

A survey among mothers of children 0-6 years old in Northwest Argentina examining the relationship between beverage intake and obesity found that 44% of children consumed coffee/tea/cocoa. Alderete 2015

Risk factors: Moderate coffee drinking is associated with lower risk of death from CVD. [No abstract] Comment on: Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective Cohorts. [Circulation. 2015] Ruiz 2015

A cross-sectional study of 1,817 Chinese postmenopausal women found that that frequency of coffee intake was independently and significantly associated with osteoporosis. The prevalence of osteoporosis was greater in women who consumed coffee less frequently. Yang 2015

Regular coffee consumption may improve survival in patients with colon cancer. [No abstract] Printz 2015

Among 90,317 US adults, coffee drinkers had lower risk for overall mortality compared with nondrinkers. Inverse associations were observed for deaths from heart disease, chronic respiratory diseases, diabetes, pneumonia and influenza, and intentional self-harm, but not cancer. Loftfield 2015

Consumption of caffeine had beneficial effects in male schizophrenic patients in complex tasks requiring deeper cognitive processing, such as semantic fluency, cognitive speed, working memory, and visual memory. Núñez 2015

Results from assessment of a cohort of 14,563 public service workers (35-74 years old) suggest that coffee consumption might slightly benefit memory in elderly subjects but lacks a dose response relationship. Araújo 2015

A meta-analysis of prospective studies evaluating the impact of dietary factors, such as coffee consumption, on the risk of gastric cancer. Fang 2015

Maternal serum paraxanthine level, representing caffeine intake, had no meaningful association with offspring's IQ or problem behaviors at ages 4 and 7. Klebanoff 2015

Data from 3 large propective cohorts found consumption of coffee was nonlinearly associated with mortality. Inverse associations were observed between coffee consumption and deaths attributed to cardiovascular disease, neurologic disease, and suicide, but not cancer mortality. Ding 2015

A descriptive, cross-sectional study of 60 independent community-dwelling older adults with mild cognitive impairment found milk, plain water, and tea/coffee to be the most frequently consumed beverages, which contributed substantially to overall micronutrient intake. Venci 2015

Among 6,661 Polish subjects aged 20-74, tea was the primary source of polyphenols and flavonoids for the studied population, including mainly flavanols, while coffee was the most important contributor of phenolic acids, mostly hydroxycinnamic acids. Witkowska 2015

A cross-sectional study among 542 Japanese people who consumed "Shikohin", such as alcohol, tea, coffee, or tobacco, found that participants experienced common psychological effects in each "Shikohin," such as relaxation, sociability, or positive mood. [Article in Japanese] Yokomitsu 2015

Data from a European prospective nested case-control study suggest that the inverse association of coffee intake with hepatocellular carcinoma was partly accounted for by biomarkers of inflammation and hepatocellular injury. Aleksandrova 2015

Meta-analysis of 16 studies including 3,032 coffee consumers and 13,2076 non-consumers indicated that coffee consumption can significantly reduce the risk for hepatic fibrosis and cirrhosis, even among a patients with alcoholic liver disease and chronic hepatitis C infection. Liu 2015

Among 300 urban families of Anzoátegui, Venezuela, coffee was found to be among the foods most consumed daily. [Article in Spanish] Ekmeiro Salvador2015

A cross-sectional study (n=1452) found no evidence for an association between caffeine consumption and either the prevalence of fatty liver (hepatic steatosis) or serum ALT concentrations. Graeter 2015

Total weekly caffeine intake was positively associated with anxiety and depression in a large cohort of secondary school children from the South West of England. Coffee was the major contributor to high overall caffeine intake. Richards 2015

A cross-sectional online survey of ≥ 16-year-old students in the Canton of Zurich revealed coffee was commonly used as a soft enhancer explicitly for cognitive enhancement. Liakoni 2015

A cross-sectional descriptive survey among Jazan university students investigating the association of awake bruxism with khat, coffee, tobacco, and stress found no association between bruxism and coffee consumption. Quadri 2015

A meta-analysis of prospective studies (3,368 cases; 1,372,811 participants) did not find an association between coffee consumption and the risk of gastric cancer, in general. It did find increased risk of gastric cancer for US participantsd the equal to or less than 10 years follow-up subgroup Li 2015

