A review of 21 prospective cohort studies provided convincing evidence that a healthy dietary pattern may lower chronic kidney disease risk, and that plant-based foods, coffee, and dairy may be beneficial.
van Westing 2020
Scientific Name:
Coffea spp.
Family Name:
Rubiaceae
Common Name:
coffee
Evidence for Efficacy (Human Data)
Evidence of Activity
Other Information
Safety Data
Formulas/Blends
Dynamic Updates
Evidence of Activity
Literature Reviews
Review discussed the effects of decaffeinated coffee compounds on systemic disorders, mainly inflammation, cardiovascular diseases, hepatic dysfunctions and cancer, in light of two decades of research.
Colombo 2020
A position document by the European Society of Hypertension on the use of nutraceuticals for blood pressure control notes that antioxidant rich beverages, including teas and coffee, could be considered for suggestion to patients with high-normal blood pressure.
Borghi 2020
Reviewed the effect of flavonoids from foods, including coffee, on atherosclerosis and adipose tissue inflammation, as well the underlying molecular and cellular mechanisms of action for these flavonoids.
Fardoun 2020
Coffee and type 2 diabetes: time to consider alternative mechanisms? [No abstract]
Cornelis 2020
Review summarized advances made in understanding acrylamide formation and described the potential acrylamide reduction strategies along all coffee production steps, from raw material to coffee brew preparation, with a dominant focus on roasting stage.
Schouten 2020
Qualitative analysis of 74 observational and clinical trials indicated sex, BMI, smoking, alcohol intake, menopausal status, and genetic polymorphisms are probable or possible determinants of inter-individual variability in cancer and cardiometabolic outcomes in response to coffee and caffeine.
Visser 2020
Review of the main health promotion mechanisms associated with coffee consumption. Discussed related topics on coffee production chain, world consumption and reuse of coffee by-products in the production of high-value-adding molecules with potential applications in the food industry.
de Melo Pereira 2020
Review which investigated the effects and molecular mechanism of physical activity interventions on Parkinson's disease and providing guidance for the prevention and treatment of PD noted that coffee is a known protective factor.
Fan 2020
Reply to Comments On: Lifestyles and Myeloproliferative Neoplasms With Special Reference to Coffee Consumption [No abstract]
Podoltsev 2020
An editorial discussed a study by Tran et al. (2019) that used data from the UK Biobank to explore the inverse association between coffee intake and liver cancer, especially in regards to active constituents and method of preparation.
Loftfield 2020
Review summarized the association between colorectal cancer and caffeine.
Cui 2020
An overview of novel coffee products in the food sector and their current legal classification in the European Union including a review of the literature on the composition and safety of coffee flowers, leaves, pulp, husk, parchment, green coffee, silver skin, and spent coffee grounds.
Klingel 2020
Filtered, Not Unfiltered, Coffee in Cardiovascular Disease [No abstract]
Fukumoto 2020
Bitter substances such as coffee may be agonists of Type 2 taste receptors, such as TAS2R10, which may play an important role in host defense mechanisms and thus may be of use in targeting the most common symptoms caused by 2019-nCoV (COVID-19).
Li 2020
Review discussed the role of neurotransmitters in the effects of caffeine on neurobehavioral disorders.
Alasmari 2020
A review on Vitamin B1 (thiamine) deficiency noted that coffee is among foods that contain thiaminases (enzymes that destroy thiamine).
Wiley 2020
Review of evidence on potential preventative effect of nutritional habits and lifestyle factors on glioma incidence found further studies are necessary to determine whether fish, coffee, and tea consumption may prevent glioma.
Bielecka 2020
Investigated the lived experience of reducing caffeine consumption including specific techniques (what), implementation strategies (how), and harm and withdrawal symptoms (why) through a review and classification of data from of 112 internet sources.
Rodda 2020
Review presented evidence on the cardiovascular-protective effects, pharmacokinetics, sources, and safety of chlorogenic acids from coffee (Coffea spp.), yerba mate, Eucommia ulmodies leaves, and Lonicera japonica flowers.
Li 2020
Review discussed natural sources (including coffee) and pharmacokinetic properties of hydroxycinnamic acids and their esters, with the main focus on their metabolism along with biological activities and health benefits.
Sova 2020
Caffeine and Doping-What Have We Learned since 2004 [No abstract]
Diel 2020
Coffee, Caffeine, and Health [No Abstract]
van Dam 2020
Review examined the potential of tropical foods and their waste products, including coffee pulp and spent coffee grounds, to treat signs of metabolic syndrome.
John 2020
Reviewed pharmaceutical actions and potential for liver injury of xanthines (alkaloid found in plants like coffee) and xanthine derivatives. Xanthines very rarely cause drug induced liver injury, mostly mild and due to a hypersensitivity reaction or due to hepatic ischemia associated with overdose.
[No authors listed] 2020
Overview of evidence on green coffee beans, their active constituents, traditional and modern methods of extraction of chlorogenic acids, the effects of processing, with an emphasis on green coffee's anti-diabetic and anti-obesity effects.
Pimpley 2020
A literature review of the definition of coffee by-products (cascara or husk, parchment, mucilage, silverskin and spent coffee grounds), their composition, safety and those food applications which have been proposed or made commercially available to date based on their chemical composition.
Iriondo-DeHond 2020
A review of studies investigating the effect of caffeine on cells using the model eukaryote Saccharomyces cerevisiae, highlighting the caffeine synergy with external cell stressors or exposure to various chemical hazards including cigarette smoke or chemical carcinogens.
Ruta 2020
A review of 32 studies including clinical trials, cross-over studies, and animal studies found conflicting evidence on the effect of green coffee extract and chlorogenic acid in the treatment of dyslipidemia.
Nikpayam 2020
Review cultivated the hypothesis that the best management of pancreatic ductal adenocarcinoma, the 4th highest cause of cancer mortality worldwide, would integrate clinical medicine with complementary measures, including dietary factors such as coffee, nutraceutical agents, and lifestyle.
Jentzsch 2020
Summarized the role of a range of beverages in the context of rheumatoid arthritis. The molecular contents of beverages, including coffee, tea, and wine, have been found to interfere with immune signalling pathways, some beneficial for disease progression and others less so.
Dey 2020
Reviewed conflicting evidence from human studies regarding the putative anti-cancer effects of green tea, coffee, epigallocatechin gallate, and chlorogenic acid as well as proposed mechanisms of action based on cell-based and animal studies.
Hayakawa 2020
Guidelines on prenatal maternal and fetal health recommended that caffeine intake should be limited to 200 mg per day (about two small cups of coffee) during pregnancy.
Caro 2020
Summarized evidence demonstrating that the promotion of a healthy life style, including physical activity and a dietary intake of natural polyphenols present in coffee and tea, may improve the prevention and management of insulin resistance and diabetes in the time of COVID-19 pandemic.
