A retrospective study of samples from a prior trial conducted in sickle cell disease patients found that daily intake of gum arabic had also significantly decreased C reactive protein levels. Kaddam 2020

Gum arabic (Acacia Senegal) administration (30 g/day for 12 weeks) significantly decreased total cholesterol, triglyceride, and low-density lipoprotein concentrations, with no effect on high-density lipoprotein cholesterol, in patients with sickle cell anemia (N=47). Kaddam 2019

In a human study (N=47), administration of gum arabic (30 g/day) from Acacia senegal for up to 12 weeks significantly decreased serum levels of direct bilirubin and alanine transaminase but not aspartate transaminase at 4-8 weeks, as well as urea for the first month only, in patients with sickle cell anemia. Kaddam 2019

In a comparative observational study of peristomal skin care in the management of enterocutaneous fistula, gum acacia showed superior or more cost-effective performance in the treatment of inflamed, excoriated, and ulcerative skin as compared to karaya gum and aluminum paint. Kumar 2015

Gum arabic administered at 30 g/day for 12 weeks significantly increased fetal hemoglobin levels in subjects (N=47; aged 5-42 years)) with sickle cell disease. Kaddam 2015

A gum arabic lozenge used for 2 min increased the oral pH following hydrochloric acid-induced erosive exposure (10 ml of 10 mM or 100 mM HCl, pH 1 or pH2, respectively, for 1 min) in human subjects compared to no use. Lindquist 2011

A historical review highlights the role of William Maddock Bayliss in the discovery of the effect of gum arabic on colloid osmotic pressure of the blood in the treatment of wound shock. Van der Kloott 2010

A study provides additional details of a case of a lone survivor of a group of 6 patients with end-stage renal disease who achieved 6-year freedom from dialysis following adoption of a therapeutic strategy combining conservative measures with acacia gum supplementation. Al Mosawi 2009

The case id presented of an 11-year-old girl with chronic renal failure, initially requiring intermittent peritoneal dialysis, who achieved a 4-year freedom from dialysis and improved well-being following addition of 1 g/kg per day of acacia gum to the traditional conservative management. Al Mosawi 2007

Dietary supplementation with Acacia(sen) SUPERGUM EM2 (25 g/day for 8 weeks) increased serum levels of butyrate in normal human subjects (n = 7), whereas in vitro elevated concentrations of butyrate suppressed TGF-beta1 production associated with renal fibrosis by renal epithelial cells. Matsumoto 2006

Dietary supplementation with acacia gum (1 g/kg per day in divided doses) improved well-being and maintained urinary creatinine and urea levels not previously achieved without dialysis in two out of three pediatric patients with end-stage renal disease. The third patient died after discontinuing the study protocol. Al-Mosawi 2004

The challenge of chronic renal failure in the developing world: possible use of acacia gum. [No abstract] Al-Mosawi 2002

Addition of 10 g gum arabic/day to a human diet induced rapid and transient increases in the proportion of the Bacteroides and Bifidobacterium species in the gut. Wyatt 1986

Administration of gum arabic to men for 3 weeks had little effect on glucose tolerance and stool weight but decreased serum cholesterol. Ross 1983

The influence of gum arabic and dextran on the blood-aqueous barrier and intraocular pressure [No abstract] Barany 1948

HAEMORRHAGE IN RELATION TO SHOCK: EXPERIMENTAL EFFECT OF INTRAVENOUS INJECTIONS OF SALINE, GUM ACACIA, AND BLOOD ON THE RATE OF ADRENAL SECRETION RESULTING FROM HAEMORRHAGE {No abstract] Freeman 1935

HYPERTONIC GUM ACACIA AND GLUCOSE IN THE TREATMENT OF SECONDARY TRAUMATIC SHOCK [No abstract] Erlanger 1919