A study of men born in 1913 show the art of becoming 100 years. Nonsmoking, moderate coffee consumption and good income helps. [No abstract][Article in Swedish] Wilhelmsen 2015

Coffee is one of the major sources of polyphenols in Japanese daily life, according to a survey taken by more than 10,000 Japanese subjects aged 1-99 y old each year from 1996-2013. Taguchi 2015

A cross-sectional survey administered to 1st and 2nd year podiatric medical students showed that higher odds of developing poor sleep quality were associated with coffee intake. Sawah 2015

An Italian case-control study on 690 bladder cancer cases and 665 hospital controls conducted between 2003-2014 found no significant relation between coffee consumption and bladder cancer risk, and in particular a lack of dose and duration relationships. Turati 2015

A meta-analysis of prospective cohort studies between 1996-2015 (1,289,314 participants) found no nonlinear association between coffee consumption and gastric cancer risk, but consumption of more than 6.5 cups/day may increase risk of gastric cancer in the US population. Zeng 2015

Data from the large prospective US NIH-AARP Diet and Health Study did not reveal an association between total, caffeinated, or decaffeinated coffee intake and pancreatic cancer. Guertin 2015

Among subjects aged 65-84 from the Italian Longitudinal Study on Aging, cognitively normal older individuals who increased their coffee consumption had a higher rate of developing mild cognitive impairments (MCI), while a consistent moderate consumption was associated with reduced rate of MCI. Solfrizzi 2015

Neither prospective data from 41,881 Swedish men and 34,594 Swedish women nor meta-analysis of 6 cohort studies (248,910 individuals) indicated any association between coffee consumption and atrial fibrillation incidence. Larsson 2015

A meta-analysis of 12 epidemiological studies including 4,037 oral cancer cases and 1,872,231 participants indicated that higher coffee consumption was associated with lower oral cancer risk. The association was significant in Europe, but not in America. Zhang 2015

A dose-response meta-analysis of data from 1,534,039 participants from 13 studies found that intake of caffeinated coffee, decaffeinated coffee, or caffeine may reduce the incidence of endometrial cancer, especially in those never treated with hormones and in those with a BMI ≥25 kg/m(2) Zhou 2015

In a prospective observational study, among 953 patients with stage III colon cancer, those consuming ≥4 cups caffeinated coffee daily experienced reduced risk of colon cancer recurrence or mortality compared with abstainers. Guercio 2015

Among the 442 Swiss study subjects with inflammatory bowel disease, 38% supposed that coffee has an effect (mostly detrimental) on their symptoms of disease, significantly more in Crohn's disease (54%) compared to ulcerative colitis patients (22%). Barthel 2015

Review provided information pertaining to various antioxidants found in food, including coffee, that have demonstrated utility in improving liver diseases. Casas-Grajales 2015

Results from a Japanese prospective study (2013-2014) of 455 participants aged 25-92 years indicated that daily coffee consumption is associated with reduced risk of cerebral microbleeds in men, but not in women. Shinoda 2015

Based on analysis of caffeine in foods available in Korean markets with consumption data from the Korea National Health and Nutrition Examination Survey, mean caffeine intake from all sources in the general population and consumers were 67.8 and 102.6 mg day(-1) for all age groups, respectively. Lim 2015

A critical review of three observational studies suggested that a modest intake of coffee may be associated with an 11% increased risk of venous thromboembolism compared to abstainers, whereas a larger intake may be associated with a 25% decreased risk, creating a U-shaped relationship. Lippi 2015

An investigation into the correlation between syndrome types of late-onset acne in female patients and their Chinese medicine constitution listed coffee consumption as an adversely influencing factor. [Article in Chinese] Li 2015

A cross-sectional study of 6,000 subjects aged 20-74 found that the consumption of tea, coffee, and apples was associated with the largest contribution to dietary total antioxidant capacity and flavonoid content in all participants Zujko 2015

Data from the 2010 National Health Interview Survey indicated that total frequency and types of sugar-sweetened beverage consumption, such as coffee, differed by geographic region. Park 2015

Corrigendum to "Reliable estimation of dietary exposure to furan from coffee: An automatic vending machine as a case study" [Food Research International 61 (2014) 257-263]. [No abstract] Mesías 2015