Semiz 2020
Reply to: "Coffee and Skin - Considerations Beyond the Caffeine Perspective". [No abstract]
Oh 2019
Coffee consumption and pancreatic cancer. [No abstract]
Kawada 2019
Reviewed the neuroprotective effects of methylxanthines in coffee, cacao beans, and tea, and their potential applications of those with age-related neurodegenerative disorders.
Camandola 2019
Overview of caffeine, its indications, mechanisms, adverse effects, etc.
Evans 2019
Review evaluated and discussed the evidence on the topic of caffeine supplementation when performing resistance exercise, as well as provided practical guidelines for the ingestion of caffeine prior to resistance exercise.
Grgic 2019
Review summarized the chemical compositions in coffee leaves and the influence of environmental conditions and processing methods on them, as well as applications in ethnomedicine, coffee leaf tea, therapeutic agent, packaging material, tobacco substitute, personal hygiene, and other areas.
Chen 2019
Reviewed the impact of nutrition, including the consumption of coffee, on the health of patients with diabetes. [Article in German]
Brede 2019
A review on the impact of caffeine and coffee on human health.
Cornelis 2019
A review on Vitamin B1 (thiamine) deficiency noted that coffee is among food products containing thaiminase, enzymes that destroy thiamine.
Wiley 2019
A comprehensive overview of the potential benefits of decaffeinated coffee constituents, focusing on neurological processes and pathologies, such as memory disorders, Parkinson's Disease, neuropathic pain disorders, and cerebral ischemia.
Colombo 2019
A review on familial paroxysmal nonkinesigenic dyskinesia, characterized by unilateral or bilateral involuntary movements, notes that attacks are typically triggered by coffee, tea, or alcohol.
Erro 2019
Effects of Caffeine on Colon: A Potential Clinical Use of Coffee in Surgical Patients. [No abstract]
Mattioli 2019
Review discussed various definitions of plant-based diets and summarized their associations with cardiovascular disease (CVD) risk. Diets containing higher amounts of healthy foods, including coffee, are associated with lower CVD risk.
Hemler 2019
Coffee and health: what we still don't know. [No abstract]
El-Sohemy 2019
A narrative review of the effects of modifiable risk factors associated with multiple sclerosis incidence or progression discussed the potential influence of coffee consumption.
Jakimovski 2019
Reviewed the pharmacological, phytochemical and technological aspects of plant species with classical ethnobotanical and traditional use in the context of new trends in traditional functional and medicinal beverages.
Valduga 2019
Does coffee consumption impact sleep-disordered breathing? [No abstract]
Mysliwiec 2019
Narrative review examined various methodological inaccuracies/aspects and other factors that could account for the conflicting results of studies on role of caffeine consumption on blood pressure and hypertension risk/incidence.
De Giuseppe 2019
Comprehensive literature overview on the effects of coffee beverages and their compounds on gastrointestinal/liver carcinogenesis, including epidemiological and experimental findings and the main molecular mechanisms in these in vitro and in vivo bioassays.
Romualdo 2019
Review summarized the constituents of coffee with estrogenic activity and their mechanisms of action at the molecular and cellular levels.
Kiyama 2019
Review noted that coffee may reduce levels of fetuin-A levels, a glycoprotein released by the liver which has positive effects on some health conditions, like cardiovascular disease and tumor development progress, and negative effects in others, like obesity, diabetes and fatty liver disease.
Icer 2019
Coffee as a nutraceutical beverage. [No abstract]
Mattioli 2019
Review of the protective effects of coffee against several metabolic diseases and some types of cancer focused on liver function. Coffee has several components, not just caffeine, with anti-inflammatory and antioxidant properties.
Contaldo 2019
Review systematized information and provided a critical overview of the sources of coffee active ingredients and the mechanisms of action in vivo or in vitro, and their combined effects on common human diseases.
Hu 2019
Caffeine effects and schizophrenia: Is there a need for more research? [No abstract]
Topyurek 2019
Review of nutritional interventions in the control of gallstones and renal lithiasis noted that the intake of coffee is associated with protection against gallstones, but recommended that coffee consumption should be limited with calcium phosphate kidney stones. [Article in Spanish]
Martínez García 2019
Caffeinated beverages and cardiovascular disease. [No abstract]
Kawada 2019
Chlorogenic acid, a polyphenol naturally present in substantial amount in the green coffee beans, shows promise as an antioxidant, glycemic control agent, anti-hypertensive, anti-inflammatory, antimicrobial, neuro-protective and anti-obesity agent. Mechanisms are explored.
Kumar 2019
An overview of the chemical and pharmacological parameters of caffeic acid, a phenolic compound found in coffee and other foods, and its derivatives, demonstrating its mechanism of action and pharmacokinetic aspects, as well as a critical analysis of its action against hepatocarcinoma.
Espíndola 2019
Systematic review of 10 years of literature (Jan 2008 through Dec 2018) regarding the evaluation of polyphenol intake, including from coffee, and its association with specific disease markers and/or endpoints.
Del Bo' 2019
A systematic review included 32 studies assessing the efficacy and safety of commonly used phytochemicals, including those from Coffea, with appetite-suppressing and/or satiety-increasing properties. No extract tested in several trials showed consistent positive treatment effect.
Stuby 2019
Review of evidence concerning the mechanisms of action of the dietary components of the Mediterranean diet, including coffee, in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease.
Román 2019
Review of approximately 100 articles evaluating the possible role of functional foods, including coffee, and their bioactive compounds as an alternative way to promote weight management and prevent obesity and its metabolic consequences.
Konstantinidi 2019
Review focused on the effects of coffee and caffeine on endothelial function in the context of cardiovascular disease, from molecular mechanisms to clinical perspectives.
Higashi 2019
Review presenting epidemiological evidence for both concordant and discordant associations between cardiovascular disease (CVD) and Parkinson's disease (PD) noted that coffee consumption is associated with a lower risk of both PD and CVD.
Potashkin 2019
Review summarized the pharmacological properties and the underlying mechanisms of cafestol-type diterpenoids, including cafestol and kahweol, natural diterpenes extracted from coffee beans.
Ren 2019
Review of data on nutritional interventions in the management of gallstones and renal lithiasis noted there is evidence supporting the protection action of coffee intake against gallstones, while coffee intake should be limited in those with calcium phosphate kidney stones. [Article in Spanish]
Martínez García 2019
A chapter on the antioxidant action and phenolic compounds of natural antioxidants found in plant-based foods, mentioned that coffee was a source of plant antioxidants.
Amarowicz 2019
A critical appraisal of knowledge about the use of different beans, including coffee beans, cocoa beans, broad beans, common beans, soybeans, and Mucuna pruriens, and their compounds, in animal models and in patients with Parkinson's disease.
Rijntjes 2019
Review of the anti-inflammatory actions of flavonoids, including those from coffee, via inhibition of NF?B mechanism.
