Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. 2010 Feb 1;24(2): 168-172.
Aloe (Aloe vera) gel has anti-inflammatory and wound-healing properties. Clinical research has provided mixed evidence regarding the efficacy of aloe preparations in the treatment of psoriasis.1,2 In this double-blind, randomized clinical trial, researchers compared the efficacy of topical aloe with 0.1% triamcinolone acetonide (TA) in the treatment of mild to moderate plaque psoriasis.
was conducted between October 2006 and September 2007. The researchers
recruited patients with chronic plaque psoriasis from the Division of Dermatology
There were 80 patients at baseline, and 3 in the aloe group and 2 in the TA group were lost to follow-up. There were no significant differences between the groups in baseline DLQI or PASI scores. None of the patients experienced a complete recovery after 8 weeks of treatment. In the aloe group, 6 patients (16.2%) experienced a marked response, while 4 patients (10.5%) in the TA group did so. In the aloe group, 20 patients (54.1%) experienced a moderate response to treatment, while 25 patients (65.8%) in the TA group had a moderate response. The researchers found that 10 patients (27%) in the aloe group and 9 patients (23.7%) in the TA group had a slight response to treatment. In the aloe group, 1 patient showed no response to treatment. After 8 weeks, the average change in PASI scores was significantly greater in the aloe group, when compared to the TA group (P=0.0237); however, the average PASI scores were not significantly different between the groups. There were no statistically significant changes in DLQI scores after 8 weeks of treatment, although both groups experienced decreases. The authors report that no serious adverse events occurred during the study, but 6 patients in the aloe group experienced stinging and itching at the plaques during the first week.
The authors propose that aloe's anti-inflammatory effects may be responsible for the effects observed in this study. They conclude that aloe cream "can be considered a safe, alternative treatment for mild to moderate chronic plaque psoriasis." More research is needed to confirm the results of this study.
Ahmad SA, Holt AH, et al. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled,
double-blind study. Trop Med Int Health.
E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a
commercial Aloe vera gel in the
treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. May 2005;19(3):326-331.