According to data from the National Youth Physical Activity and Nutrition Study, students consumed more servings of coffee/tea and other sugar sweetened beverages (SSB) if they resided in a state that banned soda in school but attended a school with vending machines that sold other SSBs. Taber 2015

Data from the Insulin Resistance Atherosclerosis Study(n=1,005 multi-ethnic, non-diabetic adults) indicated a beneficial impact of caffeinated coffee on liver morphology and/or function. This relationship may mediate the well-established inverse association of coffee with risk of type 2 diabetes. Dickson 2015

Among police officers, ambulance workers, hospital staff, and office workers, a cross-sectional postal survey found doctors had the highest daily caffeine consumption. Tsiga 2015

A meta-analysis of 6 observational studies (227,749 participants and 11,477 gallstone disease cases) revealed a nonlinear dose-response association between coffee consumption and reduced risk of gallstone disease, specifically in females. Zhang 2015

A meta-analysis of articles published up to Mar 2014 confirmed a dose-dependent relationship between caffeine consumption during pregnancy and risk of low birth weight. Every additional 100mg of caffeine intake per day during pregnancy was associated with a 3% increase in risk of low birth weight. Rhee 2015

Higher caffeine intake was significantly associated with higher skin intrinsic fluorescence (SIF) in participants with Type 1 diabetes. The effect of N-acetyltransferase 2 variant rs1495741 on SIF is partially independent of caffeine consumption. Eny 2015

Among healthy male college student volunteers in Chongqing, China, coffee consumption was found to be associated with increased progressive and non-progressive sperm motility of 8.9% or 15.4% for subjects consuming 1-2 cups/wk or ≥3 cups/wk of coffee, respectively. Yang 2015

Data from three large prospective cohorts indicated that higher total caffeine intake and caffeinated coffee consumption was associated with a lower risk of cutaneous malignant melanomas, especially in women. No association was found with decaffeinated coffee. Wu 2015

A meta-analysis of 15 observational studies including 9,601 cases and 351,081 total participants found only a borderline reverse association between coffee intake and risk of kidney stone. Subgroup and sensitivity analyses showed inconsistent results. Xu 2015

A survey of the nutritional habits of Italian university students indicated that the eating habits of young adults do not follow national recommendations. 11.3% of the survey respondents consumed excessive amounts of caffeine. Teleman 2015

Coffee brewing technique as a confounder in observational studies. [No abstract] Comment on: Coffee consumption and coronary artery calcium in young and middle-aged asymptomatic adults. [Heart. 2015] Hingston 2015

Among 122 Turkish subjects, there were no significant associations between the consumption of Turkish or instant coffee and serum lipid levels. Karabudak 2015

A retrospective study of 90 patients with chronic obstructive pulmonary disease (COPD) found no correlation between mean daily caffeine consumption in the last 20 years and COPD exacerbations in the last 3 years. Lopes 2015

Data from 587 premenopausal women in the Nurses' Health Study II indicated that consumption of caffeine and coffee may alter patterns of estrogen metabolism. Sisti 2015

In a study comparing family history and dietary habits of 55 pregnant women with preeclampsia and 50 healthy pregnant women, coffee intake did not differ significantly between groups. Bobić 2015

Among older Korean adults, the pattern of higher intakes of white rice, noodles, and coffee was associated with lower cognitive function impairment than the pattern involving higher intake of multigrain rice, fish, dairy products, fruits, and fruit juices. Kim 2015

Investigation into the intake of snacks, beverages, caffeine, alcohol, and cigarette smoking among children 9-20 years old in Krakow orphanages revealed 10% of girls and 21% of boys aged 9-12 drank coffee, while among the oldest respondents, about 35% reported drinking coffee. Pysz 2015

Meta-analysis of 9 prospective cohort studies involving 1,250,825 participants and 3,027 gastric cancer cases indicated that coffee consumption was not associated with overall gastric cancer risk, but may be a risk factor for gastric cardia cancer. Liu 2015

A dietary study found coffee was among the food items consumed by most adults in a probabilistic sample of adults in Niterói in the State of Rio de Janeiro. [Article in Portuguese] de Souza 2015

Analysis of blood samples from coffee and noncoffee drinkers (n=50) revealed a high exposure of coffee consumers to 2'R-ochratoxin A (2'R-OTA), a compound formed from ochratoxin A during coffee roasting. Cramer 2015