Choy 2019
A comprehensive review examining human studies of plant-based dietary patterns and polyphenol-rich plant foods noted that randomized controlled trials support the role of coffee in improving specific domains of cognition, notably frontal executive function.
Rajaram 2019
Results of a narrative review showed that several observational studies reinforce the benefits of the consumption of seeds (including coffee) on telomere length.
Crous-Bou 2019
A systematic review of 6 international clinical practice guidelines noted the limitation of coffee consumption among nonpharmacological recommendations for osteoporosis treatment.
Coronado-Zarco 2019
A review of research pertaining to the use of coffee as an ergogenic aid to enhance performance in exercise or athletics.
Pickering 2019
Coffee and Skin - Considerations Beyond the Caffeine Perspective. [No abstract]
Bray 2019
Narrative review evaluated the methods and analyses of cohort studies investigating coffee and mortality, with a specific focus on adjustment for confounding relating to smoking, healthy and unhealthy foods, and alcohol.
Thomas 2019
A review of allergy reports related to green coffee bean and castor bean in dock workers and in coffee processing workers from 1980-current day in Trieste, Italy. [Article in Italian]
Larese 2019
Review highlighted the therapeutic potentials of differnt coffee components, including caffeine, caffeic acid, chlorogenic acids, cafestol, ferulic acid, and kahweol, and their mechanisms of action.
Islam 2018
Comment on: Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline. [Ann Intern Med. 2018][No abstract]
Cainzos-Achirica 2018
Review summarized the most promising results about coffee's preventative properties in dermal malignancies, along with the mechanisms behind its complex stimulation effects and possible new therapeutic indications of caffeine. [Article in Hungarian]
Bors 2018
A literature review on vitamin D, smoking, alcohol, and coffee consumption and autoimmune ecology found that coffee intake appeared to be a risk factor for type 1 diabetes mellitus and rheumatoid arthritis and a protective factor for multiple sclerosis and primary biliary cholangitis.
Anaya 2018
Review described the results of studies exploring the putative effects of coffee components, especially in protecting vascular endothelial function and preventing metabolic syndrome.
Yamagata 2018
Research into the etiology of gallstone disease did not identify certain modifiable factors such as tobacco smoking, coffee consumption, dietary habits, physical activity, and blood pressure as determinants of incident gallstone disease.
Shabanzadeh 2018
Review focused on polyphenols, including those from coffee, and their effects on several cardiovascular risk factors such as hypertension, oxidative stress, atherogenesis, endothelial dysfunction, carotid artery intima-media thickness, diabetes and lipid disorders.
Giglio 2018
Review summarized information on the physiological effects of the administration of caffeine in alternative forms such as chewing gum, bars, gels, mouth rinses, energy drinks and aerosols.
Wickham 2018
Review evaluated health effects of green coffee.
Sanlier 2018
A review on the prevention of Alzheimer's disease development recommended the consumption of antioxidants, such as quercitin from coffee, as part of series of steps in lifestyle modification for self-treatment.
McGeer 2018
Review focused on the reciprocal interaction between functional foods, including coffee, and the potential link to cardiovascular health and the possible mechanisms of action.
Asgary 2018
Decaffeinated green coffee bean extract and the components of the metabolic syndrome. [No abstract]
Kawada 2018
Coffee, caffeine and atrial fibrillation [No abstract]
Thelle 2018
Review highlighted literature which reported on changes in phytochemicals and bioactivities following thermal processing of selected plant-derived foods and herbal medicines, including coffee.
Wong 2018
Review of published scientific papers concerned with the presence of furan in roasted non-brewed and brewed coffee. Discussed The formation mechanisms and occurrence of furan in coffee and the harmful influence of furan on the consumer health.
Gruczynska 2018
Contradictions concerning the implications of coffee/caffeine consumption for health between observational and experimental research are attributable mostly to poor control over potential confounders in observational studies.
James 2018
Reviewed lifestyle and environmental factors which potently influence the risk of multiple sclerosis. High coffee consumption is associated with a reduced risk of multiple sclerosis.
Alfredsson 2018
A review on the antioxidant effect of the fiber content of foods, including coffee beans. [Article in Hungarian]
Mézes 2018
A review of literature from the last decade on the major lifestyle factors, including coffee consumption, associated with male infertility and semen quality.
Durairajanayagam 2018
A review on the effect of dietary factors on cardiac rhythm noted there is some evidence for coffee to have some antiarrhythmic properties.
Voskoboinik 2018
A comprehensive review of the impact of caffeinated beverages on cardiac rhythm.
Voskoboinik 2018
Review elaborated on the potency of chlorogenic acid (found abundantly in coffee) as a chemosensitizer in suppressing tumor growth through metabolic pathways.
Lukitasari 2018
Review addressed some of the more popular foods and dietary patterns, including coffee consumption, that are recommended for cardiovascular health to provide clinicians with current information for patient discussions in the clinical setting.
Freeman 2018
Coffee intake, glucose metabolism and gene polymorphisms. [No abstract]
Kawada 2018
Review highlighted relevant and putative thyroid disruptors that effect populations through their diet, including foods such as coffee, as well as through cultivation, food storage, and cooking.
Oliveira 2018
A summary of evidence on the impact of maternal caffeine intake on breast fed infants.
[No authors listed] 2018
Moderate coffee intake and cardiovascular health; no grounds for concern. [No abstract]
Tzoulaki 2018
Reviewed the demonstrated and potential actions of some selected nutrients, nutraceuticals, and xenobiotics on renal health and function, including the direct and indirect effects common foods, including coffee, on kidney health.
Cosola 2018
A narrative review of evidenced-based complementary and integrative recommendations for women undergoing conventional treatment for breast cancer noted that liberal culinary use of coffee is advised.
Lemanne 2018
Coffee Is Not a Carcinogen. [No abstract]
DiNicolantonio 2018
A systematic review of the efficacy of various herbs and supplements for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis noted that preliminary data on several herbs have demonstrated promising antioxidant, anti-inflammatory, anti-apoptotic, and anti-adipogenic properties.
Perumpail 2018
A review on paroxysmal dyskinesias, a category of abnormal involuntary movements, noted that coffee consumption as a possible trigger factor.
Gontarz 2018
A review of concepts, epidemiology, and management strategies for nonalcoholic fatty liver disease noted that coffee consumption is known to decrease the risk of the disease.
Tomic 2018
Scientific consensus on coffee and health. [No abstract; Article in Chinese]
China Food Information Center 2018
One More Reason to Continue Drinking Coffee-It May Be Good for Your Skin. [No abstract]
Wehner 2018
Analysis of data from 380 studies published between June 2001 and 2015 confirmed that caffeine doses determined not to be associated with adverse health effects by Health Canada were in fact safe in regards to various health outcomes in healthy adults and sensitive populations.
Doepker 2018
A patient-centered comprehensive review of the cardiovascular effects of caffeinated beverages as they pertain to various common cardiac conditions. The intake of coffee, particularly in moderate doses, does not appear to be harmful and may even be beneficial in a range of cardiovascular conditions.
