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Scientific Name:
Lavandula angustifolia (syn. L. officinalis, L. vera, L. spica) ± subsp. pyrenaica
Family Name:
Lamiaceae
Common Name:
English, common lavender
Evidence of Activity
Pharmacodynamics
Lavandula angustifolia essential oil was effective as a fungicidal agent but the inhibitory efficiency varied between strains of Penicillium species. Felšöciová 2021
Moroccan Lavandula angustifolia essential oil alone, and in combination with L. pedunculata and L. maroccana, exhibited antimicrobial activity against pathogenic foodborne bacteria, particularly against Salmonella spp. Ciprofloxacin addition enhanced efficacy. Nafis 2021
A study concluded volatiles contained in hydrolates are more effective at inhibiting microbial growth of human skin pathogens than their respective essential oils in Lavandula angustifolia (lavender) and 5 other plants. Di Vito 2021
Lavandula angustifolia constituents, carvacrol and limonene, increased superoxide dismutase activity in-vitro. Glutathione-S-transferase and glutathione reductase showed a biphasic response to linalool, carvacrol and limonene. Vašková 2020
Lavandula angustifolia essential oil alleviated pain sensitivity in a model of chronic inflammatory and neuropathic pain, with proposed involvement of central and peripheral opioid and cannabinoid 2 recepors. Donatello 2020
Aqueous extract of lavender (Lavandula angustifolia) inhibited the formation of amyloid beta fibrils, demonstrated by atomic force microscopy. Soheili 2019
A systematic review of experimental studies on Iranian medicinal plants identified Lavandula angustifolia among the medicinal herbs remarkably effective on Trichomonas vaginalis. Ziaei Hezarjaribi 2019
Lavandula angustifolia essential oil prevented oviposition by myiasis-inducing blowfly Lucilia sericata for up to 24 h, also exhibiting toxicity towards both the eggs and adults. Bedini 2019
A comparative study tested the antibacterial activity of L. angustifolia (ethanolic extract), Thymus vulgaris, Rosmarinus officinalis, Cymbopogon citratus and Achillea millefolium, in vitro. Javed 2018
A L. angustifolia flower hydro-ethanolic extract had a relatively potent relaxant effect on tracheal smooth muscle (lower than that of theophylline). Possible mechanisms of action are muscarinic receptors blockade, inhibition of cyclooxygenase pathways and/or involvement of nitric oxide production. Naghdi 2018
The activity of L. angustifolia essential oil against Helicobacter pylori was tested using colorimetric broth microdilution method for assessment. Knezevic 2018
Essential oil from micropropagated narrow-leaved lavender [L. angustifolia] stimulated procollagen production in human skin cells at 0.0001-0.01% concentrations. In addition, the oil at 0.1% concentration had a preservative effect in cosmetic preparations for the period of 3 months. Andrys 2018
Volatile oil of Rosmarinus officinalis (two different chemotypes) was more effective than the other oils tested, including Lavandula angustifolia, against human head lice (Pediculus capitis. Limoncu 2017
Lavandula angustifolia essential oil showed anti-leishmanial activity on Leishmania major promastigotes (IC50=0.11 μl/mL) and amastigotes, showing no toxicity to the host cells at IC50 concentrations. Shokri 2017
Lavandula angustifolia essential oil was active against most of the pet turtle-borne pathogenic bacteria (except Pseudomonas aeruginosa), which can cause zoonotic infections in humans as well as opportunistic infections in the turtle itself. Hossain 2017
Erratum to "The common lavender (Lavandula angustifolia Mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer's patch cells" [Carbohydr. Polym. 174 (2017) 948-959]. [No abstract] Georgiev 2017
Lavandula angustifolia extract prevented DNA damage induced in hamster cells by genotoxins and Fe2+, and mildly increased the activities of superoxide dismutase, glutathione peroxidase, and catalase. Horvathova 2017
Polysaccaride complexes isolated from boiling water extraction and ethanol precipitation of L. angustifolia flowers showed immunomodulatory effects on murine Peyer's patch immune cells ex vivo, as well as stimulated human blood T cells, phagocytic leukocytes, and induced IL-6 production. Georgiev 2017
Lavender (L. angustifolia) essential oil, among other oils, was tested for repellent activity against Dermacentor reticulatus ticks, but was not among the most efficient. Štefanidesová 2017
In a mechanistic study of the effects of L. angustifolia essential oil on the central nervous system, the oil constituents showed affinity to the glutamate NMDA-receptor and serotonin transporter (SERT), but not to the GABA(A)-benzodiazepine receptor. López 2017