Data from 93,179 individuals analyzed in a Mendelian randomization study indicated that high coffee intake was associated observationally with low risk of obesity, metabolic syndrome, and type 2 diabetes and their related components, but with no genetic evidence to support causal relationships. Nordestgaard 2015

Among 1,728 older non-Hispanic whites, ten of the 77 immune and inflammatory markers were nominally associated with coffee drinking. Heavy coffee drinkers had lower circulating levels of chemotaxis of monocytes/macrophages, proinflammatory cytokines and regulators of cell growth. Loftfield 2015

Data from a sample of the general population in Athens, Greece revealed that coffee drinks were among the main contributors to energy intake from beverages. Malisova 2015

Comment on: Coffee consumption and periodontal disease in males. [J Periodontol. 2014] [No abstract] Duarte 2015

Caffeine use (especially coffee) among adolescents is strongly related to increased consumption of alcohol mixed with energy drinks. Kristjansson 2015

Data from a large Brazilian cohort of middle-aged and elderly individuals revealed an inverse relationship between coffee consumption and newly diagnosed diabetes, 2-hr postload glucose, and 2-hr postload insulin, but not with fasting glucose or insulin concentrations. Yarmolinsky 2015

Data from the ESTELLE study (747 cases and 1,421 controls) indicated that maternal consumption of >2 cups of coffee per day is associated with acute lymphoblastic leukemia in offspring, but not with childhood leukemia (CL) as a whole. The role of maternal coffee drinking in CL remains unclear. Orsi 2015

EPICOR prospective cohort study data(12,800 men and 30,449 women without history of CV disease) showed consumption of over 2 cups/day of Italian-style coffee was associated with increased coronary heart disease risk. Data from a sub-cohort did not show association with plasma lipid changes. Grioni 2015

Data from the European Prospective Investigation into Cancer and Nutrition - Norfolk study (n=25,639) did not find a positive association between consumption of sweetened tea/coffee drinks and incident type 2 diabetes, though there were positive associations found with other sweetened beverages. O'Connor 2015

A meta-analysis of prospective cohort studies (5,408 patients with hip fracture and 205,930 participants) did not reveal a statistically significant association between coffee consumption and risk of hip fracture in individuals in developed countries. Li 2015

Data for 3,724 men showed caffeine intake reduced the odds of prevalent erectile dysfunction, especially an intake equivalent to approximately 2-3 daily cups of coffee (170-375 mg/day). This reduction was also observed among overweight/obese and hypertensive, but not among diabetic men. Lopez 2015

Coffee was one of the five items most commonly purchased by consumers at four bodegas in Bronx, NY. Kiszko 2015

Data from the prospective Swedish Women's Lifestyle and Health study (n=42,099 women aged 30-49 at enrollment) showed that women with higher consumption of coffee (≥5 cups/day) had a decreased breast cancer risk compared to women consuming 1-2 cups of coffee/day. Oh 2015

A random sample of 3,042 individuals in the Athens, Greece prospective ATTICA study found that individuals who consumed 250 mL of coffee had 54% lower odds of developing diabetes compared with abstainers, with a dose-response linear trend observed that was mediated by serum amyloid-A levels. Koloverou 2015

Data from 97,334 individuals in the Prostate, Lung, Colorectal, and Ovarian cancer screening trial showed that coffee intake was not associated with overall cancer risk, but was associated with a decreased risk of endometrial cancer. Hashibe 2015

A systematic review of 323 prospective cohort and retrospective case-control studies revealed grade I evidence for coffee exposure as a protective factor for Alzheimer's disease. Xu 2015

A dietary intake survey of 15,371 German speaking individuals found that people with higher socio-economic status consumed more coffee than those with lower socio-economic status. Heuer 2015

A case-control study of 453 pregnant women in Ethiopia found that a higher incidence of pre-eclampsia was found in women who reported to have consumed coffee daily during pregnancy. Endeshaw 2015

A cross-sectional study of 700 healthy postmenopausal women assessing sleep disturbance and its associated factors did not find a correlation between sleep disturbance and coffee intake. Taavoni 2015

Characterization of the usual daily coffee intake in the Brazilian population using data from the 2008-2009 National Dietary Survey of 34,003 individuals aged 10 years and older. Sousa 2015