Voskoboinik 2018
Review of evidence on the effects of caffeine consumption on quality and quantity of nighttime rest, as well as an investigation into whether performance deficits caused by sleep deprivation linked to caffeine can be reversed by caffeine consumption the next daytime period.
O'Callaghan 2018
Reviewed the impact of coffee components -caffeine, caffeic acid, chlorogenic acids and kahweol - on proliferation, viability, invasiveness, and metastasis, as well as on susceptibility to chemo- and radiotherapy of colorectal cancer cell lines cultured in vitro.
Buldak 2018
The Alleged Health-Protective Effects of Coffee-Reply. [No abstract]
Loftfield 2018
The Alleged Health-Protective Effects of Coffee-Reply. [No abstract]
Loftfield 2018
The Alleged Health-Protective Effects of Coffee. [No abstract]
Zhou 2018
The Alleged Health-Protective Effects of Coffee. [No abstract]
Zhou 2018
The Alleged Health-Protective Effects of Coffee. [No abstract]
García-Bailo 2018
The Alleged Health-Protective Effects of Coffee. [No abstract]
James 2018
Results of a systematic review suggested that higher intake of coffee and caffeine was associated with a lower risk of developing Parkinson's disease and possibly multiple sclerosis. Coffee and caffeine may have a stronger impact on MS disease course than incidence.
Herden 2018
Reviewed the evidence about relationship between coffee and green tea, and adiponectin and leptin levels. Several findings suggested the positive association between coffee and adiponectin level. There were fewer studies on leptin and their results are controversial.
Izadi 2018
A systematic review of evidence on clinical management of idiopathic mastalgia notes that there is some benefit in reducing dietary coffee.
Hafiz 2018
Review by a International Agency for Research on Cancer Monographs Working Group of over 1000 studies that investigated the association between cancer at more than 20 sites with drinking coffee and very hot beverages.
IARC Working Group on the Evaluation of Carcinogenic Risk to Humans 2018
Coffee consumption and health: we need randomised controlled trials. [No abstract]
Comment on: Coffee gets a clean bill of health. [BMJ. 2017]; Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. [BMJ. 2017]
Henderson 2018
Erratum for: Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. [No abstract]
[No authors listed] 2018
A review of the potential effects on caffeinated beverages on insulin sensitivity. These beverages contain compounds that may have contradictory effects on insulin and glucose. The process of preparation and chosen additives may modulate the effects.
Cherniack 2018
A review on the evidence for benefit of a number of common herbs, including coffee, which may have some cardiovascular benefits.
Malone 2018
Polyphenol intake can prevent high-fat-diet-induced insulin resistance via cell surface G protein-coupled estrogen receptors by upregulating the expression of related genes, and their pathways, which are responsible for the insulin sensitivity.
Engin 2018
A review on the prevention of liver disease notes that coffee is among foods and food components with demonstrated antifibrotic activity.
Bae 2018
A literature review on the influence of nutrition and lifestyle on bladder cancer incidence and recurrence notes that coffee intake seems to have no influence on bladder cancer incidence.
Fankhauser 2018
A review of systematic reviews and meta-analyses of prospective studies indicated that moderate consumption of coffee demonstrated a protective effect against risk of stroke.
Deng 2018
A review of 76 studies published in the past 5 years exploring the role of lifestyle, medication, and nutrition factors in the prevention of kidney cancer. Coffee is noted as possibly having a protective effect against kidney cancer, but causal conclusions were not yet supported.
Tahbaz 2018
Highlights from the 26th International Conference on Coffee Sciences in Kunming, China.
Nehlig 2018
Review of the relevant issues with regard to coffee as an antifibrotic agent for patients with chronic liver disease.
Dranoff 2018
A review of functional foods and lifestyle approaches effective for diabetes prevention and management noted that polyphenols, including those from coffee, have shown clinically-meaningful benefits.
Alkhatib 2017
Coffee gets a clean bill of health. [No abstract]
Comment on: Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. [BMJ. 2017]
[No authors listed] 2017
An overview of evidence published between 2000-2017 on the discovery, biosynthesis, bioavailability, and bioactivity of acyl-quinic acids, the most studied group of chlorogenic acids.
Clifford 2017
[Article in Polish] A review on current evidence regarding coffee consumption and general health.
Wierzejska 2017
An overview of evidence supporting the role of polyphenols in protecting against developing cardiovascular disease, type 2 diabetes, and other chronic diseases. Exploration of possible mechanisms.
Williamson 2017
In 5 of 7 trials analyzed in this review, results suggested that caffeine intake increased blood glucose levels, and prolonged the period of high blood glucose levels in people with diabetes.
Dewar 2017
Anti-aging effects of coffee. [No abstract]
Takahashi 2017
An examination of evidence on the health benefits of coffee.
Gökcen 2017
An umbrella review of meta-analyses of observational studies and RCTs evaluating the associations between coffee and caffeine consumption and various health outcomes.
Grosso 2017
Evaluation of literature on caffeine regarding potential cardiovascular outcomes, such as risks of CV disease, coronary heart disease, and acute myocardial infarction, effects on arrhythmia, heart failure, sudden cardiac arrest, stroke, blood pressure, hypertension, and other biomarkers of effect.
Turnbull 2017
Is Coffee Consumption Associated With Lower Risk for Death? [No abstract]
[No authors listed] 2017
Moderate Coffee Intake Can Be Part of a Healthy Diet. [No abstract]
Guallar 2017
A review of recent literature regarding the impact of coffee on human health, including the cardiovascular system, liver diseases, diabetes, and gastrointestinal disorders.
Nieber 2017
The Urology Guide to Coffee and Tea. [No abstract]
Gomella 2017
A literature survey describing the chemical and biological properties of chlorogenic acid.
Karpinska 2017
A review cataloging evidence for coffee as a universally beneficial agent across a spectrum of chronic liver diseases.
Heath 2017
An article highlighting the current practice of natural medicines, including coffee, in the treatment of liver disease, with specific examples given to emphasize the prevention and management of adverse reactions of natural agents.
Xiong 2017
A review investigating the relationship between coffee consumption and metabolic syndrome.
Baspinar 2017
Drinking more than three cups of Italian-style espresso coffee every day could halve the risk of prostate cancer in men.
[No authors listed] 2017
A review on the role of diet in the pathogenesis of cholesterol gallstones notes coffee consumption may exert a protective role.
Di Ciaula 2017
A summary of current knowledge regarding food and gastroesophageal reflux noted that regular coffee intake induces gastroesophageal reflux, mainly in the first hour after intake.
Surdea-Blaga 2017
A systematic review of in vivo animal and human studies of the physiological and biochemical effects of chlorogenic acids on biomarkers of chronic disease, including clinical trials on cardiovascular, metabolic, cancerogenic, neurological and other functions.