Oxidant-induced DNA lesions were significantly reduced in both human hepatoma cell line HepG2 (in vitro) and freshly isolated rat hepatocytes (ex vivo) pretreated with Lavandula angustifolia essential oil. Kozics 2017
Evaluated cytotoxic activity of essential oils from four lavender species on human epithelial colorectal adenocarcinoma cells, in vitro. Donadu 2017
Organic lavender (L. angustifolia) essential oil showed the highest antibacterial activity against Listeria innocua, compared to the oils from organic fennel (F. vulgare) and parsley (P. crispum), grown in Spain. No activity was detected against Pseudomonas fluorescens CECT 844. Marín 2016
Phytochemical and pharmacological (antiproliferative) effects of essential oil of Lavandula angustifolia Mill. Lamiaceae. [No abstract] Niksic 2016
Lavandula angustifolia essential oil (33.1% linalool) inhibited adenylate cyclase 1 (ADCY1) and extracellular signal-regulated kinase (ERK) expression in human neuroblastoma cells, and concentration-dependently inhibited spontaneous electrical activity in rat cortical neurons. Caputo 2016
The activities of essential oils of Lavandula angustifolia and 14 other plant species against Aspergillus spp. (including A. flavum) and their toxin production were tested. Císarová 2016
Lavandula angustifolia essential oil was shown to increase the phagocytic rate and stimulate the containment of intracellular replication of Staphylococcus aureus by human macrophages. Giovannini 2016
The antimicrobial activity of Lavandula angustifolia, in the pure form and in combination with linalool, was investigated. Herman 2015
Flavonoids from Lavandula angustifolia decreased malondialdehyde level in D-galactose-induced aging model, possessed cytotoxicity towards Bel-7402 and Hela cell lines, and showed antioxidant, analgesic, and anti-inflammatory effects. Zhao 2015
Among 5 essential oils, including, L. angustifolia, tested against 32 clinical, erythromycin-resistant Group A Streptococci isolated from children with pharyngotonsillitis in Italy, thyme and origanum essential oils demonstrated the highest antimicrobial activity. Magi 2015
L. angustifolia was among 15 essential oils tested for antifungal activity against five Penicillium species (terverticillate penicillia). Felšöciová 2015
Among ethanol extracts of 16 medicinal plants grown in Jordan, including L. angustifolia, Aloysia triphylla and Inula viscose showed the strongest activity against clinical isolates of H. pylori. Masadeh 2014
Lavandula officinalis and 5 other essential oils were examined for their ability to inhibit the growth of 18 bacterial type strains belonging to the 18 known species of the Burkholderia cepacia complex. Maida 2014
L. angustifolia extracts and essential oil offer cytotoxic and apoptotic effects in HeLa and MCF-7 cell lines, and apoptosis is proposed as the possible mechanism of action. Tayarani-Najaran 2014
L. angustifolia essential oil had the potential to reverse bacterial resistance to piperacillin in E. coli J53 R1 by the mechanisms of altering the outer membrane permeability and inhibiting bacterial quorum sensing. Yap 2014
15 essential oils including Lavandula angustifolia were examined for their antimicrobial actions and free radical scavenging activities. Kačániová 2014
Lavandula angustifolia and other herbal essential oils are investigated for their ovicidal actions. Sinthusiri 2014
An aqueous extract of Lavandula angustifolia inhibited cell proliferation in both of the lymphocytes of patients in stages III and IV of Hodgkin's lymphoma as well as two different Hodgkin's lymphoma cell lines. Dalilan 2013
Among acetone extracts of several spices, including L. angustifolia, only Laurus nobilis and Origanum vulgare exhibited pronounced effects against a noncancerous African green monkey kidney (Vero) cell line and an adenocarcinoma cervical cancer (HeLa) cell line. Berrington 2012
Among Thymus vulgaris, Lavandula angustifolia, and Calamintha nepeta, thyme essential oil offered the highest antibacterial activity (similar to tetracycline). Lavender essential oil exhibited higher activity than C. nepeta. Miladinović 2012
The phytochemically characterized essential oils extracted from Lavandula vera, L. intermedia, L. pyrenaica , and L. stoechas had an inhibitory effect on selected Pseudomonas strain with minimum bactericidal concentration values ranging from 12.5-50 microL/mL. Végh 2012
Myrtus communis and Lavandula angustifolia essential oils displayed the highest repellency against Sitophilus zeamais Motsch. (Coleoptera Dryophthoridae) of the 6 oils tested. Bertoli 2012
Methanolic extracts of 23 Jordanian medicinal plants were tested in vitro, at 200 μg/ml concentrations, for their xanthine oxidase (XO) inhibitory potential. The L. angustifolia extract inhibited xanthine oxidase by 28.7%. Hudaib 2011