Comment on: Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis. [Am J Epidemiol. 2014] [No abstract] Aubin 2015

A nationally representative estimate of caffeine consumption in adults indicated that 89% of the adult US population consume caffeine, with 64% of that derived from coffee intake. Further breakdown by gender and category provided. Fulgoni 2015

Comment on: Coffee consumption and periodontal disease in males. [J Periodontol. 2014] Letter to the editor: re: Coffee consumption and periodontal disease in males. Ng N, Kaye EK, Garcia RI. (J Periodontol 2014;85:1042-1049.). [J Periodontol. 2015] [No abstract] Ng 2015

Comment on: Coffee consumption and periodontal disease in males. [J Periodontol. 2014] [No abstract] Gopal 2015

A survey focusing on seasonal variation in food intake among adults in southern Brazil (n=273) showed that consumption of coffee was higher in the spring than other times of year. Rossato 2015

Letter to the Editor: Re: Coffee Consumption and Periodontal Disease in Males. [No abstract] Gopal 2015

Longitudinal analyses based on over 1,010,000 individuals in 5 cohort studies indicated that neither caffeine nor coffee intake are associated with risk of amyotrophic lateral sclerosis (ALS). Fondell 2015

Gathering detailed brand-specific data rather than category-specific data will likely increase accuracy of and strengthen the assessment of caffeine exposure in the United States. Mitchell 2015

Data from a study of 1,024 Japanese male workers indicated that coffee may have beneficial effects on hepatic steatosis, and may be negatively associated with leptin levels in hepatic steatosis. Imatoh 2015

Results from a prospective cohort study including 5,132 Danish women planning pregnancy found that while preconceptional caffeine conception was not associated with an increased risk of spontaneous abortion, consumption during early pregnancy was associated with a small increased risk. Hahn 2015

Coffee consumption and bladder cancer are linked, analysis shows. [No abstract] Comment on: Coffee consumption and bladder cancer: a meta-analysis of observational studies. [Sci Rep. 2015] Gruber 2015

An evaluation of 415 women attending a general clinic found that in women, daily coffee consumption ≥ 3 cups may be associated with a lower oxidative stress status, as measured by the level of reactive oxygen metabolites (d-ROMs). Chen 2015

Data from a cross-sectional study of 910 primarily male veterans with chronic hepatitis C infection suggested that a modest daily caffeine intake (as little as 100 mg) may protect against advanced hepatic fibrosis. Khalaf 2015

Data from 858 Japanese women who delivered single infants showed maternal total caffeine intake during pregnancy was associated with increased risk of preterm birth, but not with low birth weight or small for gestational age. There were no associations between type of beverage and birth outcomes. Okubo 2015

Results of a study of 90,914 Japanese persons aged 40-69 y without a history of cancer, cerebrovascular, or ischemic heart diseases at baseline revealed an inverse association between coffee intake and total mortality and mortality from heart, cerebrovascular, and respiratory diseases. Saito 2015

Results of a meta-analysis including 34 case-control studies and 6 cohort studies indicated that coffee consumption was associated with an increased risk of bladder cancer, especially for males and non-smokers. Wu 2015

Results from a population-based cohort study of 4,077 Korean men and women aged 40-69 years with a normal glucose level at baseline revealed coffee consumption was associated with a lower risk of prediabetes and type 2 diabetes among individuals with particular genetic polymorphisms. Lee 2015

A cross-sectional questionnaire study assessed the relationship between socioeconomic and anthropometric data, frequency of food consumption, and the development of noncommunicable diseases in patients from a small rural town in northeastern Brazil. 89% of the 420 patients consumed coffee daily. Di Pietro 2015

Among 396 students who completed questionnaires evaluating sleep, dreams and dietary habits and motivations, those who perceived food-dependent dreaming differed from others by reporting more frequent and disturbing dreams, poorer sleep, higher coffee intake, and lower Intuitive Eating Scale scores. Nielsen 2015

A study matching 220 healthy subjects with 90 diabetic subjects observed higher adiponectin levels and decreased fasting blood sugar and HbA1C levels in both normal and diabetic subjects who consumed coffee compared to those who did not. Bhaktha 2015

Data from the UK Million Women Study did not reveal an association between endometrial cancer risk and the consumption of coffee. Meta-analysis of published studies showed a weak association, but the authors posited there may be publication bias limiting available evidence. Yang 2015

