Commercially available acacia gum from Acacia senegal/A. seyal significantly promoted the proliferation of Bifidobacteria while inhibiting the Clostridium histolyticum group, commonly associated with dysbiosis, in a human colon model in vitro. Rawi 2021

Gum arabic (Acacia senegal) aqueous and ethanol extracts demonstrated antimicrobial effects in vitro by significantly inhibiting growth of several Staphylococcus aureus and Escherichia coli strains, as well as exhibited immunomodulatory activity by inducing intracellular ROS production by bovine and human granulocytes. Baien 2020

Acacia seyal stem bark hydro-ethanolic extract induced apoptosis and exhibited anti-migration and anti-invasion activities in estrogen receptor-negative MDA-MB-231 but not in MCF-7 breast cancer cell lines, effects associated with the ROS-mediated mitochondrial pathway. Zingue 2018

Gum arabic performed similarly to fructooligosaccharide in promoting selective fermentation by human gut microorganisms, specifically Bifidobacterium spp. and Lactobacillus spp., resulting in the production of acetate, butyrate, and propionate. Alarifi 2018

A study of biomaterial properties, such as wound healing histology, wound fluid absorption, hemo-compatibility, bioadhesion, and drug release of hydrogel wound dressings enhanced by the addition of gum acacia, found the materials to be non-hemolytic, antioxidant, and mucoadhesive in nature. Singh 2017

The arabinogalactan protein component of gum arabic showed inhibitory effects on in vitro amyloid fibril formation. Ow 2015

A study evaluated a selection of Sudanese plants traditionally used in diabetes treatment, including the exudate of Acacia senegal, for their glycogen phosphorylase-inhibitory and antioxidant activities and in vitro toxicity. Hilmi 2014

Gum arabic significantly increased nanohardness of human enamel exposed to citric acid. Beyer 2010

Gum arabic modified the phenotypical characteristics of mouse dendritic cells known to protrude in the intestinal lumen, enhanced CD4(+) T cell proliferation, and increased IL-6 and IL-10 secretion, demonstrating immunomodulatory activity. Xuan 2010

Acacia gum was one of the few polysaccharides among those tested that very strongly inhibited Pseudomonas aeruginosa lectins, mediating bacterial adhesion to human cells. Zinger-Yosovich 2009

Gum arabic promoted remineralization of caries-like human enamel lesions similarly to fluoride. Onishi 2008

The study demonstrated concentration-dependent antioxidant activity of acacia gum against UV irradiation-induced lipid peroxidation in vitro for potential topical applications. Trommer 2005

Methanol extract of Acacia senegal var. senegal stem bark was the most potent among extracts plants traditionally used as chewing sticks in Tanzania in suppressing the growth of oral pathogenic microorganisms in vitro. Khan 2000

Acacia gum preparations did not inhibit growth but suppressed protease activities of periodontopathic bacteria in vitro. Clark 1993

[Immunogenic specificity of gum arabic and genetic regulation of Lewisa expression] [No abstract] [Article in Japanese] Narita 1985