Menu
×
News
Get Involved
About Us
Our Members
Scientific Name:
Quercus infectoria
Family Name:
Fagaceae
Common Name:
Asian holly oak
Evidence of Activity
Pharmacodynamics
Quercus infectoria (Asian holly oak) gall aqueous extract and a subsequent gallotannin-enriched methanolic fraction exhibited antioxidation and anticancer activity against a highly invasive stage IV malignant brain tumor, glioblastoma multiforme, with efficacy of the fraction comparable to temozolomide and tamoxifen. Kamarudin 2021
An ethanolic extract of Quercus infectoria (Asian holly oak) exhibited antimicrobial activity against Staphylococcus aureus and Escherichia coli. Imran 2021
An aqueous extract of Quercus infectoria (Asian holly oak) gall exhibited an immunomodulatory effect on mouse macrophages, increasing proliferation rate and phagocytic activity and significantly decreasing nitrous oxide production. Wan-Nor-Amilah 2021
A crude acetone extract of Quercus infectoria (Asian holly oak) concentration-dependently altered pH of the digestive vacuole of Plasmodium falciparum trophozoite malaria parasites grown in resealed erythrocytes. NA 2021
Two peptides from the fruit peel of Quercus infectoria (Asian holly oak) exhibited antiviral activity by inhibiting the HIV-1 reverse transcriptase enzyme. Seetaha 2021
An aqueous extract of Quercus infectoria (Asian holly oak) galls exhibited an anticancer effect against colorectal cancer cells, activity associated with inducing caspase-dependent apoptosis and suppressing the AKT/mTOR signaling pathway. Zhang 2020
Quercus infectoria (Asian holly oak) extract exhibited cytotoxic activity against HeLa cervical cancer cells by inducing apoptosis and cytoselective activity against normal fibroblast cells. Yusof 2020
An acetone extract of Quercus infectoria (Asian holly oak) gall exhibited antimalarial activity in vitro and was not toxic to brine shrimp, did not cause hemolysis in red blood cells, and did not exhibit cytotoxicty against normal embryo fibroblast or normal kidney epithelial cells. Zin 2020
Ethanolic and aqueous extracts of a Thai herbal formula containing Quercus infectoria (Asian holly oak) and three other herbs, as well as Quercus infectoria alone, exhibited antibacterial activity against Staphylococcus aureus, Vibrio cholerae, and Vibrio parahaemolyticus. No adverse effects of the extracts were reported in rats at the highest tested dose. Limsuwan 2020
Quercus infectoria (Asian holly oak) gall extract reduced production of quorum sensing-controlled virulence genes las, rhl, and exotoxin A and reduced biofilm formation in multiple drug-resistant Pseudomonas aeruginosa isolated from infected burn wounds. Ahmed 2019
Quercus infectoria (Asian holly oak) gall aqueous extract exhibited an antimicrobial effect against Leptospira interrogans. Mustafa 2018
Quercus infectoria (Asian holly oak) methanolic extract induced apoptosis of clinical isolates of protozoan parasite Trichomonas vaginalis, exhibiting a significantly higher rate than other tested extracts and control group. Mahmoudvand 2018
Quercus infectoria (Asian holly oak) galls extract significantly inhibited quorum sensing virulence factor lasR expression in Chromobacterium violaceum, an effect unrelated to antimicrobial activity. Mohabi 2017
An acetone extract of Quercus infectoria (Asian holly oak) inhibited the quorum sensing biofilm formation of Pseudomonas aeruginosa by reducing the expression of pyocyanin, protease, and elastase production. Karbasizade 2017
An aqueous extract of Quercus infectoria (Asian holly oak) exhibited antimicrobial activity against methicillin-resistant Staphylococcus aureus. Proteins upregulated and downregulated in S. aureus following treatment with the extract were involved in energy metabolism and protein stress. Khairon 2016
Methanolic, ethanolic, and acetone extracts of Quercus infectoria (Asian holly oak) galls exhibited a significant inhibitory effect against Streptococcus mutans growth and biomass formation. 2016 Mohammadi-Sichani,
Quercus infectoria (Asian holly oak) gall extract concentration- and time-dependently induced proliferation of human fetal osteoblast cell line hFOB 1.19 and induced alkaline phosphatase and osteocalcin expression. Hapidin 2015
Methanolic and aqueous extracts of Quercus infectoria (Asian holly oak) galls exhibited antifungal activity against Candida albicans, C. krusei, C. glabrata, C. parapsilosis, and C. tropicalis. Baharuddin 2015
Aqueous and ethanolic extracts of Quercus infectoria (Asian holly oak) galls exhibited an antimicrobial effect against methicillin-resistant coagulase negative Staphylococcus and methicillin-resistant Staphylococcus aureus. A slight antimicrobial effect was observed against multidrug-resistant Acinetobacter spp. and no inhibitory effect was detected against Klebsellia pneumoniae and multidrug-resistant E. coli isolates. Wan 2014
Quercus infectoria (Asian holly oak) gall extract is high in phenolic content and exhibits antioxidant and angiotensin converting enzyme-inhibitory activity. Sharifi 2013
A hydroalcoholic extract of Iranian Quercus infectoria (Asian holly oak) acorn significantly decreased endothelial cell proliferation and angiogenesis in human umbilical vein endothelial cells, dose-dependently reducing expression of VEGF, MMP-2, and MMP-9. Yarani 2013
Quercus infectoria (Asian hollly oak) gall extract and tannic acid affected biofilm formation of clinical isolates of methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus possibly via increasing the hydrophobicity index, resulting in misshapen cocci and abnormal aggregation. Chusri 2012