A prospective data analysis conducted with the use of the Singapore Chinese Health Study (n=52,584 men and women aged 45-74 y free of diabetes, cardiovascular disease, and cancer at baseline) found that higher coffee intake was inversely associated with mortality in never-smokers. Odegaard 2015

A cross-sectional study including 25,138 asymptomatic patients undergoing cardiovascular health screening found that moderate coffee consumption was associated with a lower prevalence of subclinical coronary atherosclerosis. Choi 2015

Findings from a systematic review provided critique and questioned the strength of evidence associating coffee consumption with the prevention of Alzheimer's disease and other cognitive impairments. Panza 2015

A meta-analysis of 20 epidemiological studies involving 31,479 participants found that caffeine intake from coffee or tea was not associated with the risk of cognitive disorders such as dementia, Alzheimer's disease, cognitive impairment, and cognitive decline. Kim 2015

In a case control study comparing 74 metabolic syndrome patients with 176-matched controls among an Amazonian population in Brazil, daily consumption of 2-3 cups of coffee was inversely associated with metabolic syndrome odds. Dos Santos 2015

Results from a survey of 420 women from Limpopo, South Africa suggested that coffee consumption was associated with lower anti-Müllerian hormone concentrations, a marker of ovarian reserve. Whitworth 2015

Findings from a meta-analysis of 13 cohort studies (34,105 cases; 539,577 participants) suggested that coffee consumption may be associated with a reduced risk of prostate cancer and has an inverse association with nonadvanced prostate cancer. Liu 2015

Data from a population-based cohort of 1,090 Swedish patients with invasive primary breast cancer combined with that of an in vitro study indicated that caffeine and coffee may be active against both ER(+) and ER(-) breast cancer, and may sensitize tumor cells to tamoxifen. Rosendahl 2015

Data from interviews with patients with benign prostatic hyperplasia on medical therapy (n=156) suggested that increased coffee intake was a factor associated with nocturia improvement. Singam 2015

According to data from a study of 315 mother-infant dyads, coffee consumption is not uncommon among toddlers in Boston, Massachusetts, USA. After controlling for possible confounding factors, maternal ethnicity and infant sex were significantly associated with this practice. Burnham 2015

Analysis of a USA multicenter population-based study of participants diagnosed with varied gastric adenocarinomas indicated that the odds ratios for isoflavones intake, for which coffee was the main source, were increased for all tumors except oesophageal squamous cell carcinoma. Petrick 2015

Analysis of data from the European Prospective Investigation into Cancer and Nutrition and the Nurse's Health Studies suggested that coffee consumption was inversely associated with endometrial cancer risk. Merritt 2015

Results from a dietary intake survey among Yup'ik women in Western Alaska indicated coffee to be among the most commonly consumed food items. Sharma 2015

1992-2010 European Prospective Investigation into Nutrition and Cancer Study data (335,060 women) indicated that caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer. Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Bhoo-Pathy 2015

Data from a large Danish population-based case-control study indicated that coffee consumption and total caffeine consumption from coffee and tea combined was associated with a modest decreased risk of ovarian cancer. Gosvig 2015

Higher coffee intake was associated with a modest decrease in risk of melanoma in a large US prospective cohort study of 447,357 non-Hispanic whites. Loftfield 2015

Data from longitudinal study with a cohort of 1,180 nondiabetic patients screened for stage 1 hypertension found coffee consumption increased the risk of impaired fasting glucose in hypertension, particularly among carriers of the slow CYP1A2 *1F allele. Palatini 2015

Findings from the 1999-2010 Kanter Worldpanel Beverage Consumption Panel and the NHANES showed that coffee was a key source of caffeine for children 12 years and older. A significant increasing trend in caffeine-containing energy drinks and coffee consumption and decline in soda intake was noted. Ahluwalia 2015

Review examined the limitations of the classic epidemiological approach to studies of coffee and health, and described the progress in systems epidemiology of coffee and its correlated constituent, caffeine. Cornelis 2015

The effect of Frappe coffee on blood lipid levels. [No abstract] Mirkopoulou 2015

Data from a prospective study of 224,234 Norwegian men showed an inverse relationship between number of cups of coffee consumed per day and the risk of prostate cancer, but only for boiled coffee. Tverdal 2015