Tajik 2017
Summary of findings to date of both in vitro and in vivo studies using foods or phenolic extracts isolated from foodstuffs, such as coffee, indicated these substances may be effective in inhibiting the incidence of LDL oxidation, but clinical trials would offer stronger evidence.
Amarowicz 2017
[Article in German] A review of the epidemiology and causes of Parkinson's disease notes that the understanding on the association between coffee intake and risk of Parkinson's disease is not fully understood, and that coffee intake may not in fact be a risk factor.
Lill 2017
Overview of evidence up to 2016 indicated that coffee consumption is not associated with overall cancer risk. Evidence indicates a reduced risk of liver cancer, endometrial cancer, and possibly oral/pharyngeal cancer and advanced prostate cancer. Associations with other cancers are explored.
Alicandro 2017
An review discussing potential relationships between dietary ochratoxin A exposure, such as through coffee, and chronic kidney disease.
Chen 2017
Review of the occurrence of xanthine alkaloids in the plant kingdom and their metabolism and degradation. Elucidation of the caffeine biosynthesis pathway, in particular providing details of the N-methyltransferases.
Ashihara 2017
A review evaluating the impact of coffee on expression of inflammasome-related genes.
Bhattacharya 2017
[Article in German] A review of the influence of "luxery foodstuffs," including coffee, on glaucoma. Conflicting results are reported on the effect of coffee on intraocular pressure. One study indicated a connection between heavy coffee consumption and the risk of pseudoexfoliation glaucoma.
Huber-van der Velden 2017
A review providing background information on chlorogenic acid and examining the evidence regarding the use of chlorogenic acid for BP regulation in the context of Health Canada's health claims framework.
Loader 2017
Results from a review of studies between 2010-2016 indicates that coffee consumption in moderation, is safe and is beneficial in both healthy persons and patients with high blood pressure, cardiovascular disease, heart failure, cardiac arrhythmias or diabetes mellitus.
Chrysant 2017
Critical review of experimental evidence regarding the active components and molecular bases underlying the beneficial role of coffee against chronic liver diseases.
Salomone 2017
A review on the preventative and therapeutic potential of methylxanthines coffee, tea, cacao, yerba mate and cola drinks in neurodegenerative diseases.
Oñatibia-Astibia 2017
[Article in Russian] A review of foreign literature on the potential side effects of caffeine consumption, mainly in vulnerable populations, such as pregnant and lactating women, adolescents, and children.
Bessonov 2017
A review of studies published between Jan 2013-July 2016 on lifestyle interventions in primary open angle glaucoma found that frequency of coffee intake may be associated with disease progression.
Hecht 2017
Narrative review highlighted the role of various dietary components, including coffee, in the prevention and risk reduction of non-communicable diseases in developing countries.
Passi 2017
A review of the impact of dietary and lifestyle factors on prostate cancer progression noted that coffee may have a role in reducing the disease progression.
Peisch 2017
Review summarized systematic reviews and primary studies pertaining to factors associated with the onset and progression of PD. The review found that coffee consumption was consistently negatively associated with the onset of PD.
Martino 2017
Reviewed scientific evidence regarding the neuroprotective effects of chlorogenic acid (main component of coffee) and its mechanisms of action, as well as its biosynthesis, sources, bioavailability, and metabolism, illustrating its therapeutic implications in brain health and disease.
Nabavi 2017
A review exploring evidence on the potential impact of common dietary items, including coffee, to influence rheumatic diseases. Coffee may be detrimental for rheumatoid arthritis.
Dahan 2017
A review investigating evidence on the potential effects of coffee and caffeine in reducing risk of Alzheimer's disease and Parkinson's disease.
Wierzejska 2017
[Article in Czech] An overview of the hepatoprotective effects of coffee, with a focus on mechanisms and bioactive constituents.
Szántová 2016
[Article in Czech] Recommendations for managing side effects after ovarian ablation in breast cancer patients include limiting coffee intake to decrease resulting hot flashes.
Palácová 2016
A discussion of caffeine use among servicemembers, its properties and effects on physical and cognitive performance, how to use it to optimize performance, and some of safety and regulatory considerations. Individual response depends on how the body uses and breaks down caffeine.
Yarnell 2016
An overview of the ethnomedicinal, phytochemical, and medical significance of coffee species, including Coffea arabica, C. robusta, C. liberica, and C. benghalensis.
Patay 2016
A review exploring nutrition, one-carbon metabolism, and neural tube defects stated that the consumption of coffee by women of childbearing age was associated with the increased risk of neural tube defects in offspring.
Li 2016
Women who drink 2-3 cups of coffee a day or more could reduce their risk of developing dementia by more than a third, say researchers from the University of Wisconsin-Milwaukee in the US.
[No authors listed] 2016
A review of the pathophysiology, incidence, and prevention of postoperative ileus noted that coffee consumption may play a preventive role for this condition.
Venara 2016
Exploration of the structure-bioactivity relationships of methylxanthines to better understand the possible beneficial physiologic outcomes as well as potential toxicity concerns. Caffeine is by far the most studied methylxanthine.
Monteiro 2016
Review of the use of coffee, chewing gum and gastrograffin to manage postoperative ileus and accelerate recovery postoperatively.
Flores-Funes 2016
Reviewed the possible effects that polyphenols from diverse sources, including coffee, can have on peroxisome proliferator-activated receptors (PPAR) when administered with a high fat diet. PPAR are transcription factors that modulate energy metabolism in liver, adipose tissue, and muscle.
Domínguez-Avila 2016
Reviewed research on the systemic and dental health effects of coffee.
Seidman 2016
Review of use of natural compounds and medicinal plants, including coffee, for the treatment or prevention of cardiovascular and metabolic disorders. Special emphasis on those for which efficacy and safety have been proven and which are in clinical trials, and those used traditionally.
Waltenberger 2016
Carcinogenicity of drinking coffee, mate, and very hot beverages. [No abstract]
Loomis 2016
A minireview discusseg evidence, mainly derived from animal and cell models, on the benefits of coffee for type II diabetes, hepatitis C virus, hepatocellular carcinoma, nonalcoholic fatty liver disease, and neurodegenerative disorders such as Alzheimer's, Parkinson's, and ALS.
Sc 2016
Overview of the autoimmune ecology, focusing on the immune response to environmental agents in general, and microbiota, cigarette smoking, alcohol and coffee consumption, socioeconomic status (SES), gender and sex hormones, vitamin D, organic solvents, and vaccines in particular.
Anaya 2016
Review of the effects of coffee intake on development and progression of liver diseases, and description of potential mechanisms involved.
Wadhawan 2016
A review of managing and understanding urinary stone disease identified consumption of coffee among dietary factors associated with a lower risk of stone formation.
Gambaro 2016
Reviewed evidence of the reduced risk of developing type 2 diabetes by regular coffee drinkers of 3-4 cups a day. The effects are likely due to the presence of chlorogenic acids and caffeine, the two constituents of coffee in higher concentration after the roasting process.
