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Scientific Name:
Adansonia digitata
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Evidence of Activity
Animal Studies
Administration of a crude methanol extract of Adansonia digitata fruit pulp alone significantly and more effectively ameliorated and protected against Naja nigricollis venom-induced toxicity in rats by reducing erythrocyte osmotic fragility and regulating antioxidant activity than when co-administered with antivenom. Elijah 2022
Oral administration of Adansonia digitata fruit shell extract for 28 days significantly reduced motor deficits, cerebellar cell death, and brain lead concentration in a mouse model of lead-induced neurotoxicity. Fannami 2022
The petroleum ether extract (oil) and the butanolic extract of Adansonia digitata fruit pulp improved carbohydrate metabolism and suppressed hypercholesterolemia, as compared to the total (methanol) and ethyl acetate extracts, in a rat model of diabetes; up to 91 compounds were identified in the extracts by LC-MS/MS. Mohammed 2021
Adansonia digitata fruit pulp extract exhibited a protective effect against NG-nitro-L-arginine methyl ester-induced hypertension in rats by normalizing elevated systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate possibly by interacting with the angiotensin converting enzyme. Liman 2021
Aqueous extract of Adansonia digitata exhibited a protective effect against cadmium chloride-induced testicular damage in rats via antioxidant activity. Dare 2021
Adansonia digitata stem bark extract exhibited a protective effect against arsenic toxicity by reducing the numbers of micronucleated polychromatic erythrocytes in the bone marrow in the micronucleus test, alleviating hepatic venous congestion and activities of transferase liver enzymes, in rats. Adegoke 2020
Adansonia digitata aqueous extract exhibited a protective effect against cotton seed extract-induced testicular damage in rats via increasing sperm count and antioxidant activity. Babatunde 2020
Pretreatment with Adansonia digitata aqueous leaf extract prior to lead acetate (LA) administration in male rats for 21 days reversed LA-induced oxidative stress in the prefrontal cortex and attenuated increased chromatolysis and neuronal pyknosis of the pyramidal neurons. Atuadu 2020
Co-treatment with aqueous extract of Adansonia digitata stem bark (100 & 200 mg/kg) in L-NAME-induced hypertensive rats prevented prevented hypertension-like changes in lipid profile, cardiac, hepatic, and renal affection indicators, and oxidative stress markers. Ntchapda 2020
In a rat model of metabolic syndrome, supplementation with aqueous Adansonia digitata fruit ameliorated the induced dyslipidemia and hyperglycaemia, reduced the Atherogenic Index of Plasma, and normalized elevated hepatic biomarkers after 3 weeks treatment. Suliman 2020
Methanol extract of the stem-bark of Adansonia digitata ameliorated chronic unpredictable mild stress-induced depressive-like behavior in mice. Its effect is possibly mediated via the neuroendocrine, neurotrophic, and oxidative stress pathways. Shehu 2019
The methanolic extract of Adansonia digitata leaves alleviated hyperglycemia, hyperlipidemia and oxidative stresss in streptozotocin-induced diabetic rats in a dose-dependent manner by improving the hematological properties and redox parameters. Ebaid 2019
Animals treated with aqueous bark extract of Adansonia digitata showed significantly prolonged response time to thermal stimuli compared with control group in a dose dependent manner. Owoyele 2017
Orally administered leaf extract of A. digitata showed analgesic activity described by decrease in writhes counts compared to control, significantly increased latency period in hot plate analgesic test when compared Diclofenac sodium (a standard drug),and in tail flick test compared to control. Mumtaz 2017
Adansonia digitata methanolic stem bark extract protected against Plasmodium berghei induced-malaria and reduced malaria progression in weanling albino mice. Adeoye 2017
Adansonia digitata leaf methanol extract protected against sodium arsenite-induced toxicities in male Wistar rats. Adegoke 2017
Treatment of the rats with the methanol extract of the fruit pulp of Adansonia digitata L. prior to administration of acetaminophen significantly reduced the disturbance in liver function. Hanafy 2016
Baobab (A. digitata) fruit pulp brings tissue cardiac markers, antioxidant enzymes & other parameters studied to near normal level in isoproterenol-induced myocardial infarction in rats. Histological examination showed predominantly normal myocardial structure & no inflammatory cell infiltration. Ghoneim 2016
Among selected plants used in traditional medicine for the treatment of malaria, aqueous extract of the stem bark of Adansonia digitata exhibited highest chemosuppression of parasitaemia, >60% in a murine model of Plasmodium berghei infected mice. Musila 2013
All seeds tested in a rat growth and balance trial were of inferior quality compared to casein. Among the lesser known tropical seed samples gathered in Nigeria, S. pachycarpa followed by A. digitata showed the most advantageous nutritional quality. Proll 1998
History of Record
ORIGINAL RESEARCH BY: Dr J Mohanasundaram, MD, PhD
March 2016
January 2018
February 2023