Coffee consumption and risk of lung cancer: the ICARE study. [No abstract] Sanikini 2015

Coffee consumption was associated with a reduced risk of colorectal adenoma, a precursor lesion to most colorectal cancers, in an observational study of Japanese patients undergoing total colonoscopy as part of a cancer screening program. Budhathoki 2015

Findings from a cross-sectional study in 10,177 Korean individuals aged 20-97 years support a possible protective effect of coffee on the risk of depression. Park 2015

Data from a cross-sectional cohort (n=347) and a prospectively followed subcohort (n=147) did not provide evidence for association between coffee consumption and the new onset of nonalcoholic fatty liver. High coffee intake was associated with a lower proportion of significant fibrosis, however. Zelber-Sagi 2015

A meta-analysis of 8 studies (n=312,993) indicated that coffee consumption was associated with the development of gastric cancer. Shen 2015

Data from a population-based case-control study of clubfoot suggests that drinking more than 3 servings of coffee per day throughout early pregnancy may increase clubfoot risk, but the numbers of exposed women were small and odds ratios were unstable. Werler 2015

A cross-sectional population-based survey of 8,821 adults in Krakow, Poland found high coffee consumption was negatively associated with metabolic syndrome and some of its components, including waist circumference, hypertension, and triglycerides. Grosso 2015

Data from a British birth cohort showed that consumption of coffee has decreased in the population between 1982 and 2006-11. Pot 2015

Prospective data from the Women's Health Initiative - Observational Study cohort of 66,484 postmenopausal women did not find strong evidence that increasing coffee consumption can lead to a lower melanoma risk. Wu 2015

Data from a population-based prospective multi-ethnic cohort study of 215,000 people in Hawaii and California indicated that increased coffee consumption reduces the risk of hepatocellular carcinoma and chronic liver disease. Setiawan 2015

A study of 140 bladder cancer patients and 206 healthy controls investigating the role of polycyclic aromatic hydrocarbons in bladder cancer found smoking and coffee consumption to be relevant risk factors for bladder cancer. Boada 2015

A trans-ethnic genome-wide meta-analysis of genetic data from European and African-American adults identified 6 novel loci located near genes potentially involved in the pharmacokinetics and pharmacodynamics of caffeine, and are associated with coffee consumption. Coffee and Caffeine Genetics Consortium 2015

Data from a prospective cohort study (30,989 women; 40,936 men) revealed an inverse association between coffee consumption and cholecystectomy in women who were premenopausal or used hormone replacement therapy but not in other women or in men. Nordenvall 2015

A European prospective study (477,312 participants) showed no significant association between consumption of total, caffeinated, and decaffeinated coffee and tea and over-all gastric cancer risk. Total and caffeinated coffee consumption may be associated with increased risk of gastric cardia cancer. Sanikini 2015

Cross-sectional data from the Norwegian Fit for Delivery study of 575 healthy pregnant nulliparous women found that the percentage of women drinking coffee dropped from 38% pre-pregnancy to 10% in early pregnancy. Skreden 2015

A population-based case-control study of risk factors for inflammatory bowel disease in Asia-Pacific (442 incident cases, 940 controls) found coffee consumption to be among factors that were protective against development of ulcerative colitis. Ng 2015

The scent of coffee, identified as smoking-related in previous studies, was not associated with increased craving for cigarettes, as measured by skin conductance or subjective craving in 26 adult non-treatment-seeking nicotine-dependent smokers. Cortese 2015

In a cross-sectional survey of university students in Hargeisa, Somaliland investigating the prevalence of cardiovascular risk factors, 39% of respondents reported coffee consumption. Ali 2015

A nationwide cross-sectional survey of dietary intake in those over age 10 in Brazil found caloric coffee beverages to be the greatest contributor to total energy consumption via beverages. Pereira 2015

A meta-analysis of 16 studies concerning caffeine induced diuresis and fluid balance during exercise found that caffeine exerted only a minor diuretic effect that was negated by exercise, and that concerns regarding unwanted fluid loss from caffeine consumption are unwarranted. Zhang 2015

Analysis of survey data from 951 hospital-based surgeons illustrating the most common reasons for using caffeine as well as factors in professional or private life that are associated with coffee or caffeine use. Surgeons often use caffeinated substances to cope with fatigue and long working hours. Franke 2015