Santos 2016
Review of nutritional approaches to treating gout noted that coffee intake has been seen to decrease the risk of hyperuricemia and gout by increasing the excretion of uric acid. [Article in German]
Nickolai 2016
Review focusing on the available evidence on pharmaceutical and nonpharmaceutical therapy in the treatment and the prevention of nonalcoholic fatty liver disease, primarily nonalcoholic steatohepatitis, noted that daily intake of coffee has shown potential benefits.
Hossain 2016
Reviewed the clinical effects, proposed mechanism of action, and safety profile of some of the new dietary supplements for weight loss, including white bean extract, Garcinia cambogia, bitter orange, Hoodia gordonii, forskolin, and green coffee, among others.
Ríos-Hoyo 2016
The 2015 Dutch food-based dietary guidelines include new guidelines on coffee consumption. The guidelines are based on systematic reviews of meta-analyses of randomized controlled trials and prospective cohort studies on nutrients, foods and food patterns and the risk of 10 major chronic diseases.
Kromhout 2016
Reviewed the potential therapeutic value for caffeine, a major component of coffee, and adenosine A2A receptor antagonists for the treatment of retinal diseases, especially those involving microglia-mediated neuroinflammation.
Boia 2016
Review focused on the potential anti-glycation effects of dietary polyphenols, such as coffee, particularly in regard to their influence on Maillard reaction and mitigation of advanced glycation end-products formation and the heat-induced production of toxic compounds.
Del Turco 2016
A review on knowledge of the interplay of genetic susceptibility and environmental exposure in the risk of Parkinson's disease (PD) noted that epidemiologic studies have found coffee consumption is associated with reduced risk of PD.
Polito 2016
Review of research regarding the safety of caffeine, consumed via natural sources, such as coffee and tea, in relation to cardiovascular system health.
Zulli 2016
Review presented the benefits of methylxanthine-based therapies (including those found in coffee, tea, or chocolate) in the apnea of prematurity and their translational potential in pediatric affections of the respiratory tract.
Oñatibia-Astibia 2016
A review of natural stimulant and non-stimulant thermogenic agents, including caffeine and chlorogenic acid, for addressing excess body weight.
Stohs 2016
A systematic review of evidence on the antimicrobial effects of various medicinal herbs, including Coffea canephora, against in vitro, ex vivo, and in situ formed multispecies oral biofilms.
Karygianni 2016
Review evaluated the rigor of evidence on dietary interventions, including coffee consumption, for nonalcoholic fatty liver disease.
Mahady 2016
A review on the history, new evidence, and controversies regarding modern dietary and policy priorities for cardiovascular diseases, obesity, and diabetes mellitus states that more investigation is needed on the cardiometabolic effects of coffee.
Mozaffarian 2016
Reviewed potential mechanisms of action of dietary polyphenols in the regulation of glucose homeostasis and insulin sensitivity based on in vitro and in vivo studies, and provided a comprehensive overview of the anti-diabetic effects of commonly consumed dietary polyphenols, including coffee.
Kim 2016
A historical overview of the pharmacological relationship between coffee micronutrients and vitamin deficiency syndrome. Coffee was found in the mid-17th century to be effective in preventing an curing dropsy, gout and scurvy.
Oka 2016
A summary of evidence on lifestyle modifications and stroke risk. Coffee consumption is J-shaped for overall stroke.
Niewada 2016
Review summarized information on the effects of coffee and caffeine on brain health for health care professions. Evidence indicates that daily coffee and caffeine intake can be part of a healthy balanced diet; its consumption does not need to be stopped in elderly people.
Nehlig 2016
A review of the potential role of polyphenols in the prevention of cardiovascular diseases cited fruits, greens, nuts, herbs, cocoa, tea and coffee as the most representative sources of polyphenols.
Gormaz 2016
Reviewed the available anti-diabetic polyphenols present in medicinal plants, fruits, and vegetables (including coffee), their mechanisms in the pathways of diabetes mellitus (DM), their correlations with DM, and potential roles in treatment of DM.
Solayman 2016
A review on dietary approaches to non-alcoholic fatty liver disease (NAFLD) mentions that the polyphenols present in coffee indicate its consumption as part of a healthy diet for the treatment of NAFLD.
Salomone 2016
Review delineating major food groups shown to significantly influence risk of Type 2 diabetes (T2D) noted that high consumption of coffee, whole grains, fruits and vegetables, and nuts are each independently associated with the reduced risk of T2D in high risk, glucose intolerant individuals.
Xi 2016
Coffee: worse than it's reputation? [No abstract] [Article in German]
[No authors listed] 2015
Reviewed the management of non-alcoholic fatty liver disease in 2015, including unsweetened, unfiltered coffee as a beneficial dietary recommendation.
Malhotra 2015
A review of scientific data on the relationship between coffee consumption and cancer risk found coffee consumption is not associated with the majority of cancers, though the results of studies on bladder and lung cancer remain conflicting. Coffee may be protective against some cancers.
Wierzejska 2015
Review of endothelial nitric oxide synthase activity (eNOS) stated that polyphenols from coffee enhance flow mediated dilation in endothelial tissue, and endothelial nitric oxide synthase activity is essential for this effect.
Clifton 2015
Discussion of most current Dietary Guidelines of the Health Council of the Netherlands, which recommends consumption of filtered coffee. [Article in Dutch]
Katan 2015
Review described the chemopreventive and bioactive activities of coffee and its constituents against cancer.
Gaascht 2015
A review on the benefits of coffee on skeletal muscle cited the following biological activity: induces autophagy, improves insulin sensitivity, stimulates glucose uptake, slows the progression of sarcopenia, and promotes the regeneration of injured muscle.
Dirks-Naylor 2015
An overview of foods that show the most promise in the treatment of non-alcoholic fatty liver disease, including coffee, and a summary of evidence from animal and human trials.
Gupta 2015
A review summarized various in vivo antioxidant studies on herbal creams containing botanical extracts, such as that of Coffea arabica, for protecting skin from ultraviolet radiation.
Jadoon 2015
Review described basic data about caffeine, including toxicity, pharmacokinetics, biological mechanism of action, and metabolism, as well as potential medical applications.
Pohanka 2015
Assessment of biological evidence on the effect of caffeine, chlorogenic acid, ferulic acid and caffeic acid, important coffee constituents, on markers of inflammation associated with depression in in vitro and in vivo models of inflammation, neuroinflammation, and depression.
Hall 2015
Review summarized literature regarding the neuroendocrine and intracellular regulation of gastric acid secretion noting that coffee consumption stimulates gastric acid secretion.
Schubert 2015
A review of evidence on the use of nutraceuticals for blood pressure control identified coffee among those whose efficacy is supported by a large body of evidence.