The methanol and acetone extracts of Quercus infectoria (Asian hollly oak) galls exhibited antibacterial activity against Streptococcus mutans, Streptococcus salivarius, Porphyromonas gingivalis, and Fusobacterium nucleatum oral pathogens. Basri 2012
An ethanolic extract, ethyl acetate fraction, gallic acid, and tannic acid from Quercus infectoria (Asian holly oak) galls exhibited antimicrobial activity against methicillin-resistant Staphylococcus aureus and promoted membrane instability under low osmotic pressure and high salt concentration. Chusri 2011
Quercus infectoria (Asian holly oak) extract exhibited antimicrobial activity against type strains and clinical isolates of Staphylococcus aureus, Salmonella typhi, Serratia marcescens, Vibrio cholerae, Vibrio parahaemolyticus, Pseudomonas aeruginosa, and Enterococcus faecalis. The extract also exhibited free radical scavenging antioxidant activity. Mekseepralard 2010
A methanolic extract of Quercus infectoria (Asian holly oak) galls exhibited antibacterial activity against Streptococcus mutans, Streptococcus salivarius, Staphylococcus aureus, Lactobacillus acidophilus, and Streptococcus sanguis dental pathogens, more effectively than petroleum ether, chloroform, and aqueous extracts. Vermani 2009
Quercus infectoria (Asian holly oak) methanolic extract exhibited antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, Klebsiella oxytocoa, Klebsiella pneumoniae and Proteus mirabilis, but the activity was not as high as the methanolic extract of Ruta chalepensis. Priya 2009
An ethanolic extract of Quercus infectoria (Asian holly oak) exhibited antimicrobial activity against Shiga toxin-producing Escherichia coli via modifying the hydrophobic domains, inducing membrane instability, and increasing membrane permeability. Voravuthikunchai 2009
Methanol extracts of Iranian Quercus infectoria (Asian holly oak) exhibited significant radical scavenging activity, concentration-dependently inhibited mushroom tyrosinase-induced hydroxylation of L-tyrosine, and inhibited oxidation of l-DOPA similarly to kojic acid. Khazaeli 2009
An ethanolic extract of Quercus infectoria (Asian holly oak) exhibited dose-dependent antimicrobial activity against Shiga toxin-producing Escherichia coli O157:H7. Loss of surface appendages, pronounced morphological changes, and loss of membrane integrity were observed. Suwalak 2009
An ethanolic extract and ethyl acetate fraction of the extract, as well as gallic acid and tannic acid, all from Quercus infectoria (Asian holly oak) galls, inhibited the growth of clinically isolated methicillin-resistant Staphylococcus aureus strains. Synergistic effects with amoxicillin and penicillin G were evaluated. Voravuthikunchai 2009
Quercus infectoria (Asian holly oak) extract fractions exhibited antibacterial activity against Escherichia coli O157:H7 and other verocytotoxin-producing enterohemorrhagic strains of E. coli. Voravuthikunchai 2008
Acetone, ethyl acetate, ethanol, and aqueous extracts of Quercus infectoria (Asian holly oak) exhibited significant antibacterial activities against all strains of methicillin-resistant and methicillin-susceptible strains of Staphylococcus aureus. Voravuthikunchai 2008
Quercus infectoria (Asian holly oak) gall ethanolic extract exhibited an antioxidant effect against tertiary butyl hydroperoxide-induced oxidative stress in rat peritoneal macrophages, as well as altered phagocytic functions, while scavenging free radicals and chelating metal ions in chemical models. Kaur 2008
Among eight Thai medicinal plants used traditionally for treating diarrhea, a Quercus infectoria (Asian holly oak) ethanolic extract was among those most effective against enterohemorrhagic strains of Escherichia coli strains but did not increase cell surface hydrophobicity. Piyawan 2006
Among 10 medicinal plants used in traditional Thai medicine, an ethanolic extract of Quercus infectoria (Asian holly oak) was among three which were most effective against clinical isolates of methicillin-resistant Staphylococcus aureus. Voravuthikunchai 2005
Among five Thai medicinal plants used for diarrhea, a methanolic extract of Quercus infectoria (Asian holly oak) gall exhibited an antiparasitic effect against isolates of the intestinal protozoan Blastocystis hominis. Sawangjaroen 2005
A methanolic extract of Quercus infectoria (Asian holly oak) exhibited antibacterial activity against cariogenic Streptococcus mutans. Hwang 2004
Among 38 medicinal plant species used in Thai herbal medicine for gastrointestinal infections, aqueous and ethanolic extracts of Quercus infectoria (Asian holly oak) exhibited high antimicrobial efficacy against enterohemorrhagic Escherichia coli O157:H7. Voravuthikunchai 2004
A methanolic extract of Sudanese Quercus infectoria (Asian holly oak) exhibited inhibitory activity (>/=90% inhibition at 100 microg/mL) against the hepatitis C virus protease enzyme. Hussein 2000
Hexagalloylglucose, isolated from a methanol extract of Quercus infectoria (Asian holly oak) galls, significantly inhibited alpha-glycosidase enzymes such as sucrase, maltase and isomaltase, comparable to acarbose, while inhibitory activity on alpha-amylase was 10 times lower than acarbose. Hwang 2000
History of Record
ORIGINAL RESEARCH BY: Oren Rabinowitz, MSc
June 2021
LATEST UPDATES BY: Antonia Kaz
August 2022