Melaleuca alternifolia EO, alpha-terpineol, terpinen-4-ol & Melissa officinalis EO, showed stronger anti-biofilm activity than L. angustifolia EO or linalool or linalyl acetate against Staphylococcus aureus ATCC 29213 and Escherichia coli NCTC 8196 on the surface of medical biomaterials. Budzyńska 2011
Thymus vulgaris and Lavandula angustifolia essential oils showed positive antibacterial activity against all 30 clinical bacterial strains of Escherichia coli tested; however, T. vulgaris offered the highest activity. [Article in Polish] Sienkiewicz 2011
A Lavandula angustifolia essential oil showed activity against clinical bacterial strains of Staphylococcus, Enterococcus, Escherichia and Pseudomonas genera, albeit less effective than a Thymus vulgaris oil. Sienkiewicz 2011
The oils of 10 commonly consumed herbs, including L. angustifolia, & their main components, were tested for antibacterial activity against several human pathogenic bacteria. Origanum vulgare oil had the highest & broadest activity. Carvacrol had the highest activity among the tested components. Soković 2010
L. officinalis essential oil was part of study of acetylcholinesterase (AChE) inhibitory activity & chemical composition of select commercially available essential oils. All oils, except Artemisia dracunculus from Hungary, inhibited AChE. A. dracunculus oil from France showed the most potentcy. Dohi 2009
Ultraviolet radiation altered the cycle (charge-discharge) for terpenes (low lipophilicity) from the essential oil of L. angustifolia applied to rat skin and increased the charge time. However, for terpenes (high lipophilicity), the ultraviolet radiation decreased the charge amplitude. Ben Salah 2009
Lavandula angustifolia and other essential oils supported the treatment of intestinal dysbiosis by inhibiting growth of potential pathogens at concentrations that had no effect on the beneficial bacteria. Hawrelak 2009
Of the essential oils, including L. angustifolia, extracted from flower petals of palmarosa, evening primrose, lavender and tuberose, palmarosa offered the highest antibacterial activity against gram-positive and gram-negative bacteria in comparison with other oils. Lodhia 2009
4 chemically characterized essential oils from L.angustifolia, L. latifolia, L. stoechas, & a necrodane-rich L. luisieri, used singly & in combination, inhibited growth of both methicillin-sensitive and methicillin-resistant S. aureus. Combinations proved more effective than single oils. Roller 2009
Compared the bacteriostatic and bactericidal activity of 13 chemotyped essential oils, including L. angustifolia, against 65 bacteria strains with varying sensitivity to antibiotics. L. angustifolia, an alcohol-based EO, exhibited varying degrees of activity depending on Gram status. Mayaud 2008
Almost all of the 19 essential oils (EO) obtained from cultivated plants showed a very high inhibitory activity (over 80%) against both acetyl- and butyrylcholinesterase. However, the single components widely encountered in most of the EOs were not as active as the essential oils. Orhan 2008
This dual radioligand binding and electrophysiological study, focusing on a range of ligand-gated ion channels, created a pharmacological profile of a chemically validated essential oil derived from L. angustifolia, which has shown clinical benefit in treating agitation. Huang 2008
The radical scavenging capacities of extracts and preparations from a Lavandula vera MM plant cell culture with different rosmarinic acid content was evaluated and compared with pure rosmarinic and caffeic acids. Kovacheva 2006
Investigation of 2 essential oils derived from Lavandula angustifolia and Lavandula x intermedia for any antiparasitic activity shows that at low concentrations they can completely eliminate Trichomonas vaginalis, Giardia duodenalis and Hexamita inflata in vitro. Moon 2006
Essential oil, ethanolic extract and decoction of 10 plant species from interior Portugal, including L. angustifolia were analyzed for their activity towards acetylcholinesterase (AChE) enzyme and their antioxidant activity. Ferreira 2006
Investigation for the influence of elicitation on rosmarinic acid biosynthesis by Lavandula vera MM cell suspension culture using vanadyl sulfate as an abiotic elicitor shows that the extracellular content of rosmarinic acid is 3.3 times higher compared to the control variant. Georgiev 2006
Among 11 plants, used in Danish folk medicine for improvement of memory and cognition, and 5 extracts, Ruta graveolens, Lavandula angustifolia, & Rosmarinus officinalis, exhibited moderate inhibition of the enzyme acetylcholinesterase, defined as more than 15% at 0.1 mg/ml. Adsersen 2006
Assessment of the in vitro susceptibility of 15 Helicobacter pylori strains to botanical extracts used for the treatment of gastrointestinal disorders indicated botanical extracts with a MIC of 100 microg/mL included Carum carvi, Elettaria cardamomum, Lavandula angustifolia, etc. Mahady 2005