Sirtori 2015
Literature review found the concept that fruits and vegetables, such as coffee, will act as functional foods in humans to reduce obesity and thereby improve health remains intuitive and possible rather than proven.
Brown 2015
A review of evidence on nonpharmacological management of gout and hyperuricemia found that coffee could be considered as a preventative measure, as it can lower serum uric acid levels as well as the risk of gout.
Kakutani-Hatayama 2015
Reviewed literature data from 1984-2014 on the positive and negative impacts of coffee consumption on the major depresive disorders and clarified the role of bioactive constituents of coffee in these clinical trials.
Tenore 2015
Review evaluated the ergogenic potential of creatine and caffeine in the context of high intensity exercise. Discussed research directly comparing coffee and caffeine anhydrous, along with previous studies evaluating the concurrent supplementation of creatine and caffeine.
Trexler 2015
Review of literature on the effects of coffee drinking, the incidence of cardiovascular diseases, and hypertension and its mechanism of action showed either a neutral or beneficial effect of coffee on cardiovascular health.
Chrysant 2015
A literature review on medicinal plants, including coffee used for treating diabetes and its comorbidities, as well as mechanisms of natural products as antidiabetic agents, including a review of clincial trials.
Ríos 2015
A summary of caffeine's mechanisms of action, use, abuse, dependence, intoxication, and lethal effects.
Cappelletti 2015
A review of trends and advances in the diagnosis, therapy, and prevention of hepatocellular carcinoma (HCC) cites evidence that coffee and vitamin K2 have been proven to provide protective effects against HCC.
Wang 2015
A review of evidence informing understanding of global epidemiology of hepatocellular carcinoma, including the impact of coffee and tea consumption.
McGlynn 2015
Reviewed evidence of the possible mediatory role of gut microbiota in the associations of coffee consumption and smoking with the etiology and pathogenesis of Parkinson's disease.
Scheperjans 2015
Review examined whether dietary antioxidant supplements are useful in the management of obesity and type 2 diabetes and found the evidence for green coffee to be weak.
Abdali 2015
Review of the studies of genetic polymorphisms with life-style interactions of sporadic Parkinson's disease, focusing on coffee/caffeine intake.
Yamada-Fowle 2015
Described in detail the relationship between liquids intake such as coffee, tea, pure water and sugar-sweetened beverages and risk of the occurrence of type 2 diabetes. Much research proved that coffee reduces the risk of developing diabetes. [Article in Polish]
Kotlewska 2015
Supplements for weight loss: hype or help for obesity? Part II. The inside scoop on green coffee bean extract. [No abstract]
Mullin 2015
Described evidence supporting the hypothesis that the GI tract is the main site of biological activity of melanoidins and melanoproteins extracted from food (vs. water-soluble carbohydrate-based melanoidins isolated from food sources, like coffee), and their possible role in preventing GI cancers.
Tagliazucchi 2015
A literature review exploring the complex relationships between diet (including coffee consumption) and upper GI malignancies. Evidence indicates that the strength and direction of dietary associations is organ-site and histology specific.
Abnet 2015
Dietary guidelines for caffeine and chocolate after digital replantation. [No abstract]
Shaughness 2015
Coffee or caffeine intake and effects on menopausal symptoms: unsolved issue. [No abstract]
Comment on: Caffeine and menopausal symptoms: what is the association? [Menopause. 2015]
Bouchard 2015
Coffee: grounds for concern? [No abstract]
Weisse 2015
A review outlining potential benefits and risks for the cardiovascular system from consuming coffee.
Whayne 2015
A review of experimental and clinical evidence showing that polyphenol-rich natural products, including coffee, may offer unique treatment modalities in type 2 diabetes mellitus.
Dragan 2015
Review summarized published research regarding dietary impact on the risk of gout and serum uric acid levels. Focused on associations between vitamin C, alcohol, coffee, tea, milk and yogurt with uric acid and the risk of gout.
Towiwat 2015
Review of evidence on stroke prevention noted that individual stroke risk may be modified by consumption of special dietary supplements, such as coffee, along with other lifestyle and dietary modifications. [Article in German]
Gerischer 2015
Review summarized the effects of dietary compounds, including coffee polyphenols, on epigenetic mechanism in the regulation of gene expression in cancer, metabolic syndrome, neurodegenerative disorders, and hormonal dysfunction.
Remely 2015
Review of observational cohort studies and randomized controlled trials suggested that drinking coffee may contributed to the reduced incidence of cardiovascular disease and rates of noncardiovascular, noncancer chronic inflammatory-related mortality associated with a plant-centered, varied diet.
Jacobs 2015
Review focused on the relative composition of different chlorogenic acids (CGAs) in coffee beverages; in vitro and in vivo evidence that CGAs can mitigate oxidative and inflammatory stresses; and description of the molecular mechanisms that have a key role in the cell signaling activity.
Liang 2015
Reviewed scientific literature for data on "anti-inflammaging" additives such as vitamins A, C and E and green tea and analyzed available evidence for five product ingredients commonly found in anti-aging products - argan oil, rosemary, pomegranate, Coenzyme Q10, and Coffeeberry.
Suggs 2014
Review of select basic science and clinical studies examining the mechanisms and efficacy of natural cosmetic ingredients for photoaging, such as mushrooms, feverfew, green tea, licorice, olive oil, soy, and coffee berry
Bowe 2014
A summary of the beneficial and harmful effects of coffee consumption on the cardiovascular system.
Whayne 2014
Reviewed the chemopreventative and angiopreventative properties of selected phytochemicals found in common beverages, including caffeine from coffee, with a focus on their molecular mechanisms.
Rossi 2014
Brief summary of the effects of coffee on human health.
Bae 2014
The new rules for coffee and wine drinkers. Healthful? In moderation, perhaps. In vast quantities? Dream on. [No abstract]
[No authors listed] 2014
Review described different in vitro, cell-free and cell-based assays that both characterize and compare the antioxidant capacity and mechanism of action of coffee and its bioactive constituents.
Liang 2014
Daily intake of at least 3 cups of coffee is likely to have beneficial health effects in patients at risk of liver diseases. Coffee has been associated with decreased liver inflammation, prevention of cirrhosis, reduced steatosis and lower incidence of hepatocellular carcinoma. [Article in Danish]
Kjærgaard 2014
Coffee may help reduce type 2 diabetes risk, say Harvard researchers. [No abstract]
[No authors listed] 2014
Reviewed evidence on the association between coffee consumption and liver health.
Morisco 2014
At the grocery store I saw coffee labeled "low-acid." Would this type of coffee be better than regular coffee for my heartburn? [No abstract]
[No authors listed] 2014
Review of substances used for and prevalence rates of pharmacological cognitive enhancement among healthy subjects included coffee as an over-the-counter substance.
Franke 2014
Review of black hairy tongue syndrome cited excessive coffee or black tea consumption as a known predisposing factor.