Data from a cross-sectional survey showed coffee and polyphenol consumption was associated with low facial pigmented spots in Japanese middle-aged females. Fukushima 2015

A prospective cohort of 49,259 Swedish women found that high coffee consumption (>5 cups/day) was associated with lower all-cause mortality than 0-1 cups/day. However, it was associated with increased cancer mortality in women over 50 yrs of age, indicating differential effects depending on age. Löf 2015

Coffee and tea consumption in pregnancy not associated with gestational diabetes mellitus. [No abstract] Comment on: First trimester coffee and tea intake and risk of gestational diabetes mellitus: a study within a national birth cohort. [BJOG. 2015] Simhan 2015

Data from the population-based Danish National Birth Cohort (n=71,239) of non-diabetic women with singleton pregnancies suggest that moderate first trimester coffee and tea intake were not associated with increased risk of gestational diabetes mellitus. Hinkle 2015

Data from the Korean Multi-Rural Communities Cohort (n=9,400) suggested that caffeine consumption might have an effect on serum uric acid in females. However, coffee, tea, and caffeine intake amounts were not associated with the risk of hyperuricemia. Bae 2015

Data from a cross-sectional survey of Japanese workers aged 20-68 (n=509) showed coffee consumption was inversely associated with serum leptin and plasminogen activator inhibitor-1 in men and women, and positively associated with adiponectin in men and with resistin in current male smokers. Pham 2015

Data from an observational study of 2077 students aged 18-24 found that xerostomia (dryness of the mouth) was indirectly related to gingival disease activity through the accumulation of dental plaque. Nasal congestion and coffee/tea intake also affected xerostomia. Mizutani 2015

In a study of 106 healthy volunteers exploring the relationship of diet with platelet-activating factor (PAF) and its metabolic enzymes, PAF acetylhydrolase was negatively associated with coffee consumption. Detopoulou 2015

Data from 1,212,893 individuals in 9 US cohorts in the Liver Cancer Pooling Project found that higher coffee consumption was associated with lower risk of heptocellular carcinoma, especially among women. There was no association with intrahepatic cholangiocarcinoma. Petrick 2015

Among a sample of women of the Omsk region of Siberia, coffee consumption was not found to be a relevant nutritional factor related to breast cancer risk. [Article in Russian] Shirlina 2015

Energy product consumption, including caffeinated coffee, by service members during deployment was not dramatically different than predeployment and was not associated with insomnia. Waits 2014

The impact of green tea and coffee consumption on risk of stroke in Japanese population. [No abstract] Shaikh 2014

Data from 1,685 survey respondents in an Iranian cross-sectional descriptive study indicated that coffee consumption was a risk factor for GERD. Vossoughinia 2014

In a study of 157 primary school teachers, coffee consumption was not associated with vocal cord disorders. Lira Luce 2014

A meta-analysis of data from 8 studies including 2596 laryngeal cancer cases suggested that coffee consumption was not associated with the risk of laryngeal cancer. Ouyang 2014

Epidemiological evidence collected from 3 large US cohorts of health professionals on lifestyle factors in the development of type 2 diabetes showed that higher consumption of coffee is among factors associated with lower diabetes risk. Ardisson 2014

In a Turkish study, consumption of coffee was seen to be markedly lower in gastric cancer patients compared to healthy controls. Karagulle 2014

An exploratory cross-sectional analysis found that coffee consumption significantly decreased red blood cell counts and hemoglobin, and modulated risk of anemia, in Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption. Kokaze 2014

Examination of cross-sectional data from the 2001-2011 Korean National Health and Nutrition Examination Survey showed the prevalence of daily coffee consumption increased by 20.3%. Changes were observed in types of coffee consumed among different age groups. Je 2014

The cross-sectional UK Biobank resource study (n=171,722) provided data indicating that persistent and transient tinnitus were negatively associated with caffeinated coffee consumption. McCormack 2014

Results from a meta-analysis of 10 case control and cohort studies indicated that coffee consumption increases the risk of laryngeal carcinoma in a dose-dependent manner. Chen 2014

A systematic review of literature pertaining to miscarriage epidemiology lists excessive coffee intake as a risk factor.[Article in French] Delabaere 2014 <