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Caffeine promoted the growth of cancer cells treated with paclitaxel, enhanced their migration ability, inhibited apoptosis, and decreased acetylation of a-tubulin in paclitaxel-treated cancer cells, and decreased the inhibitory effect of paclitaxel on tumor growth. Xu 2020
A review of in vitro and in vivo research findings, clinical case reports, and expert panels on the effect of coffee on the pharmacokinetic properties of drugs indicated that coffee may significantly affect the absorption, distribution, metabolism, and excretion of many drugs. Belayneh 2020
An investigation using genome-wide association studies to discover genetic markers of clozapine plasma concentrations in a large sample of patients with treatment-resistant schizophrenia noted that corroborative evidence was found for interactions between the metabolism of clozapine and coffee. Pardiñas 2019
Findings from the sex-linked recessive lethal test in a Drosophila melanogaster germ cell model showed that co-administration of coffee with the chemootherapuetic drug cyclophosphamide (CPH) reduced CPH-induced lethal mutations in the germ cells of larvae and adult flies. Nagpal 2018
Caffeine had the capacity to inhibit the metabolism of warfarin and enhance its plasma concentration and hence anticoagulant effects in healthy adult male albino rabbits. Zafar 2018
Interactions between insoluble fractions of coffee infusions and catechins were synergistic for espresso and additive/antagonistic for other infusion types. Interactions between coffee infusions and chocolate were synergistic for French press and Turkish coffee and additive/antagonistic for others. Çelik 2018
Among 120 patients with schizophrenia treated with olanzapine for 30 days, cigarette smoking and heavy coffee consumption were associated with decreased efficacy and increased safety of olanzapine treatment. Djordjevic 2018
A review on the factors affecting gastrointestinal absorption of levothyroxine implicated coffee as having a significant impact on the reduction of absorption. Skelin 2017
Caffeine, not chlorogenic acid, modulates the cytotoxicity of chemotherapy drugs doxorubicin, gemcitabine, and paclitaxel in SH-SY5Y cells via different mechanisms in vitro. Hall 2017
Combined treatment with sorafenib (approved for the treatment of hepatocellular carcinoma and advanced renal cell carcinoma) and kahweol markedly induced apoptotic cell death in renal carcinoma Caki cells, human lung carcinoma, and breast carcinoma cells, through down-regulation of Mcl-1 expression. Min 2017
[Article in Chinese] Determination of possible correlation between caffeine and the difference in the efficacy of acupuncture analgesia (AA) in China compared to western countries. Caffeine may inhibit AA. Cui 2017
Despite high in vitro potency of CYP3A4 inhibition, coffee fractions did not cause a clinical pharmacokinetic interaction with felodipine in human trials, possibly from insufficient amount of inhibitor(s) in coffee reaching intestinal CYP3A4 during the absorption phase of felodipine. Dresser 2017
Review of common complementary and alternative medicines used in patients with inflammatory bowel disease and potential interactions with medications used in elderly patients. CAM products discussed include an herbal preparation of myrrh, chamomile, and coffee extract. Rahman 2017
Among 120 patients moderate or severe methotrexate (MTX) intolerance, 55% had complete relief of symptoms and were able to continue taking the advised dose of MTX when caffeine (coffee or dark chocolate) intake was synchronized with the MTX dose; 13.3 % had partial improvement. Malaviya 2017
A analysis of the association between smoking and caffeine consumption found no evidence for causal effects of smoking on caffeine consumption or vice versa. Rather, genetic factors appear to explain most of the association between smoking and caffeine consumption. Treur 2017
A prospective study of 50 patients did not find any significant attenuation effect upon adenosine-induced hemodynamic response and similar negative predictive value of a normal adenosine-gated myocardial perfusion imaging in patients with or without caffeine abstinence. Uz Zaman 2016
A randomized, single-dose, crossover study which assessed hemodynamic and pharmacokinetic effects following 2 days without coffee and caffeine-containing foods found evidence for pharmacodynamic interactions between coffee consumption and the antihypertensive effect of felodipine. Bailey 2016
Smokers with heavy caffeine or marijuana use have higher α4β2* nicotinic acetylcholine receptors (nAChRs) availability than smokers without these drug usages. These findings are likely due to increased nicotine exposure but could also be due to an interaction on a cellular/molecular level. Brody 2016
A review of clinical trials on the synergistic action of single dose ibuprofen plus caffeine for acute postoperative pain in adults. Results showed strong analgesic action. The combination is not commonly available, but benefit probably can be achieved by combining ibuprofen with strong coffee. Derry 2015
Caffeine exposure 12-24 hours prior to regadenoson administration attenuates the vasoactive effects of regadenoson, as evidenced by a blunted rise in heart rate and systolic blood pressure, possibly reducing the effects of regadenoson administered for vasodilatory cardiac stress testing. Bitar 2015
In a study evaluating the interactions between active compounds in water extracts from coffee and willow bark, synergism was observed for ability of inhibition of lipid peroxidation and reducing power. Some antagonisms and stabilizing effects observed as well. Durak 2014
In vitro evaluation of the potential bioaccessibility and interactions between antiradical and anti-inflammatory compounds from coffee and cinnamon. Durak 2014
A literature review of experimental data on the convulsive activity of methylxanthines indicated that caffeine and aminophylline both signficantly reduce the anticonvulsant activity of antiepileptic drugs. Chrościńska-Krawczyk 2014
Both synergistic and antagonistic effects were clearly observed in U937 cells expressing an NF-κB-luciferase reporter and treated with lipopolysaccharide and phytochemical-rich plant extracts. Observed synergy was most pronounced for the combinations of oregano and coffee, and thyme and oregano. Kolberg 2013
History of Record
ORIGINAL RESEARCH BY: J. Mohanasundaram, MD, PhD
April 2013
May 2019
LATEST UPDATES BY: Oren Rabinowitz, MSc
December 2020