Among 34 essential oils tested for insecticidal activity against larvae Spodoptera littoralis, 8 essential oils including Mentha citrata, and Lavandula angustifolia were highly toxic with LD50 < or =0.05 microl/larvae. Pavela 2005
Lavandula angustifolia oil shows both fungistatic and fungicidal activity against Candida albicans strains and at lower concentrations, it inhibits germ tube formation and hyphal elongation. D'Auria 2005
Lavandula angustifolia oil (0.80 mg/plate) showed moderate antimutagenic activity against the TA98 strain exposed to the direct mutagen 1-nitropyrene. Its antimutagenic property makes lavender oil a promising candidate for new applications in human healthcare. Evandri 2005
Seven Lebanese plants, used traditionally for Alzheimer's disease, epilepsy and depression, when tested for inhibition of acetylcholinesterase, ethyl acetate extracts of 3 plants including Lavandula officinalis, exhibited weak activity. Salah 2005
The effectiveness of 18 selected essential oils, including Lavandula latifolia, L. angustifolia, and three hybrids, was examined for control of growth and survival of pathogenic microorganisms of significant importance in food hygiene. Rota 2004
It is demonstrated that lavender oil from L. angustifolia is cytotoxic to human skin cells in vitro (endothelial cells and fibroblasts) at a concentration of 0.25% (v/v) in all cell types tested (HMEC-1, HNDF and 153BR). Prashar 2004
Cell cultures of Lavandula officinalis were analyzed for the metabolite profile under normal growth conditions and under stress as well as jasmonic acid treatment. Caffeic acid and rosmarinic acid from the culture have a low cytotoxic potential in vitro using acute myeloid leukemia cells. Nitzsche 2004
The antifungal effect of 6 essential oils including Lavandula angustifolia, L. Reverchon, and six chemotypes of Thymus vulgaris L. on Candida albicans growth were studied. Giordani 2004
Antifungal activities of the essential oils of 8 plants including Lavandula angustifolia were investigated by disk diffusion assay and the broth dilution method against Aspergillus niger and A. flavus with minimal inhibitory concentrations in the range 0.78-12.5 mg/mL. Shin 2003
The essential oils from aerial parts of plants like Lavandula angustifolia, Salvia officinalis, and Mentha piperita were evaluated for their antimicrobial activities against five food spoilage yeasts including Torulaspora delbrueckii, Zygosaccharomyces bailii. Araújo 2003
Aqueous extract of Lavandula angustifolia flower at doses of 100 microg ml(-1) and 1 mg ml(-1) significantly blocked glutamate-induced neurotoxicity, in rat pups cerebellar granular cell culture. Büyükokuroðlu 2003
Some essential oils from plants like Artemisia verlotorum, Lavandula augustifolia & Ocimum gratissimum have proved to have acaricidal, antifungal and antibacterial activity. Cafarchia 2002
Essential oils of Eulcalyptus globulus, Lavender officinalis, Rosemarinus officinalis, and Thymus vulgaris effectively repelled adult mosquitoes Culex pipiens pallens on hairless mice. Choi 2002
The short-term actions of Lavandula officinalis and Equisetum arvense dry extracts, and of isoquercitrin, flavonoid present in Equisetum arvense, on in vitro fermentation by rumen microbes were studied in batch culture. Broudiscou 2000
Lavandula angustifolia has a spasmolytic activity on guinea pig ileum and rat uterus in vitro and it also decreases the tone in the skeletal muscle preparation of the phrenic nerve-diaphragm of rats. Lis-Balchin 1999
Lipid peroxidation is inhibited, concentration dependently, by aqueous methanolic extracts from the aerial parts of Salvia officinalis, Melissa officinalis and Lavandula angustifolia. Hohmann 1999
Raloxifene, retinoids, and lavender: "me too" tamoxifen alternatives under study. Ziegler 1996
Mecamylamine, a nicotinic receptor antagonist, reduced conditioned learning by bees without affecting responsiveness to olfactory stimuli (geraniol, lavender and vanillin) Lozano 1996
Bacteria, filamentous fungi & yeasts were subjected to action of Lavandula officinalis, Melissa officinalis & Rosmarinus officinalis essences in steam phase, using a microatmospheric technique. L. officinalis essence was more active in filamentous fungi than other essential oils studied. Larrondo 1995
Lavandula angustifolia Miller essential oil and some of its main constituents, i.e. linalool, linalyl acetate, and camphor were tested in vitro for their bioactivities against Psoroptes cuniculi (Delafond, 1859), mite of the rabbit. Perrucci 1994
History of Record
ORIGINAL RESEARCH BY: Soaring Bear, PhD
1998
MAJOR REVISION BY: Michael Tims, PhD
2001
LATEST UPDATES BY: Bernard Somers, BS, PhD candidate
April 2021