Gurvits 2014
Review presented evidence from meta-analyses of studies on the association of blood pressure with coffee intake. Lack of a definitive understanding of the BP-coffee relationship is partially attributable to issues discussed in the review.
Guessous 2014
Review described the cardiovascular benefits and risks of consuming various coffee constituents and the impact of coffee species, roasting degree, brewing method, and serving size.
Godos 2014
A review and summary of epidemiological and research evidence concerning the effects of coffee consumption on type 2 diabetes mellitus, with focus on different mechanistic factors involved.
Akash 2014
A literature review on the role of adiponectin in metabolic syndrome, diabetes, and coronary disease states that coffee consumption is among diet modifications noted for increasing adiponectin levels.
Fisman 2014
Review of the effects of caffeine, a secondary metabolite of tea and coffee plants, on the cholinergic system.
Pohanka 2014
[No abstract] Comment on:
Review article: coffee consumption, the metabolic syndrome and non-alcoholic fatty liver disease. [Aliment Pharmacol Ther. 2013]
Letter: gut microbiota modulation contributes to coffee's benefits for non-alcoholic fatty liver disease. [Aliment Pharmacol Ther. 2014]
Yesil 2014
The authors propose a hypothesis that both cigarette and coffee consumption change the composition of the microbiota in the gut in a way that mitigates intestinal inflammation, leading to less misfolding of alpha-synuclein in enteric nerves, and reducing the risk of Parkinson's disease.
Derkinderen 2014
Comment on: Is coffee harmful? If looking for longevity, say yes to the coffee, no to the sugar. [Mayo Clin Proc. 2014] [No abstract]
Liu 2014
Is coffee harmful? If looking for longevity, say yes to the coffee, no to the sugar. [No abstract]
Comment on: Association of coffee consumption with all-cause and cardiovascular disease mortality. [Mayo Clin Proc. 2013]
DiNicolantonio 2014
Critical analysis of the validity of varied forms of evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease.
Carman 2014
Reviewed phytochemical changes between green and roasted coffee beans, evidence for mechanisms of action, and epidemiological findings linking coffee consumption to potential health benefits including prevention of chronic diseases.
Ludwig 2014
A review investigating the interaction between hepatitis C and metabolic factors stated that patients are suggested to increase their intake of green tea and coffee to attain the beneficial effects of caffeine and polyphenols.
Kawaguchi 2014
Data from a systematic review of clinical interventions that enhance the endocannabinoid system identified coffee as one of the lifestyle factors that modulate this system.
McPartland 2014
A literature review of the impact of diet and nutrition on hepatocellular carcinoma showed that consumption of coffee, among other dietary items, may have chemopreventive effects.
Mandair 2014
Reviewed evidence regarding whether methylxanthine derivatives, caffeine, theophylline, and pentoxifylline may be associated with the inhibition of CHI3L1-induced cytoplasmic signaling cascades in epithelial cells, and thus be a possible therapy for inflammatory bowel disease.
Lee 2014
A literature review by scientists of the Zurich University of Applied Sciences investigating the antioxidant capacity of coffee.
[No authors listed] 2014
How does coffee prevent liver fibrosis? Biological plausibility for recent epidemiological observations. [No abstract]
Dranoff 2014
Reviewed evidence from experimental studies in animals and humans along with findings from prospective studies on coffee, tea, and cocoa and risk of stroke. The majority of prospective studies have reported a weak inverse association between moderate consumption of coffee and risk of stroke.
Larsson 2014
A review of relevant literature on management of chronic hepatitis C in patients with contraindications to anti-viral therapy. Life interventions like weight loss, exercise, and coffee consumption are associated with biochemical improvement.
Carreño 2014
Comment on: Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality. [J Am Coll Cardiol. 2013]; Effects of habitual coffee consumption on vascular function. [J Am Coll Cardiol. 2014] [No abstract]
DiNicolantonio 2014
Review summarized the published information on the determination of antioxidant activity in coffee samples by various methods and the antiradical activity of coffee products.
Yashin 2013
A review and editorial on the less well-known effects of coffee on mental and physical capacity and mortality.[Article in Danish]
Landex 2013
Review summarized the effects of caffeine, nicotine, and THC on exercise performance for the purpose of evaluating their impact as performance-altering aids used in recreational and elite sports. Only caffeine, a coffee compound, has enough scientific evidence indicating an ergogenic effect.
Pesta 2013
Review discussed evidence on the metabolism and absorption of phenolic compounds abundant in foods and beverages, including coffee, and gave an overview of strategies for enhancing their bioavailability.
Lewandowska 2013
A literature review on the role of diet and personalized nutrition management in non-alcoholic fatty liver disease. Coffee consumption may be a protective factor for NAFLD.
Fan 2013
Habitual coffee consumption is associated with reduced mortality, reduced risks of heart failure, stroke, diabetes mellitus and some cancers, and neutral to reduced risks for both atrial and ventricular arrhythmias. Caffeine at high doses can increase anxiety, insomnia, and calcium loss.
Bhatti 2013
A position paper by the Israel Heart Association and Israel Dietetic Association summarized the current literature on the association of nutrition and cardiovascular disease. Impacts of coffee and caffeine intake are evaluated alongside other common foods, supplements, and dietary patterns.
Eilat-Adar 2013
A literature review of studies investigated the roles of chlorogenic acids, an important component of coffee, in glucose and lipid metabolism.
Meng 2013
In praise of coffee ... and caffeine. [No abstract]
Carroll 2013
Reviewed experimental, epidemiological and clinical articles on the association between coffee consumption, metabolic syndrome and non-alcoholic fatty liver disease. Results indicate coffee intake can reduce the risk of non-alcoholic fatty liver disease.
Yesil 2013
Discussion of metabolic factors associated with chronic hepatitis C infection, including insulin resistance, steatosis, visceral obesity, atherosclerosis, vitamin D, menopause, fructose and coffee intake, lipoproteins, methylenetetrahydrofolate reductase status, and hyperuricaemia.
Macaluso 2013
Review described the most common natural ingredients used for skin depigmentation and their major published studies. Ingredients include soy, licorice extracts, kojic acid, arbutin, niacinamide, N-acetylglucosamine, COFFEEBERRY(™) and green tea.
Leyden 2011
Discussed botanical compounds that have been used for dermatologic purposes or show promise for such applications, including: rosemary, polypodium leucotomos, propolis, oatmeal, olive oil, grape seed extract, lavender, mushrooms, and coffeeberry.
Baumann 2007
Discussed the science behind some of the newest topical antioxidants: idebenone, green tea, and coffeeberry extract and outlined how they can be used as part of a comprehensive skin care regimen.
Farris 2007
History of Record
ORIGINAL RESEARCH BY: J. Mohanasundaram, MD, PhD
April 2013
MAJOR REVISION BY: Selena Rowan
May 2019
LATEST UPDATES BY: Oren Rabinowitz, MSc
December 2020